Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0046 | 0.0681 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0074 | 0.1247 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0125 | 0.0408 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0074 | 0.1247 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0074 | 0.1247 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0035 | 0.0454 | 0.3223 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0507 | 1 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0043 | 0.0616 | 0.4606 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0024 | 0.0227 | 0.128 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0507 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.1247 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0024 | 0.0227 | 0.0151 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0125 | 0.0408 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0074 | 0.1247 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.1247 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0454 | 0.3223 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0507 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0035 | 0.0454 | 0.3223 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.1247 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0046 | 0.0681 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0507 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0074 | 0.1247 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0565 | 0.4172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Giardia lamblia | DINP protein human, muc B family | 0.0024 | 0.0227 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0074 | 0.1247 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0565 | 0.4172 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0565 | 0.4172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0039 | 0.0531 | 0.3879 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0565 | 0.4172 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0923 | 0.7227 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0507 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0074 | 0.1247 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0024 | 0.0227 | 0.128 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Echinococcus multilocularis | dna polymerase kappa | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0024 | 0.0227 | 0.128 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0012 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0125 | 0.0408 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0043 | 0.0616 | 0.4606 |
Trypanosoma brucei | unspecified product | 0.0039 | 0.0531 | 0.3879 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0046 | 0.0681 | 0.516 |
Brugia malayi | polk-prov protein | 0.0035 | 0.0454 | 0.3223 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.0681 | 0.516 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.0014 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.0014 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.0014 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.0014 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.0018 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.0018 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.1 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 0.1 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 56 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | = 56 mg kg-1 | Analgesic activity (ED50) measured using HCl writhing assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Blockade of morphine-induced elevation of tail-flick latency | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Analgesic activity (ED50) using tail-flick assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Analgesic activity (ED50) using tail-pinch assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Analgesic activity (ED50) using inclined screen assay in mice | ChEMBL. | 7265128 |
ED50 (functional) | > 100 mg kg-1 | Blockade of morphine-induced elevation of tail-flick latency | ChEMBL. | 7265128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.