TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 426.252 | Formula: C21H13Cl2N3O3
H donors: 2 H acceptors: 4 LogP: 4.35 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(c(c1)Cl)n1cc(C(=O)N)c(=O)c2c1cc(cc2)c1ccncc1Cl
InChi: 1S/C21H13Cl2N3O3/c22-16-8-12(27)2-4-18(16)26-10-15(21(24)29)20(28)14-3-1-11(7-19(14)26)13-5-6-25-9-17(13)23/h1-10,27H,(H2,24,29)
InChiKey: XSQLNMFYTBVBOK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	calpain 1, (mu/I) large subunit	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	family C2 unassigned peptidase C02 family	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Calpain-A, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Calpain-1 catalytic subunit, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Onchocerca volvulus		Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	calpain family protein 1, d	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	ko:K08585 calpain, invertebrate, putative	Get druggable targets OG5_127139	All targets in OG5_127139

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	calpain A	calpain 1, (mu/I) large subunit	714 aa	753 aa	31.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0417	0.0417
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0057	0.0406	0.034
Schistosoma mansoni	hypothetical protein	0.0057	0.0406	0.034
Echinococcus multilocularis	neuropeptide Y receptor	0.0057	0.0406	0.034
Echinococcus granulosus	calpain A	0.0069	0.0523	0.046
Echinococcus granulosus	7tm_1 domain containing protein	0.0057	0.0406	0.034
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.012	0.1048	0.1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0057	0.0406	0.034
Leishmania major	cathepsin L-like protease	0.0535	0.5267	1
Entamoeba histolytica	cysteine protease, putative	0.0288	0.2759	0.5238
Onchocerca volvulus		0.0057	0.0406	0.049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0406	0.034
Echinococcus granulosus	g-protein coupled receptor	0.0057	0.0406	0.034
Brugia malayi	Serotonin receptor	0.0318	0.306	0.306
Loa Loa (eye worm)	hypothetical protein	0.0367	0.3557	0.3557
Echinococcus granulosus	cathepsin L cysteine protease	0.0288	0.2759	0.2759
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0057	0.0406	0.034
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0057	0.0406	0.0406
Entamoeba histolytica	cysteine protease, putative	0.0288	0.2759	0.5238
Echinococcus granulosus	biogenic amine 5HT receptor	0.0126	0.1109	0.1062
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0086	0.001
Loa Loa (eye worm)	hypothetical protein	0.012	0.1048	0.1048
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.5267	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0367	0.3557	0.358
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Toxoplasma gondii	cathepsin CPL	0.0535	0.5267	1
Leishmania major	pyruvate kinase	0.0033	0.0156	0.0297
Echinococcus granulosus	cysteine protease	0.0288	0.2759	0.2759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.5267	1
Echinococcus multilocularis	orexin receptor type 2	0.0057	0.0406	0.034
Loa Loa (eye worm)	G-protein coupled receptor	0.0057	0.0406	0.0406
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0057	0.0406	0.049
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0057	0.0406	0.034
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0057	0.0406	0.034
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.012	0.1048	0.1746
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.012	0.1048	0.1768
Loa Loa (eye worm)	hypothetical protein	0.0168	0.1533	0.1533
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0076	0.0144
Echinococcus multilocularis	calpain A	0.0069	0.0523	0.046
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0126	0.1109	0.1062
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.012	0.1048	0.1991
Plasmodium vivax	vivapain-1	0.0288	0.2759	0.5168
Schistosoma mansoni	cathepsin F (C01 family)	0.0535	0.5267	0.5339
Schistosoma mansoni	hypothetical protein	0.0166	0.1515	0.148
Echinococcus granulosus	7TM GPCR rhodopsin	0.0057	0.0406	0.034
Echinococcus multilocularis	cathepsin L cysteine protease	0.0535	0.5267	0.5339
Trypanosoma cruzi	cruzipain precursor, putative	0.0535	0.5267	0.5375
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.012	0.1048	0.1048
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Entamoeba histolytica	cysteine protease, putative	0.012	0.1048	0.1991
Entamoeba histolytica	cysteine protease, putative	0.012	0.1048	0.1991
Trypanosoma brucei	pyruvate kinase 1, putative	0.0033	0.0156	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0535	0.5267	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0057	0.0406	0.034
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0406	0.034
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1414	0.1414
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0288	0.2759	0.2815
Loa Loa (eye worm)	TYRA-2 protein	0.0057	0.0406	0.0406
Brugia malayi	cathepsin B-like cysteine proteinase	0.098	0.9798	0.9798
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0156	0.0156
Echinococcus granulosus	pyruvate kinase	0.0033	0.0156	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Echinococcus granulosus	sex peptide receptor	0.0057	0.0406	0.034
Onchocerca volvulus		0.0057	0.0406	0.049
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0057	0.0406	0.0406
Giardia lamblia	Cathepsin B precursor	0.0386	0.3754	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.012	0.1048	0.1
Schistosoma mansoni	amine GPCR	0.0057	0.0406	0.034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0535	0.5267	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.5267	1
Onchocerca volvulus		0.0057	0.0406	0.049
Onchocerca volvulus	Cathepsin L homolog	0.0535	0.5267	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0034	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Onchocerca volvulus		0.0057	0.0406	0.049
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0025	0.0076	0.0078
Giardia lamblia	Cathepsin L-like protease	0.012	0.1048	0.248
Echinococcus granulosus	G protein coupled receptor 139	0.0057	0.0406	0.034
Onchocerca volvulus		0.0051	0.0346	0.0372
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0288	0.2759	0.5105
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0057	0.0406	0.034
Brugia malayi	putative neuropeptide receptor NPR1	0.0057	0.0406	0.0406
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.012	0.1048	0.1
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0156	0.0156
Entamoeba histolytica	cysteine protease, putative	0.0288	0.2759	0.5238
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0535	0.5267	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0535	0.5267	1
Echinococcus multilocularis	somatostatin receptor	0.0057	0.0406	0.034
Echinococcus multilocularis	G protein coupled receptor 139	0.0057	0.0406	0.034
Loa Loa (eye worm)	hypothetical protein	0.0168	0.1533	0.1533
Giardia lamblia	Cathepsin B precursor	0.0386	0.3754	1
Leishmania major	cathepsin L-like protease	0.0535	0.5267	1
Brugia malayi	Papain family cysteine protease containing protein	0.0288	0.2759	0.2759
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.012	0.1048	0.1768
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0057	0.0406	0.034
Plasmodium falciparum	serine repeat antigen 9	0.012	0.1048	0.1746
Brugia malayi	Cathepsin L-like precursor	0.0367	0.3557	0.3557
Schistosoma mansoni	myosin xvIII	0.0057	0.0406	0.034
Entamoeba histolytica	cysteine proteinase, putative	0.0535	0.5267	1
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1414	0.1414
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0057	0.0406	0.034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.5267	1
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0076	0.0144
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0033	0.0156	0.5
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.012	0.1048	0.1874
Treponema pallidum	sodium- and chloride- dependent transporter	0.0051	0.0346	0.5
Schistosoma mansoni	hypothetical protein	0.0057	0.0406	0.034
Brugia malayi	Papain family cysteine protease containing protein	0.012	0.1048	0.1048
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0535	0.5267	1
Entamoeba histolytica	cysteine protease, putative	0.012	0.1048	0.1991
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.012	0.1048	0.1874
Echinococcus multilocularis	neuropeptide s receptor	0.0057	0.0406	0.034
Loa Loa (eye worm)	hypothetical protein	0.098	0.9798	0.9798
Giardia lamblia	Cathepsin L precursor	0.012	0.1048	0.248
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.5267	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.012	0.1048	0.1874
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.5267	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0535	0.5267	1
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0156	0.0159
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0076	0.0078
Loa Loa (eye worm)	norepinephrine transporter	0.0051	0.0346	0.0346
Loa Loa (eye worm)	fibroinase	0.0535	0.5267	0.5267
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Brugia malayi	cathepsin F-like cysteine proteinase	0.0168	0.1533	0.1533
Schistosoma mansoni	cathepsin B (C01 family)	0.012	0.1048	0.1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.012	0.1048	0.1874
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.012	0.1048	0.1768
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.012	0.1048	0.1
Schistosoma mansoni	amine GPCR	0.0057	0.0406	0.034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0535	0.5267	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0076	0.0078
Echinococcus granulosus	cathepsin L	0.0288	0.2759	0.2759
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.012	0.1048	0.1768
Echinococcus granulosus	neuropeptides capa receptor	0.0057	0.0406	0.034
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0493	0.0493
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.1048	0.1768
Plasmodium falciparum	serine repeat antigen 5	0.012	0.1048	0.1746
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.012	0.1048	0.1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0535	0.5267	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Onchocerca volvulus		0.0057	0.0406	0.049
Loa Loa (eye worm)	hypothetical protein	0.0029	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.012	0.1048	0.1048
Brugia malayi	Serotonin receptor	0.0057	0.0406	0.0406
Echinococcus granulosus	somatostatin receptor	0.0057	0.0406	0.034
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0057	0.0406	0.034
Giardia lamblia	Cysteine protease	0.012	0.1048	0.248
Echinococcus multilocularis	serotonin transporter	0.0051	0.0346	0.0278
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.012	0.1048	0.1746
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0076	0.0078
Brugia malayi	Cathepsin L-like precursor	0.0535	0.5267	0.5267
Trypanosoma cruzi	major cysteine proteinase, putative	0.012	0.1048	0.107
Schistosoma mansoni	cathepsin S (C01 family)	0.012	0.1048	0.1
Brugia malayi	cathepsin L precursor	0.012	0.1048	0.1048
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.5267	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.012	0.1048	0.1768
Brugia malayi	cathepsin Z-like cysteine proteinase	0.012	0.1048	0.1048
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.012	0.1048	0.1874
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.098	0.9798	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0535	0.5267	0.5339
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Plasmodium falciparum	serine repeat antigen 3	0.012	0.1048	0.1746
Onchocerca volvulus		0.0041	0.024	0.0165
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0057	0.0406	0.034
Brugia malayi	G protein-coupled receptor	0.0057	0.0406	0.0406
Plasmodium vivax	vivapain-2	0.0535	0.5267	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.012	0.1048	0.1
Onchocerca volvulus		0.0057	0.0406	0.049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.5267	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0057	0.0406	0.034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0535	0.5267	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.012	0.1048	0.248
Schistosoma mansoni	neuropeptide F-like receptor	0.0057	0.0406	0.034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.012	0.1048	0.1768
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0057	0.0406	0.034
Schistosoma mansoni	cathepsin C	0.012	0.1048	0.1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0034	0.0165	0.0165
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0535	0.5267	0.5267
Echinococcus granulosus	orexin receptor type 2	0.0057	0.0406	0.034
Plasmodium falciparum	serine repeat antigen 4	0.012	0.1048	0.1746
Entamoeba histolytica	cysteine protease, putative	0.0288	0.2759	0.5238
Trypanosoma cruzi	cysteine peptidase, putative	0.0535	0.5267	0.5375
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.5267	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0316	0.0316
Brugia malayi	hypothetical protein	0.0057	0.0406	0.0406
Schistosoma mansoni	hypothetical protein	0.0057	0.0406	0.034
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.012	0.1048	0.1768
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.012	0.1048	0.1991
Schistosoma mansoni	hypothetical protein	0.0057	0.0406	0.034
Entamoeba histolytica	hypothetical protein	0.012	0.1048	0.1991
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0033	0.0156	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0535	0.5267	1
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0069	0.0523	0.046
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0025	0.0076	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Loa Loa (eye worm)	neuropeptide F receptor	0.0057	0.0406	0.0406
Echinococcus granulosus	microtubule associated protein 2	0.0677	0.6711	0.6825
Echinococcus granulosus	fmrfamide receptor	0.0057	0.0406	0.034
Plasmodium falciparum	serine repeat antigen 1	0.012	0.1048	0.1746
Entamoeba histolytica	cysteine proteinase, putative	0.0288	0.2759	0.5238
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0386	0.3754	0.7129
Loa Loa (eye worm)	G-protein coupled receptor	0.0057	0.0406	0.0406
Brugia malayi	neuropeptide F receptor	0.0057	0.0406	0.0406
Leishmania major	cathepsin L-like protease	0.0535	0.5267	1
Schistosoma mansoni	pyruvate kinase	0.0033	0.0156	0.0083
Loa Loa (eye worm)	calpain family protein 1	0.0066	0.0493	0.0493
Brugia malayi	G-protein coupled receptor	0.0057	0.0406	0.0406
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0051	0.0346	0.0346
Echinococcus multilocularis	fmrfamide receptor	0.0057	0.0406	0.034
Echinococcus granulosus	neuropeptide s receptor	0.0057	0.0406	0.034
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0367	0.3557	0.6663
Entamoeba histolytica	cysteine protease, putative	0.012	0.1048	0.1991
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0051	0.0346	0.0346
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0034	0.0165	0.0092
Giardia lamblia	Cathepsin B precursor	0.012	0.1048	0.248
Entamoeba histolytica	cysteine proteinase, putative	0.0288	0.2759	0.5238
Onchocerca volvulus		0.0535	0.5267	1
Giardia lamblia	Cathepsin L precursor	0.012	0.1048	0.248
Echinococcus multilocularis	allatostatin A receptor	0.0057	0.0406	0.034
Onchocerca volvulus		0.0057	0.0406	0.049
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0076	0.0144
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0168	0.1533	0.1533
Trypanosoma brucei	antigen, putative	0.0025	0.0076	0.0144
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Echinococcus granulosus	neuropeptide FF receptor 2	0.0057	0.0406	0.034
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0156	0.0083
Giardia lamblia	Hypothetical protein	0.012	0.1048	0.248
Entamoeba histolytica	pyruvate kinase, putative	0.0023	0.0055	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Plasmodium vivax	unspecified product	0.0288	0.2759	0.5168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0535	0.5267	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.1048	0.1048
Loa Loa (eye worm)	hypothetical protein	0.0126	0.1109	0.1109
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0069	0.0523	0.046
Brugia malayi	neuropeptide F receptor	0.0057	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0051	0.0346	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Brugia malayi	GnHR receptor homolog	0.0057	0.0406	0.0406
Plasmodium vivax	serine-repeat antigen (SERA)	0.012	0.1048	0.1874
Onchocerca volvulus		0.0057	0.0406	0.049
Onchocerca volvulus		0.0057	0.0406	0.049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Entamoeba histolytica	cysteine protease, putative	0.0288	0.2759	0.5238
Plasmodium vivax	serine-repeat antigen (SERA)	0.012	0.1048	0.1874
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0406	0.034
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Brugia malayi	Cathepsin L-like precursor	0.0168	0.1533	0.1533
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0057	0.0406	0.034
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0535	0.5267	0.5339
Giardia lamblia	Cathepsin L precursor	0.012	0.1048	0.248
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.012	0.1048	0.1768
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.012	0.1048	0.1768
Schistosoma mansoni	neuropeptide F-like receptor	0.0057	0.0406	0.034
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0406	0.034
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.012	0.1048	0.1048
Echinococcus granulosus	neuropeptide receptor	0.0057	0.0406	0.034
Entamoeba histolytica	cysteine protease, putative	0.0288	0.2759	0.5238
Schistosoma mansoni	sodium/chloride dependent transporter	0.0051	0.0346	0.0278
Brugia malayi	Papain family cysteine protease containing protein	0.0288	0.2759	0.2759
Echinococcus granulosus	serotonin receptor	0.0057	0.0406	0.034
Brugia malayi	cathepsin F-like cysteine proteinase	0.012	0.1048	0.1048
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0406	0.034
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0057	0.0406	0.034
Echinococcus granulosus	neuropeptide receptor	0.0057	0.0406	0.034
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0406	0.034
Brugia malayi	hypothetical protein	0.0057	0.0406	0.0406
Loa Loa (eye worm)	cathepsin B	0.0386	0.3754	0.3754
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0406	0.034
Giardia lamblia	Cathepsin L-like protease	0.012	0.1048	0.248
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0386	0.3754	0.3832
Loa Loa (eye worm)	hypothetical protein	0.0168	0.1533	0.1533
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.0055	0.0055
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0057	0.0406	0.034
Brugia malayi	Papain family cysteine protease containing protein	0.012	0.1048	0.1048
Echinococcus multilocularis	neuropeptide receptor A26	0.0057	0.0406	0.034
Giardia lamblia	Cathepsin B precursor	0.0386	0.3754	1
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.012	0.1048	0.1048
Toxoplasma gondii	preprocathepsin c precursor, putative	0.012	0.1048	0.1746
Onchocerca volvulus	Cathepsin F homolog	0.0535	0.5267	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.098	0.9798	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0057	0.0406	0.034
Giardia lamblia	Cathepsin B precursor	0.012	0.1048	0.248
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0535	0.5267	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0406	0.034
Loa Loa (eye worm)	hypothetical protein	0.0367	0.3557	0.3557
Brugia malayi	hypothetical protein	0.0057	0.0406	0.0406
Brugia malayi	Dopamine receptor	0.0057	0.0406	0.0406
Brugia malayi	cathepsin L-like cysteine proteinase	0.012	0.1048	0.1048
Schistosoma mansoni	opsin-like receptor	0.0057	0.0406	0.034
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0535	0.5267	1
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.1048	0.1768
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0076	0.0144
Brugia malayi	cathepsin Z-like cysteine proteinase	0.012	0.1048	0.1048
Brugia malayi	calpain 7	0.0025	0.0076	0.0076
Onchocerca volvulus		0.0057	0.0406	0.049
Loa Loa (eye worm)	hypothetical protein	0.0367	0.3557	0.3557
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0066	0.0493	0.0429
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0535	0.5267	0.5339
Schistosoma mansoni	amine GPCR	0.0057	0.0406	0.034
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0057	0.0406	0.0406
Brugia malayi	hypothetical protein	0.0057	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0156	0.0026
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0057	0.0406	0.034
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0057	0.0406	0.034
Echinococcus granulosus	biogenic amine 5HT receptor	0.0057	0.0406	0.034
Leishmania major	cathepsin L-like protease	0.0535	0.5267	1
Leishmania major	cathepsin L-like protease	0.0535	0.5267	1
Echinococcus granulosus	cathepsin l1	0.0535	0.5267	0.5339
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0406	0.034
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0288	0.2759	0.2759
Echinococcus multilocularis	cysteine protease	0.0535	0.5267	0.5339
Schistosoma mansoni	hypothetical protein	0.0166	0.1515	0.148
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0535	0.5267	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0406	0.034
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0288	0.2759	0.2759
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0406	0.034
Entamoeba histolytica	cysteine proteinase, putative	0.0288	0.2759	0.5238
Echinococcus multilocularis	microtubule associated protein 2	0.0677	0.6711	0.6825
Loa Loa (eye worm)	hypothetical protein	0.012	0.1048	0.1048
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0076	0.0144
Giardia lamblia	Cathepsin B precursor	0.012	0.1048	0.248
Trypanosoma cruzi	cysteine peptidase, putative	0.0535	0.5267	0.5375
Brugia malayi	Cathepsin L-like precursor	0.0535	0.5267	0.5267
Brugia malayi	calpain family protein 1	0.0066	0.0493	0.0493
Toxoplasma gondii	cathepsin CPC2	0.012	0.1048	0.1746
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0057	0.0406	0.034
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0406	0.034
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0069	0.0523	0.046
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.012	0.1048	0.1
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0406	0.034
Echinococcus granulosus	geminin	0.0166	0.1515	0.148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.5267	1
Loa Loa (eye worm)	calpain family protein 1	0.0048	0.0316	0.0316
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0535	0.5267	1
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0406	0.034
Loa Loa (eye worm)	neuropeptide F receptor	0.0057	0.0406	0.0406
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0406	0.034
Entamoeba histolytica	cysteine protease, putative	0.0288	0.2759	0.5238
Echinococcus multilocularis	geminin	0.0166	0.1515	0.148
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.012	0.1048	0.248
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0288	0.2759	0.5238
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.012	0.1048	0.1874
Brugia malayi	Papain family cysteine protease containing protein	0.0535	0.5267	0.5267
Echinococcus granulosus	neuropeptide Y receptor	0.0057	0.0406	0.034
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0197	0.0124
Brugia malayi	hypothetical protein	0.0057	0.0406	0.0406
Brugia malayi	RE15519p	0.0057	0.0406	0.0406
Toxoplasma gondii	hypothetical protein	0.0156	0.1414	0.2461
Onchocerca volvulus		0.0535	0.5267	1
Entamoeba histolytica	cysteine protease, putative	0.0288	0.2759	0.5238
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0406	0.034
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0535	0.5267	0.5267
Brugia malayi	Cathepsin L-like precursor	0.0535	0.5267	0.5267
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0288	0.2759	0.5092
Echinococcus multilocularis	g-protein coupled receptor	0.0057	0.0406	0.034
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0126	0.1109	0.1109
Echinococcus granulosus	cathepsin L	0.012	0.1048	0.1
Brugia malayi	ORL1-like opioid receptor	0.0057	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Leishmania major	cysteine peptidase A (CPA)	0.0535	0.5267	1
Echinococcus granulosus	hypothetical protein	0.0057	0.0406	0.034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0288	0.2759	0.5105
Echinococcus granulosus	neuropeptide receptor A26	0.0057	0.0406	0.034
Onchocerca volvulus		0.0367	0.3557	0.6654
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0535	0.5267	1
Schistosoma mansoni	microtubule-associated protein tau	0.0677	0.6711	0.6825
Echinococcus multilocularis	neuropeptides capa receptor	0.0057	0.0406	0.034
Brugia malayi	Melatonin receptor type 1A	0.0057	0.0406	0.0406
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0076	0.0078
Onchocerca volvulus		0.0535	0.5267	1
Schistosoma mansoni	opsin-like receptor	0.0057	0.0406	0.034
Echinococcus granulosus	neuropeptide Y receptor	0.0057	0.0406	0.034
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0406	0.034
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0057	0.0406	0.034
Giardia lamblia	Cathepsin L precursor	0.012	0.1048	0.248
Trypanosoma cruzi	cysteine peptidase, putative	0.0535	0.5267	0.5375
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0057	0.0406	0.034
Brugia malayi	calpain family protein 1	0.0066	0.0493	0.0493
Toxoplasma gondii	cathepsin CPC1	0.012	0.1048	0.1746
Entamoeba histolytica	cysteine protease, putative	0.0288	0.2759	0.5238
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0406	0.034
Schistosoma mansoni	opsin-like receptor	0.0057	0.0406	0.034
Brugia malayi	Cathepsin L-like precursor	0.0535	0.5267	0.5267
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.5267	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0367	0.3557	0.3557
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0386	0.3754	0.7049
Chlamydia trachomatis	pyruvate kinase	0.0033	0.0156	0.5
Plasmodium vivax	unspecified product	0.012	0.1048	0.1874
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0535	0.5267	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0535	0.5267	1
Brugia malayi	Cathepsin L-like precursor	0.0535	0.5267	0.5267
Entamoeba histolytica	cysteine protease, putative	0.0288	0.2759	0.5238
Echinococcus multilocularis	sex peptide receptor	0.0057	0.0406	0.034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.5267	1
Echinococcus granulosus	serotonin transporter	0.0051	0.0346	0.0278
Giardia lamblia	Cysteine protease	0.012	0.1048	0.248
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0406	0.034
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0386	0.3754	0.7129
Schistosoma mansoni	cathepsin F (C01 family)	0.0535	0.5267	0.5339
Plasmodium falciparum	serine repeat antigen 2	0.012	0.1048	0.1746
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0076	0.0078
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0535	0.5267	1
Brugia malayi	putative neuropeptide receptor	0.0057	0.0406	0.0406
Schistosoma mansoni	voltage-gated potassium channel	0.0037	0.0197	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0055	0.0055
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0406	0.034
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0057	0.0406	0.0406
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0069	0.0523	0.046
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0406	0.034
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0057	0.0406	0.034
Onchocerca volvulus		0.0535	0.5267	1
Brugia malayi	hypothetical protein	0.0057	0.0406	0.0406
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0386	0.3754	0.3784
Echinococcus multilocularis	cathepsin L	0.0288	0.2759	0.2759
Loa Loa (eye worm)	hypothetical protein	0.0041	0.024	0.024
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0535	0.5267	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Entamoeba histolytica	cysteine protease, putative	0.012	0.1048	0.1991
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Entamoeba histolytica	cysteine proteinase, putative	0.0288	0.2759	0.5238
Trypanosoma cruzi	cruzipain precursor, putative	0.0168	0.1533	0.1565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0367	0.3557	0.6663
Trypanosoma brucei	pyruvate kinase 1	0.0033	0.0156	0.0297
Onchocerca volvulus		0.0535	0.5267	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0346	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.012	0.1048	0.1768
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0535	0.5267	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0346	0.0346
Toxoplasma gondii	cathepsin B	0.0386	0.3754	0.7041
Giardia lamblia	Cathepsin B precursor	0.012	0.1048	0.248
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0034	0.0165	0.0092
Giardia lamblia	Cysteine protease	0.012	0.1048	0.248
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0168	0.1533	0.1533
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0076	0.0078
Onchocerca volvulus		0.0057	0.0406	0.049
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0156	0.0156
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0057	0.0406	0.034
Trypanosoma cruzi	cysteine peptidase, putative	0.0288	0.2759	0.2815
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0076	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1414	0.1414
Plasmodium falciparum	serine repeat antigen 6	0.012	0.1048	0.1746
Echinococcus multilocularis	cysteine protease	0.0535	0.5267	0.5339
Brugia malayi	G-protein coupled receptor	0.0057	0.0406	0.0406
Echinococcus multilocularis	neuropeptide receptor	0.0057	0.0406	0.034
Brugia malayi	hypothetical protein	0.0057	0.0406	0.0406
Schistosoma mansoni	amine GPCR	0.0057	0.0406	0.034
Leishmania major	cathepsin L-like protease	0.0535	0.5267	1
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0406	0.034
Onchocerca volvulus		0.0535	0.5267	1
Giardia lamblia	Cathepsin B precursor	0.012	0.1048	0.248
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0057	0.0406	0.0406
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.012	0.1048	0.1874
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0076	0.0144
Schistosoma mansoni	adenoreceptor	0.0057	0.0406	0.034
Echinococcus multilocularis	fmrfamide receptor	0.0057	0.0406	0.034
Echinococcus multilocularis	neuropeptide Y receptor	0.0057	0.0406	0.034
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.098	0.9798	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0057	0.0406	0.034
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0288	0.2759	0.2759
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.012	0.1048	0.1768
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.012	0.1048	0.248
Brugia malayi	cathepsin L-like precursor	0.0367	0.3557	0.3557
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0057	0.0406	0.034
Schistosoma mansoni	amine GPCR	0.0057	0.0406	0.034
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0057	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.012	0.1048	0.1768
Brugia malayi	Cathepsin L-like precursor	0.0367	0.3557	0.3557
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.012	0.1048	0.1874
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0057	0.0406	0.0406
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0057	0.0406	0.034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0406	0.034
Echinococcus multilocularis	cathepsin b	0.098	0.9798	1
Echinococcus multilocularis	serotonin receptor	0.0126	0.1109	0.1062
Brugia malayi	sulfakinin receptor protein	0.0057	0.0406	0.0406
Onchocerca volvulus		0.0057	0.0406	0.049
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0057	0.0406	0.034
Onchocerca volvulus		0.012	0.1048	0.1746
Echinococcus multilocularis	cathepsin b	0.098	0.9798	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0057	0.0406	0.0406
Brugia malayi	Cathepsin L-like precursor	0.0535	0.5267	0.5267
Brugia malayi	G protein-coupled receptor F59B2.13	0.0057	0.0406	0.0406
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.012	0.1048	0.248
Onchocerca volvulus		0.0057	0.0406	0.049
Onchocerca volvulus		0.0057	0.0406	0.049
Trypanosoma cruzi	cysteine proteinase, putative	0.0288	0.2759	0.2815
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0057	0.0406	0.034
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.012	0.1048	0.1874
Echinococcus granulosus	cathepsin b	0.098	0.9798	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0406	0.034
Loa Loa (eye worm)	melatonin receptor type 1A	0.0057	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.5267	1
Echinococcus granulosus	allatostatin A receptor	0.0057	0.0406	0.034
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0535	0.5267	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0057	0.0406	0.034
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0535	0.5267	0.5339
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0346	0.0346
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0057	0.0406	0.034
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.012	0.1048	0.1768
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0057	0.0406	0.034
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Loa Loa (eye worm)	cysteine protease	0.0535	0.5267	0.5267
Mycobacterium ulcerans	pyruvate kinase	0.0033	0.0156	0.5
Echinococcus granulosus	pyruvate kinase	0.0033	0.0156	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Brugia malayi	follicle stimulating hormone receptor	0.0057	0.0406	0.0406
Brugia malayi	hypothetical protein	0.0057	0.0406	0.0406
Brugia malayi	hypothetical protein	0.0057	0.0406	0.0406
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0057	0.0406	0.0406
Entamoeba histolytica	cysteine protease, putative	0.012	0.1048	0.1991
Loa Loa (eye worm)	serotonin transporter b	0.0051	0.0346	0.0346
Giardia lamblia	Encystation-specific protease	0.012	0.1048	0.248
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.012	0.1048	0.1
Entamoeba histolytica	cysteine protease, putative	0.0288	0.2759	0.5238
Trypanosoma cruzi	cysteine peptidase, putative	0.0168	0.1533	0.1565
Brugia malayi	Dopamine receptor protein 2	0.0057	0.0406	0.0406
Leishmania major	cathepsin L-like protease	0.0535	0.5267	1
Plasmodium vivax	unspecified product	0.0168	0.1533	0.2808
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0406	0.034
Loa Loa (eye worm)	hypothetical protein	0.012	0.1048	0.1048
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.012	0.1048	0.1768
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0156	0.1414	0.1414
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0076	0.0144
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0406	0.034
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0406	0.034
Schistosoma mansoni	pyruvate kinase	0.0033	0.0156	0.0083
Leishmania major	pyruvate kinase	0.0033	0.0156	0.0297
Onchocerca volvulus		0.0057	0.0406	0.049
Brugia malayi	hypothetical protein	0.0057	0.0406	0.0406
Brugia malayi	fibroinase precursor	0.012	0.1048	0.1048
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0406	0.034
Echinococcus multilocularis	cathepsin L cysteine protease	0.0535	0.5267	0.5339
Loa Loa (eye worm)	hypothetical protein	0.1	1	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Giardia lamblia	Cysteine protease	0.012	0.1048	0.248
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.012	0.1048	0.1768
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0156	0.0155
Onchocerca volvulus	Cathepsin L homolog	0.012	0.1048	0.1746
Giardia lamblia	Cathepsin L precursor	0.012	0.1048	0.248
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Trypanosoma cruzi	major cysteine proteinase, putative	0.012	0.1048	0.107
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Echinococcus granulosus	cathepsin l1	0.0367	0.3557	0.358
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.012	0.1048	0.1768
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0288	0.2759	0.5238
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Giardia lamblia	Cathepsin L precursor	0.012	0.1048	0.248
Entamoeba histolytica	cysteine protease, putative	0.0535	0.5267	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0057	0.0406	0.034
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0406	0.034
Schistosoma mansoni	histamine h1 receptor	0.0057	0.0406	0.034
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0535	0.5267	1
Echinococcus granulosus	neuropeptides capa receptor	0.0057	0.0406	0.034
Entamoeba histolytica	cysteine proteinase, putative	0.0367	0.3557	0.6753
Entamoeba histolytica	cysteine protease, putative	0.0288	0.2759	0.5238
Echinococcus multilocularis	cathepsin L	0.012	0.1048	0.1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0057	0.0406	0.034
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.098	0.9798	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0057	0.0406	0.034
Echinococcus multilocularis	dro:myosuppressin receptor	0.0057	0.0406	0.034
Echinococcus multilocularis	neuropeptide receptor	0.0057	0.0406	0.034
Trypanosoma cruzi	cysteine peptidase, putative	0.0535	0.5267	0.5375
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0535	0.5267	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0057	0.0406	0.034
Onchocerca volvulus		0.0057	0.0406	0.049
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0057	0.0406	0.0406
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.012	0.1048	0.1874
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0156	0.0156
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.012	0.1048	0.1
Onchocerca volvulus	Cathepsin L homolog	0.0535	0.5267	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0057	0.0406	0.0406
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0367	0.3557	0.363
Plasmodium falciparum	serine repeat antigen 7	0.012	0.1048	0.1746
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0406	0.034
Onchocerca volvulus		0.0535	0.5267	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Brugia malayi	Papain family cysteine protease containing protein	0.012	0.1048	0.1048
Schistosoma mansoni	cathepsin s	0.0168	0.1533	0.1499
Plasmodium vivax	vivapain-3	0.0288	0.2759	0.5168
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0535	0.5267	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0057	0.0406	0.049
Brugia malayi	larval opioid receptor	0.0057	0.0406	0.0406
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0406	0.034
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0406	0.0406
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0076	0.0078
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.012	0.1048	0.1048
Echinococcus granulosus	cathepsin b	0.098	0.9798	1
Loa Loa (eye worm)	ctsf protein	0.0535	0.5267	0.5267
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0076	0.0144
Loa Loa (eye worm)	calpain	0.0025	0.0076	0.0076
Entamoeba histolytica	cysteine proteinase 2	0.0288	0.2759	0.5238
Echinococcus multilocularis	calpain family protein 1, d	0.0048	0.0316	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0535	0.5267	0.5267
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0057	0.0406	0.034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.5267	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0288	0.2759	0.2815
Onchocerca volvulus		0.0057	0.0406	0.049
Plasmodium vivax	vivapain-2	0.0535	0.5267	1
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0156	0.0083
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0156	0.0159
Trypanosoma cruzi	cysteine protease, putative	0.0288	0.2759	0.2815
Brugia malayi	AKH receptor	0.0057	0.0406	0.0406
Entamoeba histolytica	cysteine proteinase 1, putative	0.0288	0.2759	0.5238
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0076	0.0078
Plasmodium falciparum	serine repeat antigen 8	0.012	0.1048	0.1746
Entamoeba histolytica	cysteine proteinase, putative	0.0535	0.5267	1
Giardia lamblia	Hypothetical protein	0.012	0.1048	0.248
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.012	0.1048	0.1768
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0406	0.034
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0057	0.0406	0.034
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0156	0.0156
Echinococcus multilocularis	serotonin receptor	0.0126	0.1109	0.1062
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.012	0.1048	0.1048
Leishmania major	cathepsin L-like protease	0.0535	0.5267	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.012	0.1048	0.1746
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.098	0.9798	1
Entamoeba histolytica	cysteine protease, putative	0.0288	0.2759	0.5238
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0156	0.0026

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2 uM	In vitro inhibitory activity against human erythrocyte Calpain 1	ChEMBL.	No reference
IC50 (binding)	= 2 uM	In vitro inhibitory activity against human erythrocyte Calpain 1	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 220722