Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.2212 | 0.4789 | 0.5603 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.2212 | 0.4789 | 0.5605 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase small chain, putative | 0.029 | 0.0528 | 0.0429 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit beta | 0.029 | 0.0528 | 0.0739 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0169 | 0.0258 | 0.0183 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0151 | 0.0218 | 0.0137 |
Leishmania major | ribonucleoside-diphosphate reductase small chain, putative | 0.029 | 0.0528 | 0.0429 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.2212 | 0.4789 | 0.5603 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.2212 | 0.4789 | 1 |
Schistosoma mansoni | integrin alpha | 0.0148 | 0.0213 | 0.0245 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.2043 | 0.4415 | 0.5109 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0735 | 0.1513 | 0.167 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3905 | 0.8544 | 1 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.2212 | 0.4789 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.3905 | 0.8544 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4561 | 1 | 1 |
Echinococcus multilocularis | adam | 0.0127 | 0.0166 | 0.019 |
Loa Loa (eye worm) | reprolysin | 0.009 | 0.0083 | 0.0097 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0117 | 0.0144 | 0.0164 |
Loa Loa (eye worm) | integrin beta-2 | 0.0316 | 0.0586 | 0.0685 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase small chain | 0.029 | 0.0528 | 0.0614 |
Plasmodium falciparum | dihydrofolate synthase/folylpolyglutamate synthase | 0.0099 | 0.0103 | 0.0001 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0054 | 0.0004 | 0.0004 |
Echinococcus multilocularis | folylpolyglutamate synthase, mitochondrial | 0.0099 | 0.0103 | 0.0117 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1716 | 0.3691 | 0.4317 |
Echinococcus multilocularis | folylpolyglutamate synthase, mitochondrial | 0.0099 | 0.0103 | 0.0117 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.1238 | 0.263 | 0.3075 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0099 | 0.0103 | 0.0002 |
Loa Loa (eye worm) | ribonucleotide reductase M2 B | 0.029 | 0.0528 | 0.0618 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) | 0.029 | 0.0528 | 0.0503 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1858 | 0.4004 | 0.4621 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1716 | 0.3691 | 0.4251 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4561 | 1 | 1 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.2043 | 0.4415 | 0.5109 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.2043 | 0.4415 | 1 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.009 | 0.0083 | 0.0092 |
Echinococcus multilocularis | integrin alpha 3 | 0.0114 | 0.0136 | 0.0155 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0151 | 0.0218 | 0.0137 |
Onchocerca volvulus | 0.3905 | 0.8544 | 1 | |
Schistosoma mansoni | integrin alpha-ps | 0.0067 | 0.0031 | 0.0032 |
Brugia malayi | thymidylate synthase | 0.3905 | 0.8544 | 1 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.2212 | 0.4789 | 0.4736 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0133 | 0.0155 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase small subunit | 0.029 | 0.0528 | 0.0429 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1858 | 0.4004 | 0.3941 |
Brugia malayi | FolC bifunctional protein | 0.0099 | 0.0103 | 0.0121 |
Schistosoma mansoni | dihydrofolate reductase | 0.1716 | 0.3691 | 0.4317 |
Echinococcus granulosus | folylpolyglutamate synthase mitochondrial | 0.0099 | 0.0103 | 0.0117 |
Echinococcus multilocularis | thymidylate synthase | 0.3905 | 0.8544 | 1 |
Brugia malayi | ribonucleotide reductase 2 | 0.029 | 0.0528 | 0.0618 |
Echinococcus multilocularis | integrin beta 2 | 0.0234 | 0.0404 | 0.0468 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0054 | 0.0004 | 0.0004 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.029 | 0.0528 | 0.043 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit beta | 0.029 | 0.0528 | 0.0596 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.009 | 0.0083 | 0.0092 |
Echinococcus granulosus | ribonucleoside diphosphate reductase subunit | 0.029 | 0.0528 | 0.0614 |
Trypanosoma brucei | folylpolyglutamate synthase, putative | 0.0099 | 0.0103 | 0.0001 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase small chain, putative | 0.029 | 0.0528 | 0.043 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.2212 | 0.4789 | 0.4735 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.2043 | 0.4415 | 0.5108 |
Echinococcus granulosus | integrin beta 2 | 0.0234 | 0.0404 | 0.0468 |
Brugia malayi | hypothetical protein | 0.0117 | 0.0144 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0083 | 0.0097 |
Echinococcus granulosus | folylpolyglutamate synthase, mitochondrial | 0.0099 | 0.0103 | 0.0117 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0678 | 0.1387 | 0.162 |
Brugia malayi | hypothetical protein | 0.1858 | 0.4004 | 0.4686 |
Schistosoma mansoni | integrin beta subunit | 0.0186 | 0.0297 | 0.0343 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1716 | 0.3691 | 0.7576 |
Echinococcus granulosus | integrin alpha 3 | 0.0114 | 0.0136 | 0.0155 |
Brugia malayi | Dihydrofolate reductase | 0.1716 | 0.3691 | 0.4319 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase subunit | 0.029 | 0.0528 | 0.0614 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1716 | 0.3691 | 0.425 |
Mycobacterium leprae | conserved hypothetical protein | 0.0169 | 0.0258 | 0.0184 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3905 | 0.8544 | 1 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.2212 | 0.4789 | 0.4735 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4561 | 1 | 1 |
Brugia malayi | ribonucleoside-diphosphate reductase large chain, putative | 0.2212 | 0.4789 | 0.5605 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain, putative | 0.029 | 0.0528 | 0.043 |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0169 | 0.0258 | 0.0184 |
Brugia malayi | dihydrofolate reductase family protein | 0.1716 | 0.3691 | 0.4319 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0229 | 0.0391 | 0.0458 |
Loa Loa (eye worm) | FolC protein | 0.0099 | 0.0103 | 0.0121 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.2212 | 0.4789 | 0.4736 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.2212 | 0.4789 | 0.5603 |
Leishmania major | ribonucleoside-diphosphate reductase small chain, putative | 0.029 | 0.0528 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0065 | 0.0077 |
Echinococcus granulosus | dihydrofolate reductase | 0.1716 | 0.3691 | 0.4317 |
Echinococcus granulosus | adam | 0.0127 | 0.0166 | 0.019 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1858 | 0.4004 | 0.9046 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0316 | 0.0586 | 0.0685 |
Echinococcus granulosus | thymidylate synthase | 0.3905 | 0.8544 | 1 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.2212 | 0.4789 | 0.4736 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4561 | 1 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0067 | 0.0031 | 0.0032 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit beta | 0.029 | 0.0528 | 0.0906 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.029 | 0.0528 | 0.043 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0112 | 0.0133 | 0.0155 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.009 | 0.0083 | 0.0092 |
Schistosoma mansoni | folylpolyglutamate synthase | 0.0099 | 0.0103 | 0.0117 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1716 | 0.3691 | 0.4319 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4561 | 1 | 1 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0099 | 0.0103 | 0.0002 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.2043 | 0.4415 | 1 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0678 | 0.1387 | 0.162 |
Mycobacterium ulcerans | thymidylate synthase | 0.3905 | 0.8544 | 1 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase small chain, putative | 0.029 | 0.0528 | 0.0429 |
Echinococcus multilocularis | integrin alpha ps | 0.0067 | 0.0031 | 0.0032 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.2212 | 0.4789 | 0.4735 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0148 | 0.0213 | 0.0249 |
Plasmodium vivax | dihydrofolate synthase/folylpolyglutamate synthase, putative | 0.0099 | 0.0103 | 0.0001 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0225 | 0.0383 | 0.0444 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.009 | 0.0083 | 0.0092 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.029 | 0.0528 | 0.043 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) | 0.029 | 0.0528 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0142 | 0.0167 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0004 | 0.0004 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1716 | 0.3691 | 0.4251 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0627 | 0.1274 | 0.1183 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3905 | 0.8544 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0067 | 0.0031 | 0.0032 |
Plasmodium vivax | ribonucleoside-diphosphate reductase small chain, putative | 0.029 | 0.0528 | 0.043 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.31 uM | In vitro inhibitory concentration that relaxed KCL induced contraction in rat detrusor strip by 50% | ChEMBL. | 10737753 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.