Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.9135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.541 | 0.5807 | 0.5717 |
Trypanosoma cruzi | AMP deaminase, putative | 0.5729 | 0.6166 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.9135 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.9135 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.5729 | 0.6166 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.5729 | 0.6166 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.9135 | 1 | 0.5 |
Echinococcus multilocularis | AMP deaminase 2 | 0.5729 | 0.6166 | 0.6136 |
Loa Loa (eye worm) | hypothetical protein | 0.541 | 0.5807 | 0.5717 |
Loa Loa (eye worm) | hypothetical protein | 0.2005 | 0.1972 | 0.18 |
Trypanosoma cruzi | AMP deaminase, putative | 0.5729 | 0.6166 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.9135 | 1 | 1 |
Echinococcus granulosus | AMP deaminase 2 | 0.5729 | 0.6166 | 0.6136 |
Entamoeba histolytica | adenosine deaminase, putative | 0.9135 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.5729 | 0.6166 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3725 | 0.3909 | 0.3778 |
Brugia malayi | adenosine monophosphate deaminase | 0.5729 | 0.6166 | 0.6084 |
Trypanosoma cruzi | AMP deaminase, putative | 0.5729 | 0.6166 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.9135 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.9135 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.9135 | 1 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.5729 | 0.6166 | 0.3705 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.5729 | 0.6166 | 0.3705 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.5729 | 0.6166 | 0.3705 |
Trypanosoma brucei | AMP deaminase, putative | 0.5729 | 0.6166 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.9135 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.9135 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.9135 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.9135 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.9135 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.5729 | 0.6166 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.9135 | 1 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.5729 | 0.6166 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.5729 | 0.6166 | 0.3705 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.9135 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.541 | 0.5807 | 0.5717 |
Leishmania major | AMP deaminase, putative | 0.5729 | 0.6166 | 0.3705 |
Trypanosoma cruzi | AMP deaminase, putative | 0.5729 | 0.6166 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.541 | 0.5807 | 0.5717 |
Schistosoma mansoni | AMP deaminase | 0.5729 | 0.6166 | 0.6166 |
Plasmodium vivax | adenosine deaminase, putative | 0.9135 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.5729 | 0.6166 | 0.6084 |
Mycobacterium ulcerans | adenosine deaminase | 0.9135 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.9135 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.5729 | 0.6166 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.6 uM | Ability to block the interaction between integrin LFA-1 and its adhesion partner ICAM-1 in a time-resolved fluorescent LFA-1/ICAM-1 biochemical interaction assay | ChEMBL. | 11052808 |
IC50 (binding) | = 2.6 uM | Ability to block the interaction between integrin LFA-1 and its adhesion partner ICAM-1 in a time-resolved fluorescent LFA-1/ICAM-1 biochemical interaction assay | ChEMBL. | 11052808 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.