Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.009 | 0.0083 | 0.0092 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit beta | 0.029 | 0.0528 | 0.0596 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.029 | 0.0528 | 0.043 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0054 | 0.0004 | 0.0004 |
Echinococcus multilocularis | integrin beta 2 | 0.0234 | 0.0404 | 0.0468 |
Brugia malayi | ribonucleotide reductase 2 | 0.029 | 0.0528 | 0.0618 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.2212 | 0.4789 | 0.4735 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase small chain, putative | 0.029 | 0.0528 | 0.043 |
Trypanosoma brucei | folylpolyglutamate synthase, putative | 0.0099 | 0.0103 | 0.0001 |
Echinococcus granulosus | ribonucleoside diphosphate reductase subunit | 0.029 | 0.0528 | 0.0614 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0678 | 0.1387 | 0.162 |
Echinococcus granulosus | folylpolyglutamate synthase, mitochondrial | 0.0099 | 0.0103 | 0.0117 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0083 | 0.0097 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.2043 | 0.4415 | 0.5108 |
Echinococcus granulosus | integrin beta 2 | 0.0234 | 0.0404 | 0.0468 |
Brugia malayi | hypothetical protein | 0.0117 | 0.0144 | 0.0168 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1716 | 0.3691 | 0.7576 |
Schistosoma mansoni | integrin beta subunit | 0.0186 | 0.0297 | 0.0343 |
Brugia malayi | hypothetical protein | 0.1858 | 0.4004 | 0.4686 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1716 | 0.3691 | 0.425 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase subunit | 0.029 | 0.0528 | 0.0614 |
Brugia malayi | Dihydrofolate reductase | 0.1716 | 0.3691 | 0.4319 |
Echinococcus granulosus | integrin alpha 3 | 0.0114 | 0.0136 | 0.0155 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3905 | 0.8544 | 1 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.2212 | 0.4789 | 0.4735 |
Mycobacterium leprae | conserved hypothetical protein | 0.0169 | 0.0258 | 0.0184 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0229 | 0.0391 | 0.0458 |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0169 | 0.0258 | 0.0184 |
Brugia malayi | dihydrofolate reductase family protein | 0.1716 | 0.3691 | 0.4319 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4561 | 1 | 1 |
Brugia malayi | ribonucleoside-diphosphate reductase large chain, putative | 0.2212 | 0.4789 | 0.5605 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain, putative | 0.029 | 0.0528 | 0.043 |
Leishmania major | ribonucleoside-diphosphate reductase small chain, putative | 0.029 | 0.0528 | 0.0429 |
Echinococcus granulosus | dihydrofolate reductase | 0.1716 | 0.3691 | 0.4317 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0065 | 0.0077 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.2212 | 0.4789 | 0.4736 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.2212 | 0.4789 | 0.5603 |
Loa Loa (eye worm) | FolC protein | 0.0099 | 0.0103 | 0.0121 |
Echinococcus multilocularis | integrin alpha ps | 0.0067 | 0.0031 | 0.0032 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4561 | 1 | 1 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit beta | 0.029 | 0.0528 | 0.0906 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.2212 | 0.4789 | 0.4736 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1858 | 0.4004 | 0.9046 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0316 | 0.0586 | 0.0685 |
Echinococcus granulosus | thymidylate synthase | 0.3905 | 0.8544 | 1 |
Echinococcus granulosus | adam | 0.0127 | 0.0166 | 0.019 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.029 | 0.0528 | 0.043 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.009 | 0.0083 | 0.0092 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0112 | 0.0133 | 0.0155 |
Mycobacterium ulcerans | thymidylate synthase | 0.3905 | 0.8544 | 1 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0678 | 0.1387 | 0.162 |
Echinococcus multilocularis | integrin alpha ps | 0.0067 | 0.0031 | 0.0032 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase small chain, putative | 0.029 | 0.0528 | 0.0429 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.2043 | 0.4415 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4561 | 1 | 1 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0099 | 0.0103 | 0.0002 |
Schistosoma mansoni | folylpolyglutamate synthase | 0.0099 | 0.0103 | 0.0117 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1716 | 0.3691 | 0.4319 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0225 | 0.0383 | 0.0444 |
Plasmodium vivax | dihydrofolate synthase/folylpolyglutamate synthase, putative | 0.0099 | 0.0103 | 0.0001 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0148 | 0.0213 | 0.0249 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.2212 | 0.4789 | 0.4735 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.029 | 0.0528 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0142 | 0.0167 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) | 0.029 | 0.0528 | 0.0503 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.009 | 0.0083 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0004 | 0.0004 |
Plasmodium vivax | ribonucleoside-diphosphate reductase small chain, putative | 0.029 | 0.0528 | 0.043 |
Echinococcus granulosus | integrin alpha ps | 0.0067 | 0.0031 | 0.0032 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3905 | 0.8544 | 1 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0627 | 0.1274 | 0.1183 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1716 | 0.3691 | 0.4251 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0151 | 0.0218 | 0.0137 |
Leishmania major | ribonucleoside-diphosphate reductase small chain, putative | 0.029 | 0.0528 | 0.0429 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0169 | 0.0258 | 0.0183 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit beta | 0.029 | 0.0528 | 0.0739 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase small chain, putative | 0.029 | 0.0528 | 0.0429 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.2212 | 0.4789 | 0.5603 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.2212 | 0.4789 | 0.5605 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.2212 | 0.4789 | 1 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.2212 | 0.4789 | 0.5603 |
Schistosoma mansoni | integrin alpha | 0.0148 | 0.0213 | 0.0245 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0735 | 0.1513 | 0.167 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.2043 | 0.4415 | 0.5109 |
Loa Loa (eye worm) | thymidylate synthase | 0.3905 | 0.8544 | 1 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.2212 | 0.4789 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3905 | 0.8544 | 1 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase small chain | 0.029 | 0.0528 | 0.0614 |
Plasmodium falciparum | dihydrofolate synthase/folylpolyglutamate synthase | 0.0099 | 0.0103 | 0.0001 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0117 | 0.0144 | 0.0164 |
Loa Loa (eye worm) | reprolysin | 0.009 | 0.0083 | 0.0097 |
Loa Loa (eye worm) | integrin beta-2 | 0.0316 | 0.0586 | 0.0685 |
Echinococcus multilocularis | adam | 0.0127 | 0.0166 | 0.019 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4561 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1716 | 0.3691 | 0.4317 |
Echinococcus multilocularis | folylpolyglutamate synthase, mitochondrial | 0.0099 | 0.0103 | 0.0117 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0054 | 0.0004 | 0.0004 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0099 | 0.0103 | 0.0002 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.1238 | 0.263 | 0.3075 |
Echinococcus multilocularis | folylpolyglutamate synthase, mitochondrial | 0.0099 | 0.0103 | 0.0117 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1858 | 0.4004 | 0.4621 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) | 0.029 | 0.0528 | 0.0503 |
Loa Loa (eye worm) | ribonucleotide reductase M2 B | 0.029 | 0.0528 | 0.0618 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4561 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1716 | 0.3691 | 0.4251 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.009 | 0.0083 | 0.0092 |
Echinococcus multilocularis | integrin alpha 3 | 0.0114 | 0.0136 | 0.0155 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.2043 | 0.4415 | 1 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.2043 | 0.4415 | 0.5109 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0151 | 0.0218 | 0.0137 |
Onchocerca volvulus | 0.3905 | 0.8544 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0133 | 0.0155 |
Brugia malayi | thymidylate synthase | 0.3905 | 0.8544 | 1 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.2212 | 0.4789 | 0.4736 |
Schistosoma mansoni | integrin alpha-ps | 0.0067 | 0.0031 | 0.0032 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase small subunit | 0.029 | 0.0528 | 0.0429 |
Schistosoma mansoni | dihydrofolate reductase | 0.1716 | 0.3691 | 0.4317 |
Brugia malayi | FolC bifunctional protein | 0.0099 | 0.0103 | 0.0121 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1858 | 0.4004 | 0.3941 |
Echinococcus multilocularis | thymidylate synthase | 0.3905 | 0.8544 | 1 |
Echinococcus granulosus | folylpolyglutamate synthase mitochondrial | 0.0099 | 0.0103 | 0.0117 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.53 uM | In vitro inhibitory concentration that relaxed KCL induced contraction in rat detrusor strip by 50% | ChEMBL. | 10737753 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.