Detailed information for compound 225174

Basic information

Technical information
  • TDR Targets ID: 225174
  • Name: tert-butyl N-[5-[(2,6-dichlorophenyl)carbamoy l]-4-methyl-1,3-thiazol-2-yl]carbamate
  • MW: 402.295 | Formula: C16H17Cl2N3O3S
  • H donors: 2 H acceptors: 3 LogP: 4.68 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(OC(C)(C)C)Nc1nc(c(s1)C(=O)Nc1c(Cl)cccc1Cl)C
  • InChi: 1S/C16H17Cl2N3O3S/c1-8-12(13(22)20-11-9(17)6-5-7-10(11)18)25-14(19-8)21-15(23)24-16(2,3)4/h5-7H,1-4H3,(H,20,22)(H,19,21,23)
  • InChiKey: MQPQHDGTTOFMHE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • tert-butyl N-[5-[(2,6-dichlorophenyl)carbamoyl]-4-methyl-thiazol-2-yl]carbamate
  • N-[5-[(2,6-dichloroanilino)-oxomethyl]-4-methyl-2-thiazolyl]carbamic acid tert-butyl ester
  • N-[5-[(2,6-dichlorophenyl)carbamoyl]-4-methyl-thiazol-2-yl]carbamic acid tert-butyl ester
  • N-[5-[[(2,6-dichlorophenyl)amino]-oxomethyl]-4-methyl-2-thiazolyl]carbamic acid tert-butyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0758 0.4131
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0012 0.0093
Onchocerca volvulus 0.0006 0.0012 0.1103
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.1278 1
Brugia malayi nuclear receptor NHR-88 0.0011 0.0111 0.0872
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.034 0.1025
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0012 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0111 0.0872
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0111 0.0872
Loa Loa (eye worm) glutaminyl-tRNA synthetase 0.0014 0.0167 0.1306
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0111 0.0872
Leishmania major DNA polymerase kappa, putative 0.0023 0.034 0.1025
Echinococcus multilocularis tyrosine protein kinase Src64B 0.001 0.0097 0.0762
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0097 0.0762
Treponema pallidum polypeptide deformylase (def) 0.0225 0.4213 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0111 0.0872
Mycobacterium ulcerans peptide deformylase 0.0225 0.4213 0.3739
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0111 0.0872
Entamoeba histolytica hypothetical protein 0.0039 0.0651 0.5048
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0549 0.3064
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0111 0.0872
Brugia malayi nuclear receptor RXR 0.0006 0.0012 0.0093
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0097 0.0762
Entamoeba histolytica hypothetical protein 0.0039 0.0651 0.5048
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0225 0.4213 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0111 0.0872
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0111 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0006 0.0012 0.0096
Echinococcus multilocularis tyrosine protein kinase shark 0.0006 0.0012 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0111 0.0872
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0012 0.0096
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0111 0.0872
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.1278 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1278 0.8006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0111 0.0872
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0758 0.4513
Echinococcus granulosus growth factor receptor bound protein 2 0.0009 0.0073 0.057
Schistosoma mansoni DNA polymerase eta 0.0016 0.0203 0.1585
Trypanosoma cruzi Peptide deformylase 2, putative 0.0086 0.1546 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0111 0.0872
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0012 0.0093
Echinococcus granulosus dna polymerase eta 0.0016 0.0203 0.1585
Trypanosoma brucei Peptide deformylase 2 0.0086 0.1546 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0111 0.0872
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0203 0.1585
Loa Loa (eye worm) hypothetical protein 0.0011 0.0111 0.0872
Mycobacterium leprae Isocitrate lyase 0.0247 0.4635 0.0728
Loa Loa (eye worm) hypothetical protein 0.0011 0.0111 0.0872
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0006 0.0012 0.0096
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0012 0.0096
Loa Loa (eye worm) SRC-1 0.001 0.0097 0.0762
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0012 0.0096
Echinococcus granulosus tyrosine protein kinase ABL1 0.0006 0.0012 0.0096
Schistosoma mansoni glutaminyl-tRNA synthetase (glutamine--tRNA ligase) (glnrs) 0.001 0.0091 0.0714
Trypanosoma brucei unspecified product 0.0037 0.062 0.3555
Loa Loa (eye worm) hypothetical protein 0.0011 0.0111 0.0872
Brugia malayi Protein kinase domain containing protein 0.0006 0.0012 0.0096
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0111 0.0872
Loa Loa (eye worm) hypothetical protein 0.0011 0.0111 0.0872
Brugia malayi Protein kinase domain containing protein 0.0006 0.0012 0.0096
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0111 0.0872
Schistosoma mansoni nck2/grb4 0.0009 0.0073 0.057
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0006 0.0012 0.0096
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0111 0.0872
Schistosoma mansoni tyrosine kinase 0.001 0.0097 0.0762
Echinococcus granulosus c src tyrosine kinase 0.001 0.0097 0.0762
Echinococcus granulosus NCK adaptor protein 0.0009 0.0073 0.057
Loa Loa (eye worm) hypothetical protein 0.0011 0.0111 0.0872
Schistosoma mansoni tyrosine kinase 0.001 0.0097 0.0762
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0097 0.0762
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0758 0.4513
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0111 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0111 0.0872
Leishmania major polypeptide deformylase-like protein, putative 0.0086 0.1546 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0203 0.1585
Schistosoma mansoni hypothetical protein 0.0056 0.098 0.7666
Brugia malayi glutaminyl-tRNA synthetase 0.0014 0.0167 0.1306
Loa Loa (eye worm) hypothetical protein 0.0006 0.0012 0.0093
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.1278 1
Brugia malayi hypothetical protein 0.0006 0.0012 0.0093
Brugia malayi hypothetical protein 0.0006 0.0012 0.0096
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0073 0.057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0111 0.0872
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0111 0.0872
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0073 0.057
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0012 0.0093
Echinococcus multilocularis growth factor receptor bound protein 2 0.0009 0.0073 0.057
Echinococcus multilocularis dna polymerase eta 0.0016 0.0203 0.1585
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0758 0.4513
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0111 0.0872
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0758 0.4513
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0203 0.0652
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0111 0.0872
Loa Loa (eye worm) TK/ABL protein kinase 0.0006 0.0012 0.0096
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.062 0.3555
Echinococcus granulosus glutaminyl tRNA synthetase 0.001 0.0091 0.0714
Loa Loa (eye worm) hypothetical protein 0.0011 0.0111 0.0872
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0225 0.4213 0.4191
Trypanosoma brucei Polypeptide deformylase 1 0.0086 0.1546 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.1278 0.8006
Brugia malayi protein-tyrosine kinase 0.0006 0.0012 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.034 0.161
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0111 0.0872
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0097 0.0762
Toxoplasma gondii hypothetical protein 0.0225 0.4213 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0097 0.0762
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0758 0.4131
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0009 0.0073 0.057
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.001 0.0097 0.0762
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0203 0.1585
Loa Loa (eye worm) hypothetical protein 0.0006 0.0012 0.0093
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0111 0.0872
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0012 0.0096
Brugia malayi Sex muscle abnormal protein 5 0.0009 0.0073 0.057
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0086 0.1546 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.001 0.0097 0.0762
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0111 0.0872
Brugia malayi Protein kinase domain containing protein 0.0006 0.0012 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.001 0.0079
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.001 0.0097 0.0762
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0012 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0111 0.0872
Schistosoma mansoni coup transcription factor 0.0011 0.0111 0.0872
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0203 0.1585
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0012 0.0096
Brugia malayi nuclear hormone receptor 0.0011 0.0111 0.0872
Loa Loa (eye worm) hypothetical protein 0.0009 0.0073 0.057
Schistosoma mansoni tyrosine kinase 0.001 0.0097 0.0762
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0097 0.0762
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0758 0.4513
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0111 0.0872
Chlamydia trachomatis peptide deformylase 0.0225 0.4213 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.001 0.0097 0.0762
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0009 0.0073 0.057
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0758 0.4513
Schistosoma mansoni tyrosine kinase 0.0006 0.0012 0.0096
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1278 0.8136
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0111 0.0872
Brugia malayi hypothetical protein 0.0006 0.0012 0.0093
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0006 0.0012 0.0096
Schistosoma mansoni tyrosine kinase 0.001 0.0097 0.0762
Onchocerca volvulus 0.0006 0.0012 0.1103
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0651 0.5096
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0111 0.0872
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0111 0.0872
Schistosoma mansoni hypothetical protein 0.0039 0.0651 0.5096
Loa Loa (eye worm) hypothetical protein 0.0006 0.0012 0.0093
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0111 0.0872
Echinococcus multilocularis tyrosine protein kinase Srms 0.0006 0.0012 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0758 0.4513
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0111 0.0872
Loa Loa (eye worm) hypothetical protein 0.0006 0.0012 0.0093
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0203 0.1585
Onchocerca volvulus 0.0006 0.0012 0.1103
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0097 0.0762
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0758 1
Echinococcus granulosus tyrosine kinase 0.0006 0.0012 0.0096
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0073 0.057
Schistosoma mansoni adapter molecule crk 0.0009 0.0073 0.057
Onchocerca volvulus 0.0006 0.0012 0.1103
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0651 0.5096
Echinococcus granulosus tyrosine protein kinase Src42A 0.001 0.0097 0.0762
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0009 0.0073 0.057
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0758 0.5927
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0758 0.4131
Mycobacterium ulcerans isocitrate lyase AceAb 0.0526 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0111 0.0872
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0012 0.0093
Brugia malayi Protein kinase domain containing protein 0.0006 0.0012 0.0096
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0651 0.5096
Mycobacterium ulcerans isocitrate lyase Icl 0.0526 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0111 0.0872
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0203 0.0165
Brugia malayi steroid hormone receptor 0.0011 0.0111 0.0872
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1278 0.8006
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0111 0.0872
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0111 0.0872
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0111 0.0872
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0111 1
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0012 0.0093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0111 0.0872
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0111 0.0872
Brugia malayi hypothetical protein 0.0039 0.0651 0.5096
Echinococcus granulosus tyrosine kinase 0.0006 0.0012 0.0096
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0111 0.0872
Brugia malayi SRC-1 0.001 0.0097 0.0762
Brugia malayi SH2 domain containing protein 0.0006 0.0012 0.0096
Echinococcus multilocularis NCK adaptor protein 0.0009 0.0073 0.057
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.1278 1
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0203 0.1585
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0111 0.0872
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0111 0.0872
Brugia malayi polk-prov protein 0.0034 0.0549 0.4297
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0203 0.1585
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0203 0.1585
Echinococcus granulosus tyrosine protein kinase Lyn 0.001 0.0097 0.0762
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0086 0.1546 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.1278 1
Entamoeba histolytica hypothetical protein 0.0039 0.0651 0.5048
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0758 0.4513
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0006 0.0012 0.0096
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0111 0.0872
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0111 0.0872
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0698 0.5461
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0111 0.0872
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.001 0.0097 0.0762
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0526 1 1
Plasmodium falciparum peptide deformylase 0.0225 0.4213 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0111 0.0872
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0012 0.0096
Onchocerca volvulus 0.0006 0.0012 0.1103
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0111 0.0872
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0526 1 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.001 0.0097 0.0762
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0758 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0111 0.0872
Echinococcus granulosus dna polymerase kappa 0.0045 0.0758 0.5927
Echinococcus multilocularis tyrosine kinase 0.0006 0.0012 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0758 0.4513
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0111 0.0872
Schistosoma mansoni tyrosine kinase 0.0006 0.0012 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0247 0.0958
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.1278 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.0082
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0012 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0111 0.0872
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.034 0.0303
Trypanosoma cruzi Peptide deformylase 2, putative 0.0086 0.1546 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0012 0.0093
Loa Loa (eye worm) hypothetical protein 0.0006 0.0012 0.0093
Echinococcus granulosus tyrosine protein kinase shark 0.0006 0.0012 0.0096
Entamoeba histolytica hypothetical protein 0.0039 0.0651 0.5048
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0247 0.0958
Echinococcus granulosus tyrosine protein kinase Src64B 0.001 0.0097 0.0762
Entamoeba histolytica glutaminyl-tRNA synthetase, putative 0.0007 0.0036 0.0189
Giardia lamblia DINP protein human, muc B family 0.0023 0.034 1
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0012 0.0096
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0006 0.0012 0.0096
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0012 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0549 0.3064
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0526 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0111 0.0872
Echinococcus multilocularis glutaminyl tRNA synthetase 0.001 0.0091 0.0714
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0111 0.0872
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0111 0.0872
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0758 0.4513
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0097 0.0762
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0097 0.0762
Entamoeba histolytica deoxycytidyl transferase, putative 0.0016 0.0203 0.1503
Echinococcus multilocularis tyrosine protein kinase Src42A 0.001 0.0097 0.0762
Loa Loa (eye worm) TK protein kinase 0.0006 0.0012 0.0096
Echinococcus granulosus tyrosine protein kinase Srms 0.0006 0.0012 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0111 0.0872
Loa Loa (eye worm) hypothetical protein 0.0011 0.0111 0.0872
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0097 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0111 0.0872
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0247 0.0958
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0097 0.0762
Onchocerca volvulus 0.0011 0.0111 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0111 0.0872
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0097 0.0762
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0111 0.0872
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0698 0.5461
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0758 0.4513
Brugia malayi SH2 domain containing protein 0.0006 0.0012 0.0096
Brugia malayi Protein kinase domain containing protein 0.0006 0.0012 0.0096
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0758 0.4131
Brugia malayi ecdysteroid receptor 0.0011 0.0111 0.0872
Plasmodium vivax peptide deformylase, putative 0.0225 0.4213 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0073 0.057
Onchocerca volvulus 0.0006 0.0012 0.1103
Loa Loa (eye worm) hypothetical protein 0.0034 0.0549 0.4297
Echinococcus granulosus tyrosine protein kinase Blk 0.0006 0.0012 0.0096
Loa Loa (eye worm) hypothetical protein 0.0006 0.0012 0.0096

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 12.5 uM Inhibition of human Lck(hLck) kinase ChEMBL. 14592495
IC50 (binding) = 12.5 uM Inhibition of human Lck in presence of ATP ChEMBL. 17154512
IC50 (binding) = 12.5 uM Inhibition of human Lck(hLck) kinase ChEMBL. 14592495
IC50 (binding) = 12.5 uM Inhibition of human Lck in presence of ATP ChEMBL. 17154512

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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