EC50 (functional)
|
nM
|
Concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
|
ChEMBL.
|
9464368
|
EC50 (functional)
|
0 nM
|
Concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
|
ChEMBL.
|
9464368
|
EC50 (functional)
|
= 135.8 nM
|
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
|
ChEMBL.
|
9464368
|
EC50 (functional)
|
= 135.8 nM
|
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
|
ChEMBL.
|
9464368
|
EC50 (functional)
|
= 433.3 nM
|
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
|
ChEMBL.
|
9464368
|
EC50 (functional)
|
= 433.3 nM
|
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
|
ChEMBL.
|
9464368
|
IC50 (binding)
|
= 1.4 nM
|
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes
|
ChEMBL.
|
9464368
|
IC50 (binding)
|
= 1.4 nM
|
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes
|
ChEMBL.
|
9464368
|
IC50 (binding)
|
= 2.7 nM
|
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.
|
ChEMBL.
|
9464368
|
IC50 (binding)
|
= 2.7 nM
|
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.
|
ChEMBL.
|
9464368
|
IC50 (binding)
|
= 3.7 nM
|
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.
|
ChEMBL.
|
9464368
|
IC50 (binding)
|
= 3.7 nM
|
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.
|
ChEMBL.
|
9464368
|
IC50 (binding)
|
= 4.4 nM
|
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes
|
ChEMBL.
|
9464368
|
IC50 (binding)
|
= 4.4 nM
|
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes
|
ChEMBL.
|
9464368
|
IC50 (binding)
|
= 6.4 nM
|
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes
|
ChEMBL.
|
9464368
|
IC50 (binding)
|
= 6.4 nM
|
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes
|
ChEMBL.
|
9464368
|
IC50 (binding)
|
= 9 nM
|
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.
|
ChEMBL.
|
9464368
|
IC50 (binding)
|
= 9 nM
|
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.
|
ChEMBL.
|
9464368
|
Max (functional)
|
= 15.3 %
|
Maximum stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the muscarinic acetylcholine receptor M1 at 100 uM
|
ChEMBL.
|
9464368
|
Max (functional)
|
= 15.3 %
|
Maximum stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the muscarinic acetylcholine receptor M1 at 100 uM
|
ChEMBL.
|
9464368
|
Max (functional)
|
= 68.9 %
|
Maximum stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the muscarinic acetylcholine receptor M1 at 100 uM
|
ChEMBL.
|
9464368
|
Max (functional)
|
= 68.9 %
|
Maximum stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the muscarinic acetylcholine receptor M1 at 100 uM
|
ChEMBL.
|
9464368
|
Max (functional)
|
= 76.2 %
|
Maximum stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the muscarinic acetylcholine receptor M1 at 100 uM
|
ChEMBL.
|
9464368
|
Max (functional)
|
= 76.2 %
|
Maximum stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the muscarinic acetylcholine receptor M1 at 100 uM
|
ChEMBL.
|
9464368
|
Score (functional)
|
= 0
|
Intraperitoneal dose of 10 mg/Kg was tested for salivation in mice expressed as score.
|
ChEMBL.
|
9464368
|
Score (functional)
|
= 0.6
|
Compound at an intraperitoneal dose of 10 mg/Kg was tested for salivation in mice expressed as score
|
ChEMBL.
|
9464368
|
Score (functional)
|
= 1.2
|
Compound at an intraperitoneal dose of 10 mg/Kg was tested for salivation in mice expressed as score
|
ChEMBL.
|
9464368
|
Score (functional)
|
= 0
|
Intraperitoneal dose of 10 mg/Kg was tested for salivation in mice expressed as score.
|
ChEMBL.
|
9464368
|
Score (functional)
|
= 0.6
|
Compound at an intraperitoneal dose of 10 mg/Kg was tested for salivation in mice expressed as score
|
ChEMBL.
|
9464368
|
Score (functional)
|
= 1.2
|
Compound at an intraperitoneal dose of 10 mg/Kg was tested for salivation in mice expressed as score
|
ChEMBL.
|
9464368
|