Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0425 | 0.6064 | 0.4101 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0636 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0194 | 0.1761 | 0.5 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0636 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0508 | 0.7602 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0194 | 0.1761 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0508 | 0.7602 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0194 | 0.1761 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0508 | 0.7602 | 1 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0628 | 0.9838 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0194 | 0.1761 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0508 | 0.7602 | 0.4075 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0628 | 0.9838 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0508 | 0.7602 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.0798 | 0.105 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0508 | 0.7602 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0194 | 0.1761 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0508 | 0.7602 | 0.4075 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0508 | 0.7602 | 0.6505 |
Schistosoma mansoni | dihydrofolate reductase | 0.0508 | 0.7602 | 1 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0628 | 0.9838 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0194 | 0.1761 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 400 nM | In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined | ChEMBL. | 8254620 |
IC50 (binding) | = 400 nM | In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined | ChEMBL. | 8254620 |
IC50 (binding) | = 280 uM | Inhibition of Prostaglandin G/H synthase activity in sheep seminal vesicle was determined | ChEMBL. | 8254620 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.