Detailed information for compound 21747

Basic information

Technical information
  • TDR Targets ID: 21747
  • Name: N-(1-adamantyl)-4,6-dimethylpyridin-2-amine
  • MW: 256.386 | Formula: C17H24N2
  • H donors: 1 H acceptors: 1 LogP: 4.61 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(nc(c1)C)NC12CC3CC(C2)CC(C1)C3
  • InChi: 1S/C17H24N2/c1-11-3-12(2)18-16(4-11)19-17-8-13-5-14(9-17)7-15(6-13)10-17/h3-4,13-15H,5-10H2,1-2H3,(H,18,19)
  • InChiKey: MQKSYCZTUUVJGS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(1-adamantyl)-4,6-dimethyl-pyridin-2-amine
  • N-(1-adamantyl)-4,6-dimethyl-2-pyridinamine
  • 1-adamantyl-(4,6-dimethyl-2-pyridyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0026 0.0035 0.0018
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0141 0.1449 0.2491
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0395 0.4555 1
Onchocerca volvulus Cell death protein 3 homolog 0.022 0.2416 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Schistosoma mansoni glutamate receptor kainate 0.0036 0.0156 0.0139
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.0046 0.0279 0.0541
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0018
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0426 0.4941 1
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0051 0.0342 0.0435
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0174 0.1849 0.3699
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0046 0.0279 0.0303
Echinococcus granulosus apoptotic protease activating factor 1 0.0046 0.0287 0.055
Brugia malayi Glutamate receptor 2 precursor 0.0036 0.0156 0.0247
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0097 0.0905 0.1746
Trypanosoma brucei ubiquitin-conjugating enzyme E2, putative 0.0051 0.0342 0.0136
Loa Loa (eye worm) hypothetical protein 0.0141 0.1449 0.2933
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0135 0.1369 0.1354
Brugia malayi Pepsin A precursor 0.0034 0.0133 0.0201
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) 0.0046 0.0279 0.0389
Echinococcus granulosus glycoprotein Antigen 5 0.0026 0.0035 0.0037
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Echinococcus multilocularis Mastin 0.0026 0.0035 0.0037
Brugia malayi aspartic protease BmAsp-1, identical 0.0034 0.0133 0.0201
Brugia malayi ube2i2 protein 0.0051 0.0342 0.0627
Brugia malayi Kelch motif family protein 0.0046 0.0283 0.0507
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0156 0.0282
Schistosoma mansoni caspase-3 (C14 family) 0.041 0.474 0.4731
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0133 0.0117
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0097 0.0905 0.1805
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Loa Loa (eye worm) trypsin family protein 0.0026 0.0035 0.007
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0026 0.0035 0.0037
Plasmodium vivax metacaspase 1, putative 0.0174 0.1849 0.3569
Echinococcus granulosus enteropeptidase 0.0026 0.0035 0.0037
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0051 0.0342 0.0111
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0097 0.0905 0.1321
Brugia malayi Eukaryotic aspartyl protease family protein 0.0034 0.0133 0.0201
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0121 0.1204 0.1963
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0097 0.0905 0.3656
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0097 0.0905 0.1797
Plasmodium falciparum SUMO-conjugating enzyme UBC9 0.0051 0.0342 0.0435
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0395 0.4555 1
Schistosoma mansoni ubiquitin-conjugating enzyme E2 I 0.0051 0.0342 0.0326
Echinococcus granulosus cathepsin b 0.0141 0.1449 0.2909
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0018
Schistosoma mansoni hypothetical protein 0.0095 0.0879 0.0863
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0426 0.4941 1
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.1849 0.3881
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0426 0.4941 1
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0135 0.1369 0.2746
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.1849 0.3881
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.1849 0.3881
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0036 0.0156 0.0282
Loa Loa (eye worm) reprolysin 0.0044 0.0258 0.0522
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0174 0.1849 0.3569
Loa Loa (eye worm) hypothetical protein 0.0034 0.0132 0.0266
Schistosoma mansoni glutamate receptor AMPA 0.0036 0.0156 0.0139
Echinococcus granulosus glutamate NMDA receptor subunit 0.0036 0.0156 0.0282
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.2172 0.4357
Loa Loa (eye worm) hypothetical protein 0.0046 0.0287 0.0581
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0018
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0174 0.1849 0.1836
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Toxoplasma gondii subtilisin SUB1 0.0175 0.1868 0.3608
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0135 0.1369 0.2318
Echinococcus multilocularis enteropeptidase 0.0026 0.0035 0.0037
Echinococcus granulosus caspase 8 0.0174 0.1849 0.3722
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0135 0.1369 0.2337
Brugia malayi Guanylate kinase family protein 0.0027 0.0047 0.0025
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0097 0.0905 0.089
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0097 0.0905 0.1343
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0174 0.1849 0.3569
Loa Loa (eye worm) aspartyl protease 6 0.0034 0.0133 0.027
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0036 0.0156 0.0282
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0036 0.0156 0.0282
Schistosoma mansoni integrin beta subunit 0.0178 0.1902 0.1889
Echinococcus multilocularis ubiquitin conjugating enzyme e2 i 0.0051 0.0342 0.0661
Brugia malayi Cell death protein 3 precursor 0.022 0.2416 0.4854
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0426 0.4941 1
Brugia malayi hypothetical protein 0.0046 0.0283 0.0507
Echinococcus granulosus adam 0.0067 0.0543 0.107
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0034 0.0133 0.0237
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Echinococcus granulosus transmembrane protease serine 3 0.0026 0.0035 0.0037
Plasmodium falciparum eukaryotic initiation factor 4A 0.0097 0.0905 0.1606
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0426 0.4941 0.4932
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0426 0.4941 1
Toxoplasma gondii cathepsin B 0.0047 0.0291 0.0328
Echinococcus multilocularis adam 0.0067 0.0543 0.107
Echinococcus multilocularis caspase 8 0.0174 0.1849 0.3722
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0135 0.1369 0.2612
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0051 0.0342 0.0111
Plasmodium falciparum metacaspase-like protein 0.0174 0.1849 0.3569
Brugia malayi aspartic protease BmAsp-2, identical 0.0034 0.0133 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.1849 0.3881
Echinococcus multilocularis caspase 3 0.0236 0.2611 0.5269
Echinococcus multilocularis caspase 0.041 0.474 0.9592
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0156 0.0282
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0142 0.1459 0.3041
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Echinococcus granulosus ubiquitin conjugating enzyme e2 i 0.0051 0.0342 0.0661
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.1449 0.1435
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0097 0.0905 0.1746
Schistosoma mansoni glutamate receptor kainate 0.0036 0.0156 0.0139
Schistosoma mansoni caspase-7 (C14 family) 0.022 0.2416 0.2403
Onchocerca volvulus 0.0034 0.0133 0.0414
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0044 0.0258 0.049
Trichomonas vaginalis ubiquitin-conjugating enzyme rad6, putative 0.0051 0.0342 0.0473
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0034 0.0133 0.027
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0133 0.0117
Schistosoma mansoni caspase-7 (C14 family) 0.041 0.474 0.4731
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0156 0.0282
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Echinococcus granulosus eukaryotic initiation factor 4A 0.0097 0.0905 0.1805
Plasmodium falciparum subtilisin-like protease 1 0.0175 0.1868 0.3608
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0156 0.0282
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Giardia lamblia UBC3 0.0051 0.0342 0.0838
Echinococcus multilocularis caspase 2 0.022 0.2416 0.4873
Trypanosoma brucei metacaspase 0.0174 0.1849 0.3368
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0046 0.0279 0.0303
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0097 0.0905 1
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0135 0.1369 0.2337
Trypanosoma brucei cysteine peptidase C (CPC) 0.0047 0.0291 0.0025
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0135 0.1369 0.2337
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.1849 0.3881
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0322 0.0652
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0135 0.1369 0.2318
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Brugia malayi hypothetical protein 0.0057 0.0424 0.0793
Mycobacterium ulcerans transcriptional regulator NrdR 0.0031 0.0106 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0047 0.0291 0.0356
Trypanosoma brucei metacaspase 5, putative 0.0174 0.1849 0.3368
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0258 0.0242
Echinococcus multilocularis glutamate receptor 2 0.0036 0.0156 0.0282
Trypanosoma brucei Metacaspase-4 0.0174 0.1849 0.3368
Plasmodium vivax SUMO-conjugating enzyme UBC9, putative 0.0051 0.0342 0.0435
Echinococcus granulosus kelch ECH associated protein 1 like 0.0094 0.0875 0.1744
Loa Loa (eye worm) cathepsin B 0.0047 0.0291 0.0589
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Echinococcus granulosus kelch ECH associated protein 1 0.0094 0.0875 0.1744
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0426 0.4941 1
Trypanosoma cruzi metacaspase, putative 0.0174 0.1849 0.3352
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0156 0.0282
Brugia malayi Probable ATP-dependent helicase DHX35 0.0033 0.012 0.0173
Trypanosoma brucei metacaspase MCA2 0.0174 0.1849 0.3368
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0156 0.0282
Loa Loa (eye worm) hypothetical protein 0.0046 0.0283 0.0573
Leishmania major metacaspase, putative 0.0174 0.1849 0.3352
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Brugia malayi hypothetical protein 0.0034 0.0133 0.0201
Schistosoma mansoni glutamate receptor AMPA 0.0036 0.0156 0.0139
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.041 0.474 0.9592
Brugia malayi ribonucleotide reductase 2 0.0135 0.1369 0.2719
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0132 0.0198
Trypanosoma cruzi metacaspase 5, putative 0.0174 0.1849 0.3352
Brugia malayi Reprolysin 0.0026 0.0035 0.0001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Echinococcus granulosus integrin beta 2 0.0224 0.2465 0.4972
Echinococcus multilocularis glycoprotein Antigen 5 0.0026 0.0035 0.0037
Treponema pallidum ribonucleotide-diphosphate reductase subunit beta 0.0135 0.1369 0.1148
Loa Loa (eye worm) hypothetical protein 0.022 0.2416 0.489
Leishmania major eukaryotic initiation factor 4a, putative 0.0097 0.0905 0.1321
Loa Loa (eye worm) ube2i2 protein 0.0051 0.0342 0.0693
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0426 0.4941 1
Trypanosoma cruzi metacaspase, putative 0.0174 0.1849 0.3352
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Brugia malayi hypothetical protein 0.0046 0.0287 0.0515
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0135 0.1369 0.2318
Trypanosoma cruzi metacaspase, putative 0.0174 0.1849 0.3352
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0135 0.1369 0.257
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0426 0.4941 1
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0097 0.0905 0.1805
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0426 0.4941 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.0046 0.0287 0.055
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0051 0.0342 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.1849 0.3881
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0135 0.1369 0.257
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.1449 0.1435
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0135 0.1369 0.2318
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0097 0.0905 1
Brugia malayi hypothetical protein 0.0034 0.0133 0.0201
Trypanosoma cruzi metacaspase, putative 0.0174 0.1849 0.3352
Leishmania major eukaryotic initiation factor 4a, putative 0.0097 0.0905 0.1321
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0395 0.4555 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0037
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0018
Trypanosoma brucei metacaspase MCA3 0.0174 0.1849 0.3368
Loa Loa (eye worm) hypothetical protein 0.0034 0.0133 0.027
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0135 0.1369 0.257
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0097 0.0905 0.1805
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0034 0.0133 0.027
Loa Loa (eye worm) hypothetical protein 0.0097 0.0905 0.1832
Trypanosoma cruzi metacaspase 5, putative 0.0174 0.1849 0.3352
Schistosoma mansoni hypothetical protein 0.0046 0.0287 0.0271
Loa Loa (eye worm) hypothetical protein 0.0033 0.012 0.0242
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0026 0.0035 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0322 0.0586
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0426 0.4941 1
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0097 0.0905 0.1606
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0135 0.1369 0.2337
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0141 0.1449 0.1435
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Echinococcus multilocularis cathepsin b 0.0141 0.1449 0.2909
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0395 0.4555 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0167 0.1761 0.3543
Loa Loa (eye worm) DEAH box polypeptide 35 0.0033 0.012 0.0242
Echinococcus granulosus kelch ECH associated protein 1 like 0.0094 0.0875 0.1744
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.041 0.474 0.9592
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Plasmodium falciparum metacaspase 1 0.0174 0.1849 0.3569
Echinococcus multilocularis glutamate receptor 2 0.0036 0.0156 0.0282
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0135 0.1369 0.2838
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0018
Loa Loa (eye worm) integrin beta-2 0.0303 0.3425 0.6932
Brugia malayi Integrin beta pat-3 precursor 0.0303 0.3425 0.6911
Echinococcus multilocularis kelch ECH associated protein 1 0.0094 0.0875 0.1744
Brugia malayi eukaryotic initiation factor 4A 0.0097 0.0905 0.1774
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Schistosoma mansoni hypothetical protein 0.0034 0.0132 0.0115
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0034 0.0133 0.0237
Loa Loa (eye worm) hypothetical protein 0.0034 0.0133 0.027
Brugia malayi Glutamate receptor 1 precursor 0.0036 0.0156 0.0247
Echinococcus multilocularis Kelch repeat type 1 0.0095 0.0879 0.1751
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0135 0.1369 0.277
Schistosoma mansoni glutamate receptor kainate 0.0036 0.0156 0.0139
Loa Loa (eye worm) hypothetical protein 0.0034 0.0133 0.027
Onchocerca volvulus 0.0034 0.0133 0.0414
Echinococcus granulosus caspase 3 0.0236 0.2611 0.5269
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Echinococcus granulosus cathepsin b 0.0141 0.1449 0.2909
Echinococcus granulosus caspase 2 0.022 0.2416 0.4873
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0167 0.1761 0.3543
Echinococcus granulosus caspase 0.041 0.474 0.9592
Echinococcus multilocularis kelch ECH associated protein 1 0.0094 0.0875 0.1744
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0097 0.0905 0.1321
Plasmodium vivax subtilisin-like protease 1 0.0175 0.1868 0.3608
Onchocerca volvulus 0.0046 0.0287 0.1061
Loa Loa (eye worm) hypothetical protein 0.0044 0.0258 0.0522
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0135 0.1369 0.2838
Schistosoma mansoni glutamate receptor NMDA 0.0036 0.0156 0.0139
Loa Loa (eye worm) glutamate receptor 1 0.0036 0.0156 0.0315
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.007
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0046 0.0283 0.0573
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0097 0.0905 0.1746
Echinococcus granulosus Mastin 0.0026 0.0035 0.0037
Schistosoma mansoni hypothetical protein 0.0026 0.0035 0.0018
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0018
Schistosoma mansoni glutamate receptor NMDA 0.0036 0.0156 0.0139
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0057 0.0424 0.0408
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0044 0.0258 0.049
Echinococcus multilocularis cathepsin b 0.0141 0.1449 0.2909
Schistosoma mansoni cercarial elastase (S01 family) 0.0026 0.0035 0.0018
Schistosoma mansoni ATP-binding cassette transporter 0.0036 0.0156 0.0139
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0026 0.0035 0.0037
Loa Loa (eye worm) glutamate receptor 2 0.0036 0.0156 0.0315
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0047 0.0291 0.0275
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0426 0.4941 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0141 0.1449 0.2883
Echinococcus multilocularis transmembrane protease serine 3 0.0026 0.0035 0.0037
Loa Loa (eye worm) hypothetical protein 0.0174 0.1849 0.3743
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0133 0.0117
Echinococcus multilocularis integrin beta 2 0.0224 0.2465 0.4972
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0026 0.0035 0.0018
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0395 0.4555 1
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0426 0.4941 1
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0097 0.0905 0.089
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0258 0.0242
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0174 0.1849 0.3569
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0026 0.0035 0.0037
Plasmodium vivax RNA helicase-1, putative 0.0097 0.0905 0.1606
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0141 0.1449 0.1435
Plasmodium vivax hypothetical protein, conserved 0.0174 0.1849 0.3569
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0135 0.1369 0.2746
Loa Loa (eye worm) hypothetical protein 0.02 0.2172 0.4397
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0174 0.1849 0.3881
Echinococcus granulosus glutamate receptor 2 0.0036 0.0156 0.0282

Activities

Activity type Activity value Assay description Source Reference
Control (functional) ~ 250 % TNF-alpha stimulatory activity of the compound in B78/TNF/9 melanoma cells evaluated by ELISA method ChEMBL. 11354376
Enhancement (functional) 0 % Tested for the ability to stimulate TNF-alpha production in B78-H1 murine melanoma cells transduced with gene for human TNF-alpha, clone-9 at 10 uM concentration; In active ChEMBL. 11354376

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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