Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1764 | 1 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0658 | 0.986 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0129 | 0.1764 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0129 | 0.1764 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0298 | 0.4349 | 0.375 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0446 | 0.661 | 0.6348 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.007 | 0.0858 | 0.4866 |
Schistosoma mansoni | amine GPCR | 0.0328 | 0.4804 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0129 | 0.1764 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0658 | 0.986 | 1 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0446 | 0.661 | 0.6348 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0658 | 0.986 | 1 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0298 | 0.4349 | 0.3809 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0667 | 1 | 1 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0446 | 0.661 | 0.6348 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.007 | 0.0858 | 0.4866 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1764 | 1 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0667 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0076 | 0.0959 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity rating (functional) | = 0 | Effect on heart rate of spontaneously hypertensive rats, 2 hr after peroral administration at 50 mg/kg | ChEMBL. | 7265125 |
Activity rating (functional) | = 0 | Effect on heart rate of spontaneously hypertensive rats, 10 hr after peroral administration at 50 mg/kg | ChEMBL. | 7265125 |
Activity rating (functional) | = 0 | Effect on heart rate of spontaneously hypertensive rats, 24 hr after peroral administration at 50 mg/kg | ChEMBL. | 7265125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.