Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0021 | 0.0447 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0157 | 1 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.0867 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0832 | 0.2494 |
Plasmodium vivax | cytochrome b | 0.0062 | 0.3337 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0157 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0447 | 0.1341 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0136 | 0.8553 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0867 | 0.0517 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0867 | 0.2597 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0157 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0867 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0447 | 0.1341 |
Toxoplasma gondii | cytochrome b | 0.0062 | 0.3337 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0867 | 0.0439 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0867 | 0.0439 |
Plasmodium falciparum | cytochrome b | 0.0062 | 0.3337 | 1 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0447 | 0.1341 |
Loa Loa (eye worm) | cytochrome b | 0.0062 | 0.3337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0447 | 0.1341 |
Leishmania major | UDP-galactopyranose mutase | 0.0021 | 0.0447 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0062 | 0.3337 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.0867 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0867 | 0.2597 |
Brugia malayi | cytochrome b | 0.0062 | 0.3337 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0867 | 0.2597 |
Onchocerca volvulus | 0.0027 | 0.0867 | 1 | |
Echinococcus granulosus | lamin | 0.0027 | 0.0867 | 0.0517 |
Brugia malayi | SWIRM domain containing protein | 0.0021 | 0.0447 | 0.1341 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0021 | 0.0447 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0867 | 0.0517 |
Echinococcus granulosus | cytochrome B | 0.0062 | 0.3337 | 0.3565 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0021 | 0.0447 | 0.1341 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0867 | 0.2597 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0447 | 0.1341 |
Schistosoma mansoni | cytochrome b | 0.0062 | 0.3337 | 0.3025 |
Schistosoma mansoni | cytochrome b | 0.0062 | 0.3337 | 0.3025 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0867 | 0.0439 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0157 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0447 | 0.1341 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0136 | 0.8553 | 1 |
Toxoplasma gondii | apocytochrome b, putative | 0.0062 | 0.3337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0447 | 0.1341 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0867 | 0.2597 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0867 | 0.0439 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2 mM | Concentration at which the compound inhibits half of the response of N-methyl-D-aspartic acid (NMDA) | ChEMBL. | 6827527 |
IC50 (functional) | = 3 mM | Concentration at which the compound inhibits half of the response of kainic acid (KA) | ChEMBL. | 6827527 |
Response (functional) | < 36 % | Percentage response to 30 microM of N-methyl-D-aspartic acid (NMDA) at 3 mM of the compound in rat striatum slices. | ChEMBL. | 6827527 |
Response (functional) | < 50 % | Percentage response to 0.1 mM of kainic acid (KA) at 3 mM of the compound in rat striatum slices. | ChEMBL. | 6827527 |
Response (functional) | = 94 % | Percentage response to 0.1 mM of quisqualic acid at 3 mM of the compound in rat striatum slices. | ChEMBL. | 6827527 |
Response (functional) | = 106 % | Percentage response to 0.5 mM of L-Glutamic acid at 3 mM of the compound in rat striatum slices. | ChEMBL. | 6827527 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.