Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | pancreatic lipase | Starlite/ChEMBL | References |
Homo sapiens | lipase, hepatic | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Homo sapiens | lipase, hormone-sensitive | Starlite/ChEMBL | References |
Rattus norvegicus | Hormone-sensitive lipase | Starlite/ChEMBL | References |
Homo sapiens | lipoprotein lipase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.5 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0506 | 0.5 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 0.5 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 0.5 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 19.41 nM | Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | ChEMBL. | 18808096 |
IC50 (binding) | = 0.75 uM | Inhibitory concentration against acetylcholinesterase | ChEMBL. | 14711311 |
IC50 (binding) | = 0.75 uM | Inhibitory concentration against acetylcholinesterase | ChEMBL. | 14711311 |
IC50 (binding) | = 0.92 uM | Inhibitory concentration against butrylcholinesterase. | ChEMBL. | 14711311 |
IC50 (binding) | = 0.92 uM | Inhibitory concentration against butrylcholinesterase. | ChEMBL. | 14711311 |
IC50 (binding) | = 1.1 uM | Inhibition of hormone sensitive lipase (HSL). | ChEMBL. | 14711311 |
IC50 (binding) | = 1.1 uM | Inhibition of hormone sensitive lipase (HSL). | ChEMBL. | 14711311 |
IC50 (binding) | > 10 uM | Compound was tested to inhibit pancreatic lipase (PL) | ChEMBL. | 14711311 |
IC50 (binding) | > 10 uM | Compound was tested to inhibit lipoprotein lipase (LPL) | ChEMBL. | 14711311 |
IC50 (binding) | > 10 uM | Compound was tested to inhibit pancreatic lipase (PL) | ChEMBL. | 14711311 |
IC50 (binding) | > 10 uM | Compound was tested to inhibit lipoprotein lipase (LPL) | ChEMBL. | 14711311 |
IC50 (binding) | = 15 uM | Compound was tested to inhibit hepatic lipase (HL) | ChEMBL. | 14711311 |
IC50 (binding) | = 15 uM | Compound was tested to inhibit hepatic lipase (HL) | ChEMBL. | 14711311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.