Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.2706 | 0.4411 | 0.2279 |
Plasmodium vivax | adenosine deaminase, putative | 0.5201 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5201 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.5201 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.2706 | 0.4411 | 0.4411 |
Trypanosoma brucei | AMP deaminase, putative | 0.2706 | 0.4411 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.2706 | 0.4411 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.2706 | 0.4411 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.2706 | 0.4411 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2706 | 0.4411 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.5201 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.5201 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.5201 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.5201 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.5201 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3232 | 0.5589 | 0.5589 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2706 | 0.4411 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.5201 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.5201 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2706 | 0.4411 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.2706 | 0.4411 | 0.2279 |
Plasmodium falciparum | adenosine deaminase | 0.5201 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2706 | 0.4411 | 1 |
Leishmania major | AMP deaminase, putative | 0.2706 | 0.4411 | 0.2279 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.5201 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3232 | 0.5589 | 0.5589 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.5201 | 1 | 0.5 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.2706 | 0.4411 | 0.2279 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.2706 | 0.4411 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.5201 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.5201 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.2706 | 0.4411 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.5201 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3232 | 0.5589 | 0.5589 |
Entamoeba histolytica | adenosine deaminase, putative | 0.5201 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3232 | 0.5589 | 0.5589 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2706 | 0.4411 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1969 | 0.2762 | 0.2762 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.2706 | 0.4411 | 0.2279 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.5201 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.5201 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 390 nM | Displacement of [3H]WIN35,428 from Dopamine Transporter of guinea pig striatal membrane | ChEMBL. | 12213053 |
IC50 (binding) | = 390 nM | Displacement of [3H]WIN35,428 from Dopamine Transporter of guinea pig striatal membrane | ChEMBL. | 12213053 |
Ratio (functional) | = 0.1 | Ratio of the IC50 value of Mazindol to that of the compound. | ChEMBL. | 12213053 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.