Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0275 | 0.9377 | 0.9377 |
Trichomonas vaginalis | glutaminase, putative | 0.0273 | 0.9271 | 0.9031 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0201 | 0.6444 | 0.6474 |
Brugia malayi | Blistered cuticle protein 3 | 0.0275 | 0.9377 | 0.9216 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0191 | 0.6042 | 0.599 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.0291 | 1 | 0.5 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.0291 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.0291 | 1 | 1 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 0.5 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0191 | 0.6042 | 0.4737 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.009 | 0.2078 | 0.0023 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.009 | 0.2078 | 0.0023 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.009 | 0.2078 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0163 | 0.4961 | 0.4069 |
Onchocerca volvulus | Peroxidasin homolog | 0.0275 | 0.9377 | 0.5 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.009 | 0.2078 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.0291 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.6042 | 0.599 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0078 | 0.1582 | 0.0092 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0201 | 0.6444 | 0.6474 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0163 | 0.4961 | 0.4961 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.009 | 0.206 | 0.206 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.3423 | 0.2842 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Schistosoma mansoni | peroxidasin | 0.0275 | 0.9377 | 0.9267 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0275 | 0.9377 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.009 | 0.206 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Brugia malayi | WGR domain containing protein | 0.0163 | 0.4961 | 0.3654 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0275 | 0.9377 | 0.5 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0191 | 0.6042 | 0.6042 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.009 | 0.206 | 0.1622 |
Mycobacterium leprae | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0101 | 0.2487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.0291 | 1 | 0.5 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0273 | 0.9271 | 0.9873 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0191 | 0.6042 | 0.5824 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0275 | 0.9377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Schistosoma mansoni | glutaminase | 0.0273 | 0.9271 | 0.9142 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.0291 | 1 | 0.5 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0275 | 0.9377 | 0.9216 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0273 | 0.9271 | 0.9082 |
Onchocerca volvulus | Peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.009 | 0.2078 | 0.0023 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0076 | 0.1504 | 0.1036 |
Schistosoma mansoni | peroxidasin | 0.0275 | 0.9377 | 0.9267 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0076 | 0.1504 | 0.1504 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0191 | 0.6042 | 0.4737 |
Echinococcus granulosus | peroxidasin | 0.0275 | 0.9377 | 0.9343 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.009 | 0.2078 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Mycobacterium tuberculosis | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0101 | 0.2487 | 0.5 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0163 | 0.4961 | 0.4683 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Brugia malayi | Peroxidasin | 0.0275 | 0.9377 | 0.9216 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0191 | 0.6042 | 0.599 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.01 | 0.248 | 0.053 |
Loa Loa (eye worm) | glutaminase | 0.0273 | 0.9271 | 0.9873 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.206 | 0.1202 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Trypanosoma brucei | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.3 M | Inhibitory concentration of the Compound was tested against LTD4 induced contraction of guinea pig trachea . | ChEMBL. | 1560434 |
IC50 (functional) | = 5.6 M | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea . | ChEMBL. | 1560434 |
Inhibition (functional) | = 17 % | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea at 3*10e-6 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 58.3 % | Inhibitory activity of the Compound was tested against LTD4 induced contraction of guinea pig trachea at 3*10e-6 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 80.4 % | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea at 2*10e-5 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 95 % | Inhibitory activity of the Compound was tested against LTD4 induced contraction of guinea pig trachea at 2*10e-5 M concentration. | ChEMBL. | 1560434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.