Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cysteinyl leukotriene receptor 1 | Starlite/ChEMBL | References |
Cavia porcellus | Cysteinyl leukotriene receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2617 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.156 | 0.3225 | 0.3225 |
Echinococcus multilocularis | adenosine deaminase | 0.2617 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.1604 | 0.3507 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1604 | 0.3507 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.2617 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.2617 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1604 | 0.3507 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.1604 | 0.3507 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1604 | 0.3507 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.2617 | 1 | 1 |
Leishmania major | AMP deaminase, putative | 0.1604 | 0.3507 | 0.3507 |
Schistosoma mansoni | adenosine deaminase-related | 0.2617 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.2617 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.2617 | 1 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.1604 | 0.3507 | 0.3507 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1604 | 0.3507 | 1 |
Treponema pallidum | adenosine deaminase | 0.2617 | 1 | 0.5 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.1604 | 0.3507 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.1604 | 0.3507 | 0.3507 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.1604 | 0.3507 | 0.3507 |
Loa Loa (eye worm) | hypothetical protein | 0.156 | 0.3225 | 0.3225 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.2617 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.2617 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.2617 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1604 | 0.3507 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.2617 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.156 | 0.3225 | 0.3225 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.2617 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.2617 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.2617 | 1 | 0.5 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.1604 | 0.3507 | 0.3507 |
Loa Loa (eye worm) | hypothetical protein | 0.156 | 0.3225 | 0.3225 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1604 | 0.3507 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1604 | 0.3507 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.2617 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.1604 | 0.3507 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.2617 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.1604 | 0.3507 | 0.3507 |
Leishmania major | adenine aminohydrolase | 0.2617 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.5 nM | Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge | ChEMBL. | 20621485 |
Ki (binding) | = 1.5 nM | In vitro binding affinity towards Cysteinyl leukotriene D4 receptor | ChEMBL. | 10669566 |
Ki (binding) | = 1.5 nM | In vitro binding affinity towards Cysteinyl leukotriene D4 receptor | ChEMBL. | 10669566 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.