Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Hormone-sensitive lipase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | lipase, hormone-sensitive | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.1637 | 0.1637 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.1637 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0119 | 0.0536 | 0.0536 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.1637 | 0.1637 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.1637 | 0.1637 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.1637 | 0.1637 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.1637 | 0.1637 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.1637 | 0.1637 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.1637 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0506 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0119 | 0.0536 | 0.0536 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0119 | 0.0536 | 0.0536 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.1637 | 0.1637 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10.59 nM | Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | ChEMBL. | 18808096 |
IC50 (binding) | = 0.2 uM | Inhibitory concentration against acetylcholinesterase | ChEMBL. | 14711311 |
IC50 (binding) | = 0.2 uM | Inhibitory concentration against acetylcholinesterase | ChEMBL. | 14711311 |
IC50 (binding) | = 0.46 uM | Inhibitory concentration against butrylcholinesterase. | ChEMBL. | 14711311 |
IC50 (binding) | = 0.46 uM | Inhibitory concentration against butrylcholinesterase. | ChEMBL. | 14711311 |
IC50 (binding) | = 0.6 uM | Inhibition of hormone sensitive lipase (HSL). | ChEMBL. | 14711311 |
IC50 (binding) | = 0.6 uM | Inhibition of hormone sensitive lipase (HSL). | ChEMBL. | 14711311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.