Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (small chain) | 0.0069 | 0.0919 | 0.0919 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0526 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.0971 | 0.7778 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0037 | 0.0289 | 0.2319 |
Echinococcus granulosus | dna polymerase kappa | 0.0045 | 0.0432 | 0.1694 |
Plasmodium falciparum | peptide deformylase | 0.0225 | 0.4009 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0086 | 0.1248 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0086 | 0.1248 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0362 | 0.6743 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0122 | 0.1975 | 0.1975 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0225 | 0.4009 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.0971 | 0.6602 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0072 | 0.0971 | 0.7778 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0225 | 0.4009 | 0.4009 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0122 | 0.1975 | 0.1613 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0322 | 0.1401 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0171 | 0.2939 | 0.2939 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0086 | 0.1248 | 1 |
Treponema pallidum | quinoline 2-oxidoreductase | 0.0057 | 0.0688 | 0.0512 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0086 | 0.1248 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0045 | 0.0432 | 0.1694 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0526 | 1 | 1 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.024 | 0.4313 | 0.4056 |
Chlamydia trachomatis | peptide deformylase | 0.0225 | 0.4009 | 0.5 |
Mycobacterium leprae | Isocitrate lyase | 0.0247 | 0.4446 | 0.0728 |
Mycobacterium ulcerans | hypothetical protein | 0.0059 | 0.0715 | 0.0296 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.0971 | 0.6602 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0526 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0122 | 0.1975 | 0.1613 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0362 | 0.6743 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0072 | 0.0971 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0171 | 0.2939 | 0.262 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0362 | 0.6743 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0086 | 0.1248 | 1 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0526 | 1 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0069 | 0.0919 | 0.0509 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.0216 | 0.1733 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0042 | 0.037 | 0.0744 |
Plasmodium vivax | peptide deformylase, putative | 0.0225 | 0.4009 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0072 | 0.0971 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0045 | 0.0432 | 0.346 |
Mycobacterium ulcerans | peptide deformylase | 0.0225 | 0.4009 | 0.3739 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0045 | 0.0432 | 0.346 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0042 | 0.037 | 0.0744 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.0971 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.0971 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0662 | 0.5241 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0086 | 0.1248 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0171 | 0.2939 | 0.262 |
Toxoplasma gondii | hypothetical protein | 0.0225 | 0.4009 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.0971 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0069 | 0.0919 | 0.0509 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.0216 | 0.1733 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.0971 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0086 | 0.1248 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0107 | 0.1678 | 0.1303 |
Treponema pallidum | hypothetical protein | 0.0059 | 0.0715 | 0.059 |
Treponema pallidum | polypeptide deformylase (def) | 0.0225 | 0.4009 | 1 |
Trypanosoma brucei | unspecified product | 0.0037 | 0.0289 | 0.2319 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0526 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 19 % | In vitro inhibition of collagen-induced platelet aggregation in human platelet-rich plasma (PRP) at 273 uM | ChEMBL. | 8831771 |
Inhibition (functional) | = 19 % | In vitro inhibition of collagen-induced platelet aggregation in human platelet-rich plasma (PRP) at 273 uM | ChEMBL. | 8831771 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.