Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0767 | 1 | 1 |
Plasmodium vivax | glutamine synthetase, putative | 0.0219 | 0.2566 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0376 | 0.4688 | 0.4596 |
Echinococcus multilocularis | geminin | 0.0043 | 0.0172 | 0.0001 |
Loa Loa (eye worm) | Gln-2 protein | 0.0107 | 0.1038 | 0.1038 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0767 | 1 | 1 |
Trichomonas vaginalis | glutamine synthetase, putative | 0.0057 | 0.0358 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0376 | 0.4688 | 0.4688 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0376 | 0.4688 | 0.4595 |
Echinococcus granulosus | carbonic anhydrase II | 0.0767 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | glutamine synthetase | 0.0169 | 0.1886 | 0.5 |
Schistosoma mansoni | glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) | 0.0107 | 0.1038 | 0.0881 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0767 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0376 | 0.4688 | 0.4596 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) | 0.0169 | 0.1886 | 0.5305 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0376 | 0.4688 | 0.4688 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0376 | 0.4688 | 0.4688 |
Onchocerca volvulus | Glutamine synthetase homolog | 0.0107 | 0.1038 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0288 | 0.0288 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0376 | 0.4688 | 0.4688 |
Echinococcus multilocularis | carbonic anhydrase | 0.0376 | 0.4688 | 0.4596 |
Schistosoma mansoni | carbonic anhydrase | 0.0376 | 0.4688 | 0.4595 |
Echinococcus granulosus | geminin | 0.0043 | 0.0172 | 0.0001 |
Echinococcus granulosus | carbonic anhydrase | 0.0376 | 0.4688 | 0.4596 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0376 | 0.4688 | 0.4595 |
Entamoeba histolytica | glutamine synthetase, putative | 0.0057 | 0.0358 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0376 | 0.4688 | 1 |
Mycobacterium ulcerans | glutamine synthetase | 0.0219 | 0.2566 | 1 |
Echinococcus granulosus | glutamine synthetase | 0.0107 | 0.1038 | 0.0882 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) | 0.0219 | 0.2566 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0376 | 0.4688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 0.4688 | 0.4688 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0767 | 1 | 1 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0169 | 0.1886 | 0.1745 |
Mycobacterium leprae | PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) | 0.0219 | 0.2566 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0376 | 0.4688 | 0.4596 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0169 | 0.1886 | 0.1745 |
Trichomonas vaginalis | glutamine synthetase-bacteria, putative | 0.0057 | 0.0358 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 0.4688 | 0.4688 |
Mycobacterium ulcerans | glutamine synthetase GlnA1 | 0.0219 | 0.2566 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0767 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 0.4688 | 0.4688 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0288 | 0.0288 |
Schistosoma mansoni | hypothetical protein | 0.0376 | 0.4688 | 0.4595 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0767 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0767 | 1 | 1 |
Echinococcus multilocularis | glutamine synthetase | 0.0107 | 0.1038 | 0.0882 |
Entamoeba histolytica | glutamine synthetase, putative | 0.0057 | 0.0358 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0767 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0376 | 0.4688 | 0.4595 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0376 | 0.4688 | 0.4688 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0376 | 0.4688 | 0.4688 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0767 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0113 | 0.1118 | 0.3441 |
Leishmania major | carbonic anhydrase-like protein | 0.0767 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0376 | 0.4688 | 0.4596 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 90 uM | In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparation | ChEMBL. | 1433210 |
IC50 (binding) | = 90 uM | In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparation | ChEMBL. | 1433210 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.