Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0145 | 0.6296 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0186 | 1 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0186 | 1 | 1 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0145 | 0.6296 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0074 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0145 | 0.6296 | 0.5 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0074 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0186 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0186 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.2 mg kg-1 | Tested for potentiation of gamma-butyrolactone induced sleep (gamma-B) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.2 mg kg-1 | Tested for potentiation of gamma-butyrolactone induced sleep (gamma-B) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.5 mg kg-1 | Tested for antagonism of nicotine-induced death (D) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.5 mg kg-1 | Tested for antagonism of nicotine-induced death (D) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.56 mg kg-1 | Tested for antagonism of nicotine-induced tonic extensor convulsions (TE) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.56 mg kg-1 | Tested for antagonism of nicotine-induced tonic extensor convulsions (TE) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 1.1 mg kg-1 | Tested for antagonism of bicuculline-induced tonic-extensor convulsions (B) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 1.1 mg kg-1 | Tested for antagonism of pentylenetetrazole-induced clonic convulsions (P) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 1.1 mg kg-1 | Tested for antagonism of bicuculline-induced tonic-extensor convulsions (B) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 1.1 mg kg-1 | Tested for antagonism of pentylenetetrazole-induced clonic convulsions (P) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 5.3 mg kg-1 | Tested for antagonism of oxotremorine hypothermia (OX) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 5.3 mg kg-1 | Tested for antagonism of oxotremorine hypothermia (OX) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 6.3 mg kg-1 | Prolongation of hypoxic survival time (HS) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 6.3 mg kg-1 | Prolongation of hypoxic survival time (HS) in mice | ChEMBL. | 6103958 |
ED50 (functional) | > 50 mg kg-1 | Tested for stereotyped gnawing and licking behavior of mice pretreated with apomorphine (AG) | ChEMBL. | 6103958 |
ED50 (functional) | > 50 mg kg-1 | Tested for potentiation of yohimbine toxicity in aggregated mice(Y) | ChEMBL. | 6103958 |
ED50 (functional) | > 50 mg kg-1 | Tested for stereotyped gnawing and licking behavior of mice pretreated with apomorphine (AG) | ChEMBL. | 6103958 |
ED50 (functional) | > 50 mg kg-1 | Tested for potentiation of yohimbine toxicity in aggregated mice(Y) | ChEMBL. | 6103958 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.