Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.3423 | 0.2842 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.009 | 0.206 | 0.206 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0163 | 0.4961 | 0.4961 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0201 | 0.6444 | 0.6474 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.0291 | 1 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0078 | 0.1582 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.6042 | 0.599 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.009 | 0.2078 | 0.0023 |
Onchocerca volvulus | Peroxidasin homolog | 0.0275 | 0.9377 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0163 | 0.4961 | 0.4069 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.009 | 0.2078 | 0.0023 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0191 | 0.6042 | 0.4737 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.009 | 0.2078 | 0.0023 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.009 | 0.2078 | 0.0023 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.0291 | 1 | 1 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0191 | 0.6042 | 0.599 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.0291 | 1 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0275 | 0.9377 | 0.9377 |
Trichomonas vaginalis | glutaminase, putative | 0.0273 | 0.9271 | 0.9031 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0201 | 0.6444 | 0.6474 |
Brugia malayi | Blistered cuticle protein 3 | 0.0275 | 0.9377 | 0.9216 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Trypanosoma brucei | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.206 | 0.1202 |
Loa Loa (eye worm) | glutaminase | 0.0273 | 0.9271 | 0.9873 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0191 | 0.6042 | 0.599 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.01 | 0.248 | 0.053 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Brugia malayi | Peroxidasin | 0.0275 | 0.9377 | 0.9216 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.0291 | 1 | 1 |
Mycobacterium tuberculosis | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0101 | 0.2487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0163 | 0.4961 | 0.4683 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.009 | 0.2078 | 0.0023 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0191 | 0.6042 | 0.4737 |
Echinococcus granulosus | peroxidasin | 0.0275 | 0.9377 | 0.9343 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0076 | 0.1504 | 0.1504 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.0291 | 1 | 1 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0076 | 0.1504 | 0.1036 |
Schistosoma mansoni | peroxidasin | 0.0275 | 0.9377 | 0.9267 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.009 | 0.2078 | 0.0023 |
Brugia malayi | glutaminase DH11.1 | 0.0273 | 0.9271 | 0.9082 |
Onchocerca volvulus | Peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Brugia malayi | hypothetical protein | 0.0275 | 0.9377 | 0.9216 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.0291 | 1 | 0.5 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Schistosoma mansoni | glutaminase | 0.0273 | 0.9271 | 0.9142 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0191 | 0.6042 | 0.5824 |
Onchocerca volvulus | Dual oxidase homolog | 0.0275 | 0.9377 | 0.5 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.0291 | 1 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0273 | 0.9271 | 0.9873 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Mycobacterium leprae | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0101 | 0.2487 | 0.5 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.009 | 0.206 | 0.1622 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0275 | 0.9377 | 0.5 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0191 | 0.6042 | 0.6042 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Brugia malayi | WGR domain containing protein | 0.0163 | 0.4961 | 0.3654 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0275 | 0.9377 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.009 | 0.206 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Schistosoma mansoni | peroxidasin | 0.0275 | 0.9377 | 0.9267 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5.9 M | Inhibitory concentration of the Compound was tested against LTD4 induced contraction of guinea pig trachea . | ChEMBL. | 1560434 |
IC50 (functional) | = 6.9 M | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea . | ChEMBL. | 1560434 |
Inhibition (functional) | = 25.3 % | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea at 3*10e-6 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 28.5 % | Inhibitory activity of the Compound was tested against LTD4 induced contraction of guinea pig trachea at 3*10e-6 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 81.7 % | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea at 2*10e-5 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 88.5000000000002 % | Inhibitory activity of the Compound was tested against LTD4 induced contraction of guinea pig trachea at 2*10e-5 M concentration. | ChEMBL. | 1560434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.