Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0011 | 0.0522 | 0.1485 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.005 | 0.3695 | 0.6488 |
Schistosoma mansoni | glutaminase | 0.0047 | 0.343 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0007 | 0.0173 | 0.1273 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0007 | 0.0173 | 0.2858 |
Echinococcus granulosus | dna polymerase kappa | 0.0007 | 0.0173 | 0.138 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.001 | 0.0401 | 0.113 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.005 | 0.3695 | 0.6488 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0049 | 0.3613 | 0.3514 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0006 | 0.008 | 0.0969 |
Brugia malayi | glutaminase DH11.1 | 0.0047 | 0.343 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0014 | 0.0763 | 0.6098 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.005 | 0.3695 | 1 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0072 | 0.5492 | 0.5433 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0072 | 0.5492 | 0.9724 |
Plasmodium vivax | SET domain protein, putative | 0.0005 | 0.0015 | 0.5 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0126 | 0.9962 | 0.994 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0007 | 0.0173 | 0.2858 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0014 | 0.0763 | 0.2188 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0033 | 0.0051 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0026 | 0.1734 | 0.2619 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0014 | 0.0763 | 0.605 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.001 | 0.0401 | 0.3124 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0011 | 0.0522 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.2515 | 0.7321 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.002 | 0.1251 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0127 | 1 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0047 | 0.343 | 0.5999 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0045 | 0.3316 | 0.429 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0072 | 0.5492 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0007 | 0.0173 | 0.2858 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.005 | 0.3695 | 0.6488 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0073 | 0.5602 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0011 | 0.0522 | 0.1485 |
Trichomonas vaginalis | set domain proteins, putative | 0.004 | 0.2918 | 0.5057 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0026 | 0.1734 | 0.0339 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.005 | 0.3695 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0007 | 0.0173 | 0.2858 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.001 | 0.0401 | 0.0233 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0011 | 0.0522 | 0.1485 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0011 | 0.0522 | 0.4105 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0011 | 0.0522 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.005 | 0.3695 | 0.6488 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0007 | 0.0173 | 0.2858 |
Brugia malayi | polk-prov protein | 0.0005 | 0.0033 | 0.0051 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0007 | 0.0173 | 0.2858 |
Loa Loa (eye worm) | glutaminase 2 | 0.0047 | 0.343 | 1 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0014 | 0.0763 | 0.2188 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0036 | 0.2515 | 0.7321 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0007 | 0.0173 | 0.2858 |
Onchocerca volvulus | 0.004 | 0.2918 | 1 | |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0011 | 0.0522 | 1 |
Schistosoma mansoni | lipoxygenase | 0.002 | 0.1251 | 0.3617 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0026 | 0.1734 | 0.1595 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.005 | 0.3695 | 0.6488 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.005 | 0.3695 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0007 | 0.0173 | 0.2858 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.001 | 0.0401 | 0.3208 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.005 | 0.3695 | 0.6488 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0073 | 0.5602 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0007 | 0.0133 | 0.106 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0007 | 0.0173 | 0.2858 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.002 | 0.1251 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0009 | 0.0347 | 0.0971 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0024 | 0.1599 | 0.2353 |
Mycobacterium ulcerans | glutaminase | 0.0047 | 0.343 | 0.3327 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0049 | 0.3613 | 0.5031 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0049 | 0.3613 | 0.631 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0073 | 0.5602 | 0.5546 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0005 | 0.0015 | 0.5 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0045 | 0.3316 | 0.5727 |
Schistosoma mansoni | lipoxygenase | 0.0014 | 0.0753 | 0.216 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0127 | 1 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0011 | 0.0522 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0007 | 0.0173 | 0.2858 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0126 | 0.9962 | 1 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0024 | 0.1586 | 0.2327 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0073 | 0.5602 | 0.3024 |
Onchocerca volvulus | 0.0014 | 0.0763 | 0.2574 | |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0007 | 0.0133 | 0.0949 |
Loa Loa (eye worm) | glutaminase | 0.0047 | 0.343 | 1 |
Trypanosoma brucei | unspecified product | 0.0006 | 0.008 | 0.0969 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.005 | 0.3695 | 0.6488 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0007 | 0.0173 | 0.2858 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0005 | 0.0015 | 0.0123 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.001 | 0.0401 | 0.113 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0011 | 0.0522 | 0.4178 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.005 | 0.3695 | 0.6488 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0024 | 0.1599 | 0.1457 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0763 | 0.2188 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.001 | 0.0401 | 0.0233 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 0.71 | Calculated partition coefficient (clogP) (SlogP) | ChEMBL. | 11784145 |
clogP | = 1.04 | Calculated partition coefficient (clogP) | ChEMBL. | 11784145 |
IC50 (functional) | = 3.322 | In vitro antitumor activity against L1210 cancer cell line | ChEMBL. | 14521406 |
IC50 (functional) | = 3.322 | Cytotoxicity against mouse L1210 cells after 65 hrs by MTS/PES microculture tetrazolium assay | ChEMBL. | 21536434 |
IC50 (functional) | = 476.6 uM | Activity against lymphocytic murine leukemia cell line L1210 using MTS/PES microculture tetrazolium assay | ChEMBL. | 11784145 |
IC50 (functional) | = 476.6 uM | Activity against lymphocytic murine leukemia cell line L1210 using MTS/PES microculture tetrazolium assay | ChEMBL. | 11784145 |
Log IC50 (functional) | = 3.322 | In vitro antitumor activity against L1210 cancer cell line | ChEMBL. | 14521406 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.