Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0124 | 0.3021 | 0.5 |
Echinococcus granulosus | AMP deaminase 2 | 0.0183 | 1 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.0183 | 1 | 0.5 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0183 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.3021 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0183 | 1 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0124 | 0.3021 | 0.5 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0124 | 0.3021 | 0.5 |
Toxoplasma gondii | AMP deaminase | 0.0183 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.3021 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.3021 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.3021 |
Schistosoma mansoni | AMP deaminase | 0.0183 | 1 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.0183 | 1 | 0.5 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.0183 | 1 | 1 |
Entamoeba histolytica | AMP deaminase, putative | 0.0183 | 1 | 0.5 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.0183 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.3021 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0183 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.3021 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.3021 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0183 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0183 | 1 | 0.5 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0183 | 1 | 0.5 |
Leishmania major | AMP deaminase, putative | 0.0183 | 1 | 0.5 |
Plasmodium falciparum | AMP deaminase, putative | 0.0183 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.3021 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.3021 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0124 | 0.3021 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.3021 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.3021 |
Entamoeba histolytica | AMP deaminase, putative | 0.0183 | 1 | 0.5 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0183 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.3021 |
Loa Loa (eye worm) | AMP deaminase | 0.0183 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0183 | 1 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0183 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0183 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0183 | 1 | 0.5 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.0183 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.3021 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0183 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.6638 | 0.6638 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0124 | 0.3021 | 0.3021 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
E0 | = 0.57 | Redox potential of the compound was determined from cyclic voltammogram | ChEMBL. | No reference |
IC50 (functional) | = 7.9 uM | Antiproliferative effect of the compound against human Daudi Burkitt lymphoma cells | ChEMBL. | No reference |
IC50 (functional) | = 11.2 uM | Antiproliferative effect of the compound against human HL60 promyelocyiic leukemia cells | ChEMBL. | No reference |
IC50 (functional) | = 14.6 uM | Antiproliferative effect of the compound against human COLO 320 colon adenocarcinoma cells | ChEMBL. | No reference |
IC50 (functional) | = 14.8 uM | Antiproliferative effect of the compound against human U937 histiocytic lymphoma cells | ChEMBL. | No reference |
IC50 (functional) | = 16.1 uM | Antiproliferative effect of the compound against mouse NIH3T3 embryonic cells | ChEMBL. | No reference |
IC50 (functional) | = 16.5 uM | Antiproliferative effect of the compound against mouse LX830 lymphoma cells | ChEMBL. | No reference |
IC50 (functional) | = 19.3 uM | Antiproliferative effect of the compound against mouse S180 sarcoma cells | ChEMBL. | No reference |
Oxidation rate (binding) | = 96 nM min-1 | Rate of oxidation by the compound at 0.44 mM versus 0.49 mM of reduced cytochrome was determined at 30 degree C | ChEMBL. | No reference |
Oxidation rate (binding) | = 13 uM min-1 | Rate of oxidation by the compound at 0.5 mM versus 0.24 mM of NADH was determined | ChEMBL. | No reference |
Oxygen consumption rate (functional) | = 6.8 nM min-1 | Rate of oxygen consumption of human U937 cells (10e7 cells) at 200 uM concentration was determined at 30 degree C | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.