Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | homeobox | 0.0262 | 0.945 | 0.945 |
Mycobacterium tuberculosis | Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoseri | 0.0262 | 0.945 | 0.9338 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0041 | 0.0041 |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0274 | 1 | 1 |
Leishmania major | 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative | 0.0274 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 0.1692 | 0.5 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0274 | 1 | 1 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.0274 | 1 | 1 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0274 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 1 | 1 |
Mycobacterium tuberculosis | 1-acylglycerol-3-phosphate O-acyltransferase | 0.0274 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0104 | 0.1692 | 0.1692 |
Mycobacterium ulcerans | bifunctional transmembrane phospholipid biosynthesis enzyme PlsC | 0.0274 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 0.1692 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1692 | 0.1692 |
Echinococcus granulosus | adenosine deaminase | 0.0104 | 0.1692 | 0.1692 |
Echinococcus granulosus | Msx-like | 0.0262 | 0.945 | 0.945 |
Trypanosoma brucei | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0274 | 1 | 0.5 |
Schistosoma mansoni | 1-acyl-sn-glycerol-3-phosphate o-acyltransferase | 0.0274 | 1 | 1 |
Trypanosoma cruzi | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0274 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.945 | 0.945 |
Mycobacterium leprae | POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI | 0.0274 | 1 | 1 |
Echinococcus multilocularis | Phospholipid glycerol acyltransferase | 0.0274 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0041 | 0.0041 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0104 | 0.1692 | 0.1692 |
Wolbachia endosymbiont of Brugia malayi | 1-acyl-sn-glycerol-3-phosphate acyltransferase | 0.0274 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 0.1692 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 1 | 1 |
Plasmodium vivax | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0274 | 1 | 1 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.0274 | 1 | 1 |
Mycobacterium ulcerans | 1-acylglycerol-3-phosphate O-acyltransferase | 0.0274 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0041 | 0.0041 |
Treponema pallidum | lysophosphatidic acid acyltransferase | 0.0274 | 1 | 1 |
Schistosoma mansoni | transcription factor | 0.0262 | 0.945 | 0.945 |
Echinococcus multilocularis | adenosine deaminase | 0.0104 | 0.1692 | 0.1692 |
Schistosoma mansoni | adenosine deaminase | 0.0104 | 0.1692 | 0.1692 |
Chlamydia trachomatis | glycerol-3-phosphate acyltransferase | 0.0274 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0041 | 0.0041 |
Echinococcus granulosus | Phospholipid glycerol acyltransferase | 0.0274 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 0.1692 | 0.5 |
Loa Loa (eye worm) | acyltransferase | 0.0274 | 1 | 1 |
Plasmodium falciparum | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0274 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0104 | 0.1692 | 1 |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0274 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 100 uM | In vitro evaluation of anti-HIV-1 activity in C8166 cells infected with HIV-1 IIIB. | ChEMBL. | 7562937 |
Ki (binding) | = 0.19 uM | Inhibition calf intestine adenosine deaminase | ChEMBL. | 7562937 |
TC50 (ADMET) | > 100 uM | In vitro evaluation of cytotoxicity in C8166 cells infected with HIV-1 IIIB. | ChEMBL. | 7562937 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.