Detailed information for compound 249514

Basic information

Technical information
  • TDR Targets ID: 249514
  • Name: N'-(7-chloroquinolin-4-yl)-N,N-diethylpropane -1,3-diamine
  • MW: 291.819 | Formula: C16H22ClN3
  • H donors: 1 H acceptors: 1 LogP: 3.93 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCCNc1ccnc2c1ccc(c2)Cl)CC
  • InChi: 1S/C16H22ClN3/c1-3-20(4-2)11-5-9-18-15-8-10-19-16-12-13(17)6-7-14(15)16/h6-8,10,12H,3-5,9,11H2,1-2H3,(H,18,19)
  • InChiKey: NCPLTAGJJVCHOW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(7-chloro-4-quinolyl)-N,N-diethyl-propane-1,3-diamine
  • N'-(7-chloro-4-quinolyl)-N,N-diethylpropane-1,3-diamine
  • N'-(7-chloroquinolin-4-yl)-N,N-diethyl-propane-1,3-diamine
  • 3-[(7-chloro-4-quinolyl)amino]propyl-diethyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus granulosus neuropeptide s receptor 0.0108215 0.166356 0.152444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0108215 0.166356 0.152444
Brugia malayi Cathepsin L-like precursor 0.0183016 0.341261 0.338832
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0108215 0.166356 0.166356
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.00692828 0.07532 0.0719097
Loa Loa (eye worm) animal heme peroxidase 0.00521854 0.0353413 0.0353413
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.00692828 0.07532 0.0598895
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0108215 0.166356 0.152444
Toxoplasma gondii preprocathepsin c precursor, putative 0.00477541 0.0249796 0.0209211
Echinococcus granulosus g protein coupled receptor 0.0108215 0.166356 0.152444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Onchocerca volvulus Matrilysin homolog 0.00857075 0.113726 0.333251
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Onchocerca volvulus Peroxidase homolog 0.00521854 0.0353413 0.103561
Plasmodium falciparum plasmepsin IV 0.0146914 0.256844 0.740132
Onchocerca volvulus Peroxidase homolog 0.00521854 0.0353413 0.103561
Echinococcus multilocularis neuropeptide FF receptor 2 0.0108215 0.166356 0.152444
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.00477541 0.0249796 0.0263695
Echinococcus granulosus neuropeptides capa receptor 0.0108215 0.166356 0.152444
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Loa Loa (eye worm) G-protein coupled receptor 0.0108215 0.166356 0.166356
Schistosoma mansoni opsin-like receptor 0.0108215 0.166356 0.163281
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Loa Loa (eye worm) animal heme peroxidase 0.00521854 0.0353413 0.0353413
Loa Loa (eye worm) hypothetical protein 0.00681016 0.072558 0.072558
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012818 0.213039 0.469116
Echinococcus granulosus sex peptide receptor 0.0108215 0.166356 0.152444
Brugia malayi Serotonin receptor 0.0108215 0.166356 0.163281
Brugia malayi G protein-coupled receptor F59B2.13 0.0108215 0.166356 0.163281
Plasmodium vivax unspecified product 0.00477541 0.0249796 0.0263695
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0183016 0.341261 0.788967
Schistosoma mansoni cathepsin F (C01 family) 0.012818 0.213039 0.210136
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Schistosoma mansoni neuropeptide receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Schistosoma mansoni amine GPCR 0.0108215 0.166356 0.163281
Onchocerca volvulus 0.0108215 0.166356 0.487473
Brugia malayi cathepsin L precursor 0.00477541 0.0249796 0.0213836
Schistosoma mansoni cathepsin D (A01 family) 0.0433167 0.926185 0.925913
Echinococcus granulosus somatostatin receptor 0.0108215 0.166356 0.152444
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Echinococcus multilocularis serotonin receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.00548359 0.041539 0.041539
Echinococcus multilocularis cathepsin L cysteine protease 0.0183016 0.341261 0.330268
Brugia malayi Papain family cysteine protease containing protein 0.00477541 0.0249796 0.0213836
Entamoeba histolytica cysteine proteinase, putative 0.012818 0.213039 0.594595
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012818 0.213039 0.469116
Onchocerca volvulus Arrow homolog 0.00681016 0.072558 0.212617
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.00477541 0.0249796 0.0213836
Echinococcus multilocularis fibrillin 1 0.00796296 0.0995136 0.0844869
Onchocerca volvulus Cathepsin L homolog 0.0183016 0.341261 1
Echinococcus granulosus Two pore potassium channel protein sup 9 0.03568 0.747619 0.743408
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Brugia malayi Cathepsin L-like precursor 0.012818 0.213039 0.210136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Onchocerca volvulus 0.0183016 0.341261 1
Brugia malayi cathepsin F-like cysteine proteinase 0.00477541 0.0249796 0.0213836
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni neuropeptide receptor 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.00493017 0.0285983 0.0285983
Onchocerca volvulus 0.00547919 0.0414359 0.12142
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Echinococcus multilocularis cathepsin L cysteine protease 0.0183016 0.341261 0.330268
Echinococcus multilocularis fmrfamide receptor 0.0108215 0.166356 0.152444
Trypanosoma cruzi cysteine proteinase, putative 0.010259 0.153202 0.139071
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) melatonin receptor type 1A 0.0108215 0.166356 0.166356
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Brugia malayi Animal haem peroxidase family protein 0.00521854 0.0353413 0.0317836
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Entamoeba histolytica cysteine proteinase, putative 0.0183016 0.341261 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0108215 0.166356 0.166356
Onchocerca volvulus Cathepsin L homolog 0.00477541 0.0249796 0.0731978
Schistosoma mansoni cathepsin S (C01 family) 0.00477541 0.0249796 0.0213836
Loa Loa (eye worm) hypothetical protein 0.00477541 0.0249796 0.0249796
Onchocerca volvulus 0.0108215 0.166356 0.487473
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Schistosoma mansoni neuropeptide F-like receptor 0.0108215 0.166356 0.163281
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0464735 1 1
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Toxoplasma gondii aspartyl protease ASP1 0.0146914 0.256844 0.587208
Echinococcus granulosus Tolloid protein 1 0.0286024 0.582124 0.575151
Brugia malayi Cathepsin L-like precursor 0.0183016 0.341261 0.338832
Onchocerca volvulus Chorion peroxidase homolog 0.00521854 0.0353413 0.103561
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0344678 0.719274 0.719274
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.00477541 0.0249796 0.0263695
Echinococcus granulosus biogenic amine 5HT receptor 0.0108215 0.166356 0.152444
Plasmodium falciparum serine repeat antigen 6 0.00477541 0.0249796 0.0263695
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus granulosus rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus granulosus cathepsin l1 0.0183016 0.341261 0.330268
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.00681016 0.072558 0.072558
Loa Loa (eye worm) AStacin protease 0.0197604 0.375371 0.375371
Loa Loa (eye worm) hypothetical protein 0.00477541 0.0249796 0.0249796
Schistosoma mansoni alpha-1 adrenergic receptor 0.0108215 0.166356 0.163281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Brugia malayi Fibulin-1 precursor 0.00796296 0.0995136 0.0961926
Brugia malayi cathepsin B-like cysteine proteinase 0.0464735 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.00477541 0.0249796 0.0213836
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00477541 0.0249796 0.0213836
Schistosoma mansoni amine GPCR 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.00548359 0.041539 0.041539
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Loa Loa (eye worm) cysteine protease 0.0183016 0.341261 0.341261
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus multilocularis fmrfamide receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Brugia malayi Papain family cysteine protease containing protein 0.0183016 0.341261 0.338832
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0108215 0.166356 0.152444
Loa Loa (eye worm) calpain family protein 1 0.00493017 0.0285983 0.0285983
Plasmodium vivax serine-repeat antigen (SERA), putative 0.00477541 0.0249796 0.0263695
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Brugia malayi G-protein coupled receptor 0.0108215 0.166356 0.163281
Onchocerca volvulus Matrilysin homolog 0.00386427 0.0036745 0.0107674
Onchocerca volvulus 0.0108215 0.166356 0.487473
Echinococcus granulosus cathepsin L 0.00477541 0.0249796 0.008709
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00477541 0.0249796 0.0213836
Brugia malayi AKH receptor 0.0108215 0.166356 0.163281
Loa Loa (eye worm) G-protein coupled receptor 0.0108215 0.166356 0.166356
Brugia malayi Kringle domain containing protein 0.00440907 0.0164135 0.012786
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Echinococcus multilocularis G protein coupled receptor 139 0.0108215 0.166356 0.152444
Schistosoma mansoni adenoreceptor 0.0108215 0.166356 0.163281
Onchocerca volvulus 0.00521854 0.0353413 0.103561
Onchocerca volvulus 0.00386427 0.0036745 0.0107674
Loa Loa (eye worm) matrixin family protein 0.00857075 0.113726 0.113726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Echinococcus granulosus neuropeptide Y receptor 0.0108215 0.166356 0.152444
Toxoplasma gondii cathepsin CPC2 0.00477541 0.0249796 0.0209211
Plasmodium vivax serine-repeat antigen (SERA) 0.00477541 0.0249796 0.0263695
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0108215 0.166356 0.152444
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0183016 0.341261 1
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Plasmodium vivax serine-repeat antigen (SERA) 0.00477541 0.0249796 0.0263695
Brugia malayi Animal haem peroxidase family protein 0.00521854 0.0353413 0.0317836
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.00407895 0.00869437 0.00503839
Schistosoma mansoni hypothetical protein 0.0108215 0.166356 0.163281
Entamoeba histolytica cysteine proteinase, putative 0.010259 0.153202 0.405405
Schistosoma mansoni cathepsin D (A01 family) 0.0433167 0.926185 0.925913
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0140499 0.241845 0.229193
Schistosoma mansoni hypothetical protein 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Schistosoma mansoni peroxidasin 0.00521854 0.0353413 0.0317836
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Brugia malayi G protein-coupled receptor 0.0108215 0.166356 0.163281
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0108215 0.166356 0.487473
Onchocerca volvulus 0.0108215 0.166356 0.487473
Echinococcus granulosus laminin 0.00796296 0.0995136 0.0844869
Giardia lamblia Cathepsin B precursor 0.0219196 0.42586 1
Schistosoma mansoni opsin-like receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.00477541 0.0249796 0.0213836
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.00477541 0.0249796 0.0263695
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus multilocularis peroxidasin 0.00521854 0.0353413 0.0192436
Trypanosoma cruzi major cysteine proteinase, putative 0.00477541 0.0249796 0.008709
Onchocerca volvulus 0.00477541 0.0249796 0.0731978
Onchocerca volvulus 0.00521854 0.0353413 0.103561
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Echinococcus multilocularis neuropeptide Y receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00477541 0.0249796 0.0213836
Loa Loa (eye worm) hypothetical protein 0.03568 0.747619 0.747619
Onchocerca volvulus 0.0108215 0.166356 0.487473
Onchocerca volvulus 0.0108215 0.166356 0.487473
Brugia malayi Cathepsin L-like precursor 0.0183016 0.341261 0.338832
Brugia malayi Papain family cysteine protease containing protein 0.010259 0.153202 0.150079
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Trypanosoma cruzi cruzipain precursor, putative 0.0183016 0.341261 0.330268
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.00678035 0.071861 0.068438
Echinococcus multilocularis g-protein coupled receptor 0.0108215 0.166356 0.152444
Brugia malayi Cathepsin L-like precursor 0.0183016 0.341261 0.338832
Brugia malayi Papain family cysteine protease containing protein 0.00477541 0.0249796 0.0213836
Echinococcus multilocularis g protein coupled receptor 0.0108215 0.166356 0.152444
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0140499 0.241845 0.229193
Echinococcus multilocularis cysteine protease 0.0183016 0.341261 0.330268
Trypanosoma cruzi cysteine protease, putative 0.010259 0.153202 0.139071
Entamoeba histolytica cysteine proteinase 1, putative 0.010259 0.153202 0.405405
Onchocerca volvulus 0.0183016 0.341261 1
Loa Loa (eye worm) hypothetical protein 0.012818 0.213039 0.213039
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.00477541 0.0249796 0.0249796
Schistosoma mansoni hypothetical protein 0.0108215 0.166356 0.163281
Plasmodium falciparum serine repeat antigen 1 0.00477541 0.0249796 0.0263695
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0108215 0.166356 0.163281
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0108215 0.166356 0.152444
Schistosoma mansoni biogenic amine receptor 0.0108215 0.166356 0.163281
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Onchocerca volvulus Putative cubilin 0.00487067 0.0272071 0.0797252
Echinococcus granulosus dro:myosuppressin receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.00681016 0.072558 0.072558
Schistosoma mansoni neuropeptide F-like receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Brugia malayi Peroxidasin 0.00521854 0.0353413 0.0317836
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Brugia malayi larval opioid receptor 0.0108215 0.166356 0.163281
Brugia malayi Dopamine receptor protein 1 0.0108215 0.166356 0.163281
Echinococcus granulosus cathepsin l1 0.012818 0.213039 0.199906
Echinococcus multilocularis dro:myosuppressin receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108215 0.166356 0.163281
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.00470648 0.0233679 0.5
Entamoeba histolytica cysteine proteinase 2 0.010259 0.153202 0.405405
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0108215 0.166356 0.152444
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0286024 0.582124 0.580583
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.00477541 0.0249796 0.0263695
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0108215 0.166356 0.163281
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0183016 0.341261 0.330268
Echinococcus multilocularis Tolloid protein 1 0.0286024 0.582124 0.575151
Echinococcus granulosus allatostatin A receptor 0.0108215 0.166356 0.152444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Onchocerca volvulus 0.0108215 0.166356 0.487473
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0183016 0.341261 0.330268
Loa Loa (eye worm) hypothetical protein 0.0464735 1 1
Entamoeba histolytica cysteine proteinase, putative 0.010259 0.153202 0.405405
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Onchocerca volvulus 0.0108215 0.166356 0.487473
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0108215 0.166356 0.152444
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Echinococcus granulosus 7tm_1 domain containing protein 0.0108215 0.166356 0.152444
Echinococcus granulosus g protein coupled receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni cathepsin F (C01 family) 0.0183016 0.341261 0.338832
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0146914 0.256844 0.244442
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Brugia malayi cahepsin L-like non-peptiedase homolog 0.00477541 0.0249796 0.0213836
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Loa Loa (eye worm) hypothetical protein 0.00386427 0.0036745 0.0036745
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Entamoeba histolytica cysteine protease, putative 0.0183016 0.341261 1
Echinococcus granulosus neuropeptide receptor 0.0108215 0.166356 0.152444
Brugia malayi Calcium binding EGF domain containing protein 0.00487067 0.0272071 0.0236194
Trypanosoma cruzi cysteine peptidase, putative 0.0183016 0.341261 0.330268
Echinococcus multilocularis calpain A 0.00692828 0.07532 0.0598895
Plasmodium vivax aspartyl proteinase, putative 0.0146914 0.256844 0.740132
Plasmodium falciparum serine repeat antigen 3 0.00477541 0.0249796 0.0263695
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0108215 0.166356 0.163281
Brugia malayi cathepsin L-like precursor 0.012818 0.213039 0.210136
Plasmodium falciparum cysteine proteinase falcipain 1 0.010259 0.153202 0.421085
Brugia malayi Cathepsin L-like cysteine proteinase 0.012818 0.213039 0.210136
Schistosoma mansoni biogenic amine (5HT) receptor 0.0108215 0.166356 0.163281
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0108215 0.166356 0.152444
Brugia malayi G-protein coupled receptor 0.0108215 0.166356 0.163281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.010259 0.153202 0.319851
Plasmodium falciparum serine repeat antigen 5 0.00477541 0.0249796 0.0263695
Onchocerca volvulus Cathepsin F homolog 0.0183016 0.341261 1
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) papain family cysteine protease containing protein 0.00477541 0.0249796 0.0249796
Onchocerca volvulus 0.012818 0.213039 0.624269
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.00678035 0.071861 0.071861
Plasmodium vivax unspecified product 0.010259 0.153202 0.421085
Plasmodium falciparum cysteine proteinase falcipain 3 0.0183016 0.341261 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0108215 0.166356 0.152444
Echinococcus granulosus tm gpcr rhodopsin 0.0108215 0.166356 0.152444
Schistosoma mansoni biogenic amine receptor 0.0108215 0.166356 0.163281
Brugia malayi cathepsin Z-like cysteine proteinase 0.00477541 0.0249796 0.0213836
Echinococcus granulosus rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Onchocerca volvulus Peroxidasin homolog 0.00521854 0.0353413 0.103561
Plasmodium falciparum serine repeat antigen 4 0.00477541 0.0249796 0.0263695
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Echinococcus granulosus neuropeptide Y receptor 0.0108215 0.166356 0.152444
Toxoplasma gondii cathepsin B 0.0219196 0.42586 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Brugia malayi Cathepsin L-like precursor 0.00548359 0.041539 0.0380041
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0108215 0.166356 0.163281
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Schistosoma mansoni hypothetical protein 0.00440907 0.0164135 0.012786
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0464735 1 1
Brugia malayi neuropeptide F receptor 0.0108215 0.166356 0.163281
Mycobacterium ulcerans hydrolase 0.00470648 0.0233679 0.5
Loa Loa (eye worm) hypothetical protein 0.00548359 0.041539 0.041539
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.010259 0.153202 0.150079
Echinococcus multilocularis neuropeptides capa receptor 0.0108215 0.166356 0.152444
Echinococcus granulosus rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.00440907 0.0164135 0.0164135
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.0183016 0.341261 0.341261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0286024 0.582124 0.582124
Schistosoma mansoni myosin xvIII 0.0108215 0.166356 0.163281
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0108215 0.166356 0.152444
Echinococcus granulosus rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Onchocerca volvulus Neuropeptide F receptor homolog 0.0108215 0.166356 0.487473
Echinococcus granulosus rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.03568 0.747619 0.743408
Loa Loa (eye worm) hypothetical protein 0.0146914 0.256844 0.256844
Brugia malayi Animal haem peroxidase family protein 0.00521854 0.0353413 0.0317836
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Schistosoma mansoni neuropeptide f receptor 76f 0.0108215 0.166356 0.163281
Entamoeba histolytica cysteine proteinase, putative 0.010259 0.153202 0.405405
Echinococcus granulosus cathepsin l cysteine peptidase 0.0183016 0.341261 0.330268
Schistosoma mansoni neuropeptide receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0146914 0.256844 0.256844
Brugia malayi ORL1-like opioid receptor 0.0108215 0.166356 0.163281
Plasmodium vivax vivapain-3 0.010259 0.153202 0.421085
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0183016 0.341261 0.788967
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.00681016 0.072558 0.0691375
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.00477541 0.0249796 0.0263695
Schistosoma mansoni biogenic amine receptor 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Entamoeba histolytica cysteine proteinase, putative 0.0183016 0.341261 1
Leishmania major cysteine peptidase A (CPA) 0.0183016 0.341261 0.793382
Echinococcus granulosus serotonin receptor 0.0108215 0.166356 0.152444
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.00477541 0.0249796 0.0263695
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.010259 0.153202 0.150079
Loa Loa (eye worm) calpain family protein 1 0.00678035 0.071861 0.071861
Giardia lamblia Cathepsin B precursor 0.0219196 0.42586 1
Brugia malayi Dopamine receptor protein 2 0.0108215 0.166356 0.163281
Trypanosoma cruzi cysteine peptidase, putative 0.0183016 0.341261 0.330268
Onchocerca volvulus 0.00521854 0.0353413 0.103561
Brugia malayi calpain family protein 1 0.00678035 0.071861 0.068438
Echinococcus granulosus neuropeptide receptor A26 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.012818 0.213039 0.213039
Schistosoma mansoni opsin-like receptor 0.0108215 0.166356 0.163281
Plasmodium falciparum serine repeat antigen 7 0.00477541 0.0249796 0.0263695
Echinococcus multilocularis cathepsin b 0.0464735 1 1
Brugia malayi Papain family cysteine protease containing protein 0.010259 0.153202 0.150079
Onchocerca volvulus 0.0108215 0.166356 0.487473
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00477541 0.0249796 0.0213836
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0219196 0.42586 1
Echinococcus multilocularis cysteine protease 0.0183016 0.341261 0.330268
Brugia malayi Hemopexin family protein 0.00547919 0.0414359 0.0379007
Loa Loa (eye worm) hypothetical protein 0.00796296 0.0995136 0.0995136
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0146914 0.256844 0.244442
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0464735 1 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.00477541 0.0249796 0.0213836
Echinococcus granulosus hypothetical protein 0.0108215 0.166356 0.152444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Echinococcus multilocularis somatostatin receptor 0.0108215 0.166356 0.152444
Echinococcus granulosus alpha 1A adrenergic receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.00477541 0.0249796 0.0213836
Brugia malayi hypothetical protein 0.00521854 0.0353413 0.0317836
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0146914 0.256844 0.578387
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0219196 0.42586 0.423743
Onchocerca volvulus 0.0108215 0.166356 0.487473
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Plasmodium vivax vivapain-2 0.0183016 0.341261 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.00470648 0.0233679 0.0233679
Loa Loa (eye worm) hypothetical protein 0.00477541 0.0249796 0.0249796
Loa Loa (eye worm) hypothetical protein 0.00477541 0.0249796 0.0249796
Echinococcus multilocularis sex peptide receptor 0.0108215 0.166356 0.152444
Echinococcus multilocularis cathepsin L 0.00477541 0.0249796 0.008709
Plasmodium vivax plasmepsin IV, putative 0.0146914 0.256844 0.740132
Onchocerca volvulus 0.0108215 0.166356 0.487473
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0183016 0.341261 0.341261
Echinococcus granulosus fmrfamide receptor 0.0108215 0.166356 0.152444
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0219196 0.42586 1
Onchocerca volvulus 0.0108215 0.166356 0.487473
Echinococcus granulosus tachykinin peptides receptor 99D 0.0457634 0.983397 0.98312
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Loa Loa (eye worm) papain family cysteine protease containing protein 0.00548359 0.041539 0.041539
Loa Loa (eye worm) hypothetical protein 0.00386427 0.0036745 0.0036745
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Onchocerca volvulus Matrix metalloproteinase homolog 0.00857075 0.113726 0.333251
Echinococcus granulosus cathepsin L cysteine protease 0.010259 0.153202 0.139071
Entamoeba histolytica cysteine proteinase, putative 0.010259 0.153202 0.405405
Echinococcus multilocularis allatostatin A receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni twik family of potassium channels-related 0.03568 0.747619 0.746688
Loa Loa (eye worm) TK/ROR protein kinase 0.00440907 0.0164135 0.0164135
Loa Loa (eye worm) hypothetical protein 0.00555731 0.0432627 0.0432627
Brugia malayi follicle stimulating hormone receptor 0.0108215 0.166356 0.163281
Echinococcus granulosus cathepsin L cysteine proteinase 0.0183016 0.341261 0.330268
Loa Loa (eye worm) hypothetical protein 0.00999484 0.147025 0.147025
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.00477541 0.0249796 0.0263695
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0464735 1 1
Brugia malayi Dopamine receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni hypothetical protein 0.00547919 0.0414359 0.0379007
Plasmodium falciparum serine repeat antigen 8 0.00477541 0.0249796 0.0263695
Loa Loa (eye worm) cathepsin B 0.0219196 0.42586 0.42586
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0108215 0.166356 0.163281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Echinococcus granulosus tm gpcr rhodopsin 0.0108215 0.166356 0.152444
Schistosoma mansoni biogenic amine (5HT) receptor 0.0108215 0.166356 0.163281
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.012818 0.213039 0.199906
Onchocerca volvulus Dual oxidase homolog 0.00521854 0.0353413 0.103561
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus granulosus orexin receptor type 2 0.0108215 0.166356 0.152444
Toxoplasma gondii calcium binding egf domain-containing protein 0.00796296 0.0995136 0.202957
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0464735 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni amine GPCR 0.0108215 0.166356 0.163281
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0219196 0.42586 0.416279
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Brugia malayi putative neuropeptide receptor NPR1 0.0108215 0.166356 0.163281
Schistosoma mansoni peroxidasin 0.00521854 0.0353413 0.0317836
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Plasmodium vivax unspecified product 0.00548359 0.041539 0.0773453
Onchocerca volvulus 0.0108215 0.166356 0.487473
Brugia malayi GnHR receptor homolog 0.0108215 0.166356 0.163281
Echinococcus multilocularis cathepsin b 0.0464735 1 1
Brugia malayi Animal haem peroxidase family protein 0.00521854 0.0353413 0.0317836
Echinococcus granulosus G protein coupled receptor 139 0.0108215 0.166356 0.152444
Trypanosoma cruzi cysteine peptidase, putative 0.0183016 0.341261 0.330268
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Schistosoma mansoni cathepsin C 0.00477541 0.0249796 0.0213836
Onchocerca volvulus 0.0108215 0.166356 0.487473
Echinococcus multilocularis serotonin receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Echinococcus granulosus peroxidasin 0.00521854 0.0353413 0.0192436
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus granulosus cathepsin b 0.0464735 1 1
Toxoplasma gondii cathepsin CPL 0.0183016 0.341261 0.793382
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0108215 0.166356 0.166356
Loa Loa (eye worm) neuropeptide F receptor 0.0108215 0.166356 0.166356
Loa Loa (eye worm) animal heme peroxidase 0.00521854 0.0353413 0.0353413
Loa Loa (eye worm) matrix metalloproteinase 0.00386427 0.0036745 0.0036745
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.010259 0.153202 0.319851
Loa Loa (eye worm) hypothetical protein 0.00477541 0.0249796 0.0249796
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0108215 0.166356 0.163281
Echinococcus granulosus biogenic amine 5HT receptor 0.0108215 0.166356 0.152444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Loa Loa (eye worm) hypothetical protein 0.00487067 0.0272071 0.0272071
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.00477541 0.0249796 0.0263695
Echinococcus granulosus neuropeptide FF receptor 2 0.0108215 0.166356 0.152444
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0108215 0.166356 0.166356
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0108215 0.166356 0.152444
Echinococcus multilocularis neuropeptides capa receptor 0.0108215 0.166356 0.152444
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0146914 0.256844 0.254103
Echinococcus multilocularis g protein coupled receptor 0.0108215 0.166356 0.152444
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0108215 0.166356 0.152444
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.010259 0.153202 0.150079
Echinococcus granulosus tm gpcr rhodopsin 0.0108215 0.166356 0.152444
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.00477541 0.0249796 0.0263695
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0108215 0.166356 0.152444
Mycobacterium leprae PROBABLE HYDROLASE 0.00470648 0.0233679 0.5
Brugia malayi Serotonin receptor 0.0108215 0.166356 0.163281
Plasmodium falciparum serine repeat antigen 9 0.00477541 0.0249796 0.0263695
Schistosoma mansoni growth hormone secretagogue receptor 0.0108215 0.166356 0.163281
Brugia malayi putative neuropeptide receptor 0.0108215 0.166356 0.163281
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.00477541 0.0249796 0.0263695
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) ctsf protein 0.0183016 0.341261 0.341261
Schistosoma mansoni neuropeptide receptor 0.0108215 0.166356 0.163281
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Trypanosoma cruzi cysteine peptidase, putative 0.010259 0.153202 0.139071
Loa Loa (eye worm) TYRA-2 protein 0.0108215 0.166356 0.166356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.00470648 0.0233679 0.019766
Echinococcus multilocularis G-protein coupled receptor, putative 0.0108215 0.166356 0.152444
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Plasmodium vivax serine-repeat antigen (SERA), putative 0.00477541 0.0249796 0.0263695
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0108215 0.166356 0.152444
Brugia malayi Cathepsin L-like precursor 0.0183016 0.341261 0.338832
Brugia malayi Papain family cysteine protease containing protein 0.00477541 0.0249796 0.0213836
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108215 0.166356 0.163281
Onchocerca volvulus 0.0108215 0.166356 0.487473
Plasmodium falciparum plasmepsin II 0.0146914 0.256844 0.740132
Brugia malayi neuropeptide F receptor 0.0108215 0.166356 0.163281
Plasmodium vivax vivapain-1 0.010259 0.153202 0.421085
Brugia malayi Blistered cuticle protein 3 0.00521854 0.0353413 0.0317836
Plasmodium falciparum serine repeat antigen 2 0.00477541 0.0249796 0.0263695
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0108215 0.166356 0.163281
Echinococcus multilocularis calpain family protein 1, d 0.00493017 0.0285983 0.0123881
Schistosoma mansoni cathepsin F (C01 family) 0.0183016 0.341261 0.338832
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0108215 0.166356 0.163281
Loa Loa (eye worm) papain family cysteine protease containing protein 0.00477541 0.0249796 0.0249796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Onchocerca volvulus 0.0183016 0.341261 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00477541 0.0249796 0.0213836
Brugia malayi cathepsin F-like cysteine proteinase 0.00548359 0.041539 0.0380041
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0108215 0.166356 0.163281
Trypanosoma cruzi cysteine proteinase, putative 0.010259 0.153202 0.139071
Loa Loa (eye worm) fibroinase 0.0183016 0.341261 0.341261
Giardia lamblia Cathepsin B precursor 0.0219196 0.42586 1
Onchocerca volvulus 0.0183016 0.341261 1
Echinococcus granulosus neuropeptide receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.012818 0.213039 0.213039
Onchocerca volvulus 0.0183016 0.341261 1
Brugia malayi Protein kinase domain containing protein 0.00440907 0.0164135 0.012786
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Plasmodium falciparum plasmepsin I 0.0146914 0.256844 0.740132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Brugia malayi calpain family protein 1 0.00678035 0.071861 0.068438
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.00796296 0.0995136 0.0995136
Echinococcus granulosus rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Onchocerca volvulus 0.0183016 0.341261 1
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Brugia malayi Melatonin receptor type 1A 0.0108215 0.166356 0.163281
Loa Loa (eye worm) animal heme peroxidase 0.00521854 0.0353413 0.0353413
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Echinococcus granulosus cathepsin b 0.0464735 1 1
Brugia malayi Matrixin family protein 0.00934345 0.131794 0.128592
Entamoeba histolytica cysteine protease, putative 0.010259 0.153202 0.405405
Schistosoma mansoni histamine h1 receptor 0.0108215 0.166356 0.163281
Echinococcus multilocularis neuropeptide Y receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.00386427 0.0036745 0.0036745
Echinococcus granulosus cathepsin L 0.010259 0.153202 0.139071
Trypanosoma cruzi cysteine peptidase, putative 0.00548359 0.041539 0.0255447
Brugia malayi Cathepsin L-like precursor 0.0183016 0.341261 0.338832
Onchocerca volvulus Peroxidasin homolog 0.00521854 0.0353413 0.103561
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Schistosoma mansoni cathepsin B (C01 family) 0.00477541 0.0249796 0.0213836
Onchocerca volvulus Cathepsin L homolog 0.0183016 0.341261 1
Echinococcus multilocularis cathepsin L 0.010259 0.153202 0.139071
Trypanosoma cruzi major cysteine proteinase, putative 0.00477541 0.0249796 0.008709
Echinococcus granulosus cysteine protease 0.010259 0.153202 0.139071
Schistosoma mansoni amine GPCR 0.0108215 0.166356 0.163281
Echinococcus multilocularis neuropeptide receptor 0.0108215 0.166356 0.152444
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0108215 0.166356 0.152444
Schistosoma mansoni hypothetical protein 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.00477541 0.0249796 0.0249796
Loa Loa (eye worm) neuropeptide F receptor 0.0108215 0.166356 0.166356
Echinococcus multilocularis neuropeptide s receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Schistosoma mansoni egf-like domain protein 0.00681016 0.072558 0.0691375
Onchocerca volvulus 0.00440907 0.0164135 0.0480966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183016 0.341261 0.689725
Onchocerca volvulus 0.0108215 0.166356 0.487473
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.03568 0.747619 0.746688
Loa Loa (eye worm) hypothetical protein 0.03568 0.747619 0.747619
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.00692828 0.07532 0.0598895
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0146914 0.256844 0.587208
Toxoplasma gondii cathepsin CPC1 0.00477541 0.0249796 0.0209211
Brugia malayi RE15519p 0.0108215 0.166356 0.163281
Brugia malayi sulfakinin receptor protein 0.0108215 0.166356 0.163281
Echinococcus multilocularis orexin receptor type 2 0.0108215 0.166356 0.152444
Echinococcus multilocularis neuropeptide receptor 0.0108215 0.166356 0.152444
Plasmodium vivax vivapain-2 0.0183016 0.341261 1
Brugia malayi Animal haem peroxidase family protein 0.00521854 0.0353413 0.0317836
Brugia malayi Tachykinin-like peptides receptor 99D 0.0108215 0.166356 0.163281
Plasmodium falciparum plasmepsin VI 0.0146914 0.256844 0.740132
Echinococcus granulosus calpain A 0.00692828 0.07532 0.0598895
Brugia malayi hypothetical protein 0.0108215 0.166356 0.163281
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus multilocularis g protein coupled receptor 0.0108215 0.166356 0.152444
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Brugia malayi cathepsin L-like cysteine proteinase 0.00477541 0.0249796 0.0213836
Brugia malayi Calcium binding EGF domain containing protein 0.00796296 0.0995136 0.0961926
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.010259 0.153202 0.139071
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0183016 0.341261 0.341261
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0108215 0.166356 0.152444
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Echinococcus granulosus rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0108215 0.166356 0.163281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108215 0.166356 0.163281
Onchocerca volvulus 0.0183016 0.341261 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0108215 0.166356 0.152444
Trypanosoma brucei cysteine peptidase C (CPC) 0.0219196 0.42586 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Trypanosoma cruzi cysteine peptidase, putative 0.0183016 0.341261 0.330268
Schistosoma mansoni amine GPCR 0.0108215 0.166356 0.163281
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0108215 0.166356 0.152444
Brugia malayi Cathepsin L-like precursor 0.012818 0.213039 0.210136
Echinococcus granulosus 7TM GPCR rhodopsin 0.0108215 0.166356 0.152444
Trypanosoma cruzi cruzipain precursor, putative 0.00548359 0.041539 0.0255447
Loa Loa (eye worm) hypothetical protein 0.0108215 0.166356 0.166356
Loa Loa (eye worm) hypothetical protein 0.0271962 0.549241 0.549241
Loa Loa (eye worm) hypothetical protein 0.00521854 0.0353413 0.0353413
Echinococcus multilocularis laminin 0.00796296 0.0995136 0.0844869
Brugia malayi fibroinase precursor 0.00477541 0.0249796 0.0213836
Leishmania major cathepsin L-like protease 0.0183016 0.341261 0.793382
Schistosoma mansoni cathepsin s 0.00548359 0.041539 0.0380041
Toxoplasma gondii calcium binding egf domain-containing protein 0.00796296 0.0995136 0.202957
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108215 0.166356 0.152444
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.00548359 0.041539 0.0380041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183016 0.341261 0.788967
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.00477541 0.0249796 0.0263695
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0457634 0.983397 0.98312
Echinococcus granulosus g-protein coupled receptor 0.0108215 0.166356 0.152444
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0183016 0.341261 1
Echinococcus granulosus g protein coupled receptor 0.0108215 0.166356 0.152444
Loa Loa (eye worm) matrixin family protein 0.00934345 0.131794 0.131794
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0108215 0.166356 0.163281
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.00692828 0.07532 0.0719097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183016 0.341261 0.788967
Echinococcus multilocularis neuropeptide receptor A26 0.0108215 0.166356 0.152444
Loa Loa (eye worm) blistered cuticle protein 3 0.00521854 0.0353413 0.0353413
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0108215 0.166356 0.152444
Onchocerca volvulus 0.0108215 0.166356 0.487473

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2 nM Effective concentration of the compound against plasmodium falciparum 3D7 was determined ChEMBL. 15686903
EC50 (functional) = 2 nM Effective concentration of the compound against plasmodium falciparum 3D7 was determined ChEMBL. 15686903
EC50 (functional) = 23 nM Effective concentration of the compound against plasmodium falciparum W2 was determined ChEMBL. 15686903
EC50 (functional) = 23 nM Effective concentration of the compound against plasmodium falciparum W2 was determined ChEMBL. 15686903
GI50 (functional) = 17.85 uM Antiproliferative activity against human p53+/- MCF7 cells after 48 hrs by SRB assay ChEMBL. 20561720
GI50 (functional) = 27.81 uM Antiproliferative activity against human p53, pRB mutant and estrogen receptor deficient MDA-MB-231 cells after 48 hrs by SRB assay ChEMBL. 20561720
IC50 (functional) = 5 nM In vitro anti-plasmodial activity against Haiti 135 (chloroquine-susceptible) P. falciparum. ChEMBL. 9836608
IC50 (functional) = 5 nM In vitro anti-plasmodial activity against Haiti 135 (chloroquine-susceptible) P. falciparum. ChEMBL. 9836608
IC50 (functional) = 6 nM In vitro anti-plasmodial activity against Indochina I (chloroquine-resistant) P. falciparum. ChEMBL. 9836608
IC50 (functional) = 6 nM In vitro anti-plasmodial activity against Indochina I (chloroquine-resistant) P. falciparum. ChEMBL. 9836608
IC50 (functional) = 0.005 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Haiti 135 by [3H]hypoxanthine uptake ChEMBL. 18512900
IC50 (functional) = 0.006 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 72 hrs by SYBR green assay ChEMBL. 18512900
IC50 (functional) = 0.006 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum Indochina I by [3H]hypoxanthine uptake ChEMBL. 18512900
IC50 (functional) = 0.007 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum GCO3 after 72 hrs by SYBR green assay ChEMBL. 18512900
IC50 (functional) = 0.018 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 by [3H]hypoxanthine uptake ChEMBL. 18512900
IC50 (functional) = 0.026 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay ChEMBL. 18512900
IC50 (functional) = 0.029 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCB after 72 hrs by SYBR green assay ChEMBL. 18512900
IC50 (functional) = 0.06 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake ChEMBL. 18512900
Ratio IC50 (functional) = 1.2 Selectivity for chloroquine-resistant Plasmodium falciparum Indochina I over chloroquine-sensitive Plasmodium falciparum Haiti 135 as IC50 ratio by [3H]hypoxanthine uptake ChEMBL. 18512900
Ratio IC50 (functional) = 3.33 Selectivity for chloroquine-resistant Plasmodium falciparum K1 over chloroquine-sensitive Plasmodium falciparum NF54 as IC50 ratio by [3H]hypoxanthine uptake ChEMBL. 18512900
Ratio IC50 (functional) = 4.14 Selectivity for chloroquine-resistant Plasmodium falciparum FCB over chloroquine-sensitive Plasmodium falciparum GCO3 as IC50 ratio by SYBR green assay ChEMBL. 18512900
Ratio IC50 (functional) = 4.33 Selectivity for chloroquine-resistant Plasmodium falciparum Dd2 over chloroquine-sensitive Plasmodium falciparum HB3 as IC50 ratio by SYBR green assay ChEMBL. 18512900

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum 15686903

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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