Detailed information for compound 225562

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 396.526 | Formula: C23H32N4O2
  • H donors: 0 H acceptors: 2 LogP: 3.64 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCOc1cc(C)nc2c1cc1c(OCCN(C)C)cc(nc1c2C)C)C
  • InChi: 1S/C23H32N4O2/c1-15-12-20(28-10-8-26(4)5)18-14-19-21(29-11-9-27(6)7)13-16(2)25-23(19)17(3)22(18)24-15/h12-14H,8-11H2,1-7H3
  • InChiKey: NFLXOPUYYBYXPM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lipoxygenase 0.0935 0.2002 0.2002
Schistosoma mansoni loxhd1 0.0238 0.043 0.043
Brugia malayi nuclear hormone receptor 0.0172 0.0281 0.1097
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0172 0.0281 0.092
Trichomonas vaginalis sucrase-isomaltase, putative 0.0172 0.0282 0.3803
Trichomonas vaginalis alpha-glucosidase, putative 0.0122 0.0167 0.1984
Schistosoma mansoni hypothetical protein 0.014 0.0208 0.0208
Giardia lamblia 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase 0.0129 0.0184 0.1658
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0122 0.0167 0.1984
Brugia malayi Nuclear hormone receptor-like 1 0.0091 0.0098 0.0382
Leishmania major alpha glucosidase II subunit, putative 0.0172 0.0282 0.4507
Loa Loa (eye worm) hypothetical protein 0.0091 0.0098 0.0251
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.0164
Echinococcus granulosus Nuclear hormone receptor HR96 0.0081 0.0076 0.0228
Brugia malayi Steroid receptor seven-up type 2 0.0172 0.0281 0.1097
Brugia malayi hypothetical protein 0.0091 0.0098 0.0382
Brugia malayi Nuclear hormone receptor E75 0.0081 0.0076 0.0296
Brugia malayi ecdysteroid receptor 0.0172 0.0281 0.1097
Trichomonas vaginalis alpha-glucosidase, putative 0.0172 0.0282 0.3803
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0091 0.0098 0.0098
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0081 0.0076 0.0228
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0081 0.0076 0.0228
Echinococcus multilocularis thyroid hormone receptor alpha 0.0312 0.0596 0.1984
Loa Loa (eye worm) hypothetical protein 0.0172 0.0281 0.0975
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0081 0.0076 0.0164
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0345 0.0672 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.0281 0.0975
Schistosoma mansoni alpha-glucosidase 0.1133 0.2448 0.2448
Onchocerca volvulus Protein ultraspiracle homolog 0.0172 0.0281 0.1551
Trichomonas vaginalis alpha-glucosidase, putative 0.0122 0.0167 0.1984
Loa Loa (eye worm) hypothetical protein 0.0233 0.0419 0.152
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.0164
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0172 0.0281 0.092
Schistosoma mansoni rab6-interacting 0.0238 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0172 0.0281 0.0975
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0172 0.0281 0.1097
Schistosoma mansoni hypothetical protein 0.0093 0.0103 0.0103
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0172 0.0281 0.092
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.0564 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0122 0.0167 0.0922
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0172 0.0281 0.0975
Loa Loa (eye worm) hypothetical protein 0.0091 0.0098 0.0251
Loa Loa (eye worm) nuclear receptor NHR-67 0.0081 0.0076 0.0164
Schistosoma mansoni polycystin 1-related 0.0238 0.043 0.043
Echinococcus granulosus thyroid hormone receptor alpha 0.0081 0.0076 0.0228
Trichomonas vaginalis alpha-glucosidase, putative 0.0122 0.0167 0.1984
Echinococcus multilocularis lysosomal alpha glucosidase 0.1184 0.2563 0.8625
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.014 0.0208 0.0673
Loa Loa (eye worm) transcription factor SMAD2 0.0076 0.0064 0.0116
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0172 0.0281 0.092
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0341 0.0661 1
Echinococcus granulosus dihydrofolate reductase 0.0182 0.0303 0.0995
Trichomonas vaginalis nh(3)-dependent NAD(+) synthetase, putative 0.0087 0.0089 0.0742
Schistosoma mansoni alpha-l-fucosidase 0.0787 0.1669 0.1669
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.007 0.005 0.022
Entamoeba histolytica glycogen debranching enzyme, putative 0.0129 0.0184 0.1658
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.1184 0.2563 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0172 0.0281 0.1097
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0172 0.0281 0.092
Loa Loa (eye worm) hypothetical protein 0.0172 0.0281 0.0975
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0182 0.0303 0.0782
Schistosoma mansoni hypothetical protein 0.0166 0.0267 0.0267
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0172 0.0281 0.1097
Trichomonas vaginalis maltase-glucoamylase, putative 0.0172 0.0282 0.3803
Brugia malayi hypothetical protein 0.0081 0.0076 0.0296
Brugia malayi photoreceptor-specific nuclear receptor 0.0172 0.0281 0.1097
Brugia malayi dihydrofolate reductase family protein 0.0182 0.0303 0.1183
Plasmodium vivax glutamine-dependent NAD(+) synthetase, putative 0.0087 0.0089 0.1029
Loa Loa (eye worm) alpha-L-fucosidase 0.0787 0.1669 0.6465
Brugia malayi nuclear receptor NHR-88 0.0081 0.0076 0.0296
Plasmodium vivax multidomain scavenger receptor, putative 0.0238 0.043 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0081 0.0076 0.0228
Echinococcus multilocularis lysosomal alpha glucosidase 0.1184 0.2563 0.8625
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0172 0.0281 0.0281
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0172 0.0281 0.092
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0081 0.0076 0.0419
Echinococcus granulosus glycogen debranching enzyme 0.0129 0.0184 0.0592
Brugia malayi hypothetical protein 0.0233 0.0419 0.1633
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0172 0.0281 0.092
Loa Loa (eye worm) doublecortin family protein 0.0238 0.043 0.1566
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0182 0.0303 0.0782
Echinococcus granulosus ecdysone induced protein 78C 0.0172 0.0281 0.092
Echinococcus granulosus lysosomal alpha glucosidase 0.1184 0.2563 0.8625
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.007 0.005 0.0751
Echinococcus granulosus FTZ F1 alpha 0.0172 0.0281 0.092
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0081 0.0076 0.0076
Echinococcus granulosus fucosidase alpha L 1 tissue 0.0787 0.1669 0.5607
Schistosoma mansoni coup transcription factor 0.0172 0.0281 0.0281
Echinococcus granulosus RUN 0.0238 0.043 0.1424
Trichomonas vaginalis alpha-glucosidase, putative 0.0122 0.0167 0.1984
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0172 0.0281 0.0975
Echinococcus multilocularis microsomal glutathione S transferase 3 0.1027 0.2209 0.7431
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0172 0.0281 0.1097
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.0581 0.1203 0.1203
Mycobacterium ulcerans alpha-L-fucosidase 0.0787 0.1669 0.5765
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0052 0.001 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0172 0.0282 0.3803
Brugia malayi Nuclear hormone receptor-like 1 0.0091 0.0098 0.0382
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0172 0.0281 0.1097
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0172 0.0281 0.1097
Onchocerca volvulus 0.0081 0.0076 0.0419
Onchocerca volvulus 0.0081 0.0076 0.0419
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0172 0.0281 0.1097
Echinococcus granulosus neutral alpha glucosidase AB 0.0172 0.0282 0.0922
Trypanosoma cruzi NAD+ synthase, putative 0.0087 0.0089 0.1455
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0081 0.0076 0.0228
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.0419 0.1385
Trypanosoma brucei glucosidase, putative 0.0172 0.0282 0.4507
Loa Loa (eye worm) hypothetical protein 0.0122 0.0167 0.0525
Brugia malayi ecdysone receptor 0.0081 0.0076 0.0296
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0246 0.0575
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.0164
Schistosoma mansoni zinc finger protein 0.0081 0.0076 0.0076
Echinococcus multilocularis neutral alpha glucosidase AB 0.0172 0.0282 0.0922
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.1302 0.2829 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0081 0.0076 0.0296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0172 0.0281 0.0975
Trichomonas vaginalis alpha-glucosidase, putative 0.0172 0.0282 0.3803
Brugia malayi Glycosyl hydrolases family 31 protein 0.1184 0.2563 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0238 0.043 0.1424
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0172 0.0281 0.1097
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0211 0.3127
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.1364 0.297 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0238 0.043 0.1424
Echinococcus multilocularis nuclear receptor nhr 48 0.0081 0.0076 0.0228
Schistosoma mansoni retinoic acid receptor RXR 0.0172 0.0281 0.0281
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0172 0.0282 0.3369
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0172 0.0281 0.092
Loa Loa (eye worm) dihydrofolate reductase 0.0182 0.0303 0.1063
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0172 0.0281 0.0281
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0345 0.0672 1
Onchocerca volvulus 0.0851 0.1812 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0122 0.0167 0.1984
Plasmodium falciparum LCCL domain-containing protein 0.0238 0.043 1
Onchocerca volvulus 0.0172 0.0281 0.1551
Loa Loa (eye worm) hypothetical protein 0.0172 0.0281 0.0975
Schistosoma mansoni alpha glucosidase 0.0172 0.0282 0.0282
Echinococcus multilocularis FTZ F1 alpha 0.0172 0.0281 0.092
Brugia malayi Glycosyl hydrolases family 31 protein 0.0122 0.0167 0.0652
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0081 0.0076 0.0419
Schistosoma mansoni thyroid hormone receptor 0.0312 0.0596 0.0596
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0091 0.0098 0.0302
Loa Loa (eye worm) hypothetical protein 0.0238 0.043 0.1566
Brugia malayi hypothetical protein 0.0091 0.0098 0.0382
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0172 0.0281 0.0281
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.0564 1
Brugia malayi nuclear receptor NHR-88 0.0172 0.0281 0.1097
Schistosoma mansoni lipoxygenase 0.1364 0.297 0.297
Echinococcus multilocularis glycogen debranching enzyme 0.0129 0.0184 0.0592
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.0164
Leishmania major NAD synthase, putative 0.0087 0.0089 0.0761
Trypanosoma cruzi hypothetical protein, conserved 0.0172 0.0282 0.492
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.0164
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0172 0.0281 0.092
Echinococcus multilocularis RUN 0.0238 0.043 0.1424
Trichomonas vaginalis alpha-glucosidase, putative 0.0122 0.0167 0.1984
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0122 0.0167 0.1367
Brugia malayi MH2 domain containing protein 0.0076 0.0064 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0172 0.0281 0.1097
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.014 0.0208 0.0673
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.0164
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.0164
Brugia malayi nuclear receptor RXR 0.0091 0.0098 0.0382
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0182 0.0303 1
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.1302 0.2829 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0172 0.0281 0.1097
Loa Loa (eye worm) hypothetical protein 0.0091 0.0098 0.0251
Brugia malayi Dihydrofolate reductase 0.0182 0.0303 0.1183
Echinococcus granulosus Nuclear hormone receptor HR96 0.0081 0.0076 0.0228
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.0419 0.1385
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0172 0.0281 0.092
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0122 0.0167 0.2861
Brugia malayi tailless protein 0.0081 0.0076 0.0296
Schistosoma mansoni dihydrofolate reductase 0.0182 0.0303 0.0303
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0172 0.0281 0.0975
Schistosoma mansoni microsomal glutathione s-transferase 0.1027 0.2209 0.2209
Loa Loa (eye worm) hypothetical protein 0.0091 0.0098 0.0251
Schistosoma mansoni nuclear receptor 0.0081 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.0164
Trichomonas vaginalis alpha-glucosidase, putative 0.0172 0.0282 0.3803
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0081 0.0076 0.0296
Echinococcus multilocularis ecdysone induced protein 78C 0.0172 0.0281 0.092
Giardia lamblia DNA repair protein RAD52 0.0341 0.0661 1
Brugia malayi nuclear hormone receptor 0.0081 0.0076 0.0296
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.0564 1
Chlamydia trachomatis dihydrofolate reductase 0.0182 0.0303 0.5
Schistosoma mansoni nuclear receptor nhr-48 0.0081 0.0076 0.0076
Schistosoma mansoni nuclear receptor 0.0081 0.0076 0.0076
Loa Loa (eye worm) DR-78 0.0081 0.0076 0.0164
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0091 0.0098 0.0302
Brugia malayi steroid hormone receptor 0.0172 0.0281 0.1097
Onchocerca volvulus 0.0238 0.043 0.2375
Toxoplasma gondii MAPEG family protein 0.1027 0.2209 1
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0097 0.0111 0.0394
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0172 0.0281 0.092
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0172 0.0281 0.1097
Schistosoma mansoni thyroid hormone receptor 0.0312 0.0596 0.0596
Schistosoma mansoni rab6-interacting 0.0238 0.043 0.043
Brugia malayi Amylo-alpha-1,6-glucosidase family protein 0.0129 0.0184 0.0717
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0172 0.0282 0.1271
Toxoplasma gondii glutamine-dependent NAD(+) synthetase protein, putative 0.0087 0.0089 0.0397
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0172 0.0281 0.0975
Echinococcus multilocularis dihydrofolate reductase 0.0182 0.0303 0.0995
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0211 0.3643
Brugia malayi hypothetical protein 0.0081 0.0076 0.0296
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0172 0.0281 0.092
Loa Loa (eye worm) nuclear hormone receptor 0.0081 0.0076 0.0164
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0172 0.0282 0.3803
Mycobacterium ulcerans hypothetical protein 0.0157 0.0246 0.0575
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0172 0.0281 0.092
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0211 0.3127
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0172 0.0281 0.1551
Brugia malayi nuclear receptor NHR-67 0.0081 0.0076 0.0296
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0172 0.0282 0.3803
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0172 0.0281 0.0281
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0172 0.0281 0.0281
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0129 0.0184 0.0827
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0081 0.0076 0.0228
Brugia malayi Nuclear hormone receptor E75 0.0081 0.0076 0.0296
Schistosoma mansoni nuclear hormone receptor 0.0081 0.0076 0.0076
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0129 0.0184 0.2249
Onchocerca volvulus Bile acid receptor homolog 0.0172 0.0281 0.1551
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0076 0.0228
Schistosoma mansoni nuclear hormone receptor 0.0081 0.0076 0.0076
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0106 0.0131 0.0131
Echinococcus granulosus microsomal glutathione S transferase 3 0.1027 0.2209 0.7431
Brugia malayi Nuclear hormone receptor-like 1 0.0172 0.0281 0.1097
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.0164
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.0787 0.1669 0.5607
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0172 0.0282 0.3369
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.0164
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0076 0.0228
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.0164
Trypanosoma brucei glycosyl hydrolase-like protein 0.0122 0.0167 0.2281
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0091 0.0098 0.0251
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.0564 1
Brugia malayi conserved hypotetical protein 0.0081 0.0076 0.0296
Schistosoma mansoni alpha-glucosidase 0.1133 0.2448 0.2448
Schistosoma mansoni RAR-like nuclear receptor 0.0172 0.0281 0.0281
Brugia malayi hypothetical protein 0.0238 0.043 0.1679
Loa Loa (eye worm) hypothetical protein 0.0091 0.0098 0.0251
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0129 0.0184 0.2249
Loa Loa (eye worm) hypothetical protein 0.0129 0.0184 0.0591
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.0164
Echinococcus multilocularis lipoxygenase domain containing protein 0.0238 0.043 0.1424
Leishmania major glycosyl hydrolase-like protein 0.0122 0.0167 0.2281
Entamoeba histolytica hypothetical protein 0.0097 0.0111 0.0394
Treponema pallidum NAD synthetase 0.0087 0.0089 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0091 0.0098 0.0098
Echinococcus multilocularis Polycystic kidney disease protein 0.0238 0.043 0.1424
Brugia malayi nuclear hormone receptor family member nhr-6 0.0081 0.0076 0.0296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0172 0.0281 0.0975
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0087 0.0089 0.0089
Schistosoma mansoni hypothetical protein 0.0238 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0172 0.0281 0.0975
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0172 0.0281 0.1097
Trichomonas vaginalis alpha-glucosidase, putative 0.0172 0.0282 0.3803
Brugia malayi Doublecortin family protein 0.0238 0.043 0.1679
Loa Loa (eye worm) steroid hormone receptor 0.0172 0.0281 0.0975
Brugia malayi orphan nuclear receptor NR2E1 0.0081 0.0076 0.0296
Echinococcus granulosus nuclear receptor nhr 48 0.0081 0.0076 0.0228
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0122 0.0167 0.1984
Trypanosoma cruzi NAD+ synthase, putative 0.0087 0.0089 0.1455
Onchocerca volvulus 0.0238 0.043 0.2375
Loa Loa (eye worm) hypothetical protein 0.0238 0.043 0.1566
Brugia malayi nuclear receptor RXR 0.0081 0.0076 0.0296
Plasmodium falciparum glutamine-dependent NAD(+) synthetase, putative 0.0087 0.0089 0.1029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0172 0.0281 0.0975
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0172 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0172 0.0281 0.0975
Schistosoma mansoni steroid hormone receptor ad4bp 0.0172 0.0281 0.0281
Trypanosoma cruzi hypothetical protein, conserved 0.0172 0.0282 0.492
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0172 0.0281 0.1097
Echinococcus granulosus lipoxygenase domain containing protein 0.0238 0.043 0.1424
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.3094 0.6872 0.6872
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.0282 0.1099
Loa Loa (eye worm) MH2 domain-containing protein 0.0076 0.0064 0.0116
Schistosoma mansoni nuclear hormone receptor 0.0172 0.0281 0.0281
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.0282 0.0978
Brugia malayi Alpha-L-fucosidase family protein 0.0787 0.1669 0.6512
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.0164
Trypanosoma brucei NAD+ synthase, putative 0.0087 0.0089 0.0761
Schistosoma mansoni hypothetical protein 0.0102 0.0123 0.0123
Echinococcus granulosus Polycystic kidney disease protein 0.0238 0.043 0.1424
Brugia malayi hypothetical protein 0.0238 0.043 0.1679
Echinococcus granulosus arachidonate 5 lipoxygenase 0.1364 0.297 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.0281 0.0975
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0122 0.0167 0.2861

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.025 ug ml-1 Inhibitory activity against ATCC 13048 strain(E. aerogenes) in the presence of ciprofloxacin fluoroquinolone at 16 ug/mL ChEMBL. 11689091
MIC (functional) = 0.1 ug ml-1 Inhibitory activity against ATCC 13048 strain(E. aerogenes) in the presence of Norfloxacin and fluoroquinolone at a concentration of 16 ug/mL ChEMBL. 11689091
MIC (functional) = 0.25 ug ml-1 Inhibitory activity against p9- (derivative of ATCC )13048 strain(E. aerogenes) in the presence of ciprofloxacin and fluoroquinolone at 16 ug/mL ChEMBL. 11689091
MIC (functional) = 1 ug ml-1 Inhibitory activity against p9- (derivative of ATCC )13048 strain(E. aerogenes) in the presence of Norfloxacin and fluoroquinolone at 16 ug/mL ChEMBL. 11689091

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.