Detailed information for compound 233004

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 556.568 | Formula: C26H32N6O8
  • H donors: 8 H acceptors: 8 LogP: -3.51 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 3
  • SMILES: O=C(CNC(=O)[C@@H](NC(=O)[C@H](CC(=O)N)N)Cc1ccc(cc1)O)NCC(=O)N[C@H](C(=O)O)Cc1ccccc1
  • InChi: 1S/C26H32N6O8/c27-18(12-21(28)34)24(37)32-19(10-16-6-8-17(33)9-7-16)25(38)30-13-22(35)29-14-23(36)31-20(26(39)40)11-15-4-2-1-3-5-15/h1-9,18-20,33H,10-14,27H2,(H2,28,34)(H,29,35)(H,30,38)(H,31,36)(H,32,37)(H,39,40)/t18-,19-,20-/m0/s1
  • InChiKey: RRVIOUQEFZCRAQ-UFYCRDLUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0153 0.0623
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0177
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.0779 0.7672
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0069 0.0152
Loa Loa (eye worm) intermediate filament protein 0.003 0.0134 0.0756
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0023 0.0092
Brugia malayi hypothetical protein 0.0027 0.0118 0.0601
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Trichomonas vaginalis thymidine kinase, putative 0.0547 0.3897 1
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0786 0.1995
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.005 0.0102
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0069 0.0152
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Trichomonas vaginalis reverse transcriptases, putative 0.0027 0.0118 0.0278
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0153 0.0368
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.0779 0.7672
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Echinococcus multilocularis ribonuclease H1 0.0282 0.1966 0.7785
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0027 0.0118 0.0124
Echinococcus multilocularis thymidylate kinase 0.0149 0.1 0.3961
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Giardia lamblia Ribonuclease H 0.0282 0.1966 0.498
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0027 0.0118 0.0278
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0786 0.0893
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0089 0.0204
Trypanosoma brucei unspecified product 0.0309 0.2164 0.2481
Entamoeba histolytica thymidine kinase, putative 0.0547 0.3897 1
Echinococcus granulosus geminin 0.0358 0.2525 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0296 0.2591
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0282 0.1966 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0069 0.0152
Schistosoma mansoni ap endonuclease 0.0021 0.0069 0.0069
Schistosoma mansoni intermediate filament proteins 0.003 0.0134 0.0134
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0058 0.0344 0.0858
Echinococcus multilocularis geminin 0.0358 0.2525 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0786 0.7742
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Echinococcus granulosus KRAB A domain containing protein 0.0027 0.0118 0.0468
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0027 0.0118 0.0118
Toxoplasma gondii ribonuclease HI protein 0.0282 0.1966 1
Leishmania major ribonuclease H1, putative 0.0282 0.1966 0.5031
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0756
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0177
Mycobacterium tuberculosis Probable reductase 0.0118 0.0779 0.7672
Trypanosoma cruzi ribonuclease H1, putative 0.0282 0.1966 0.5031
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.005 0.0102
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0149 0.1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0055 0.031
Onchocerca volvulus 0.0027 0.0118 0.0601
Schistosoma mansoni ap endonuclease 0.0021 0.0069 0.0069
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0309 0.2164 0.2481
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Trichomonas vaginalis thymidine kinase, putative 0.0547 0.3897 1
Schistosoma mansoni thymidylate kinase 0.0149 0.1 0.1
Echinococcus multilocularis lamin 0.003 0.0134 0.0532
Echinococcus multilocularis musashi 0.003 0.0134 0.0532
Trichomonas vaginalis thymidine kinase, putative 0.0547 0.3897 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0786 0.0301
Trichomonas vaginalis reverse transcriptases, putative 0.0027 0.0118 0.0278
Onchocerca volvulus 0.003 0.0134 0.0683
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.005 0.0088
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.0779 0.7672
Echinococcus multilocularis RNA directed DNA polymerase 0.0027 0.0118 0.0468
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0015 0.0078
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Schistosoma mansoni phosphoglucomutase 0.0282 0.1966 0.1966
Trypanosoma cruzi thymidine kinase, putative 0.0547 0.3897 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0786 0.4419
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0786 0.4419
Trypanosoma brucei trypanothione reductase 0.0052 0.0296 0.0329
Trypanosoma brucei RNA helicase, putative 0.1207 0.8692 1
Brugia malayi RNase H family protein 0.0282 0.1966 1
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0786 0.4419
Brugia malayi Zinc knuckle family protein 0.0027 0.0118 0.0601
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0786 0.1995
Giardia lamblia Thymidine kinase 0.0547 0.3897 1
Schistosoma mansoni protein kinase 0.0027 0.0118 0.0118
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0153 0.1089
Brugia malayi thymidylate kinase 0.0149 0.1 0.5088
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.005 0.0046
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0069 0.0198
Leishmania major hypothetical protein, conserved 0.0058 0.0344 0.0858
Brugia malayi RNase H family protein 0.0282 0.1966 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0153 0.054
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0089 0.0204
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0069 0.0203
Giardia lamblia Reverse transcriptase/endonuclease 0.0027 0.0118 0.0177
Trypanosoma cruzi thymidine kinase, putative 0.0547 0.3897 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0069 0.0275
Brugia malayi 6-phosphofructokinase 0.0119 0.0786 0.3996
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0069 0.0101
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Trypanosoma brucei ribonuclease H1 0.0282 0.1966 0.2252
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0177
Schistosoma mansoni phosphoglucomutase 0.0282 0.1966 0.1966
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0786 0.1995
Brugia malayi glutathione reductase 0.0052 0.0296 0.1507
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0069 0.005
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0786 0.0786
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.0875 0.4335
Trypanosoma cruzi thymidylate kinase, putative 0.0149 0.1 0.2547
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0134 0.0683
Echinococcus multilocularis lamin dm0 0.003 0.0134 0.0532
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0786 0.3111
Brugia malayi Thioredoxin reductase 0.0052 0.0296 0.1507
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0468
Schistosoma mansoni hypothetical protein 0.0027 0.0118 0.0118
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0027 0.0118 0.0124
Onchocerca volvulus Putative thymidylate kinase 0.0149 0.1 0.5088
Echinococcus granulosus intermediate filament protein 0.003 0.0134 0.0532
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0177
Toxoplasma gondii thymidylate kinase 0.0149 0.1 0.5004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.0779 0.7672
Brugia malayi reverse transcriptase 0.0027 0.0118 0.0601
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0027 0.0118 0.0124
Entamoeba histolytica Thymidylate kinase, putative 0.0149 0.1 0.2547
Trypanosoma cruzi thymidylate kinase, putative 0.0149 0.1 0.2547
Trichomonas vaginalis thymidylate kinase, putative 0.0149 0.1 0.2547
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0296 0.1173
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.0875 0.8681
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0153 0.1089
Mycobacterium tuberculosis Possible maturase 0.0027 0.0118 0.0717
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Brugia malayi Zinc knuckle family protein 0.0027 0.0118 0.0601
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.005 0.0102
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.005 0.0102
Loa Loa (eye worm) hypothetical protein 0.0029 0.013 0.0734
Onchocerca volvulus 0.0027 0.0118 0.0601
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0786 0.1995
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.005 0.0198
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Treponema pallidum thymidylate kinase (tmk) 0.0149 0.1 0.496
Loa Loa (eye worm) thymidylate kinase 0.0149 0.1 0.5626
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0786 0.7742
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0027 0.0118 0.0601
Trypanosoma brucei thymidylate kinase, putative 0.0149 0.1 0.114
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.005 0.0046
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0069 0.0203
Brugia malayi 6-phosphofructokinase 0.0119 0.0786 0.3996
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.005 0.0102
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.1778 1
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0786 0.1995
Brugia malayi reverse transcriptase 0.0027 0.0118 0.0601
Brugia malayi phosphofructokinase 0.0119 0.0786 0.3996
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0153 0.0269
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.005 0.0046
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0153 0.1233
Trypanosoma brucei thymidylate kinase, putative 0.0149 0.1 0.114
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0786 0.1995
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0153 0.0623
Trichomonas vaginalis ribonuclease H1, putative 0.0282 0.1966 0.5031
Chlamydia trachomatis thymidylate kinase 0.0149 0.1 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0296 0.1173
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0035 0.0195
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0015 0.0078
Schistosoma mansoni hypothetical protein 0.0358 0.2525 0.2525
Echinococcus granulosus thymidylate kinase 0.0149 0.1 0.3961
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.005 0.005
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0786 0.1995
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0069 0.0152
Brugia malayi intermediate filament protein 0.003 0.0134 0.0683
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0786 0.1995
Loa Loa (eye worm) RecQ helicase 0.0023 0.0089 0.0503
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0296 0.2711
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.013
Schistosoma mansoni phosphoglucomutase 0.0282 0.1966 0.1966
Echinococcus granulosus lamin dm0 0.003 0.0134 0.0532
Echinococcus granulosus ribonuclease H1 0.0282 0.1966 0.7785
Schistosoma mansoni lamin 0.003 0.0134 0.0134
Giardia lamblia CDC8 0.0149 0.1 0.247
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0296 0.0736
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0118 0.0278
Schistosoma mansoni hypothetical protein 0.1207 0.8692 0.8692
Brugia malayi hypothetical protein 0.0027 0.0118 0.0601
Loa Loa (eye worm) glutathione reductase 0.0052 0.0296 0.1667
Echinococcus granulosus bloom syndrome protein 0.0023 0.0089 0.0354
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0108
Onchocerca volvulus Ribonuclease H1 homolog 0.0282 0.1966 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0023 0.0092
Schistosoma mansoni hypothetical protein 0.0149 0.1 0.1
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0786 0.1995
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0118 0.0118
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0069 0.0361
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0786 0.384
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0786 0.3111
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0069 0.0353
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0153 0.1233
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Trypanosoma brucei hypothetical protein, conserved 0.0309 0.2164 0.2481
Leishmania major thymidylate kinase-like protein 0.0149 0.1 0.2547
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.005 0.0102
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0027 0.0118 0.0468
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0054 0.0054
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Echinococcus granulosus lamin 0.003 0.0134 0.0532
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.0875 0.8681
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.005 0.0102
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0069 0.0152
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0252 0.1752 0.1752
Plasmodium falciparum glutathione reductase 0.0052 0.0296 0.2591
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0134 0.0756
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.005 0.0088
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0468
Brugia malayi follicle stimulating hormone receptor 0.0256 0.1778 0.9043
Toxoplasma gondii thioredoxin reductase 0.0052 0.0296 0.1362
Echinococcus granulosus RNA directed DNA polymerase 0.0027 0.0118 0.0468
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0069 0.0152
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Onchocerca volvulus 0.003 0.0134 0.0683
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0296 0.1667
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0149 0.1 1
Brugia malayi RNase H family protein 0.0282 0.1966 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0069 0.0203
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0069 0.0275
Brugia malayi hypothetical protein 0.0027 0.0118 0.0601
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0035 0.0176
Schistosoma mansoni hypothetical protein 0.0027 0.0118 0.0118
Brugia malayi hypothetical protein 0.0027 0.0118 0.0601
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.005 0.0198
Treponema pallidum ribonuclease H (rnhA) 0.0282 0.1966 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.005 0.0046
Schistosoma mansoni lamin 0.003 0.0134 0.0134
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.005 0.0255
Leishmania major trypanothione reductase 0.0052 0.0296 0.0736
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0069 0.0068
Schistosoma mansoni thymidylate kinase 0.0149 0.1 0.1
Trypanosoma cruzi ribonuclease H1, putative 0.0282 0.1966 0.5031
Trypanosoma brucei thymidine kinase 0.0547 0.3897 0.4477
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0468
Mycobacterium ulcerans thymidylate kinase 0.0149 0.1 1
Leishmania major thymidine kinase, putative 0.0547 0.3897 1
Trypanosoma brucei ingi protein (ORF1) 0.0309 0.2164 0.2481
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0089 0.0354
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0058 0.0344 0.0858
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.0875 0.8681
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.0779 0.7672
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0069 0.039
Trypanosoma brucei ingi protein (ORF1) 0.0309 0.2164 0.2481
Schistosoma mansoni hypothetical protein 0.0358 0.2525 0.2525
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0153 0.1089
Toxoplasma gondii exonuclease III APE 0.0021 0.0069 0.0188
Plasmodium falciparum thymidylate kinase 0.0149 0.1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.005 0.0162
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0153 0.0368
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0786 0.0786
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0149 0.1 0.496
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0089 0.0455
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.005 0.0162
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0027 0.0118 0.0278
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0153 0.1089
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0153 0.0623
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0069 0.0101
Trichomonas vaginalis thymidylate kinase, putative 0.0149 0.1 0.2547
Plasmodium vivax thymidylate kinase, putative 0.0149 0.1 1
Brugia malayi reverse transcriptase 0.0027 0.0118 0.0601
Plasmodium vivax glutathione reductase, putative 0.0052 0.0296 0.2711
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0468
Plasmodium falciparum thioredoxin reductase 0.0052 0.0296 0.2591

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) 0 Affinity towards anti-beta-endorphin MAb(Clone 3-E7) using [3H]-[Leu5]-enkephalin as labeled ligand at 10 uM concentration; not active ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.