Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.0672 |
Echinococcus multilocularis | cpg binding protein | 0.0085 | 0.0343 | 0.0611 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.002 | 0.0018 | 0.0018 |
Schistosoma mansoni | jumonji domain containing protein | 0.0088 | 0.0359 | 0.0639 |
Echinococcus granulosus | dnaJ subfamily B | 0.1145 | 0.5614 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0042 | 0.013 | 0.0231 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.186 | 0.3314 |
Echinococcus granulosus | geminin | 0.039 | 0.186 | 0.3314 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0672 | 0.2814 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.019 | 0.0338 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0054 | 0.019 | 0.0794 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.002 | 0.0018 | 0.0018 |
Brugia malayi | hypothetical protein | 0.0165 | 0.0741 | 0.3103 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0018 | 0.0011 | 0.002 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0011 | 0.002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.0846 |
Onchocerca volvulus | 0.0496 | 0.2388 | 1 | |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.008 | 0.032 | 0.1341 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0052 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0046 | 0.0147 | 0.0616 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.019 | 0.0338 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.0846 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.0155 | 0.0276 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0018 | 0.0011 | 0.0048 |
Echinococcus granulosus | ferritin | 0.002 | 0.0018 | 0.0032 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0042 | 0.013 | 0.0544 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0132 | 0.0576 | 0.1025 |
Echinococcus multilocularis | GPCR, family 2 | 0.0054 | 0.019 | 0.0338 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.0576 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0052 | 0.0179 | 0.0209 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0034 | 0.0089 | 0.0372 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.013 | 0.0231 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0042 | 0.013 | 0.0231 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0132 | 0.0576 | 0.1025 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0046 | 0.0147 | 0.0262 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.019 | 0.0338 |
Echinococcus multilocularis | Smad4 | 0.0018 | 0.0011 | 0.002 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0052 | 0.0179 | 0.1551 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0034 | 0.0089 | 0.0158 |
Trichomonas vaginalis | ferritin, putative | 0.002 | 0.0018 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0151 | 0.0672 | 0.0672 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0054 | 0.019 | 0.0794 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) | 0.1583 | 0.7789 | 0.7789 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0151 | 0.0672 | 0.1197 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.2027 | 1 | 1 |
Echinococcus granulosus | expressed protein | 0.002 | 0.0018 | 0.0032 |
Onchocerca volvulus | 0.008 | 0.032 | 0.1006 | |
Loa Loa (eye worm) | runx1 | 0.0062 | 0.023 | 0.0963 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.0576 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.2027 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.013 | 0.0231 |
Brugia malayi | PHD-finger family protein | 0.0034 | 0.0089 | 0.0372 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.002 | 0.0018 | 0.0018 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.186 | 0.3314 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.0049 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0018 | 0.0011 | 0.0048 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0042 | 0.013 | 0.0544 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0025 | 0.0044 | 0.0078 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.0215 | 0.09 |
Schistosoma mansoni | single-minded | 0.0049 | 0.0165 | 0.0294 |
Echinococcus multilocularis | expressed protein | 0.002 | 0.0018 | 0.0032 |
Mycobacterium ulcerans | DNA polymerase III subunit alpha | 0.1575 | 0.775 | 0.775 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0049 | 0.0165 | 0.0294 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.019 | 0.0338 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.0286 | 0.12 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.0215 | 0.09 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0099 | 0.0413 | 0.0736 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.0286 | 0.12 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0031 | 0.0075 | 0.0133 |
Echinococcus granulosus | peregrin | 0.0034 | 0.0089 | 0.0158 |
Brugia malayi | jmjC domain containing protein | 0.0046 | 0.0147 | 0.0616 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0151 | 0.0672 | 0.9913 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0049 | 0.0207 |
Brugia malayi | PAS domain containing protein | 0.0049 | 0.0165 | 0.0691 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0034 | 0.0089 | 0.0158 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0111 | 0.0472 | 0.0841 |
Mycobacterium leprae | Isocitrate lyase | 0.095 | 0.4645 | 0.4645 |
Schistosoma mansoni | ferritin | 0.002 | 0.0018 | 0.0032 |
Echinococcus multilocularis | geminin | 0.039 | 0.186 | 0.3314 |
Echinococcus granulosus | GPCR family 2 | 0.0054 | 0.019 | 0.0338 |
Schistosoma mansoni | ferritin light chain | 0.002 | 0.0018 | 0.0032 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0018 | 0.0011 | 0.0048 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0171 | 0.0772 | 0.3232 |
Chlamydia trachomatis | DNA polymerase III subunit alpha | 0.1575 | 0.775 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) | 0.1583 | 0.7789 | 0.7789 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.2388 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.0286 | 0.12 |
Giardia lamblia | PHD finger protein 15 | 0.0034 | 0.0089 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.019 | 0.0338 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0025 | 0.0044 | 0.0078 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.8492 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0054 | 0.019 | 0.0794 |
Mycobacterium ulcerans | error-prone DNA polymerase | 0.1575 | 0.775 | 0.775 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0011 | 0.0048 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.002 | 0.002 | 0.0035 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.002 | 0.0018 | 0.0018 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.1025 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0089 | 0.0158 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.0502 | 0.0895 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0151 | 0.0672 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0052 | 0.0179 | 0.1551 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0011 | 0.0048 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.2027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0502 | 0.2104 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0041 | 0.0124 | 0.0221 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0011 | 0.0048 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.002 | 0.002 | 0.0035 |
Brugia malayi | jmjC domain containing protein | 0.0111 | 0.0472 | 0.1978 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.0089 | 0.1311 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0151 | 0.0672 | 0.9913 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.002 | 0.002 | 0.0035 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.002 | 0.0018 | 0.0018 |
Echinococcus granulosus | single minded 2 | 0.0036 | 0.0101 | 0.0181 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase III alpha subunit | 0.1575 | 0.775 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.0049 | 0.0857 |
Echinococcus multilocularis | Protein lozenge | 0.0062 | 0.023 | 0.0409 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.019 | 0.0338 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0269 | 0.1257 | 0.5266 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0099 | 0.0413 | 0.0413 |
Toxoplasma gondii | hypothetical protein | 0.0052 | 0.0179 | 0.2645 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0171 | 0.0768 | 0.1369 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0018 | 0.0011 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0741 | 0.3103 |
Schistosoma mansoni | cpg binding protein | 0.0085 | 0.0343 | 0.0611 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0132 | 0.0576 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.0576 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0099 | 0.0413 | 0.0413 |
Echinococcus multilocularis | ferritin | 0.002 | 0.0018 | 0.0032 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.0286 | 0.12 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0099 | 0.0413 | 0.0736 |
Echinococcus multilocularis | dnaJ subfamily B | 0.1145 | 0.5614 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0018 | 0.0011 | 0.002 |
Echinococcus multilocularis | smad | 0.0018 | 0.0011 | 0.002 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.1197 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0152 | 0.0678 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0046 | 0.0147 | 0.0262 |
Brugia malayi | Smad1 | 0.0018 | 0.0011 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.1145 | 0.5614 | 1 |
Schistosoma mansoni | ferritin | 0.002 | 0.0018 | 0.0032 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.0286 | 0.12 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0117 | 0.0502 | 0.2104 |
Schistosoma mansoni | apoferritin-2 | 0.002 | 0.0018 | 0.0032 |
Echinococcus granulosus | Smad4 | 0.0018 | 0.0011 | 0.002 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0269 | 0.1257 | 0.5266 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0111 | 0.0472 | 0.0841 |
Schistosoma mansoni | lozenge | 0.0062 | 0.023 | 0.0409 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0036 | 0.0098 | 0.0408 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0026 | 0.0049 | 0.0049 |
Echinococcus granulosus | cpg binding protein | 0.0085 | 0.0343 | 0.0611 |
Brugia malayi | hypothetical protein | 0.0496 | 0.2388 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0026 | 0.0049 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.019 | 0.0338 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0046 | 0.0147 | 0.0262 |
Brugia malayi | Probable ClpP-like protease | 0.0151 | 0.0672 | 0.2814 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0089 | 0.0372 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0049 | 0.0207 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0049 | 0.0207 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) | 0.1583 | 0.7789 | 0.7789 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0171 | 0.0772 | 0.3232 |
Schistosoma mansoni | smad | 0.0018 | 0.0011 | 0.002 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0099 | 0.0413 | 0.0413 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.019 | 0.0794 |
Brugia malayi | RNA binding protein | 0.0074 | 0.0286 | 0.12 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.0049 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0152 | 0.0677 | 0.2837 |
Onchocerca volvulus | 0.0036 | 0.0101 | 0.0055 | |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.019 | 0.0338 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0209 | 0.0876 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.0672 |
Schistosoma mansoni | ferritin | 0.002 | 0.0018 | 0.0032 |
Brugia malayi | Bromodomain containing protein | 0.0034 | 0.0089 | 0.0372 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.0286 | 0.051 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0026 | 0.0049 | 0.0207 |
Treponema pallidum | DNA polymerase III subunit alpha | 0.1575 | 0.775 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0918 | 0.4484 | 0.7988 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0151 | 0.0672 | 0.1197 |
Mycobacterium ulcerans | putative regulatory protein | 0.0036 | 0.0101 | 0.0101 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.2027 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0049 | 0.0207 |
Schistosoma mansoni | Smad4 | 0.0018 | 0.0011 | 0.002 |
Echinococcus multilocularis | peregrin | 0.0034 | 0.0089 | 0.0158 |
Schistosoma mansoni | ferritin | 0.002 | 0.0018 | 0.0032 |
Brugia malayi | bHLH-PAS transcription factor | 0.0036 | 0.0101 | 0.0425 |
Brugia malayi | MH2 domain containing protein | 0.0269 | 0.1257 | 0.5266 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0011 | 0.002 |
Schistosoma mansoni | cpg binding protein | 0.0085 | 0.0343 | 0.0611 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.0576 |
Brugia malayi | CXXC zinc finger family protein | 0.008 | 0.032 | 0.1341 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.002 | 0.002 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.2388 | 1 |
Schistosoma mansoni | apoferritin-2 | 0.002 | 0.0018 | 0.0032 |
Schistosoma mansoni | ferritin light chain | 0.002 | 0.0018 | 0.0032 |
Mycobacterium ulcerans | hypothetical protein | 0.0298 | 0.1401 | 0.1401 |
Echinococcus granulosus | smad | 0.0018 | 0.0011 | 0.002 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0132 | 0.0576 | 0.1025 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.013 | 0.0231 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0286 | 0.051 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.0155 | 0.0276 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0034 | 0.0089 | 0.0158 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0152 | 0.0677 | 0.2837 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0011 | 0.002 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.0089 | 0.1311 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.0268 | 0.1124 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0018 | 0.0011 | 0.002 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0042 | 0.013 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0772 | 0.3232 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.0286 | 0.051 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0011 | 0.0048 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0298 | 0.1401 | 0.1401 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0042 | 0.013 | 0.0231 |
Schistosoma mansoni | cpg binding protein | 0.008 | 0.032 | 0.057 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0171 | 0.0772 | 0.3232 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0018 | 0.0011 | 0.002 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0036 | 0.0101 | 0.0181 |
Loa Loa (eye worm) | histone methyltransferase | 0.0025 | 0.0044 | 0.0184 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.2027 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | < 100000 nM | BindingDB_Patents: Enzyme Assay. The aim of this study was to evaluate TK-112690 in vivo as an inhibitor of uridine phosphorylase (UPase) enzyme activity. The range of TK-112690 doses studied for ability to prevent metabolic breakdown of uridine, through the in vitro inhibition of mouse and human small intestinal UPase enzyme, was 0, 0.1, 0.5, 1, 5, 10, 50, 100, 500, 1000, 5000 and 10000 uM). Detection of UPase activity was determined by HPLC analysis using UV detection of uracil concentration (UPase catabolizes uridine into uracil and ribose-1-phosphate).The UPase enzyme material was prepared from homogenized mouse and human being small intestinal tissue. TK-112690 was dissolved in water (50 mg/ml) and analyzed for UPase inhibition in aqueous solution containing 5 mM uridine, 0.01 M Tris, 0.01 M phosphate, 1 mM EDTA, and 1 mM DTT. Reactions were performed at 37 C. at pH of 7.3.TK-11260 inhibition of mouse and human UPase was analyzed by reverse phase HPLC using UV detection. | ChEMBL. | No reference |
IC50 (binding) | < 100000 nM | BindingDB_Patents: Enzyme Assay. The aim of this study was to evaluate TK-112690 in vivo as an inhibitor of uridine phosphorylase (UPase) enzyme activity. The range of TK-112690 doses studied for ability to prevent metabolic breakdown of uridine, through the in vitro inhibition of mouse and human small intestinal UPase enzyme, was 0, 0.1, 0.5, 1, 5, 10, 50, 100, 500, 1000, 5000 and 10000 uM). Detection of UPase activity was determined by HPLC analysis using UV detection of uracil concentration (UPase catabolizes uridine into uracil and ribose-1-phosphate).The UPase enzyme material was prepared from homogenized mouse and human being small intestinal tissue. TK-112690 was dissolved in water (50 mg/ml) and analyzed for UPase inhibition in aqueous solution containing 5 mM uridine, 0.01 M Tris, 0.01 M phosphate, 1 mM EDTA, and 1 mM DTT. Reactions were performed at 37 C. at pH of 7.3.TK-11260 inhibition of mouse and human UPase was analyzed by reverse phase HPLC using UV detection. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.