Detailed information for compound 24808
Basic information
Technical information
- Name: Unnamed compound
- MW: 440.469 | Formula: C26H21FN4O2
-
H donors: 2
H acceptors: 2
LogP: 3.58
Rotable bonds: 5
Rule of 5 violations (Lipinski): 1 - SMILES: NC(=O)CN1C(=O)C(N=C(c2c1cccc2)c1ccccc1F)Cc1c[nH]c2c1cccc2
- InChi: 1S/C26H21FN4O2/c27-20-10-4-1-8-18(20)25-19-9-3-6-12-23(19)31(15-24(28)32)26(33)22(30-25)13-16-14-29-21-11-5-2-7-17(16)21/h1-12,14,22,29H,13,15H2,(H2,28,32)
- InChiKey: OREYHRFTKKKARD-UHFFFAOYSA-N
Network
Hover on a compound node to display the structore
Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
No curated genes were found associated with this compound
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0114 | 1 | 0.5 |
| Plasmodium vivax | steroid dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0114 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0114 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Onchocerca volvulus | 0.0114 | 1 | 1 | |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Echinococcus multilocularis | epidermal retinal dehydrogenase 2 | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Onchocerca volvulus | 0.0114 | 1 | 1 | |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0114 | 1 | 0.5 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Mycobacterium leprae | PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE | 0.0114 | 1 | 0.5 |
| Brugia malayi | Dehydrogenases, short chain protein 2 | 0.0114 | 1 | 1 |
| Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0047 | 0.0294 | 0.0294 |
| Onchocerca volvulus | Sepiapterin reductase homolog | 0.0114 | 1 | 1 |
| Schistosoma mansoni | retinal dehydrogenase | 0.0114 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0114 | 1 | 1 |
| Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0114 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0114 | 1 | 0.5 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0114 | 1 | 0.5 |
| Echinococcus granulosus | oxidoreductase | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Brugia malayi | oxidoreductase | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase/decarboxylase protein | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 1 homolog | 0.0114 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Onchocerca volvulus | 0.0114 | 1 | 1 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
| Echinococcus multilocularis | Dehydrogenase:reductase SDR family | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | carveol-like dehydrogenase | 0.0114 | 1 | 0.5 |
| Trichomonas vaginalis | steroid dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0114 | 1 | 1 |
| Trypanosoma brucei | beta-D-hydroxybutyrate dehydrogenase | 0.0114 | 1 | 0.5 |
| Onchocerca volvulus | 0.0114 | 1 | 1 | |
| Giardia lamblia | Reductase, putative | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Mycobacterium tuberculosis | Possible iron-regulated short-chain dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Echinococcus granulosus | steroid dehydrogenase | 0.0114 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0047 | 0.0294 | 0.0294 |
| Loa Loa (eye worm) | oxidoreductase | 0.0114 | 1 | 1 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Echinococcus multilocularis | 3 ketodihydrosphingosine reductase | 0.0114 | 1 | 1 |
| Onchocerca volvulus | 0.0114 | 1 | 1 | |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Onchocerca volvulus | 0.0114 | 1 | 1 | |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0114 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0114 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Giardia lamblia | Hypothetical protein | 0.0114 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Brugia malayi | hypothetical protein | 0.0114 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0114 | 1 | 0.5 |
| Brugia malayi | Hypothetical oxidoreductase F56D1.5 | 0.0114 | 1 | 1 |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0114 | 1 | 1 |
| Mycobacterium tuberculosis | Possible fatty acyl-CoA reductase | 0.0114 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0114 | 1 | 1 |
| Schistosoma mansoni | short-chain dehydrogenase/reductase | 0.0114 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0114 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0114 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Echinococcus granulosus | epidermal retinal dehydrogenase 2 | 0.0114 | 1 | 1 |
| Onchocerca volvulus | 0.0114 | 1 | 1 | |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0114 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0114 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Toxoplasma gondii | carbonyl reductase 1, putative | 0.0114 | 1 | 0.5 |
| Mycobacterium leprae | Probable oxidoreductase | 0.0114 | 1 | 0.5 |
| Loa Loa (eye worm) | dehydrogenase | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0114 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0047 | 0.0294 | 0.0294 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0047 | 0.0294 | 0.0294 |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 2 | 0.0114 | 1 | 0.5 |
| Leishmania major | pteridine reductase 1 | 0.0114 | 1 | 1 |
| Echinococcus multilocularis | oxidoreductase | 0.0114 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
| Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0047 | 0.0294 | 0.0294 |
| Mycobacterium ulcerans | dehydrogenase | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | carbonyl reductase | 0.0114 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0114 | 1 | 1 |
| Mycobacterium tuberculosis | Possible ketoacyl reductase | 0.0114 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0114 | 1 | 0.5 |
| Brugia malayi | dehydrogenases, short chain protein 2 | 0.0114 | 1 | 1 |
| Mycobacterium tuberculosis | Probable shortchain dehydrogenase | 0.0114 | 1 | 0.5 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0114 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Brugia malayi | Retinol dehydrogenase 12 | 0.0114 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short chain alcohol dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Echinococcus granulosus | ecdysone induced protein 78C | 0.0047 | 0.0294 | 0.0294 |
| Trichomonas vaginalis | hydroxyacyl dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Echinococcus multilocularis | retinol dehydrogenase 13 | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Trypanosoma cruzi | quinonoid dihydropteridine reductase, putative | 0.0114 | 1 | 0.5 |
| Onchocerca volvulus | 0.0114 | 1 | 1 | |
| Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short-chain membrane-associated dehydrogenase | 0.0114 | 1 | 0.5 |
| Brugia malayi | dehydrogenases, short chain protein 9 | 0.0114 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Echinococcus multilocularis | estradiol 17 beta dehydrogenase 12 | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | oxidoreductase | 0.0114 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0114 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0114 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
| Echinococcus granulosus | hypothetical protein | 0.0114 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0114 | 1 | 1 |
| Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0114 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 0.5 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | oxidoreductase | 0.0114 | 1 | 0.5 |
| Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0047 | 0.0294 | 0.0294 |
| Mycobacterium tuberculosis | Probable short-chain dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Brugia malayi | D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor | 0.0114 | 1 | 1 |
| Mycobacterium tuberculosis | Probable dehydrogenase | 0.0114 | 1 | 0.5 |
| Mycobacterium leprae | Possible short-chain dehydrogenase EphD | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0114 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0114 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0114 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0114 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Echinococcus granulosus | Dehydrogenase:reductase SDR family | 0.0114 | 1 | 1 |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 3, putative | 0.0114 | 1 | 0.5 |
| Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0114 | 1 | 0.5 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0114 | 1 | 0.5 |
| Echinococcus multilocularis | FTZ F1 alpha | 0.0047 | 0.0294 | 0.0294 |
| Loa Loa (eye worm) | oxidoreductase | 0.0114 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Echinococcus granulosus | WW domain containing oxidoreductase | 0.0114 | 1 | 1 |
| Trypanosoma brucei | oxidoreductase-like protein | 0.0114 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type oxidoreductase | 0.0114 | 1 | 0.5 |
| Onchocerca volvulus | 0.0114 | 1 | 1 | |
| Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0114 | 1 | 0.5 |
| Trypanosoma brucei | 3-keto-dihydrosphingosine reductase | 0.0114 | 1 | 0.5 |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0114 | 1 | 1 |
| Onchocerca volvulus | 0.0114 | 1 | 1 | |
| Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0047 | 0.0294 | 0.0294 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0114 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0114 | 1 | 0.5 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0114 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Echinococcus multilocularis | conserved hypothetical protein | 0.0114 | 1 | 1 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0114 | 1 | 0.5 |
| Toxoplasma gondii | 3-ketoacyl-CoA reductase, putative | 0.0114 | 1 | 0.5 |
| Loa Loa (eye worm) | dehydrogenase | 0.0114 | 1 | 1 |
| Plasmodium vivax | hypothetical protein, conserved | 0.0114 | 1 | 0.5 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0114 | 1 | 0.5 |
| Loa Loa (eye worm) | short chain dehydrogenase/reductase family oxidoreductase | 0.0114 | 1 | 1 |
| Mycobacterium leprae | ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE | 0.0114 | 1 | 0.5 |
| Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0047 | 0.0294 | 0.0294 |
| Leishmania major | hypothetical protein, conserved | 0.0114 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0114 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Brugia malayi | Dehydrogenases, short chain protein 30 | 0.0114 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Trichomonas vaginalis | estradiol 17 beta-dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Schistosoma mansoni | 3-keto-dihydrosphingosine reductase | 0.0114 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type oxidoreductase | 0.0114 | 1 | 0.5 |
| Onchocerca volvulus | 0.0114 | 1 | 1 | |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0114 | 1 | 1 |
| Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0047 | 0.0294 | 0.0294 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0114 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0114 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0047 | 0.0294 | 0.0294 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0114 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0114 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0114 | 1 | 0.5 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0114 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0114 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0114 | 1 | 1 |
| Leishmania major | short chain dehydrogenase, putative | 0.0114 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein | 0.0114 | 1 | 0.5 |
| Onchocerca volvulus | 0.0114 | 1 | 1 | |
| Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0047 | 0.0294 | 0.0294 |
| Echinococcus multilocularis | ecdysone induced protein 78C | 0.0047 | 0.0294 | 0.0294 |
| Leishmania major | dehydrogenase-like protein | 0.0114 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0114 | 1 | 1 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Onchocerca volvulus | 0.0114 | 1 | 1 | |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0114 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0114 | 1 | 1 |
| Giardia lamblia | Short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Leishmania major | hypothetical protein, conserved | 0.0114 | 1 | 1 |
| Plasmodium falciparum | oxidoreductase, short-chain dehydrogenase family, putative | 0.0114 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0114 | 1 | 1 |
| Leishmania major | short chain dehydrogenase, putative | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0114 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0114 | 1 | 0.5 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0114 | 1 | 0.5 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0047 | 0.0294 | 0.0294 |
| Trichomonas vaginalis | short-chain dehydrogenases/reductase, putative | 0.0114 | 1 | 0.5 |
| Leishmania major | 3-keto-dihydrosphingosine reductase | 0.0114 | 1 | 1 |
| Entamoeba histolytica | oxidoreductase, short chain dehydrogenase/reductase family | 0.0114 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | oxidoreductase short chain dehydrogenase/reductase family | 0.0114 | 1 | 1 |
| Mycobacterium tuberculosis | Possible short-chain dehydrogenase EphD | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0114 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0114 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0114 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 0.5 |
| Entamoeba histolytica | 3-ketodihydrosphingosine reductase protein, putative | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0114 | 1 | 0.5 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0114 | 1 | 0.5 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0114 | 1 | 0.5 |
| Echinococcus granulosus | 3 ketodihydrosphingosine reductase | 0.0114 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Leishmania major | short chain dehydrogenase-like protein | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0114 | 1 | 1 |
| Mycobacterium tuberculosis | Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0114 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
| Echinococcus granulosus | FTZ F1 alpha | 0.0047 | 0.0294 | 0.0294 |
| Giardia lamblia | Oxidoreductase, short chain dehydrogenase/reductase family | 0.0114 | 1 | 0.5 |
| Plasmodium falciparum | steroid dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Schistosoma mansoni | carbonyl reductase | 0.0114 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0114 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0114 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0047 | 0.0294 | 0.0294 |
| Schistosoma mansoni | carbonyl reductase | 0.0114 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Echinococcus multilocularis | transient receptor potential cation channel | 0.0114 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0114 | 1 | 0.5 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0114 | 1 | 0.5 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0114 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0114 | 1 | 1 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0114 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Trypanosoma brucei | 3-ketoacyl-CoA reductase, putative | 0.0114 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0114 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0114 | 1 | 0.5 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0114 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0114 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0114 | 1 | 1 |
| Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0047 | 0.0294 | 0.0294 |
| Leishmania major | oxidoreductase-like protein | 0.0114 | 1 | 1 |
| Mycobacterium tuberculosis | Decaprenylphosphoryl-D-2-keto erythro pentose reductase | 0.0114 | 1 | 0.5 |
| Echinococcus granulosus | hypothetical protein | 0.0114 | 1 | 1 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0114 | 1 | 1 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| IC50 (binding) | = 2.1 uM | Half-maximal inhibition of [125I]-CCK-33 binding to rat pancreas cholecystokinin receptor | ChEMBL. | 2885419 |
| IC50 (functional) | > 10 uM | Half-maximal inhibition of binding of [125I]-gastrin to guinea pig gastric glands | ChEMBL. | 2885419 |
| IC50 (binding) | = 66 uM | Half-maximal inhibition of [125I]-CCK-33 binding to guinea pig brain(cortex) cholecystokinin receptor | ChEMBL. | 2885419 |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: 125923
Bibliographic References
1 literature reference was collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.