Detailed information for compound 222720

Basic information

Technical information
  • TDR Targets ID: 222720
  • Name: 4-amino-1-[(1S,4R)-2-fluoro-4-(hydroxymethyl) cyclopent-2-en-1-yl]pyrimidin-2-one
  • MW: 225.22 | Formula: C10H12FN3O2
  • H donors: 2 H acceptors: 2 LogP: -1.1 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccn(c(=O)n1)[C@H]1C[C@H](C=C1F)CO
  • InChi: 1S/C10H12FN3O2/c11-7-3-6(5-15)4-8(7)14-2-1-9(12)13-10(14)16/h1-3,6,8,15H,4-5H2,(H2,12,13,16)/t6-,8-/m0/s1
  • InChiKey: GWTRSVUDRSVUFO-XPUUQOCRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-amino-1-[(1S,4R)-2-fluoro-4-(hydroxymethyl)-1-cyclopent-2-enyl]-2-pyrimidinone
  • 4-azanyl-1-[(1S,4R)-2-fluoro-4-(hydroxymethyl)cyclopent-2-en-1-yl]pyrimidin-2-one
  • 4-amino-1-[(1S,4R)-2-fluoro-4-methylol-cyclopent-2-en-1-yl]pyrimidin-2-one
  • 4-amino-1-[(1S,4R)-2-fluoro-4-(hydroxymethyl)-1-cyclopent-2-enyl]pyrimidin-2-one
  • 4-amino-1-[(1S,4R)-2-fluoro-4-methylol-1-cyclopent-2-enyl]pyrimidin-2-one
  • ( + )-2(1H)-Pyrimidinone, 4-amino-1-[(1S,4R)-2-fluoro-4-(hydroxymethyl)-2-cyclopenten-1-yl]-
  • AIDS-292554
  • AIDS292554
  • L-2'F-C-d4C

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cathepsin b 0.1378 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0142 0.08 0.08
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0076 0.0303 0.0303
Entamoeba histolytica cysteine protease, putative 0.0077 0.0312 0.1824
Mycobacterium ulcerans glutaminase 0.0301 0.1978 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0312
Brugia malayi fibroinase precursor 0.0077 0.0312 0.0312
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0465 0.1376
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0465 0.1376
Leishmania major histone deacetylase, putative 0.0054 0.014 0.0392
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0076 0.0303 0.0303
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0059 0.0178 0.0167
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1378 1 1
Giardia lamblia Cathepsin L precursor 0.0077 0.0312 0.0429
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Giardia lamblia Cathepsin L-like protease 0.0077 0.0312 0.0429
Loa Loa (eye worm) hypothetical protein 0.0066 0.0228 0.0228
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0819 0.5834 0.5834
Schistosoma mansoni hypothetical protein 0.024 0.1524 0.1524
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0077 0.0312 0.0429
Plasmodium falciparum histone deacetylase 2 0.0054 0.014 0.0313
Brugia malayi Cathepsin L-like precursor 0.0238 0.1515 0.1515
Entamoeba histolytica cysteine protease, putative 0.0077 0.0312 0.1824
Entamoeba histolytica cysteine protease, putative 0.0077 0.0312 0.1824
Brugia malayi Cathepsin L-like cysteine proteinase 0.0173 0.1027 0.1027
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0059 0.0178 0.0506
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0097 0.0465 0.1376
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0076 0.0303 0.0303
Loa Loa (eye worm) latrophilin receptor protein 2 0.0111 0.0566 0.0566
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0077 0.0312 0.0312
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0076 0.0303 0.0303
Trypanosoma brucei cysteine peptidase C (CPC) 0.0479 0.3308 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0076 0.0303 0.0303
Onchocerca volvulus 0.0238 0.1515 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Trypanosoma cruzi cysteine peptidase, putative 0.0142 0.08 0.079
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0041 0.0044 0.0044
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0551 0.8565
Loa Loa (eye worm) hypothetical protein 0.0036 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0312 0.0914
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0077 0.0312 0.2003
Plasmodium vivax serine-repeat antigen (SERA) 0.0077 0.0312 0.2003
Onchocerca volvulus 0.0041 0.0044 0.0288
Schistosoma mansoni histone deacetylase hda2 0.0054 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0142 0.08 0.079
Brugia malayi Histone deacetylase family protein 0.0054 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.08 0.2392
Echinococcus multilocularis histone deacetylase 1 0.0097 0.0465 0.0465
Brugia malayi Papain family cysteine protease containing protein 0.0142 0.08 0.08
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0384 0.0384
Onchocerca volvulus Putative nachr subunit 0.0221 0.1384 0.9136
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Plasmodium vivax vivapain-2 0.0238 0.1515 1
Plasmodium vivax serine/threonine kinase-1, putative 0.0059 0.0178 0.1109
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1378 1 1
Toxoplasma gondii histone deacetylase HDAC3 0.0097 0.0465 0.1376
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0111 0.0566 0.0566
Echinococcus multilocularis 0.0058 0.0171 0.0171
Brugia malayi Cation transporter family protein 0.0076 0.0303 0.0303
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0077 0.0312 0.1824
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0312
Giardia lamblia Hypothetical protein 0.0077 0.0312 0.0429
Plasmodium falciparum cysteine proteinase falcipain 3 0.0238 0.1515 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0694 0.0694
Echinococcus granulosus cysteine protease 0.0142 0.08 0.08
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0011 0.0011
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0694 0.0694
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0077 0.0312 0.2003
Toxoplasma gondii histone deacetylase HDAC2 0.0097 0.0465 0.1376
Schistosoma mansoni histone deacetylase 0.0097 0.0465 0.0465
Trypanosoma brucei histone deacetylase 3 0.0054 0.014 0.0392
Loa Loa (eye worm) hypothetical protein 0.0066 0.0228 0.0228
Trypanosoma cruzi cysteine peptidase, putative 0.0238 0.1515 0.1506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.1027 0.3083
Echinococcus granulosus glycine receptor subunit alpha 1 0.0076 0.0303 0.0303
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Echinococcus granulosus histone deacetylase 0.0054 0.014 0.014
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0077 0.0312 0.2003
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1378 1 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0694 0.0694
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0351 0.2349 0.2349
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0096 0.0096
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0303 0.0303
Schistosoma mansoni cathepsin s 0.0066 0.0228 0.0228
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0238 0.1515 0.1515
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Trypanosoma brucei histone deacetylase 4 0.0054 0.014 0.0392
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0076 0.0303 0.0303
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0076 0.0303 0.0303
Onchocerca volvulus 0.0076 0.0303 0.2003
Giardia lamblia Cysteine protease 0.0077 0.0312 0.0429
Loa Loa (eye worm) glutaminase 2 0.0301 0.1978 0.1978
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0076 0.0303 0.0303
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0238 0.1515 1
Giardia lamblia Cathepsin B precursor 0.0077 0.0312 0.0429
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0076 0.0303 0.0303
Echinococcus multilocularis cathepsin L cysteine protease 0.0238 0.1515 0.1515
Brugia malayi Papain family cysteine protease containing protein 0.0077 0.0312 0.0312
Leishmania major histone deacetylase, putative 0.0097 0.0465 0.1376
Echinococcus multilocularis histone deacetylase 0.0054 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0036 0.0011 0.0011
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0097 0.0465 0.1376
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0077 0.0312 0.0312
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0076 0.0303 0.0303
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0077 0.0312 0.1824
Plasmodium vivax unspecified product 0.0142 0.08 0.5245
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0221 0.1384 0.1384
Brugia malayi RNA binding protein 0.0128 0.0694 0.0694
Echinococcus granulosus geminin 0.0671 0.4738 0.4738
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0059 0.0178 0.0506
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Brugia malayi Cation transporter family protein 0.0076 0.0303 0.0303
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0077 0.0312 0.0312
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0238 0.1515 0.4561
Loa Loa (eye worm) hypothetical protein 0.0036 0.0011 0.0011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.0817 0.0817
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0096 0.0096
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0041 0.0044 0.0044
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0221 0.1384 0.1384
Schistosoma mansoni glutaminase 0.0301 0.1978 0.1978
Trypanosoma cruzi major cysteine proteinase, putative 0.0077 0.0312 0.0302
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0238 0.1515 0.1515
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0817 0.0817
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0066 0.0228 0.0228
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0221 0.1384 0.1384
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0641 0.4324
Trichomonas vaginalis glutaminase, putative 0.0301 0.1978 0.5966
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0551 0.3704
Trypanosoma cruzi histone deacetylase 1, putative 0.0097 0.0465 0.0454
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0076 0.0303 0.0303
Echinococcus multilocularis cathepsin b 0.1378 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0221 0.1384 0.1384
Onchocerca volvulus 0.0036 0.0011 0.0071
Echinococcus granulosus cathepsin L 0.0142 0.08 0.08
Loa Loa (eye worm) histone deacetylase 1 0.0097 0.0465 0.0465
Schistosoma mansoni cathepsin F (C01 family) 0.0238 0.1515 0.1515
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0641 0.4324
Giardia lamblia Hypothetical protein 0.0077 0.0312 0.0429
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0087 0.0384 0.1133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0312 0.0914
Leishmania major histone deacetylase, putative 0.0097 0.0465 0.1376
Echinococcus granulosus histone deacetylase 6 0.0054 0.014 0.014
Brugia malayi histone deacetylase 3 (HD3) 0.0097 0.0465 0.0465
Loa Loa (eye worm) fibroinase 0.0238 0.1515 0.1515
Onchocerca volvulus 0.0238 0.1515 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0312 0.0914
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0041 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0076 0.0303 0.0303
Echinococcus multilocularis glycine receptor subunit beta 0.0076 0.0303 0.0303
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Echinococcus granulosus cathepsin l cysteine peptidase 0.0238 0.1515 0.1515
Entamoeba histolytica cysteine proteinase 2 0.0142 0.08 0.5139
Plasmodium falciparum histone deacetylase 1 0.0097 0.0465 0.26
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Loa Loa (eye worm) hypothetical protein 0.0066 0.0228 0.0228
Giardia lamblia Cathepsin L precursor 0.0077 0.0312 0.0429
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0312 0.0312
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0076 0.0303 0.0303
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.1234 0.1234
Entamoeba histolytica histone deacetylase, putative 0.0097 0.0465 0.2861
Trypanosoma cruzi cysteine proteinase, putative 0.0142 0.08 0.079
Entamoeba histolytica cysteine proteinase 1, putative 0.0142 0.08 0.5139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Schistosoma mansoni nAChR subunit 0.0076 0.0303 0.0303
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0221 0.1384 0.1384
Loa Loa (eye worm) cathepsin B 0.0479 0.3308 0.3308
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0479 0.3308 0.3308
Loa Loa (eye worm) beta-lactamase 0.0036 0.0011 0.0011
Plasmodium vivax unspecified product 0.0077 0.0312 0.2003
Brugia malayi cathepsin Z-like cysteine proteinase 0.0077 0.0312 0.0312
Brugia malayi Cation transporter family protein 0.0076 0.0303 0.0303
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Plasmodium vivax serine-repeat antigen (SERA) 0.0077 0.0312 0.2003
Brugia malayi Cathepsin L-like precursor 0.0238 0.1515 0.1515
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0076 0.0303 0.0303
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0142 0.08 0.08
Brugia malayi Histone deacetylase family protein 0.0054 0.014 0.014
Plasmodium falciparum serine repeat antigen 4 0.0077 0.0312 0.1525
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Echinococcus granulosus glycine receptor subunit beta 0.0076 0.0303 0.0303
Onchocerca volvulus 0.0076 0.0303 0.2003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0817 0.0817
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0076 0.0303 0.0303
Onchocerca volvulus 0.0238 0.1515 1
Plasmodium falciparum serine repeat antigen 7 0.0077 0.0312 0.1525
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0096 0.0581
Echinococcus granulosus cathepsin L cysteine proteinase 0.0238 0.1515 0.1515
Schistosoma mansoni hypothetical protein 0.0671 0.4738 0.4738
Echinococcus granulosus histone deacetylase 1 0.0097 0.0465 0.0465
Loa Loa (eye worm) hypothetical protein 0.0351 0.2349 0.2349
Plasmodium falciparum protein serine/threonine kinase-1 0.0059 0.0178 0.0578
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0076 0.0303 0.0303
Echinococcus granulosus histone deacetylase 7 0.0054 0.014 0.014
Brugia malayi glutaminase DH11.1 0.0301 0.1978 0.1978
Brugia malayi Cathepsin L-like precursor 0.0238 0.1515 0.1515
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0238 0.1515 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0312 0.0914
Brugia malayi Protein kinase domain containing protein 0.0087 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.0173 0.1027 0.1027
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0077 0.0312 0.1824
Echinococcus granulosus glycine receptor subunit alpha 1 0.0076 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0076 0.0303 0.0303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0351 0.2349 0.2349
Brugia malayi Cathepsin L-like precursor 0.0173 0.1027 0.1027
Echinococcus granulosus cathepsin L 0.0077 0.0312 0.0312
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Entamoeba histolytica protein kinase, putative 0.0087 0.0384 0.2315
Plasmodium vivax vivapain-2 0.0238 0.1515 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0238 0.1515 0.1515
Echinococcus granulosus nAChR subunit 0.0041 0.0044 0.0044
Schistosoma mansoni nAChR subunit 0.0076 0.0303 0.0303
Echinococcus granulosus histone deacetylase 3 0.0097 0.0465 0.0465
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Echinococcus multilocularis cathepsin L 0.0077 0.0312 0.0312
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0817 0.0817
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Echinococcus multilocularis nAChR subunit 0.0041 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0077 0.0312 0.2003
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0694 0.0694
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0221 0.1384 0.1384
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Leishmania major protein kinase, putative 0.0059 0.0178 0.0506
Loa Loa (eye worm) glutathione reductase 0.0048 0.0096 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0077 0.0312 0.0914
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0059 0.0178 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Trypanosoma cruzi histone deacetylase, putative 0.0054 0.014 0.0129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Giardia lamblia Cathepsin L precursor 0.0077 0.0312 0.0429
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0111 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0465 0.1376
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0076 0.0303 0.0303
Trypanosoma cruzi cysteine protease, putative 0.0142 0.08 0.079
Echinococcus multilocularis cysteine protease 0.0238 0.1515 0.1515
Entamoeba histolytica cysteine proteinase, putative 0.0238 0.1515 1
Loa Loa (eye worm) GABA receptor subunit 0.0041 0.0044 0.0044
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.0817 0.0817
Plasmodium vivax vivapain-1 0.0142 0.08 0.5245
Onchocerca volvulus 0.0077 0.0312 0.206
Loa Loa (eye worm) hypothetical protein 0.0036 0.0011 0.0011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0111 0.0566 0.0566
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Plasmodium falciparum serine repeat antigen 1 0.0077 0.0312 0.1525
Schistosoma mansoni nAChR subunit 0.0076 0.0303 0.0303
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0303 0.0303
Entamoeba histolytica cysteine protease, putative 0.0077 0.0312 0.1824
Schistosoma mansoni histone deacetylase 4 5 0.0054 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Schistosoma mansoni nAChR subunit 0.0076 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0228 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0551 0.3704
Plasmodium vivax glutathione reductase, putative 0.0048 0.0096 0.0564
Echinococcus multilocularis dual specificity 0.0087 0.0384 0.0384
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.1469 1
Toxoplasma gondii cathepsin CPC1 0.0077 0.0312 0.0914
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0303 0.0303
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0076 0.0303 0.0303
Echinococcus granulosus histone deacetylase 6 0.0054 0.014 0.014
Brugia malayi Papain family cysteine protease containing protein 0.0077 0.0312 0.0312
Brugia malayi Papain family cysteine protease containing protein 0.0077 0.0312 0.0312
Trypanosoma cruzi cysteine peptidase, putative 0.0238 0.1515 0.1506
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0077 0.0312 0.0312
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0694 0.0694
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0077 0.0312 0.2003
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.1378 1 1
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Echinococcus granulosus GPCR family 2 0.0111 0.0566 0.0566
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0551 0.3704
Leishmania major histone deacetylase, putative 0.0054 0.014 0.0392
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0465 0.1376
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Giardia lamblia Cathepsin B precursor 0.0077 0.0312 0.0429
Loa Loa (eye worm) RNA binding protein 0.0128 0.0694 0.0694
Leishmania major trypanothione reductase 0.0048 0.0096 0.0257
Loa Loa (eye worm) histone deacetylase 0.0054 0.014 0.014
Brugia malayi Papain family cysteine protease containing protein 0.0238 0.1515 0.1515
Echinococcus multilocularis GPCR, family 2 0.0111 0.0566 0.0566
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.0384 0.0374
Loa Loa (eye worm) cysteine protease 0.0238 0.1515 0.1515
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0087 0.0384 0.0384
Echinococcus granulosus dual specificity 0.0087 0.0384 0.0384
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.0384 0.0374
Loa Loa (eye worm) hypothetical protein 0.0086 0.0378 0.0378
Trypanosoma cruzi major cysteine proteinase, putative 0.0077 0.0312 0.0302
Loa Loa (eye worm) hypothetical protein 0.024 0.1524 0.1524
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Toxoplasma gondii cathepsin CPC2 0.0077 0.0312 0.0914
Loa Loa (eye worm) hypothetical protein 0.0097 0.0465 0.0465
Echinococcus multilocularis histone deacetylase 6 0.0054 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0077 0.0312 0.0914
Echinococcus granulosus cathepsin b 0.1378 1 1
Leishmania major cysteine peptidase A (CPA) 0.0238 0.1515 0.4561
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0076 0.0303 0.0303
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0077 0.0312 0.0312
Schistosoma mansoni neurotransmitter gated ion channel 0.0041 0.0044 0.0044
Entamoeba histolytica cysteine protease, putative 0.0238 0.1515 1
Brugia malayi glutathione reductase 0.0048 0.0096 0.0096
Giardia lamblia Cysteine protease 0.0077 0.0312 0.0429
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0076 0.0303 0.0303
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0221 0.1384 0.1384
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0312
Brugia malayi Calcitonin receptor-like protein seb-1 0.0351 0.2349 0.2349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Schistosoma mansoni hypothetical protein 0.0111 0.0566 0.0566
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0228 0.0217
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0011 0.0011
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0077 0.0312 0.0429
Giardia lamblia Cathepsin B precursor 0.0479 0.3308 1
Toxoplasma gondii histone deacetylase HDAC1 0.0054 0.014 0.0392
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0694 0.0694
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0694 0.0694
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0312 0.0914
Loa Loa (eye worm) glutaminase 0.0301 0.1978 0.1978
Trypanosoma cruzi histone deacetylase, putative 0.0054 0.014 0.0129
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0041 0.0044 0.0044
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0096 0.0096
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0059 0.0178 0.0167
Schistosoma mansoni hypothetical protein 0.0111 0.0566 0.0566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0077 0.0312 0.0914
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.0671 0.4738 0.4738
Echinococcus multilocularis histone deacetylase 7 0.0054 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0077 0.0312 0.0914
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.1027 0.3083
Onchocerca volvulus Cathepsin F homolog 0.0238 0.1515 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0077 0.0312 0.0312
Echinococcus granulosus hypothetical protein 0.0058 0.0171 0.0171
Trypanosoma cruzi histone deacetylase, putative 0.0054 0.014 0.0129
Trypanosoma cruzi cruzipain precursor, putative 0.0238 0.1515 0.1506
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0694 0.0694
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Onchocerca volvulus 0.0036 0.0011 0.0071
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.08 0.5139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Trypanosoma cruzi histone deacetylase 1, putative 0.0097 0.0465 0.0454
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0097 0.0465 0.1376
Giardia lamblia Cathepsin L-like protease 0.0077 0.0312 0.0429
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0076 0.0303 0.0303
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0178 0.0178
Giardia lamblia Histone deacetylase 0.0097 0.0465 0.0917
Schistosoma mansoni cathepsin C 0.0077 0.0312 0.0312
Brugia malayi excitatory GABA receptor EXP-1A 0.0076 0.0303 0.0303
Plasmodium falciparum serine repeat antigen 2 0.0077 0.0312 0.1525
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.08 0.5139
Brugia malayi cathepsin F-like cysteine proteinase 0.0066 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0077 0.0312 0.2003
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0077 0.0312 0.2003
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0465 0.1376
Brugia malayi Thioredoxin reductase 0.0048 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0173 0.1027 0.1027
Brugia malayi Cathepsin L-like precursor 0.0238 0.1515 0.1515
Echinococcus multilocularis histone deacetylase 3 0.0097 0.0465 0.0465
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0077 0.0312 0.0914
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0077 0.0312 0.0914
Schistosoma mansoni cathepsin S (C01 family) 0.0077 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Plasmodium vivax vivapain-3 0.0142 0.08 0.5245
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0312 0.0312
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0076 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0238 0.1515 0.4561
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0551 0.3704
Mycobacterium tuberculosis Probable reductase 0.0109 0.0551 0.3704
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0303 0.0303
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0077 0.0312 0.1525
Brugia malayi Cathepsin L-like precursor 0.0173 0.1027 0.1027
Plasmodium falciparum serine repeat antigen 6 0.0077 0.0312 0.1525
Schistosoma mansoni nAChR subunit 0.0076 0.0303 0.0303
Echinococcus granulosus dual specificity protein kinase clk2 0.0059 0.0178 0.0178
Giardia lamblia Cathepsin L precursor 0.0077 0.0312 0.0429
Brugia malayi Protein kinase domain containing protein 0.0059 0.0178 0.0178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0077 0.0312 0.0914
Entamoeba histolytica cysteine protease, putative 0.0077 0.0312 0.1824
Schistosoma mansoni nAChR subunit 0.0076 0.0303 0.0303
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0076 0.0303 0.0303
Trypanosoma brucei trypanothione reductase 0.0048 0.0096 0.0257
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0077 0.0312 0.1525
Trypanosoma cruzi cysteine peptidase, putative 0.0238 0.1515 0.1506
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0303 0.0303
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0551 0.3704
Brugia malayi Cathepsin L-like precursor 0.0066 0.0228 0.0228
Plasmodium vivax histone deacetylase 1, putative 0.0097 0.0465 0.3017
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0178 0.0506
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0221 0.1384 0.1384
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0041 0.0044 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0817 0.0817
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0087 0.0384 0.1133
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0077 0.0312 0.2003
Onchocerca volvulus 0.0238 0.1515 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.08 0.5139
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0111 0.0566 0.0566
Leishmania major protein kinase, putative 0.0059 0.0178 0.0506
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0303 0.0303
Loa Loa (eye worm) histone deacetylase 3 0.0097 0.0465 0.0465
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0059 0.0178 0.0167
Brugia malayi Cathepsin L-like precursor 0.0238 0.1515 0.1515
Onchocerca volvulus Cathepsin L homolog 0.0238 0.1515 1
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0178 0.0178
Toxoplasma gondii thioredoxin reductase 0.0048 0.0096 0.0257
Brugia malayi Histone deacetylase 1 0.0097 0.0465 0.0465
Loa Loa (eye worm) histone deacetylase 7A 0.0054 0.014 0.014
Brugia malayi beta-lactamase family protein 0.0036 0.0011 0.0011
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0694 0.0694
Giardia lamblia Cathepsin B precursor 0.0077 0.0312 0.0429
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Echinococcus granulosus cathepsin b 0.1378 1 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0076 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.0111 0.0566 0.0566
Brugia malayi Cathepsin L-like precursor 0.0238 0.1515 0.1515
Echinococcus multilocularis nAChR subunit 0.0076 0.0303 0.0303
Entamoeba histolytica protein kinase, putative 0.0087 0.0384 0.2315
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0076 0.0303 0.0303
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0076 0.0303 0.0303
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0096 0.0564
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0059 0.0178 0.0167
Onchocerca volvulus 0.0238 0.1515 1
Giardia lamblia Cathepsin B precursor 0.0479 0.3308 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0173 0.1027 0.1018
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0077 0.0312 0.0914
Onchocerca volvulus 0.0238 0.1515 1
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0076 0.0303 0.0303
Echinococcus multilocularis histone deacetylase 6 0.0054 0.014 0.014
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0077 0.0312 0.0312
Brugia malayi beta-lactamase 0.0036 0.0011 0.0011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0312 0.0312
Echinococcus multilocularis geminin 0.0671 0.4738 0.4738
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Schistosoma mansoni cathepsin F (C01 family) 0.0238 0.1515 0.1515
Schistosoma mansoni nAChR subunit 0.0076 0.0303 0.0303
Trypanosoma cruzi cysteine proteinase, putative 0.0142 0.08 0.079
Brugia malayi cathepsin L-like precursor 0.0173 0.1027 0.1027
Plasmodium vivax histone deacetylase, putative 0.0054 0.014 0.0859
Loa Loa (eye worm) hypothetical protein 0.0173 0.1027 0.1027
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0312 0.0914
Onchocerca volvulus 0.0076 0.0303 0.2003
Schistosoma mansoni histone deacetylase 4 5 0.0054 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Entamoeba histolytica protein kinase domain containing protein 0.0087 0.0384 0.2315
Trypanosoma brucei histone deacetylase, putative 0.0054 0.014 0.0392
Schistosoma mansoni cathepsin F (C01 family) 0.0173 0.1027 0.1027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0312 0.0914
Onchocerca volvulus 0.0076 0.0303 0.2003
Echinococcus granulosus glycine receptor subunit alpha 1 0.0076 0.0303 0.0303
Loa Loa (eye worm) ctsf protein 0.0238 0.1515 0.1515
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Trypanosoma cruzi cysteine peptidase, putative 0.0238 0.1515 0.1506
Plasmodium falciparum histone deacetylase, putative 0.0054 0.014 0.0313
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Plasmodium falciparum serine repeat antigen 3 0.0077 0.0312 0.1525
Trichomonas vaginalis set domain proteins, putative 0.0229 0.1441 0.4337
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0096 0.0085
Onchocerca volvulus Cathepsin L homolog 0.0238 0.1515 1
Entamoeba histolytica cysteine proteinase, putative 0.0173 0.1027 0.6685
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0077 0.0312 0.0914
Onchocerca volvulus 0.0173 0.1027 0.6781
Echinococcus multilocularis cathepsin L 0.0142 0.08 0.08
Echinococcus multilocularis cysteine protease 0.0238 0.1515 0.1515
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0221 0.1384 0.1384
Toxoplasma gondii preprocathepsin c precursor, putative 0.0077 0.0312 0.0914
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0076 0.0303 0.0303
Echinococcus granulosus histone deacetylase 6 0.0054 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0086 0.0378 0.0378
Echinococcus granulosus tar DNA binding protein 0.0128 0.0694 0.0694
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.08 0.5139
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0077 0.0312 0.0312
Plasmodium falciparum serine repeat antigen 5 0.0077 0.0312 0.1525
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0076 0.0303 0.0303
Brugia malayi Papain family cysteine protease containing protein 0.0142 0.08 0.08
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.08 0.2392
Toxoplasma gondii cathepsin B 0.0479 0.3308 1
Onchocerca volvulus 0.0229 0.1441 0.9511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.08 0.2392
Plasmodium vivax unspecified product 0.0066 0.0228 0.1443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0312 0.0914
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0077 0.0312 0.0429
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0479 0.3308 1
Plasmodium falciparum serine repeat antigen 8 0.0077 0.0312 0.1525
Brugia malayi cathepsin F-like cysteine proteinase 0.0077 0.0312 0.0312
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0142 0.08 0.08
Giardia lamblia Cathepsin B precursor 0.0077 0.0312 0.0429
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0817 0.0817
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1378 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0077 0.0312 0.0312
Loa Loa (eye worm) ACC-1 protein 0.0076 0.0303 0.0303
Onchocerca volvulus 0.0076 0.0303 0.2003
Plasmodium falciparum cysteine proteinase falcipain 1 0.0142 0.08 0.4961
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Entamoeba histolytica hypothetical protein 0.0077 0.0312 0.1824
Onchocerca volvulus 0.0036 0.0011 0.0071
Giardia lamblia Cysteine protease 0.0077 0.0312 0.0429
Brugia malayi cathepsin Z-like cysteine proteinase 0.0077 0.0312 0.0312
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0641 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0066 0.0228 0.0228
Plasmodium vivax histone deacetylase 2, putative 0.0054 0.014 0.0859
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0077 0.0312 0.0429
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0077 0.0312 0.0914
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0077 0.0312 0.1525
Onchocerca volvulus 0.0238 0.1515 1
Brugia malayi cathepsin L precursor 0.0077 0.0312 0.0312
Echinococcus granulosus glycine receptor subunit beta 0.0076 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Brugia malayi latrophilin 2 splice variant baaae 0.024 0.1524 0.1524
Onchocerca volvulus 0.0041 0.0044 0.0288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0817 0.0817
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0077 0.0312 0.2003
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0041 0.0044 0.0044
Echinococcus granulosus cathepsin L cysteine protease 0.0142 0.08 0.08
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Giardia lamblia Cathepsin L precursor 0.0077 0.0312 0.0429
Loa Loa (eye worm) hypothetical protein 0.0036 0.0011 0.0011
Brugia malayi Pre-SET motif family protein 0.0201 0.1234 0.1234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Onchocerca volvulus 0.0076 0.0303 0.2003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0076 0.0303 0.0303
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0479 0.3308 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.08 0.2392
Toxoplasma gondii cathepsin CPL 0.0238 0.1515 0.4561
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0817 0.0817
Brugia malayi Latrophilin receptor protein 2 0.0111 0.0566 0.0566
Echinococcus multilocularis glycine receptor subunit beta 0.0076 0.0303 0.0303
Onchocerca volvulus Cathepsin L homolog 0.0077 0.0312 0.206
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0238 0.1515 0.1515
Echinococcus granulosus nAChR subunit 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Echinococcus multilocularis dual specificity protein kinase clk2 0.0059 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0058 0.0171 0.0171
Echinococcus multilocularis cathepsin L cysteine protease 0.0238 0.1515 0.1515
Brugia malayi beta-lactamase family protein 0.0036 0.0011 0.0011
Schistosoma mansoni histone deacetylase 0.0097 0.0465 0.0465
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0641 0.4324
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0238 0.1515 0.1515
Giardia lamblia Cathepsin B precursor 0.0077 0.0312 0.0429
Brugia malayi TAR-binding protein 0.0128 0.0694 0.0694
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Brugia malayi histone deacetylase 1 (HD1) 0.0097 0.0465 0.0465
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0465 0.1376
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1378 1 1
Loa Loa (eye worm) ACC-1 protein 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0036 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0479 0.3308 0.3301
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0077 0.0312 0.0312
Giardia lamblia Cathepsin B precursor 0.0479 0.3308 1
Entamoeba histolytica cysteine proteinase, putative 0.0238 0.1515 1
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0059 0.0178 0.0506
Echinococcus granulosus cathepsin l1 0.0238 0.1515 0.1515
Echinococcus granulosus cathepsin l1 0.0173 0.1027 0.1027
Giardia lamblia Encystation-specific protease 0.0077 0.0312 0.0429
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0312 0.0312
Entamoeba histolytica hypothetical protein 0.0087 0.0384 0.2315
Trypanosoma brucei histone deacetylase 1 0.0097 0.0465 0.1376
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0111 0.0566 0.0566
Giardia lamblia Cathepsin L precursor 0.0077 0.0312 0.0429
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0111 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0312
Giardia lamblia Cysteine protease 0.0077 0.0312 0.0429
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Plasmodium falciparum serine repeat antigen 9 0.0077 0.0312 0.1525
Echinococcus multilocularis histone deacetylase 6 0.0054 0.014 0.014
Loa Loa (eye worm) LGC-31 protein 0.0076 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.0111 0.0566 0.0566
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0077 0.0312 0.2003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0077 0.0312 0.0914

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 37.7 uM Effective concentration to inhibit HIV-1 activity in human peripheral blood mononuclear cells ChEMBL. 15916425
EC50 (functional) = 37.7 uM Effective concentration to inhibit HIV-1 activity in human peripheral blood mononuclear cells ChEMBL. 15916425
EC90 (functional) = 1.8 uM Antiviral activity was determined against lamivudine-resistant mutant M184V strain ChEMBL. 12540238
EC90 (functional) = 2.1 uM Antiviral activity was determined against WT (HIV-1xxBRU) ChEMBL. 12540238
EC90 (functional) = 8 uM Antiviral activity was determined against WT (HIV-1xxBRU) ChEMBL. 12540238
EC90 (functional) > 100 uM Antiviral activity was determined against lamivudine-resistant mutant M184V strain ChEMBL. 12540238
FI (functional) = 0.2 Fold increase was determined from the ratio of EC90(HIV-1M184V)/EC90(HIV-1xxBRU) ChEMBL. 12540238
FI (functional) > 100 Fold increase was determined from the ratio of EC90(HIV-1M184V)/EC90(HIV-1xxBRU) ChEMBL. 12540238
IC50 (functional) > 100 uM Inhibitory concentration was determined against PHA stimulated human peripheral blood mononuclear cells ChEMBL. 15916425
IC50 (functional) > 100 uM Inhibitory concentration of the compound was determined against CEM cell line ChEMBL. 15916425
IC50 (functional) > 100 uM Inhibitory concentration of the compound was determined against uninfected Vero cells ChEMBL. 15916425
IC50 (functional) > 100 uM Inhibitory concentration was determined against PHA stimulated human peripheral blood mononuclear cells ChEMBL. 15916425
IC50 (functional) > 100 uM Inhibitory concentration of the compound was determined against CEM cell line ChEMBL. 15916425

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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