Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Cholesteryl ester transfer protein | Starlite/ChEMBL | References |
Homo sapiens | cholesteryl ester transfer protein, plasma | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.061 | 0.9843 | 1 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0413 | 0.6177 | 0.4101 |
Onchocerca volvulus | 0.0081 | 0 | 0.5 | |
Onchocerca volvulus | 0.0081 | 0 | 0.5 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0081 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0619 | 1 | 0.5 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0619 | 1 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0081 | 0 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0081 | 0 | 0.5 |
Onchocerca volvulus | 0.0081 | 0 | 0.5 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0081 | 0 | 0.5 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.061 | 0.9843 | 1 |
Onchocerca volvulus | 0.0081 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0 | 0.5 |
Onchocerca volvulus | 0.0081 | 0 | 0.5 | |
Onchocerca volvulus | 0.0081 | 0 | 0.5 | |
Onchocerca volvulus | 0.0081 | 0 | 0.5 | |
Onchocerca volvulus | 0.0081 | 0 | 0.5 | |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.061 | 0.9843 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 uM | Concentration required for 50% inhibition of cholesteryl ester transfer protein in presence of buffer. | ChEMBL. | 12190312 |
IC50 (binding) | = 5 uM | Inhibition of recombinant human CETP-mediated transfer of [3H]-CE from HDL to LDL | ChEMBL. | 11101348 |
IC50 (binding) | = 5 uM | Concentration required for 50% inhibition of cholesteryl ester transfer protein in presence of buffer. | ChEMBL. | 12190312 |
IC50 (binding) | = 5 uM | Inhibition of recombinant human CETP-mediated transfer of [3H]-CE from HDL to LDL | ChEMBL. | 11101348 |
IC50 (binding) | = 5 uM | Inhibition of CETP in rabbit serum after 1 hr by fluorescent cholesteryl esters transfer assay | ChEMBL. | 20116902 |
Inhibition (binding) | Concentration required for 50% Inhibition against cholesteryl ester transfer protein in presence of human serum; ND denotes Not determined | ChEMBL. | 12190312 | |
Inhibition (binding) | Tested for inhibiting CETP-mediated transfer of [3H]-CE from HDL to LDL in vitro under buffered assay conditions in human serum; ND is Not determined | ChEMBL. | 11101348 | |
ND (binding) | 0 | Concentration required for 50% Inhibition against cholesteryl ester transfer protein in presence of human serum; ND denotes Not determined | ChEMBL. | 12190312 |
ND (binding) | 0 | Tested for inhibiting CETP-mediated transfer of [3H]-CE from HDL to LDL in vitro under buffered assay conditions in human serum; ND is Not determined | ChEMBL. | 11101348 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.