Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | V type proton ATPase 116 kDa subunit a | 0.0014 | 0.0244 | 0.0244 |
Brugia malayi | V-type ATPase 116kDa subunit family protein | 0.0014 | 0.0244 | 0.0244 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0044 | 1 | 1 |
Leishmania major | ATPase beta subunit, putative | 0.0014 | 0.0253 | 0.0009 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit alpha | 0.0014 | 0.0253 | 0.5 |
Trypanosoma cruzi | V-type proton ATPase subunit B, putative | 0.0044 | 1 | 1 |
Giardia lamblia | Vacuolar ATP synthase catalytic subunit A | 0.0014 | 0.0253 | 0.0009 |
Brugia malayi | vacuolar ATP synthase catalytic subunit A, osteoclast isoform | 0.0014 | 0.0253 | 0.0253 |
Chlamydia trachomatis | V-type ATP synthase subunit B | 0.0044 | 1 | 1 |
Toxoplasma gondii | vacuolar ATP synthase subunit b, putative | 0.0044 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 0.0014 | 0.0253 | 0.5 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit beta | 0.0014 | 0.0253 | 0.5 |
Echinococcus granulosus | vacuolar H ATPase v1 sector subunit A | 0.0014 | 0.0253 | 0.0253 |
Plasmodium vivax | ATP synthase subunit beta, mitochondrial, putative | 0.0014 | 0.0253 | 0.0009 |
Trypanosoma brucei | V-type ATPase, A subunit, putative | 0.0014 | 0.0253 | 0.0009 |
Schistosoma mansoni | vacuolar proton atpases | 0.0014 | 0.0244 | 0.0244 |
Plasmodium vivax | vacuolar ATP synthase subunit b, putative | 0.0044 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA | 0.0014 | 0.0253 | 0.5 |
Schistosoma mansoni | vacuolar proton atpases | 0.0014 | 0.0244 | 0.0244 |
Leishmania major | ATPase beta subunit, putative | 0.0014 | 0.0253 | 0.0009 |
Echinococcus multilocularis | vacuolar H+ ATPase v1 sector subunit A | 0.0014 | 0.0253 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | vacuolar proton pump | 0.0014 | 0.0244 | 0.0244 |
Schistosoma mansoni | ATP synthase alpha subunit vacuolar | 0.0014 | 0.0253 | 0.0253 |
Mycobacterium tuberculosis | Probable ATP synthase alpha chain AtpA | 0.0014 | 0.0253 | 0.5 |
Plasmodium vivax | ATP synthase alpha chain, putative | 0.0014 | 0.0253 | 0.0009 |
Plasmodium falciparum | V-type proton ATPase catalytic subunit A | 0.0014 | 0.0253 | 0.0009 |
Trypanosoma brucei | Vacuolar proton pump subunit B, putative | 0.0044 | 1 | 1 |
Plasmodium falciparum | ATP synthase F1, alpha subunit | 0.0014 | 0.0253 | 0.0009 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.0014 | 0.0253 | 0.0009 |
Echinococcus multilocularis | vacuolar ATP synthase subunit b | 0.0044 | 1 | 1 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0044 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE BETA CHAIN ATPD | 0.0014 | 0.0253 | 0.5 |
Echinococcus granulosus | ATP synthase subunit beta mitochondrial | 0.0014 | 0.0253 | 0.0253 |
Trichomonas vaginalis | ATP synthase beta subunit, putative | 0.0014 | 0.0253 | 0.0009 |
Schistosoma mansoni | ATP synthase beta subunit | 0.0014 | 0.0253 | 0.0253 |
Brugia malayi | vacuolar proton pump | 0.0014 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0244 | 0.0244 |
Trypanosoma cruzi | ATP synthase subunit beta, mitochondrial, putative | 0.0014 | 0.0253 | 0.0009 |
Plasmodium falciparum | ATP synthase subunit beta, mitochondrial | 0.0014 | 0.0253 | 0.0009 |
Entamoeba histolytica | V-type ATPase, A subunit, putative | 0.0014 | 0.0253 | 0.0009 |
Leishmania major | vacuolar ATP synthase subunit b, putative | 0.0044 | 1 | 1 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit alpha | 0.0014 | 0.0253 | 0.5 |
Echinococcus multilocularis | ATP synthase subunit beta, mitochondrial | 0.0014 | 0.0253 | 0.0253 |
Giardia lamblia | Vacuolar ATP synthase subunit B | 0.0044 | 1 | 1 |
Loa Loa (eye worm) | V-type ATPase 116kDa subunit family protein | 0.0014 | 0.0244 | 0.0244 |
Brugia malayi | ATP synthase alpha chain, mitochondrial precursor, putative | 0.0014 | 0.0253 | 0.0253 |
Toxoplasma gondii | vacuolar ATP synthase subunit A, putative | 0.0014 | 0.0253 | 0.0009 |
Loa Loa (eye worm) | vacuolar ATP synthase subunit B | 0.0044 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit beta | 0.0014 | 0.0253 | 0.5 |
Onchocerca volvulus | ATP synthase subunit alpha, mitochondrial homolog | 0.0014 | 0.0253 | 1 |
Loa Loa (eye worm) | vacuolar H ATPase family member | 0.0014 | 0.0253 | 0.0253 |
Echinococcus granulosus | vacuolar ATP synthase subunit b | 0.0044 | 1 | 1 |
Entamoeba histolytica | V-type ATPase, B subunit, putative | 0.0044 | 1 | 1 |
Echinococcus granulosus | V type proton ATPase 116 kDa subunit a | 0.0014 | 0.0244 | 0.0244 |
Plasmodium vivax | vacuolar ATP synthase catalytic subunit A, putative | 0.0014 | 0.0253 | 0.0009 |
Leishmania major | vacuolar ATP synthase catalytic subunit A, putative | 0.0014 | 0.0253 | 0.0009 |
Echinococcus multilocularis | V type proton ATPase 116 kDa subunit a | 0.0014 | 0.0244 | 0.0244 |
Toxoplasma gondii | ATP synthase beta subunit ATP-B | 0.0014 | 0.0253 | 0.0009 |
Brugia malayi | ATP synthase beta chain, mitochondrial precursor, putative | 0.0014 | 0.0253 | 0.0253 |
Echinococcus multilocularis | ATP synthase subunit alpha, mitochondrial | 0.0014 | 0.0253 | 0.0253 |
Echinococcus granulosus | ATP synthase subunit alpha mitochondrial | 0.0014 | 0.0253 | 0.0253 |
Schistosoma mansoni | ATP synthase alpha subunit mitochondrial | 0.0014 | 0.0253 | 0.0253 |
Plasmodium falciparum | V-type proton ATPase subunit B | 0.0044 | 1 | 1 |
Echinococcus granulosus | V type proton ATPase 116 kDa subunit a | 0.0014 | 0.0244 | 0.0244 |
Schistosoma mansoni | vacuolar proton atpases | 0.0014 | 0.0244 | 0.0244 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.0014 | 0.0253 | 0.0009 |
Trichomonas vaginalis | ATP synthase, putative | 0.0044 | 1 | 1 |
Trichomonas vaginalis | ATP synthase alpha subunit mitochondrial, putative | 0.0044 | 1 | 1 |
Schistosoma mansoni | ATP synthase subunit beta vacuolar | 0.0044 | 1 | 1 |
Trypanosoma brucei | ATP synthase subunit beta, mitochondrial | 0.0014 | 0.0253 | 0.0009 |
Brugia malayi | vacuolar proton pump | 0.0014 | 0.0244 | 0.0244 |
Trypanosoma cruzi | Vacuolar proton pump subunit B, putative | 0.0044 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 57 uM | Micro molar potency of the compound to inhibit human cytomegalovirus (HCMV) protease | ChEMBL. | 9406601 |
IC50 (binding) | = 57 uM | Micro molar potency of the compound to inhibit human cytomegalovirus (HCMV) protease | ChEMBL. | 9406601 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.