Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0128 | 0.0132 | 0.0425 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0697 | 0.0905 | 0.2448 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0374 | 0.0466 | 0.132 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0112 | 0.0111 | 0.0314 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.0328 | 0.093 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.069 | 0.0895 | 0.2537 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0472 | 0.0599 | 0.1697 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0059 | 0.0038 | 0.0038 |
Chlamydia trachomatis | transcriptional repressor NrdR | 0.0356 | 0.0442 | 0.1116 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0078 | 0.0065 | 0.0029 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.0152 | 0.0152 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0272 | 0.0328 | 0.0328 |
Entamoeba histolytica | hypothetical protein | 0.0143 | 0.0152 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.2273 | 0.3044 | 1 |
Loa Loa (eye worm) | replication factor A 73 kDa subunit | 0.0034 | 0.0005 | 0.0014 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0046 | 0.0021 | 0.006 |
Brugia malayi | replication factor A 73 kDa subunit | 0.0034 | 0.0005 | 0.0014 |
Echinococcus multilocularis | integrin beta 2 | 0.0229 | 0.0269 | 0.0763 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0022 | 0.0063 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0046 | 0.0021 | 0.006 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase small chain | 0.0071 | 0.0055 | 0.0055 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0272 | 0.0328 | 0.093 |
Brugia malayi | Kelch motif family protein | 0.0047 | 0.0022 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0255 | 0.0722 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0046 | 0.0021 | 0.006 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase subunit | 0.0071 | 0.0055 | 0.0156 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0014 | 0.0014 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0014 | 0.0041 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0059 | 0.0038 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0218 | 0.0255 | 0.0722 |
Brugia malayi | hypothetical protein | 0.0047 | 0.0022 | 0.0063 |
Echinococcus granulosus | integrin beta 2 | 0.0229 | 0.0269 | 0.0763 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.2629 | 0.3528 | 1 |
Trichomonas vaginalis | replication factor A 1, rfa1, putative | 0.0034 | 0.0005 | 0.0008 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0112 | 0.0111 | 0.0314 |
Loa Loa (eye worm) | hypothetical protein | 0.069 | 0.0895 | 0.2537 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0128 | 0.0132 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.0097 | 0.0097 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0272 | 0.0328 | 0.0787 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0038 | 0.0109 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.2629 | 0.3528 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0356 | 0.0442 | 0.1296 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.2629 | 0.3528 | 0.3528 |
Schistosoma mansoni | patched 1 | 0.0112 | 0.0111 | 0.0111 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0112 | 0.0111 | 0.0314 |
Loa Loa (eye worm) | ribonucleotide reductase M2 B | 0.0071 | 0.0055 | 0.0156 |
Schistosoma mansoni | integrin beta subunit | 0.0182 | 0.0205 | 0.0205 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0078 | 0.0065 | 0.0029 |
Echinococcus multilocularis | protein patched | 0.0112 | 0.0111 | 0.0314 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0046 | 0.0021 | 0.006 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.2629 | 0.3528 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0046 | 0.0021 | 0.006 |
Onchocerca volvulus | 0.0041 | 0.0014 | 0.3735 | |
Trypanosoma brucei | RNA helicase, putative | 0.0102 | 0.0097 | 0.012 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.069 | 0.0895 | 0.2537 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.2273 | 0.3044 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0046 | 0.0021 | 0.006 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0218 | 0.0255 | 0.0722 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0272 | 0.0328 | 0.093 |
Echinococcus granulosus | glutamate receptor 2 | 0.0046 | 0.0021 | 0.006 |
Schistosoma mansoni | hypothetical protein | 0.0218 | 0.0255 | 0.0255 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.2629 | 0.3528 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.069 | 0.0895 | 0.2537 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0112 | 0.0111 | 0.0111 |
Brugia malayi | Cell death protein 3 precursor | 0.0059 | 0.0038 | 0.0109 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.2629 | 0.3528 | 1 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0078 | 0.0065 | 0.0033 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.0375 | 0.0467 | 0.1324 |
Loa Loa (eye worm) | integrin beta-2 | 0.0309 | 0.0378 | 0.1071 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0218 | 0.0255 | 0.0722 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0218 | 0.0255 | 0.0722 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.2629 | 0.3528 | 1 |
Brugia malayi | ribonucleotide reductase 2 | 0.0071 | 0.0055 | 0.0156 |
Echinococcus granulosus | replication protein A 70 kDa DNA binding | 0.0034 | 0.0005 | 0.0014 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.2629 | 0.3528 | 1 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0309 | 0.0378 | 0.1071 |
Echinococcus multilocularis | GPCR, family 2 | 0.0218 | 0.0255 | 0.0722 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0047 | 0.0022 | 0.0063 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0218 | 0.0255 | 0.0722 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.2629 | 0.3528 | 1 |
Echinococcus multilocularis | replication protein A 70 kDa DNA binding | 0.0034 | 0.0005 | 0.0014 |
Entamoeba histolytica | hypothetical protein | 0.0143 | 0.0152 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0112 | 0.0111 | 0.0314 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.2273 | 0.3044 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0218 | 0.0255 | 0.0722 |
Schistosoma mansoni | hypothetical protein | 0.0218 | 0.0255 | 0.0255 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0143 | 0.0152 | 0.0431 |
Schistosoma mansoni | hypothetical protein | 0.0375 | 0.0467 | 0.0467 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0143 | 0.0152 | 0.0152 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0374 | 0.0466 | 0.132 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0109 | 0.0106 | 0.0302 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0078 | 0.0065 | 0.0029 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0272 | 0.0328 | 0.0787 |
Schistosoma mansoni | serine-type protease inhibitor | 0.045 | 0.0569 | 0.0569 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0112 | 0.0111 | 0.0314 |
Entamoeba histolytica | hypothetical protein | 0.0143 | 0.0152 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0046 | 0.0021 | 0.006 |
Echinococcus multilocularis | protein dispatched 1 | 0.0112 | 0.0111 | 0.0314 |
Schistosoma mansoni | hypothetical protein | 0.0218 | 0.0255 | 0.0255 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0046 | 0.0021 | 0.006 |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0356 | 0.0442 | 0.1267 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0272 | 0.0328 | 0.0787 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.2273 | 0.3044 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0143 | 0.0152 | 0.5 |
Echinococcus granulosus | ribonucleoside diphosphate reductase subunit | 0.0071 | 0.0055 | 0.0156 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0112 | 0.0111 | 0.0314 |
Echinococcus granulosus | caspase 2 | 0.0059 | 0.0038 | 0.0109 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0046 | 0.0021 | 0.0021 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0272 | 0.0328 | 0.093 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.2629 | 0.3528 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.0537 | 0.1523 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0143 | 0.0152 | 0.0431 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0817 | 0.1068 | 0.3389 |
Schistosoma mansoni | serine-type protease inhibitor | 0.045 | 0.0569 | 0.0569 |
Schistosoma mansoni | hypothetical protein | 0.0218 | 0.0255 | 0.0255 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0109 | 0.0106 | 0.0302 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0272 | 0.0328 | 0.0884 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.2629 | 0.3528 | 1 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.2629 | 0.3528 | 1 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.2273 | 0.3044 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0078 | 0.0065 | 0.0029 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0272 | 0.0328 | 0.0787 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0111 | 0.0355 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0374 | 0.0466 | 0.132 |
Schistosoma mansoni | replication factor A 1 rfa1 | 0.0034 | 0.0005 | 0.0005 |
Echinococcus multilocularis | caspase 2 | 0.0059 | 0.0038 | 0.0109 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0041 | 0.0014 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0111 | 0.0314 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0046 | 0.0021 | 0.006 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0218 | 0.0255 | 0.0722 |
Brugia malayi | hypothetical protein | 0.0143 | 0.0152 | 0.0431 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0128 | 0.0132 | 0.0425 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.1345 | 0.1784 | 0.1784 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.0599 | 0.1697 |
Echinococcus granulosus | GPCR family 2 | 0.0218 | 0.0255 | 0.0722 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0429 | 0.0541 | 0.0541 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0014 | 0.0041 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0109 | 0.0106 | 0.0302 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0374 | 0.0466 | 0.132 |
Trichomonas vaginalis | replication factor A 1, rfa1, putative | 0.0034 | 0.0005 | 0.0008 |
Brugia malayi | ribonucleoside-diphosphate reductase large chain, putative | 0.2629 | 0.3528 | 1 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0374 | 0.0466 | 0.132 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0041 | 0.0014 | 0.0041 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0128 | 0.0132 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.0537 | 0.1523 |
Brugia malayi | CHE-14 protein | 0.0112 | 0.0111 | 0.0314 |
Schistosoma mansoni | hypothetical protein | 0.0472 | 0.0599 | 0.0599 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 25 uM | In vitro inhibitory activity against H+/K+ ATPase prepared from canine fundic mucosa | ChEMBL. | 2836591 |
IC50 (binding) | = 25 uM | In vitro inhibitory activity against H+/K+ ATPase prepared from canine fundic mucosa | ChEMBL. | 2836591 |
Inhibition (functional) | ND 0 % | Inhibitory activity in histamine-stimulated gastric fistula dog at 3 mg/kg,id. | ChEMBL. | 2836591 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.