Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.1247 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0454 | 0.3223 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0507 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Brugia malayi | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0074 | 0.1247 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0046 | 0.0681 | 0.516 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0507 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0024 | 0.0227 | 0.128 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0043 | 0.0616 | 0.4606 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0024 | 0.0227 | 0.0151 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0125 | 0.0408 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.1247 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0507 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0074 | 0.1247 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0035 | 0.0454 | 0.3223 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0074 | 0.1247 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0074 | 0.1247 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0046 | 0.0681 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0125 | 0.0408 |
Brugia malayi | polk-prov protein | 0.0035 | 0.0454 | 0.3223 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0043 | 0.0616 | 0.4606 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | unspecified product | 0.0039 | 0.0531 | 0.3879 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0024 | 0.0227 | 0.128 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0012 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0125 | 0.0408 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0074 | 0.1247 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0024 | 0.0227 | 0.128 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Echinococcus multilocularis | dna polymerase kappa | 0.0046 | 0.0681 | 0.516 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0507 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0923 | 0.7227 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0565 | 0.4172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0039 | 0.0531 | 0.3879 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0074 | 0.1247 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0565 | 0.4172 |
Giardia lamblia | DINP protein human, muc B family | 0.0024 | 0.0227 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0565 | 0.4172 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0074 | 0.1247 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0035 | 0.0454 | 0.3223 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0046 | 0.0681 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.1247 | 1 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0507 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.11 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.11 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.13 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.13 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.13 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.13 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 18 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 18 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 22 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 22 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 28 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 28 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 28 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 28 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Blockade of morphine-induced elevation of tail-flick latency | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Blockade of morphine-induced elevation of tail-flick latency | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.