Detailed information for compound 251347

Basic information

Technical information
  • TDR Targets ID: 251347
  • Name: N'-(7-bromoquinolin-4-yl)-N,N-diethyldecane-1 ,10-diamine
  • MW: 434.456 | Formula: C23H36BrN3
  • H donors: 1 H acceptors: 1 LogP: 7.23 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCCCCCCCCCNc1ccnc2c1ccc(c2)Br)CC
  • InChi: 1S/C23H36BrN3/c1-3-27(4-2)18-12-10-8-6-5-7-9-11-16-25-22-15-17-26-23-19-20(24)13-14-21(22)23/h13-15,17,19H,3-12,16,18H2,1-2H3,(H,25,26)
  • InChiKey: IORURFPLEGRNBH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(7-bromo-4-quinolyl)-N,N-diethyl-decane-1,10-diamine
  • N'-(7-bromo-4-quinolyl)-N,N-diethyldecane-1,10-diamine
  • N'-(7-bromoquinolin-4-yl)-N,N-diethyl-decane-1,10-diamine
  • 10-[(7-bromo-4-quinolyl)amino]decyl-diethyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Adenosine/AMP deaminase family protein 0.0118716 0.0857551 0.0876793
Entamoeba histolytica AMP deaminase, putative 0.0332985 0.299904 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0177068 0.144074 0.469976
Leishmania major adenosine kinase, putative 0.0249743 0.216709 0.702416
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0132477 0.099508 0.324021
Plasmodium vivax adenosine deaminase, putative 0.0118716 0.0857551 0.234003
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.00885075 0.0555632 0.0566032
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0338997 0.305913 1
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0221302 0.188284 0.614764
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.00758973 0.04296 0.0322667
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.00532598 0.0203351 0.0106913
Loa Loa (eye worm) hypothetical protein 0.00502368 0.0173138 0.0172338
Schistosoma mansoni adenoreceptor 0.0033484 0.000570382 0.00190188
Loa Loa (eye worm) phosphatidylinositol 3 0.0286669 0.253614 0.260454
Schistosoma mansoni growth hormone secretagogue receptor 0.0033484 0.000570382 0.00190188
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0132477 0.099508 0.3318
Mycobacterium ulcerans adenosine deaminase 0.0118716 0.0857551 0.768819
Trypanosoma cruzi AMP deaminase, putative 0.0332985 0.299904 1
Schistosoma mansoni amine GPCR 0.0033484 0.000570382 0.00190188
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.00532598 0.0203351 0.00938901
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0132477 0.099508 0.283196
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0102465 0.0695135 0.217122
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00532598 0.0203351 0.0203435
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033484 0.000570382 0.00190188
Leishmania major adenine aminohydrolase 0.0118716 0.0857551 0.234003
Echinococcus multilocularis solute carrier family 28 0.0338997 0.305913 1
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.00729537 0.0400181 0.130414
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.00825031 0.0495622 0.149327
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0132477 0.099508 0.3318
Entamoeba histolytica adenosine deaminase, putative 0.0118716 0.0857551 0.242193
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0132477 0.099508 0.29086
Loa Loa (eye worm) hypothetical protein 0.00502368 0.0173138 0.0172338
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0338997 0.305913 1
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0118716 0.0857551 1
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0132477 0.099508 1
Schistosoma mansoni amine GPCR 0.0033484 0.000570382 0.00190188
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132477 0.099508 0.319045
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.00729537 0.0400181 0.0704048
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.00532598 0.0203351 0.0367577
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0033484 0.000570382 0.00190188
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.00758973 0.04296 0.138826
Loa Loa (eye worm) hypothetical protein 0.00502368 0.0173138 0.0172338
Loa Loa (eye worm) hypothetical protein 0.0118716 0.0857551 0.0876793
Loa Loa (eye worm) hypothetical protein 0.0214268 0.181254 0.185975
Loa Loa (eye worm) phosphatidylinositol 3 0.00532598 0.0203351 0.0203435
Leishmania major hypothetical protein, conserved 0.0118716 0.0857551 0.234003
Schistosoma mansoni adenosylhomocysteinase 0.0102465 0.0695135 0.231786
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.00532598 0.0203351 0.00938901
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0033484 0.000570382 0.00190188
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.00532598 0.0203351 0.0500118
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033484 0.000570382 0.00190188
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.00532598 0.0203351 0.0106913
Echinococcus granulosus adenosylhomocysteinase 0.0102465 0.0695135 0.225789
Schistosoma mansoni biogenic amine receptor 0.0033484 0.000570382 0.00190188
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.00532598 0.0203351 0.0500118
Trypanosoma cruzi AMP deaminase 2, putative 0.0118716 0.0857551 0.272312
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0102465 0.0695135 0.7636
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0332985 0.299904 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0132477 0.099508 0.3318
Loa Loa (eye worm) hypothetical protein 0.0286669 0.253614 0.260454
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.00668696 0.0339373 0.0486543
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0132477 0.099508 1
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0332985 0.299904 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033484 0.000570382 0.00190188
Trypanosoma cruzi AMP deaminase, putative 0.0332985 0.299904 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0132477 0.099508 0.29086
Schistosoma mansoni opsin-like receptor 0.0033484 0.000570382 0.00190188
Trypanosoma cruzi AMP deaminase, putative 0.0332985 0.299904 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0132477 0.099508 0.324021
Loa Loa (eye worm) hypothetical protein 0.00532598 0.0203351 0.0203435
Trypanosoma brucei AMP deaminase, putative 0.0332985 0.299904 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033484 0.000570382 0.00190188
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0132477 0.099508 0.29086
Echinococcus multilocularis AMP deaminase 2 0.0332985 0.299904 0.98032
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132477 0.099508 0.0894466
Brugia malayi prolyl oligopeptidase family protein 0.00583802 0.0254527 0.025611
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0033484 0.000570382 0.00190188
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.00532598 0.0203351 0.0678053
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.00532598 0.0203351 0.0106913
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0132477 0.099508 0.283196
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.00532598 0.0203351 0.0106913
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.00583802 0.0254527 0.0183054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033484 0.000570382 0.00190188
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0102465 0.0695135 0.217122
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033484 0.000570382 0.00190188
Schistosoma mansoni hypothetical protein 0.0033484 0.000570382 0.00190188
Loa Loa (eye worm) hypothetical protein 0.00459435 0.013023 0.0128172
Echinococcus multilocularis Dipeptidyl peptidase 9 0.00583802 0.0254527 0.0814899
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0093943 0.0609957 0.0621949
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.00583802 0.0254527 0.0674017
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.00668696 0.0339373 0.0962327
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033484 0.000570382 0.00190188
Brugia malayi GMP synthase 0.00729537 0.0400181 0.0406029
Plasmodium falciparum adenosylhomocysteinase 0.0102465 0.0695135 0.175908
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0118716 0.0857551 0.283451
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0102465 0.0695135 0.0591169
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0286669 0.253614 0.82872
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.00758973 0.04296 0.043631
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00668696 0.0339373 0.0343441
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0132477 0.099508 0.101835
Brugia malayi adenosine monophosphate deaminase 0.0332985 0.299904 0.3081
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0132477 0.099508 0.283196
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.00532598 0.0203351 0.00938901
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0332985 0.299904 1
Schistosoma mansoni amine GPCR 0.0033484 0.000570382 0.00190188
Toxoplasma gondii AMP deaminase 0.0332985 0.299904 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.00758973 0.04296 0.143246
Echinococcus granulosus solute carrier family 28 0.0338997 0.305913 1
Schistosoma mansoni neuropeptide receptor 0.0033484 0.000570382 0.00190188
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0132477 0.099508 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033484 0.000570382 0.00190188
Schistosoma mansoni adenosine kinase 0.0249743 0.216709 0.722594
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033484 0.000570382 0.00190188
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.00668696 0.0339373 0.0486543
Schistosoma mansoni opsin-like receptor 0.0033484 0.000570382 0.00190188
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0132477 0.099508 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.00668696 0.0339373 0.109277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033484 0.000570382 0.00190188
Trypanosoma cruzi GMP synthase [glutamine-hydrolysing] 0.00613196 0.0283905 0.0773842
Loa Loa (eye worm) hypothetical protein 0.0118716 0.0857551 0.0876793
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0132477 0.099508 0.324021
Trypanosoma cruzi adenosine kinase, putative 0.0249743 0.216709 0.717299
Entamoeba histolytica adenosine deaminase, putative 0.0118716 0.0857551 0.242193
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0132477 0.099508 0.324021
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0286669 0.253614 0.82872
Schistosoma mansoni adenosylhomocysteinase 0.00633506 0.0304203 0.101434
Schistosoma mansoni alpha-1 adrenergic receptor 0.0033484 0.000570382 0.00190188
Schistosoma mansoni opsin-like receptor 0.0033484 0.000570382 0.00190188
Loa Loa (eye worm) prolyl oligopeptidase 0.0177068 0.144074 0.147706
Onchocerca volvulus 0.0118716 0.0857551 0.0852334
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.00668696 0.0339373 0.0962327
Schistosoma mansoni neuropeptide receptor 0.0033484 0.000570382 0.00190188
Schistosoma mansoni neuropeptide receptor 0.0033484 0.000570382 0.00190188
Schistosoma mansoni biogenic amine receptor 0.0033484 0.000570382 0.00190188
Loa Loa (eye worm) AMP deaminase 0.0332985 0.299904 0.3081
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.00729537 0.0400181 0.129192
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0033484 0.000570382 0.00190188
Schistosoma mansoni GMP synthetase 0.00729537 0.0400181 0.133436
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.00583802 0.0254527 0.081678
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.00885075 0.0555632 0.0450107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033484 0.000570382 0.00190188
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0286669 0.253614 0.82872
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.00502368 0.0173138 0.0548349
Trypanosoma brucei AMP deaminase, putative 0.0332985 0.299904 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.00583802 0.0254527 0.0848696
Schistosoma mansoni amine GPCR 0.0033484 0.000570382 0.00190188
Loa Loa (eye worm) hypothetical protein 0.00729537 0.0400181 0.0406029
Leishmania major AMP deaminase, putative 0.0332985 0.299904 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0033484 0.000570382 0.00190188
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.00502368 0.0173138 0.00633398
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.00532598 0.0203351 0.00938901
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0132477 0.099508 0.283196
Trypanosoma cruzi AMP deaminase, putative 0.0332985 0.299904 1
Echinococcus multilocularis adenosylhomocysteinase 0.0102465 0.0695135 0.225789
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.00375962 0.0046803 0.01346
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033484 0.000570382 0.00190188
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.00532598 0.0203351 0.0647296
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.00825031 0.0495622 0.149327
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.00758973 0.04296 0.0322667
Schistosoma mansoni neuropeptide F-like receptor 0.0033484 0.000570382 0.00190188
Echinococcus granulosus AMP deaminase 2 0.0332985 0.299904 0.98032
Loa Loa (eye worm) phosphatidylinositol 3 0.00668696 0.0339373 0.0343441
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.00532598 0.0203351 0.0647296
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.00532598 0.0203351 0.00938901
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.00758973 0.04296 0.0907538
Schistosoma mansoni biogenic amine receptor 0.0033484 0.000570382 0.00190188
Schistosoma mansoni histamine h1 receptor 0.0033484 0.000570382 0.00190188
Echinococcus granulosus equilibrative nucleoside transporter 0.00502368 0.0173138 0.0548349
Schistosoma mansoni adenosine deaminase-related 0.0118716 0.0857551 0.285942
Brugia malayi hypothetical protein 0.00502368 0.0173138 0.0172338
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132477 0.099508 0.319045
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.00825031 0.0495622 0.104543
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0132477 0.099508 0.283196
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.100557 0.972119 1
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0132477 0.099508 0.329469
Loa Loa (eye worm) phosphatidylinositol kinase 0.0286669 0.253614 0.260454
Brugia malayi Adenosine kinase-like 0.0249743 0.216709 0.222468
Schistosoma mansoni adenosylhomocysteinase 0.00633506 0.0304203 0.101434
Schistosoma mansoni neuropeptide F-like receptor 0.0033484 0.000570382 0.00190188
Giardia lamblia Phosphatidylinositol 4-kinase 0.00668696 0.0339373 0.202247
Schistosoma mansoni AMP deaminase 0.0332985 0.299904 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0132477 0.099508 0.319045
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.00885075 0.0555632 0.180102
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0102465 0.0695135 0.495804
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033484 0.000570382 0.00190188
Trichomonas vaginalis set domain proteins, putative 0.103347 1 1
Trypanosoma cruzi adenosine kinase, putative 0.0249743 0.216709 0.717299
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.00532598 0.0203351 0.0647296
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.00385338 0.0056173 0.00519472
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0033484 0.000570382 0.00190188
Trichomonas vaginalis adenosine deaminase, putative 0.0118716 0.0857551 0.07554
Toxoplasma gondii adenosylhomocysteinase, putative 0.0102465 0.0695135 0.229106
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0102465 0.0695135 0.7636
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0087216 0.0542725 0.178109
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.00502368 0.0173138 0.016753
Loa Loa (eye worm) hypothetical protein 0.0249743 0.216709 0.222468
Schistosoma mansoni amine GPCR 0.0033484 0.000570382 0.00190188
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.00885075 0.0555632 0.180102
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.00532598 0.0203351 0.0678053
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0118716 0.0857551 0.283451
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.00502368 0.0173138 0.00633398
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.00502368 0.0173138 0.016753
Echinococcus multilocularis adenosine kinase 0.0249743 0.216709 0.707855
Echinococcus multilocularis adenosine deaminase 0.0118716 0.0857551 0.278981
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0102465 0.0695135 0.175908
Schistosoma mansoni adenosine deaminase 0.0118716 0.0857551 0.285942
Trypanosoma brucei adenosine kinase, putative 0.0249743 0.216709 0.702416
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00532598 0.0203351 0.0203435
Leishmania major phosphatidylinositol 4-kinase, putative 0.00668696 0.0339373 0.0486543
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.00532598 0.0203351 0.0678053
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0132477 0.099508 0.319045
Brugia malayi Nucleoside transporter family protein 0.00502368 0.0173138 0.0172338
Plasmodium falciparum adenosine deaminase 0.0118716 0.0857551 0.234003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0286669 0.253614 0.260454
Schistosoma mansoni hypothetical protein 0.0033484 0.000570382 0.00190188
Trypanosoma brucei adenosine kinase, putative 0.0249743 0.216709 0.702416
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.00532598 0.0203351 0.00938901
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.00583802 0.0254527 0.0674017
Schistosoma mansoni adenosylhomocysteinase 0.00633506 0.0304203 0.101434
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0286669 0.253614 0.82872
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.00502368 0.0173138 0.00633398
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.00729537 0.0400181 0.0704048
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.00532598 0.0203351 0.0647296
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.00439693 0.0110498 0.0107863
Schistosoma mansoni neuropeptide receptor 0.0033484 0.000570382 0.00190188
Entamoeba histolytica adenosylhomocysteinase, putative 0.0102465 0.0695135 0.184718
Loa Loa (eye worm) phosphatidylinositol 3 0.0286669 0.253614 0.260454
Plasmodium vivax GMP synthetase, putative 0.00729537 0.0400181 0.0704048
Onchocerca volvulus 0.103347 1 1
Brugia malayi Adenosylhomocysteinase 0.0102465 0.0695135 0.070962
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.00532598 0.0203351 0.00938901
Onchocerca volvulus 0.0286669 0.253614 0.253188
Loa Loa (eye worm) hypothetical protein 0.00885075 0.0555632 0.0566032
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0332985 0.299904 1
Echinococcus granulosus Dipeptidyl peptidase 9 0.00583802 0.0254527 0.0814899
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.00532598 0.0203351 0.0500118
Plasmodium falciparum phosphatidylinositol 4-kinase 0.00668696 0.0339373 0.0486543
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0093943 0.0609957 0.0621949
Echinococcus granulosus adenosine kinase 0.0249743 0.216709 0.707855
Onchocerca volvulus AMP deaminase 2 homolog 0.0332985 0.299904 0.299505
Schistosoma mansoni phosphatidylinositol 4-kinase 0.00668696 0.0339373 0.113161
Trypanosoma cruzi AMP deaminase, putative 0.0332985 0.299904 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132477 0.099508 0.0894466
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0177068 0.144074 0.469976
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0132477 0.099508 0.329469
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.00885075 0.0555632 0.0566032
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0132477 0.099508 0.3318
Echinococcus granulosus adenosine deaminase 0.0118716 0.0857551 0.278981
Schistosoma mansoni myosin xvIII 0.0033484 0.000570382 0.00190188
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132477 0.099508 0.0894466
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.00825031 0.0495622 0.104543
Onchocerca volvulus 0.0286669 0.253614 0.253188
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.00532598 0.0203351 0.0647296
Plasmodium vivax adenosine/AMP deaminase, putative 0.0332985 0.299904 1
Brugia malayi Pre-SET motif family protein 0.100557 0.972119 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.00758973 0.04296 0.126892
Leishmania major S-adenosylhomocysteine hydrolase 0.0102465 0.0695135 0.175908
Toxoplasma gondii kinase, pfkB family protein 0.0249743 0.216709 0.721626
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.00758973 0.04296 0.043631
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0102465 0.0695135 0.229106
Brugia malayi hypothetical protein 0.00459435 0.013023 0.0128172
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132477 0.099508 0.319045
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.00502368 0.0173138 0.0548349
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.00758973 0.04296 0.138826
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0132477 0.099508 0.283196
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00532598 0.0203351 0.0203435
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.00758973 0.04296 0.0809277
Schistosoma mansoni adenosine kinase 0.0249743 0.216709 0.722594
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.00825031 0.0495622 0.392343
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0332985 0.299904 1
Loa Loa (eye worm) adenosylhomocysteinase 0.0102465 0.0695135 0.070962
Trichomonas vaginalis adenosine deaminase, putative 0.0118716 0.0857551 0.07554
Schistosoma mansoni neuropeptide f receptor 76f 0.0033484 0.000570382 0.00190188
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.00758973 0.04296 0.126892
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0132477 0.099508 0.5
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0118716 0.0857551 1
Schistosoma mansoni adenosylhomocysteinase 0.00633506 0.0304203 0.101434
Entamoeba histolytica AMP deaminase, putative 0.0332985 0.299904 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0033484 0.000570382 0.00190188
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0286669 0.253614 0.845651
Onchocerca volvulus Adenosine deaminase homolog 0.0118716 0.0857551 0.0852334
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.00583802 0.0254527 0.0183054
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.00532598 0.0203351 0.00938901
Entamoeba histolytica hypothetical protein 0.00532598 0.0203351 0.0106913
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0177068 0.144074 0.143586
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.00532598 0.0203351 0.0106913
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.00502368 0.0173138 0.00633398
Trypanosoma brucei AMP deaminase, putative 0.0332985 0.299904 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132477 0.099508 0.0894466
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033484 0.000570382 0.00190188
Echinococcus granulosus equilibrative nucleoside transporter 3 0.00502368 0.0173138 0.0548349
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132477 0.099508 0.319045
Plasmodium falciparum AMP deaminase, putative 0.0332985 0.299904 1
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.00729537 0.0400181 0.129192
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0132477 0.099508 0.319045
Onchocerca volvulus 0.0226758 0.193737 0.193277
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0033484 0.000570382 0.00190188
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.00532598 0.0203351 0.00938901
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.00532598 0.0203351 0.0645542
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0332985 0.299904 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.00532598 0.0203351 0.0106913
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0132477 0.099508 0.0894466
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0132477 0.099508 0.283196
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0102465 0.0695135 0.0591169
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0338997 0.305913 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0177068 0.144074 0.480401
Schistosoma mansoni hypothetical protein 0.0033484 0.000570382 0.00190188
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.00555508 0.0226249 0.0722159
Schistosoma mansoni hypothetical protein 0.0033484 0.000570382 0.00190188
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033484 0.000570382 0.00190188
Echinococcus multilocularis Zinc finger, PHD finger 0.00532598 0.0203351 0.0647296
Brugia malayi prolyl oligopeptidase family protein 0.0177068 0.144074 0.147706
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.00583802 0.0254527 0.0183054
Echinococcus multilocularis 0.00668696 0.0339373 0.109277
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.00729537 0.0400181 0.0704048
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0286669 0.253614 0.260454
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.00885075 0.0555632 0.0450107
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0102465 0.0695135 0.175908
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.00758973 0.04296 0.0809277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033484 0.000570382 0.00190188

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 6 nM In vitro anti-plasmodial activity against Haiti 135(chloroquine-susceptible P. falciparum). ChEMBL. 9836608
IC50 (functional) = 6 nM In vitro anti-plasmodial activity against Haiti 135(chloroquine-susceptible P. falciparum). ChEMBL. 9836608
IC50 (functional) = 17 nM In vitro anti-plasmodial activity against Indochina I(chloroquine-resistant P. falciparum). ChEMBL. 9836608
IC50 (functional) = 17 nM In vitro anti-plasmodial activity against Indochina I(chloroquine-resistant P. falciparum). ChEMBL. 9836608

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 9836608

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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