Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lipoprotein lipase | Starlite/ChEMBL | References |
Homo sapiens | lipase, hormone-sensitive | Starlite/ChEMBL | References |
Rattus norvegicus | Hormone-sensitive lipase | Starlite/ChEMBL | References |
Homo sapiens | lipase, hepatic | Starlite/ChEMBL | References |
Homo sapiens | pancreatic lipase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0682 | 0.0621 |
Echinococcus multilocularis | snurportin 1 | 0.0287 | 0.5301 | 0.527 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0282 | 0.5185 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0682 | 0.0621 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0071 | 0.0682 | 0.0621 |
Mycobacterium ulcerans | hypothetical protein | 0.0148 | 0.2329 | 0.5 |
Schistosoma mansoni | rab6-interacting | 0.0071 | 0.0682 | 0.0621 |
Toxoplasma gondii | hypothetical protein | 0.0045 | 0.0125 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Schistosoma mansoni | loxhd1 | 0.0071 | 0.0682 | 0.0621 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0071 | 0.0682 | 0.5 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0287 | 0.5301 | 0.527 |
Onchocerca volvulus | 0.0071 | 0.0682 | 0.5 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0282 | 0.5185 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.0071 | 0.0682 | 0.0621 |
Brugia malayi | hypothetical protein | 0.0071 | 0.0682 | 0.8517 |
Brugia malayi | Doublecortin family protein | 0.0071 | 0.0682 | 0.8517 |
Schistosoma mansoni | hypothetical protein | 0.0287 | 0.5301 | 0.527 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0048 | 0.0186 | 0.0358 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0071 | 0.0682 | 0.0621 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0506 | 1 | 1 |
Onchocerca volvulus | 0.0071 | 0.0682 | 0.5 | |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0282 | 0.5185 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0071 | 0.0682 | 0.0621 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0282 | 0.5185 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0287 | 0.5301 | 0.527 |
Brugia malayi | RNA, U transporter 1 | 0.0076 | 0.079 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0071 | 0.0682 | 0.0621 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0071 | 0.0682 | 0.0621 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0071 | 0.0682 | 0.5 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0071 | 0.0682 | 0.0621 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0133 | 0.2007 | 0.3871 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0148 | 0.2329 | 0.5 |
Echinococcus multilocularis | RUN | 0.0071 | 0.0682 | 0.0621 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0133 | 0.2007 | 0.3871 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0682 | 0.0621 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0071 | 0.0682 | 0.0621 |
Schistosoma mansoni | polycystin 1-related | 0.0071 | 0.0682 | 0.0621 |
Schistosoma mansoni | rab6-interacting | 0.0071 | 0.0682 | 0.0621 |
Brugia malayi | hypothetical protein | 0.0071 | 0.0682 | 0.8517 |
Echinococcus granulosus | RUN | 0.0071 | 0.0682 | 0.0621 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.41 nM | Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | ChEMBL. | 18808096 |
IC50 (binding) | = 0.023 uM | Inhibition of hormone sensitive lipase (HSL). | ChEMBL. | 14711311 |
IC50 (binding) | = 0.023 uM | Inhibition of hormone sensitive lipase (HSL). | ChEMBL. | 14711311 |
IC50 (binding) | = 0.2 uM | Compound was tested to inhibit lipoprotein lipase (LPL) | ChEMBL. | 14711311 |
IC50 (binding) | = 0.2 uM | Compound was tested to inhibit lipoprotein lipase (LPL) | ChEMBL. | 14711311 |
IC50 (binding) | = 1.8 uM | Compound was tested to inhibit hepatic lipase (HL) | ChEMBL. | 14711311 |
IC50 (binding) | = 1.8 uM | Compound was tested to inhibit hepatic lipase (HL) | ChEMBL. | 14711311 |
IC50 (binding) | > 10 uM | Compound was tested to inhibit pancreatic lipase (PL) | ChEMBL. | 14711311 |
IC50 (binding) | > 10 uM | Compound was tested to inhibit pancreatic lipase (PL) | ChEMBL. | 14711311 |
IC50 (binding) | > 50 uM | Inhibitory concentration against butrylcholinesterase. | ChEMBL. | 14711311 |
IC50 (binding) | > 50 uM | Inhibitory concentration against acetylcholinesterase | ChEMBL. | 14711311 |
IC50 (binding) | > 50 uM | Inhibitory concentration against butrylcholinesterase. | ChEMBL. | 14711311 |
IC50 (binding) | > 50 uM | Inhibitory concentration against acetylcholinesterase | ChEMBL. | 14711311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.