Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0057 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0057 | 1 | 0.5 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0057 | 1 | 0.5 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0057 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.004 | 0.004 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0057 | 1 | 0.5 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0057 | 1 | 0.5 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0057 | 1 | 0.5 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0057 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.7556 | 0.7556 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0057 | 1 | 0.5 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0057 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.7556 | 0.7546 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0057 | 1 | 0.5 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0057 | 1 | 1 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0057 | 1 | 0.5 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0057 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.7556 | 0.7556 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0057 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.7556 | 0.7546 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0057 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 6.03 | Calculated partition coefficient (clogP) | ChEMBL. | 7996539 |
pKb (binding) | < 5 | In vitro antimuscarinic activity against the M2 muscarinic receptor subtype in guinea pig atria | ChEMBL. | 7996539 |
pKb (binding) | = 7.1 | In vitro antimuscarinic activity against the M3 muscarinic receptor subtype in rat ileum | ChEMBL. | 7996539 |
pKb (binding) | = 7.2 | In vitro antimuscarinic activity against the M3 muscarinic receptor subtype in rat bladder | ChEMBL. | 7996539 |
pKb (binding) | < 5 | In vitro antimuscarinic activity against the M2 muscarinic receptor subtype in guinea pig atria | ChEMBL. | 7996539 |
pKb (binding) | = 7.1 | In vitro antimuscarinic activity against the M3 muscarinic receptor subtype in rat ileum | ChEMBL. | 7996539 |
pKb (binding) | = 7.2 | In vitro antimuscarinic activity against the M3 muscarinic receptor subtype in rat bladder | ChEMBL. | 7996539 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.