Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutaminase 2 | 0.0273 | 0.9271 | 0.9873 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.0291 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.009 | 0.206 | 0.1622 |
Mycobacterium leprae | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0101 | 0.2487 | 0.5 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0191 | 0.6042 | 0.6042 |
Onchocerca volvulus | Peroxidasin homolog | 0.0275 | 0.9377 | 0.5 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Brugia malayi | WGR domain containing protein | 0.0163 | 0.4961 | 0.3654 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.009 | 0.206 | 0.0654 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0275 | 0.9377 | 1 |
Schistosoma mansoni | peroxidasin | 0.0275 | 0.9377 | 0.9267 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0076 | 0.1504 | 0.1036 |
Schistosoma mansoni | peroxidasin | 0.0275 | 0.9377 | 0.9267 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.009 | 0.2078 | 0.0023 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Onchocerca volvulus | Peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0273 | 0.9271 | 0.9082 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0275 | 0.9377 | 0.9216 |
Schistosoma mansoni | glutaminase | 0.0273 | 0.9271 | 0.9142 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.0291 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0275 | 0.9377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0191 | 0.6042 | 0.5824 |
Loa Loa (eye worm) | glutaminase | 0.0273 | 0.9271 | 0.9873 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.01 | 0.248 | 0.053 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0191 | 0.6042 | 0.599 |
Brugia malayi | Peroxidasin | 0.0275 | 0.9377 | 0.9216 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0163 | 0.4961 | 0.4683 |
Mycobacterium tuberculosis | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0101 | 0.2487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0191 | 0.6042 | 0.4737 |
Echinococcus granulosus | peroxidasin | 0.0275 | 0.9377 | 0.9343 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.009 | 0.2078 | 0.0023 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0076 | 0.1504 | 0.1504 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trypanosoma brucei | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.206 | 0.1202 |
Onchocerca volvulus | Peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.0291 | 1 | 1 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0191 | 0.6042 | 0.599 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.0291 | 1 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0275 | 0.9377 | 0.9216 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0201 | 0.6444 | 0.6474 |
Trichomonas vaginalis | glutaminase, putative | 0.0273 | 0.9271 | 0.9031 |
Echinococcus multilocularis | peroxidasin | 0.0275 | 0.9377 | 0.9377 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.009 | 0.2078 | 0.0023 |
Onchocerca volvulus | Peroxidasin homolog | 0.0275 | 0.9377 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0163 | 0.4961 | 0.4069 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.009 | 0.2078 | 0.0023 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.009 | 0.2078 | 0.0023 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0191 | 0.6042 | 0.4737 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.009 | 0.2078 | 0.0023 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 0.5 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.0291 | 1 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0201 | 0.6444 | 0.6474 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.6042 | 0.599 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0078 | 0.1582 | 0.0092 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.0291 | 1 | 0.5 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0291 | 1 | 1 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.3423 | 0.2842 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.009 | 0.206 | 0.206 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0163 | 0.4961 | 0.4961 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.1 M | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea . | ChEMBL. | 1560434 |
IC50 (functional) | = 3.5 M | Inhibitory concentration of the Compound was tested against LTD4 induced contraction of guinea pig trachea . | ChEMBL. | 1560434 |
Inhibition (functional) | = 44.9 % | Inhibitory activity of the Compound was tested against LTD4 induced contraction of guinea pig trachea at 3*10e-7 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 49 % | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea at 3*10e-7 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 84.2 % | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea at 1*10e-6 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 87.8 % | Inhibitory activity of the Compound was tested against LTD4 induced contraction of guinea pig trachea at 1*10e-6 M concentration. | ChEMBL. | 1560434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.