Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sigma non-opioid intracellular receptor 1 | Starlite/ChEMBL | References |
Bos taurus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 465 aa | 21.7 % |
Echinococcus granulosus | alpha 1A adrenergic receptor | Dopamine D2 receptor | 444 aa | 466 aa | 20.2 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D2 receptor | 444 aa | 432 aa | 30.6 % |
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D2 receptor | 444 aa | 479 aa | 22.8 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 464 aa | 27.4 % | |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D2 receptor | 444 aa | 438 aa | 29.9 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D2 receptor | 444 aa | 464 aa | 29.3 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 417 aa | 23.3 % | |
Schistosoma mansoni | amine GPCR | Dopamine D2 receptor | 444 aa | 424 aa | 32.3 % |
Schistosoma mansoni | biogenic amine (dopamine) receptor | Dopamine D2 receptor | 444 aa | 493 aa | 26.8 % |
Schistosoma mansoni | biogenic amine receptor | Dopamine D2 receptor | 444 aa | 455 aa | 29.5 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Dopamine D2 receptor | 444 aa | 489 aa | 24.5 % |
Echinococcus multilocularis | serotonin receptor | Dopamine D2 receptor | 444 aa | 446 aa | 31.8 % |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D2 receptor | 444 aa | 456 aa | 28.7 % |
Echinococcus granulosus | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 457 aa | 21.7 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Dopamine D2 receptor | 444 aa | 430 aa | 30.5 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Dopamine D2 receptor | 444 aa | 386 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.2015 | 0.6627 | 0.6348 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0607 | 0.4531 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.0052 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 0.1339 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0014 | 0.0107 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 0.1339 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0168 | 0.0407 | 0.3038 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.2015 | 0.6627 | 0.6703 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.0052 | 0.1278 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.3017 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0014 | 0.0107 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.3017 | 1 | 0.5 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.2975 | 0.9861 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0145 | 0.0328 | 1 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.2015 | 0.6627 | 0.6703 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0052 | 0.1585 |
Onchocerca volvulus | 0.0097 | 0.0168 | 0.5 | |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0242 | 0.0655 | 0.4891 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.1339 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0345 | 0.1004 | 0.5 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.1347 | 0.4378 | 0.375 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.1347 | 0.4378 | 0.441 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0014 | 0.0107 |
Brugia malayi | follicle stimulating hormone receptor | 0.0242 | 0.0655 | 0.4891 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 0.1339 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.2975 | 0.9861 | 1 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.2975 | 0.9861 | 1 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0345 | 0.1004 | 0.0971 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0168 | 0.0407 | 0.3038 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0168 | 0.0407 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0168 | 0.0407 | 1 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0345 | 0.1004 | 0.0971 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0168 | 0.0407 | 1 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0345 | 0.1004 | 0.0971 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0445 | 0.1339 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0145 | 0.0328 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.0052 | 0.1585 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0014 | 0.0107 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.0052 | 0.1278 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 10 nM | Binding affinity against sigma receptor in bovine cerebellum using 2.0 nM [3H]- haloperidol | ChEMBL. | 7902869 |
Ki (binding) | = 10 nM | Binding affinity against sigma receptor in bovine cerebellum using 2.0 nM [3H]- haloperidol | ChEMBL. | 7902869 |
Ki (binding) | > 1000 nM | Binding affinity against Dopamine receptor D2 in bovine striatal homogenate using 200 pM [3H]- spiperone and 250 nM unlabeled ketanserin | ChEMBL. | 7902869 |
Ki (binding) | > 1000 nM | Binding affinity against Dopamine receptor D2 in bovine striatal homogenate using 200 pM [3H]- spiperone and 250 nM unlabeled ketanserin | ChEMBL. | 7902869 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.