Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Hormone-sensitive lipase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Homo sapiens | lipase, hormone-sensitive | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | neuropeptide F receptor | 0.0298 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0298 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Brugia malayi | Dopamine receptor protein 1 | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0298 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0298 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0298 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0298 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0298 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0298 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Brugia malayi | G-protein coupled receptor | 0.0298 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0298 | 0 | 0.5 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0298 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0298 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0298 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Brugia malayi | G-protein coupled receptor | 0.0298 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Brugia malayi | neuropeptide F receptor | 0.0298 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0298 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0298 | 0 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0298 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0506 | 1 | 1 |
Brugia malayi | GnHR receptor homolog | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Brugia malayi | ORL1-like opioid receptor | 0.0298 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0298 | 0 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.0298 | 0 | 0.5 | |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0298 | 0 | 0.5 |
Brugia malayi | RE15519p | 0.0298 | 0 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0298 | 0 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0298 | 0 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0298 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0298 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.76 nM | Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | ChEMBL. | 18808096 |
IC50 (binding) | = 0.026 uM | Inhibitory concentration against acetylcholinesterase | ChEMBL. | 14711311 |
IC50 (binding) | = 0.026 uM | Inhibitory concentration against acetylcholinesterase | ChEMBL. | 14711311 |
IC50 (binding) | = 0.1 uM | Inhibition of hormone sensitive lipase (HSL). | ChEMBL. | 14711311 |
IC50 (binding) | = 0.1 uM | Inhibition of hormone sensitive lipase (HSL). | ChEMBL. | 14711311 |
IC50 (binding) | = 0.9 uM | Inhibitory concentration against butrylcholinesterase. | ChEMBL. | 14711311 |
IC50 (binding) | = 0.9 uM | Inhibitory concentration against butrylcholinesterase. | ChEMBL. | 14711311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.