Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0662 | 0.5241 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0086 | 0.1248 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.0971 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.0971 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0045 | 0.0432 | 0.346 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0042 | 0.037 | 0.0744 |
Mycobacterium ulcerans | peptide deformylase | 0.0225 | 0.4009 | 0.3739 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Treponema pallidum | hypothetical protein | 0.0059 | 0.0715 | 0.059 |
Treponema pallidum | polypeptide deformylase (def) | 0.0225 | 0.4009 | 1 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0526 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0037 | 0.0289 | 0.2319 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0107 | 0.1678 | 0.1303 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0086 | 0.1248 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.0216 | 0.1733 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.0971 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.0971 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0069 | 0.0919 | 0.0509 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0171 | 0.2939 | 0.262 |
Toxoplasma gondii | hypothetical protein | 0.0225 | 0.4009 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0086 | 0.1248 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0362 | 0.6743 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0069 | 0.0919 | 0.0509 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0526 | 1 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0171 | 0.2939 | 0.262 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0526 | 1 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0072 | 0.0971 | 1 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0362 | 0.6743 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0122 | 0.1975 | 0.1613 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0042 | 0.037 | 0.0744 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0072 | 0.0971 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0045 | 0.0432 | 0.346 |
Plasmodium vivax | peptide deformylase, putative | 0.0225 | 0.4009 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.0216 | 0.1733 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Treponema pallidum | quinoline 2-oxidoreductase | 0.0057 | 0.0688 | 0.0512 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0086 | 0.1248 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0322 | 0.1401 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0086 | 0.1248 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0171 | 0.2939 | 0.2939 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0122 | 0.1975 | 0.1613 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0225 | 0.4009 | 0.4009 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.0971 | 0.6602 |
Mycobacterium ulcerans | hypothetical protein | 0.0059 | 0.0715 | 0.0296 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.024 | 0.4313 | 0.4056 |
Mycobacterium leprae | Isocitrate lyase | 0.0247 | 0.4446 | 0.0728 |
Chlamydia trachomatis | peptide deformylase | 0.0225 | 0.4009 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0045 | 0.0432 | 0.1694 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0526 | 1 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0086 | 0.1248 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0086 | 0.1248 | 1 |
Plasmodium falciparum | peptide deformylase | 0.0225 | 0.4009 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.0971 | 0.7778 |
Echinococcus granulosus | dna polymerase kappa | 0.0045 | 0.0432 | 0.1694 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0037 | 0.0289 | 0.2319 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (small chain) | 0.0069 | 0.0919 | 0.0919 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0526 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.0971 | 0.6602 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0072 | 0.0971 | 0.7778 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0225 | 0.4009 | 0.5 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0362 | 0.6743 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0122 | 0.1975 | 0.1975 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0432 | 0.346 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 47 % | In vitro inhibition of collagen-induced platelet aggregation in human platelet-rich plasma (PRP) at 273 uM | ChEMBL. | 8831771 |
Inhibition (functional) | = 47 % | In vitro inhibition of collagen-induced platelet aggregation in human platelet-rich plasma (PRP) at 273 uM | ChEMBL. | 8831771 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.