TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 580.581 | Formula: C27H36N2O12
H donors: 4 H acceptors: 7 LogP: -1.22 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)[C@@]12OC[C@]34[C@H]2[C@@H](OC(=O)C(N)C)C(=O)O[C@@H]4C[C@@H]2[C@]([C@H]3[C@H]([C@@H]1O)O)(C)CC(=O)C(=C2C)OC(=O)C(N)C
InChi: 1S/C27H36N2O12/c1-9-12-6-14-26-8-38-27(24(36)37-5,19(26)17(23(35)39-14)41-22(34)11(3)29)20(32)15(31)18(26)25(12,4)7-13(30)16(9)40-21(33)10(2)28/h10-12,14-15,17-20,31-32H,6-8,28-29H2,1-5H3/t10?,11?,12-,14+,15+,17+,18+,19+,20-,25-,26+,27-/m0/s1
InChiKey: SAEVSOOCTARCJY-YJBGFQNISA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	serine/threonine protein kinase	0.00227044	0.0234865	0.0234865
Brugia malayi	p70 ribosomal S6 kinase beta	0.00154557	0.00109473	0.00109473
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.00267556	0.0360008	0.0360008
Brugia malayi	hypothetical protein	0.00344922	0.0598996	0.0598996
Loa Loa (eye worm)	hypothetical protein	0.00291542	0.0434105	0.0434105
Schistosoma mansoni	septate junction protein	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	peroxidasin	0.00880253	0.225267	0.225267
Loa Loa (eye worm)	hypothetical protein	0.0135827	0.37293	0.37293
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.00442236	0.0899607	0.0899607
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0135827	0.37293	0.37293
Brugia malayi	EGF-like domain containing protein	0.00266744	0.0357502	0.0357502
Onchocerca volvulus	Neurogenic locus notch homolog	0.00266744	0.0357502	0.195559
Echinococcus granulosus	neurogenic locus notch protein	0.00266744	0.0357502	0.0357502
Echinococcus granulosus	roundabout 2	0.00155371	0.00134643	0.00134643
Echinococcus multilocularis	neurogenic locus notch protein	0.00266744	0.0357502	0.0357502
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0106001	0.280794	0.280794
Schistosoma mansoni	hypothetical protein	0.00155371	0.00134643	0.00134643
Echinococcus multilocularis	fat cadherin tumor suppressor	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	blistered cuticle protein 3	0.0072407	0.177021	0.177021
Schistosoma mansoni	hypothetical protein	0.00764681	0.189566	0.189566
Echinococcus multilocularis	carbonic anhydrase	0.0135827	0.37293	0.37293
Schistosoma mansoni	hypothetical protein	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Brugia malayi	hypothetical protein	0.00344922	0.0598996	0.0598996
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.00359394	0.0643703	0.0643703
Echinococcus multilocularis	peroxidasin	0.00880253	0.225267	0.225267
Trichomonas vaginalis	AGC family protein kinase	0.00154557	0.00109473	0.0160154
Echinococcus granulosus	protein jagged 1	0.00266744	0.0357502	0.0357502
Brugia malayi	basement membrane proteoglycan	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	notch	0.00266744	0.0357502	0.0357502
Brugia malayi	Animal haem peroxidase family protein	0.0072407	0.177021	0.177021
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00155371	0.00134643	0.00134643
Onchocerca volvulus		0.00266744	0.0357502	0.195559
Onchocerca volvulus	Chorion peroxidase homolog	0.0072407	0.177021	0.998576
Onchocerca volvulus		0.00344922	0.0598996	0.33283
Entamoeba histolytica	protein kinase, putative	0.00154557	0.00109473	0.5
Leishmania major	carbonic anhydrase-like protein	0.0338824	1	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.00155371	0.00134643	0.00134643
Echinococcus multilocularis	carbonic anhydrase	0.0135827	0.37293	0.37293
Plasmodium vivax	hexose transporter	0.00359394	0.0643703	1
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.00307739	0.0484138	0.0484138
Trichomonas vaginalis	AGC family protein kinase	0.00154557	0.00109473	0.0160154
Echinococcus granulosus	slit 2 protein	0.00267556	0.0360008	0.0360008
Toxoplasma gondii	rhoptry neck protein RON1	0.00344922	0.0598996	0.158147
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0106001	0.280794	0.280794
Brugia malayi	Heparan sulfate	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	nephrin	0.00155371	0.00134643	0.00134643
Brugia malayi	Immunoglobulin domain containing protein	0.00155371	0.00134643	0.00134643
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00155371	0.00134643	0.00134643
Entamoeba histolytica	protein kinase, putative	0.00154557	0.00109473	0.5
Giardia lamblia	Kinase, AGC AKT	0.003599	0.0645265	0.04277
Trichomonas vaginalis	AGC family protein kinase	0.00154557	0.00109473	0.0160154
Echinococcus multilocularis	protein kinase c iota type	0.00220891	0.0215856	0.0215856
Loa Loa (eye worm)	LAD-2 short isoform	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	glucose transport protein	0.00359394	0.0643703	0.0643703
Loa Loa (eye worm)	Notch2	0.00266744	0.0357502	0.0357502
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0338824	1	1
Echinococcus granulosus	protein jagged 1	0.00266744	0.0357502	0.0357502
Echinococcus multilocularis	leucine rich repeat containing protein 4	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	tyrosine protein kinase otk	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	atypical protein kinase C	0.00220891	0.0215856	0.0215856
Brugia malayi	Calcium binding EGF domain containing protein	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.00154557	0.00109473	0.00109473
Schistosoma mansoni	serine/threonine protein kinase	0.00154557	0.00109473	0.00109473
Trichomonas vaginalis	AGC family protein kinase	0.00154557	0.00109473	0.0160154
Schistosoma mansoni	carbonic anhydrase-related	0.0135827	0.37293	0.37293
Echinococcus granulosus	Immunoglobulin subtype	0.00155371	0.00134643	0.00134643
Mycobacterium tuberculosis	Arylamine N-acetyltransferase Nat (arylamine acetylase)	0.0278068	0.812322	1
Echinococcus granulosus	Immunoglobulin	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Onchocerca volvulus		0.00266744	0.0357502	0.195559
Plasmodium falciparum	carbonic anhydrase	0.0135827	0.37293	1
Echinococcus granulosus	contactin	0.00155371	0.00134643	0.00134643
Onchocerca volvulus	Dual oxidase homolog	0.0072407	0.177021	0.998576
Trichomonas vaginalis	AGC family protein kinase	0.00154557	0.00109473	0.0160154
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	carbonic anhydrase 3	0.0338824	1	1
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0338824	1	1
Loa Loa (eye worm)	hypothetical protein	0.0292767	0.857726	0.857726
Onchocerca volvulus		0.00344922	0.0598996	0.33283
Schistosoma mansoni	notch	0.00266744	0.0357502	0.0357502
Onchocerca volvulus		0.00188249	0.0115026	0.0577301
Brugia malayi	hypothetical protein	0.00344922	0.0598996	0.0598996
Schistosoma mansoni	carbonic anhydrase-related	0.0135827	0.37293	0.37293
Onchocerca volvulus	Putative cubilin	0.00266744	0.0357502	0.195559
Brugia malayi	protein kinase C II.	0.00227044	0.0234865	0.0234865
Schistosoma mansoni	notch	0.00266744	0.0357502	0.0357502
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.00155371	0.00134643	0.00134643
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.00155371	0.00134643	0.00134643
Brugia malayi	Blistered cuticle protein 3	0.0072407	0.177021	0.177021
Echinococcus multilocularis	neuroglian	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.00155371	0.00134643	0.00134643
Echinococcus multilocularis	neurogenic locus protein delta	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0135827	0.37293	0.37293
Echinococcus multilocularis	notch	0.00266744	0.0357502	0.0357502
Echinococcus granulosus	RNA directed DNA polymerase	0.00432749	0.08703	0.08703
Schistosoma mansoni	hypothetical protein	0.00764681	0.189566	0.189566
Brugia malayi	EGF-like domain containing protein	0.00266744	0.0357502	0.0357502
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.00155371	0.00134643	0.00134643
Brugia malayi	hypothetical protein	0.00344922	0.0598996	0.0598996
Echinococcus multilocularis	Immunoglobulin	0.00155371	0.00134643	0.00134643
Onchocerca volvulus		0.00344922	0.0598996	0.33283
Echinococcus granulosus	General substrate transporter	0.00338787	0.0580046	0.0580046
Onchocerca volvulus		0.0072407	0.177021	0.998576
Trichomonas vaginalis	AGC family protein kinase	0.00154557	0.00109473	0.0160154
Echinococcus multilocularis	conserved hypothetical protein	0.00764681	0.189566	0.189566
Onchocerca volvulus	Peroxidase homolog	0.0072407	0.177021	0.998576
Echinococcus granulosus	low density lipoprotein receptor ldl	0.00155371	0.00134643	0.00134643
Onchocerca volvulus	Matrix metalloproteinase homolog	0.00646626	0.153098	0.862592
Echinococcus multilocularis	protein kinase c epsilon type	0.00227044	0.0234865	0.0234865
Toxoplasma gondii	EGF family domain-containing protein	0.00266744	0.0357502	0.093201
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	neuroglian	0.00155371	0.00134643	0.00134643
Echinococcus multilocularis	RNA directed DNA polymerase	0.00432749	0.08703	0.08703
Onchocerca volvulus	Matrilysin homolog	0.00291542	0.0434105	0.239102
Echinococcus granulosus	carbonic anhydrase	0.0135827	0.37293	0.37293
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.00359394	0.0643703	0.0643703
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Brugia malayi	Fibroblast growth factor family protein	0.024448	0.708564	0.708564
Echinococcus granulosus	Immunoglobulin	0.00764681	0.189566	0.189566
Echinococcus granulosus	carbonic anhydrase	0.0135827	0.37293	0.37293
Schistosoma mansoni	c4b-binding protein beta chain	0.00344922	0.0598996	0.0598996
Toxoplasma gondii	facilitative glucose transporter GT1	0.00359394	0.0643703	0.170171
Schistosoma mansoni	hypothetical protein	0.00155371	0.00134643	0.00134643
Brugia malayi	Animal haem peroxidase family protein	0.0072407	0.177021	0.177021
Loa Loa (eye worm)	hypothetical protein	0.0072407	0.177021	0.177021
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.00432749	0.08703	0.08703
Loa Loa (eye worm)	hypothetical protein	0.00344922	0.0598996	0.0598996
Echinococcus multilocularis	hemicentin 1	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	hypothetical protein	0.00413381	0.0810473	0.0810473
Echinococcus multilocularis	protein jagged 1	0.00266744	0.0357502	0.0357502
Brugia malayi	Protein kinase domain containing protein	0.00154557	0.00109473	0.00109473
Loa Loa (eye worm)	animal heme peroxidase	0.0072407	0.177021	0.177021
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00155371	0.00134643	0.00134643
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.00359394	0.0643703	0.0643703
Loa Loa (eye worm)	notch protein	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	Immunoglobulin	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Trypanosoma brucei	rac serine-threonine kinase, putative	0.00154557	0.00109473	0.00109473
Loa Loa (eye worm)	hypothetical protein	0.0072407	0.177021	0.177021
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.0072407	0.177021	0.177021
Echinococcus multilocularis	carbonic anhydrase	0.0135827	0.37293	0.37293
Schistosoma mansoni	hypothetical protein	0.00266744	0.0357502	0.0357502
Schistosoma mansoni	glucose transport protein	0.00359394	0.0643703	0.0643703
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	hypothetical protein	0.00344922	0.0598996	0.0598996
Loa Loa (eye worm)	hypothetical protein	0.00432749	0.08703	0.08703
Echinococcus granulosus	neural cadherin	0.00266744	0.0357502	0.0357502
Brugia malayi	GCC2 and GCC3 family protein	0.00611666	0.142299	0.142299
Entamoeba histolytica	protein kinase, putative	0.00154557	0.00109473	0.5
Loa Loa (eye worm)	hypothetical protein	0.00344922	0.0598996	0.0598996
Schistosoma mansoni	nephrin related	0.00155371	0.00134643	0.00134643
Brugia malayi	hypothetical protein	0.00344922	0.0598996	0.0598996
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.00266744	0.0357502	0.0357502
Schistosoma mansoni	basigin related	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	serine/threonine protein kinase	0.00659792	0.157165	0.157165
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.00158706	0.0023763	0.0023763
Loa Loa (eye worm)	hypothetical protein	0.0072407	0.177021	0.177021
Onchocerca volvulus		0.0072407	0.177021	0.998576
Loa Loa (eye worm)	AGC/AKT protein kinase	0.00154557	0.00109473	0.00109473
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.00291542	0.0434105	0.0434105
Brugia malayi	EGF-like domain containing protein	0.00266744	0.0357502	0.0357502
Brugia malayi	Peroxidasin	0.00880253	0.225267	0.225267
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00920052	0.237561	0.237561
Brugia malayi	Cadherin domain containing protein	0.00266744	0.0357502	0.0357502
Echinococcus multilocularis	hemicentin 1	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.0072407	0.177021	0.177021
Brugia malayi	Matrixin family protein	0.00291542	0.0434105	0.0434105
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00155371	0.00134643	0.00134643
Brugia malayi	Animal haem peroxidase family protein	0.0072407	0.177021	0.177021
Trichomonas vaginalis	AGC family protein kinase	0.00154557	0.00109473	0.0160154
Echinococcus multilocularis	protein jagged 2	0.00266744	0.0357502	0.0357502
Echinococcus multilocularis	serine threonine protein kinase	0.00593459	0.136674	0.136674
Loa Loa (eye worm)	hypothetical protein	0.00880253	0.225267	0.225267
Echinococcus multilocularis	roundabout 2	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.0072407	0.177021	0.177021
Schistosoma mansoni	netrin receptor unc5	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.0072407	0.177021	0.177021
Echinococcus multilocularis	irregular chiasm roughest protein immunoglobulin set domain containing protein	0.00764681	0.189566	0.189566
Echinococcus multilocularis	serine:threonine protein kinase N2	0.00154557	0.00109473	0.00109473
Schistosoma mansoni	septate junction protein	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	hypothetical protein	0.00344922	0.0598996	0.0598996
Schistosoma mansoni	septate junction protein	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Onchocerca volvulus		0.00344922	0.0598996	0.33283
Echinococcus multilocularis	roundabout 2	0.00155371	0.00134643	0.00134643
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00155371	0.00134643	0.00134643
Brugia malayi	Matrixin family protein	0.00704924	0.171107	0.171107
Loa Loa (eye worm)	matrixin family protein	0.00704924	0.171107	0.171107
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.00154557	0.00109473	0.00109473
Onchocerca volvulus		0.00266744	0.0357502	0.195559
Schistosoma mansoni	hypothetical protein	0.00266744	0.0357502	0.0357502
Onchocerca volvulus		0.00291542	0.0434105	0.239102
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	serine/threonine kinase	0.00154557	0.00109473	0.00109473
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.00154557	0.00109473	0.00109473
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0338824	1	1
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.0072407	0.177021	0.177021
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Echinococcus multilocularis	tyrosine protein kinase otk	0.00155371	0.00134643	0.00134643
Onchocerca volvulus		0.0072407	0.177021	0.998576
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.00920052	0.237561	0.237561
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.00154557	0.00109473	0.00109473
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.00155371	0.00134643	0.00134643
Echinococcus multilocularis	roundabout 2	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	cell adhesion molecule	0.00155371	0.00134643	0.00134643
Onchocerca volvulus		0.00344922	0.0598996	0.33283
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00155371	0.00134643	0.00134643
Onchocerca volvulus		0.00413381	0.0810473	0.453038
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Echinococcus granulosus	hemicentin 1	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	basement membrane specific heparan sulfate	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	netrin receptor unc5	0.00155371	0.00134643	0.00134643
Onchocerca volvulus		0.00344922	0.0598996	0.33283
Echinococcus granulosus	C type lectin domian containing protein	0.00344922	0.0598996	0.0598996
Loa Loa (eye worm)	hypothetical protein	0.024448	0.708564	0.708564
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.00511123	0.11124	0.11124
Brugia malayi	Matrixin family protein	0.00291542	0.0434105	0.0434105
Toxoplasma gondii	rhoptry neck protein RON9	0.00344922	0.0598996	0.158147
Brugia malayi	Animal haem peroxidase family protein	0.0072407	0.177021	0.177021
Schistosoma mansoni	peroxidasin	0.00880253	0.225267	0.225267
Echinococcus granulosus	roundabout 2	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.0072407	0.177021	0.177021
Loa Loa (eye worm)	hypothetical protein	0.00611666	0.142299	0.142299
Echinococcus multilocularis	netrin receptor unc 5	0.00155371	0.00134643	0.00134643
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0135827	0.37293	0.37293
Echinococcus multilocularis	carbonic anhydrase II	0.0338824	1	1
Loa Loa (eye worm)	matrixin family protein	0.00646626	0.153098	0.153098
Mycobacterium ulcerans	arylamine N-acetyltransferase Nat	0.0278068	0.812322	1
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.00511123	0.11124	0.11124
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.00359394	0.0643703	0.0643703
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.00266744	0.0357502	0.195559
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.00154557	0.00109473	0.00109473
Schistosoma mansoni	hypothetical protein	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	serine:threonine protein kinase N2	0.00154557	0.00109473	0.00109473
Schistosoma mansoni	notch	0.00266744	0.0357502	0.0357502
Echinococcus granulosus	irregular chiasm roughest protein	0.00764681	0.189566	0.189566
Schistosoma mansoni	cell adhesion molecule	0.00155371	0.00134643	0.00134643
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.00359394	0.0643703	0.0643703
Echinococcus granulosus	neuroglian	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	protein kinase C gamma type	0.00593459	0.136674	0.136674
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	netrin receptor unc 5	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	c4b binding protein beta chain	0.00344922	0.0598996	0.0598996
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.00155371	0.00134643	0.00134643
Brugia malayi	EGF-like domain containing protein	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Onchocerca volvulus	Peroxidasin homolog	0.00724882	0.177272	1
Echinococcus granulosus	NDR protein kinase	0.00154557	0.00109473	0.00109473
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Brugia malayi	Sugar transporter family protein	0.00359394	0.0643703	0.0643703
Brugia malayi	basement membrane proteoglycan precursor	0.00155371	0.00134643	0.00134643
Brugia malayi	Immunoglobulin domain containing protein	0.00155371	0.00134643	0.00134643
Brugia malayi	Immunoglobulin domain containing protein	0.00155371	0.00134643	0.00134643
Echinococcus multilocularis	Immunoglobulin subtype	0.00155371	0.00134643	0.00134643
Brugia malayi	Sushi domain	0.00344922	0.0598996	0.0598996
Mycobacterium leprae	PROBABLE HYDROLASE	0.00355084	0.0630388	0.5
Onchocerca volvulus		0.00266744	0.0357502	0.195559
Echinococcus multilocularis	cell adhesion molecule:down regulated by	0.00155371	0.00134643	0.00134643
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.00227044	0.0234865	0.0234865
Trichomonas vaginalis	conserved hypothetical protein	0.00359394	0.0643703	1
Brugia malayi	Protein kinase domain containing protein	0.00154557	0.00109473	0.00109473
Schistosoma mansoni	cell adhesion molecule	0.00155371	0.00134643	0.00134643
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0135827	0.37293	0.37293
Brugia malayi	Protein kinase domain containing protein	0.02931	0.858756	0.858756
Echinococcus multilocularis	nephrin	0.00764681	0.189566	0.189566
Loa Loa (eye worm)	hypothetical protein	0.0072407	0.177021	0.177021
Schistosoma mansoni	notch	0.00266744	0.0357502	0.0357502
Onchocerca volvulus	Peroxidasin homolog	0.0072407	0.177021	0.998576
Schistosoma mansoni	hypothetical protein	0.00266744	0.0357502	0.0357502
Entamoeba histolytica	protein kinase, putative	0.00154557	0.00109473	0.5
Brugia malayi	Delta serrate ligand family protein	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Brugia malayi	hypothetical protein	0.00920052	0.237561	0.237561
Brugia malayi	hypothetical protein	0.00344922	0.0598996	0.0598996
Giardia lamblia	Hypothetical protein	0.024448	0.708564	1
Echinococcus multilocularis	General substrate transporter	0.00338787	0.0580046	0.0580046
Echinococcus multilocularis	neurogenic locus protein delta	0.00266744	0.0357502	0.0357502
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.00511123	0.11124	0.11124
Echinococcus granulosus	notch	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	hypothetical protein	0.00355084	0.0630388	0.0630388
Echinococcus multilocularis	lachesin	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Brugia malayi	ribosomal protein S6 kinase alpha 3	0.003599	0.0645265	0.0645265
Schistosoma mansoni	peroxidasin	0.0072407	0.177021	0.177021
Loa Loa (eye worm)	hypothetical protein	0.024448	0.708564	0.708564
Schistosoma mansoni	basigin related	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	septate junction protein	0.00155371	0.00134643	0.00134643
Brugia malayi	Cadherin domain containing protein	0.00266744	0.0357502	0.0357502
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0338824	1	1
Onchocerca volvulus		0.00344922	0.0598996	0.33283
Loa Loa (eye worm)	hypothetical protein	0.00499082	0.107521	0.107521
Schistosoma mansoni	hypothetical protein	0.00266744	0.0357502	0.0357502
Brugia malayi	hypothetical protein	0.00344922	0.0598996	0.0598996
Schistosoma mansoni	laminin gamma-3 chain	0.00266744	0.0357502	0.0357502
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.00659792	0.157165	0.157165
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.00355084	0.0630388	0.0630388
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.00359394	0.0643703	0.0643703
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Echinococcus multilocularis	c4b binding protein beta chain	0.00344922	0.0598996	0.0598996
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	AGC/PKN protein kinase	0.00154557	0.00109473	0.00109473
Schistosoma mansoni	hypothetical protein	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00920052	0.237561	0.237561
Schistosoma mansoni	hypothetical protein	0.0135827	0.37293	0.37293
Loa Loa (eye worm)	hypothetical protein	0.0135827	0.37293	0.37293
Loa Loa (eye worm)	hypothetical protein	0.00377259	0.0698888	0.0698888
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Brugia malayi	EGF-like domain containing protein	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	AGC/NDR protein kinase	0.00154557	0.00109473	0.00109473
Loa Loa (eye worm)	hypothetical protein	0.0072407	0.177021	0.177021
Loa Loa (eye worm)	animal heme peroxidase	0.0072407	0.177021	0.177021
Onchocerca volvulus		0.00266744	0.0357502	0.195559
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.00155371	0.00134643	0.00134643
Brugia malayi	hypothetical protein	0.0072407	0.177021	0.177021
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.00155371	0.00134643	0.00134643
Onchocerca volvulus	Slit protein homolog	0.00267556	0.0360008	0.196984
Brugia malayi	notch-like transmembrane receptor	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	sugar transporter	0.00359394	0.0643703	0.0643703
Schistosoma mansoni	hypothetical protein	0.00155371	0.00134643	0.00134643
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0135827	0.37293	0.37293
Echinococcus multilocularis	Immunoglobulin	0.00764681	0.189566	0.189566
Brugia malayi	Calcium binding EGF domain containing protein	0.00266744	0.0357502	0.0357502
Echinococcus granulosus	neurogenic locus notch protein	0.00266744	0.0357502	0.0357502
Brugia malayi	Fibroblast growth factor family protein	0.024448	0.708564	0.708564
Plasmodium falciparum	hexose transporter	0.00359394	0.0643703	0.0142819
Schistosoma mansoni	serine/threonine protein kinase	0.00659792	0.157165	0.157165
Schistosoma mansoni	septate junction protein	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	lachesin	0.00155371	0.00134643	0.00134643
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00156183	0.00159703	0.00159703
Echinococcus granulosus	carbonic anhydrase II	0.0338824	1	1
Schistosoma mansoni	carbonic anhydrase-related	0.0135827	0.37293	0.37293
Echinococcus granulosus	protein jagged 2	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	hypothetical protein	0.00266744	0.0357502	0.0357502
Schistosoma mansoni	notch	0.00266744	0.0357502	0.0357502
Schistosoma mansoni	hypothetical protein	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Brugia malayi	Calcium binding EGF domain containing protein	0.00266744	0.0357502	0.0357502
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.00155371	0.00134643	0.00134643
Echinococcus multilocularis	neurogenic locus notch protein 4	0.00266744	0.0357502	0.0357502
Echinococcus granulosus	protein kinase c iota type	0.00220891	0.0215856	0.0215856
Brugia malayi	EGF-like domain containing protein	0.00266744	0.0357502	0.0357502
Echinococcus granulosus	nephrin	0.00764681	0.189566	0.189566
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.00155371	0.00134643	0.00134643
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.00266744	0.0357502	0.0357502
Brugia malayi	Protein kinase domain containing protein	0.00154557	0.00109473	0.00109473
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.00154557	0.00109473	0.00109473
Schistosoma mansoni	hypothetical protein	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	carbonic anhydrase	0.0135827	0.37293	0.37293
Echinococcus granulosus	protein jagged 2	0.00266744	0.0357502	0.0357502
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.00359394	0.0643703	0.0643703
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0135827	0.37293	0.37293
Echinococcus multilocularis	protein jagged 1	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0338824	1	1
Trichomonas vaginalis	AGC family protein kinase	0.00154557	0.00109473	0.0160154
Brugia malayi	pregnancy-associated plasma protein-A	0.00344922	0.0598996	0.0598996
Loa Loa (eye worm)	hypothetical protein	0.00155371	0.00134643	0.00134643
Trypanosoma brucei	carbonic anhydrase-like protein	0.0338824	1	1
Schistosoma mansoni	cell polarity protein	0.00266744	0.0357502	0.0357502
Echinococcus multilocularis	serine:threonine protein kinase 38	0.00154557	0.00109473	0.00109473
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Onchocerca volvulus	Peroxidase homolog	0.0072407	0.177021	0.998576
Trichomonas vaginalis	AGC family protein kinase	0.00154557	0.00109473	0.0160154
Echinococcus multilocularis	fibropellin Ia	0.00266744	0.0357502	0.0357502
Brugia malayi	Matrixin family protein	0.00291542	0.0434105	0.0434105
Onchocerca volvulus		0.00344922	0.0598996	0.33283
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Brugia malayi	Hr1 repeat family protein	0.00154557	0.00109473	0.00109473
Brugia malayi	Animal haem peroxidase family protein	0.0072407	0.177021	0.177021
Brugia malayi	Protein kinase c protein 2	0.0050857	0.110452	0.110452
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.00155371	0.00134643	0.00134643
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0338824	1	1
Schistosoma mansoni	roundabout	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.0072407	0.177021	0.177021
Brugia malayi	EGF-like domain containing protein	0.00267556	0.0360008	0.0360008
Echinococcus multilocularis	slit 2 protein	0.00267556	0.0360008	0.0360008
Echinococcus granulosus	roundabout 2	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.00344922	0.0598996	0.0598996
Echinococcus multilocularis	C type lectin domian containing protein	0.00344922	0.0598996	0.0598996
Brugia malayi	Hemopexin family protein	0.00413381	0.0810473	0.0810473
Schistosoma mansoni	serine/threonine protein kinase	0.00511123	0.11124	0.11124
Loa Loa (eye worm)	hypothetical protein	0.0072407	0.177021	0.177021
Schistosoma mansoni	serine/threonine protein kinase	0.00154557	0.00109473	0.00109473
Echinococcus granulosus	protein kinase c epsilon type	0.00227044	0.0234865	0.0234865
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.00154557	0.00109473	0.00109473
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	animal heme peroxidase	0.0072407	0.177021	0.177021
Brugia malayi	Muscle positioning protein 4	0.00266744	0.0357502	0.0357502
Schistosoma mansoni	basigin related	0.00155371	0.00134643	0.00134643
Echinococcus multilocularis	Immunoglobulin	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.00291542	0.0434105	0.0434105
Onchocerca volvulus		0.00344922	0.0598996	0.33283
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	hypothetical protein	0.0135827	0.37293	0.37293
Onchocerca volvulus	Matrilysin homolog	0.00646626	0.153098	0.862592
Brugia malayi	Matrixin family protein	0.00291542	0.0434105	0.0434105
Loa Loa (eye worm)	hypothetical protein	0.00291542	0.0434105	0.0434105
Echinococcus granulosus	nephrin	0.00764681	0.189566	0.189566
Echinococcus granulosus	3'partial\|cell adhesion molecule:down regulated by	0.00155371	0.00134643	0.00134643
Echinococcus multilocularis	neural cadherin	0.00266744	0.0357502	0.0357502
Schistosoma mansoni	glucose transport protein	0.00359394	0.0643703	0.0643703
Schistosoma mansoni	cell adhesion molecule	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	fibropellin Ia	0.00266744	0.0357502	0.0357502
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.00359394	0.0643703	0.0643703
Echinococcus multilocularis	neurogenic locus notch protein	0.00266744	0.0357502	0.0357502
Echinococcus granulosus	neurogenic locus protein delta	0.00266744	0.0357502	0.0357502
Trichomonas vaginalis	AGC family protein kinase	0.00154557	0.00109473	0.0160154
Schistosoma mansoni	cell adhesion molecule	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	neurogenic locus notch protein 4	0.00266744	0.0357502	0.0357502
Loa Loa (eye worm)	immunoglobulin domain-containing protein	0.00155371	0.00134643	0.00134643
Onchocerca volvulus		0.00344922	0.0598996	0.33283
Schistosoma mansoni	serine/threonine protein kinase	0.00154557	0.00109473	0.00109473
Loa Loa (eye worm)	hypothetical protein	0.00344922	0.0598996	0.0598996
Brugia malayi	Prion-like-	0.00155371	0.00134643	0.00134643
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	carbonic anhydrase	0.0135827	0.37293	0.37293
Loa Loa (eye worm)	hypothetical protein	0.00154557	0.00109473	0.00109473
Loa Loa (eye worm)	matrix metalloproteinase	0.00291542	0.0434105	0.0434105
Echinococcus multilocularis	serine:threonine protein kinase N2	0.00154557	0.00109473	0.00109473
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0338824	1	1
Loa Loa (eye worm)	hypothetical protein	0.00344922	0.0598996	0.0598996
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.003599	0.0645265	0.0645265
Schistosoma mansoni	titin	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	Protein kinase C brain isozyme	0.00659792	0.157165	0.157165
Toxoplasma gondii	hypothetical protein	0.0135827	0.37293	1
Loa Loa (eye worm)	pregnancy-associated plasma protein-E	0.00344922	0.0598996	0.0598996
Schistosoma mansoni	slit	0.00267556	0.0360008	0.0360008
Schistosoma mansoni	cell adhesion molecule	0.00155371	0.00134643	0.00134643
Loa Loa (eye worm)	animal heme peroxidase	0.0072407	0.177021	0.177021
Loa Loa (eye worm)	hypothetical protein	0.00266744	0.0357502	0.0357502
Trichomonas vaginalis	AGC family protein kinase	0.00154557	0.00109473	0.0160154
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.00920052	0.237561	0.237561
Schistosoma mansoni	hypothetical protein	0.00359394	0.0643703	0.0643703
Schistosoma mansoni	tyrosine kinase	0.00155371	0.00134643	0.00134643
Echinococcus granulosus	delta-like protein 1	0.00266744	0.0357502	0.0357502

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 0.000001 M	Anti-malarial activity against the growth inhibition of chloroquine-resistant strain of Plasmodium falciparum was evaluated.	ChEMBL.	9871598
EC50 (functional)	= 0.000001 M	Anti-malarial activity against the growth inhibition of chloroquine-resistant strain of Plasmodium falciparum was evaluated.	ChEMBL.	9871598
EC50 (functional)	> 0.000016 M	Cytotoxicity against FM3A cells derived from a mammary tumor in mice was evaluated.	ChEMBL.	9871598
EC50 (functional)	> 0.000016 M	Cytotoxicity against FM3A cells derived from a mammary tumor in mice was evaluated.	ChEMBL.	9871598
Ratio (functional)	> 16	Selective toxicity was evaluated by the ratio of cytotoxicity against FM3A cells over Plasmodium falciparum	ChEMBL.	9871598
Viability (functional)	= 100 %	Antimalarial activity was evaluated by the percent viability of FM3A cells	ChEMBL.	9871598
Viability (functional)	= 100 %	Antimalarial activity was evaluated by the percent viability of FM3A cells	ChEMBL.	9871598

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	9871598
Mus musculus	ChEMBL23	9871598

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL343585

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 244105