TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 420.41 | Formula: C21H24O9
H donors: 5 H acceptors: 6 LogP: 1.32 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OCC1OC(Oc2ccccc2c2cc(OCC(=O)O)ccc2C)C(C(C1O)O)O
InChi: 1S/C21H24O9/c1-11-6-7-12(28-10-17(23)24)8-14(11)13-4-2-3-5-15(13)29-21-20(27)19(26)18(25)16(9-22)30-21/h2-8,16,18-22,25-27H,9-10H2,1H3,(H,23,24)
InChiKey: FVEADTQNNMCALC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cysteine peptidase A (CPA)	0.0501	0.5887	1
Trypanosoma cruzi	oligopeptidase b	0.0051	0.0263	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0068	0.047	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0451	0.0399
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0111	0.1006	0.0957
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0342	0.3908	0.6608
Loa Loa (eye worm)	animal heme peroxidase	0.0066	0.0451	0.0399
Echinococcus multilocularis	geminin	0.0162	0.165	0.1604
Leishmania major	cathepsin L-like protease	0.0501	0.5887	1
Entamoeba histolytica	cysteine proteinase 2	0.0269	0.2985	0.4596
Entamoeba histolytica	cysteine protease, putative	0.0111	0.1006	0.0911
Loa Loa (eye worm)	calpain	0.0041	0.0136	0.0082
Plasmodium vivax	vivapain-3	0.0269	0.2985	0.5025
Onchocerca volvulus		0.0501	0.5887	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0136	0.0136
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0136	0.0136
Onchocerca volvulus		0.0066	0.0451	0.0681
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0053	0.0285	0.3989
Entamoeba histolytica	cysteine protease, putative	0.0111	0.1006	0.0911
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0111	0.1006	0.1632
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0051	0.0263	0.3604
Giardia lamblia	Cathepsin B precursor	0.0333	0.3788	1
Onchocerca volvulus		0.0342	0.3908	0.6608
Giardia lamblia	Cathepsin B precursor	0.0111	0.1006	0.1496
Onchocerca volvulus	Peroxidase homolog	0.0066	0.0451	0.0681
Echinococcus multilocularis	peroxidasin	0.0066	0.0451	0.0399
Plasmodium falciparum	serine repeat antigen 8	0.0111	0.1006	0.0911
Brugia malayi	Papain family cysteine protease containing protein	0.0111	0.1006	0.0957
Schistosoma mansoni	calpain (C02 family)	0.0041	0.0136	0.0082
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.1006	0.1632
Leishmania major	cathepsin L-like protease	0.0501	0.5887	1
Entamoeba histolytica	cysteine protease, putative	0.0269	0.2985	0.4596
Trypanosoma cruzi	Aph-1 protein, putative	0.0291	0.3258	0.3258
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0111	0.1006	0.0957
Onchocerca volvulus	Peroxidasin homolog	0.0066	0.0451	0.0681
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0269	0.2985	0.5025
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0501	0.5887	1
Giardia lamblia	Cysteine protease	0.0111	0.1006	0.1496
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0111	0.1006	0.1496
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0501	0.5887	1
Schistosoma mansoni	peroxidasin	0.0066	0.0451	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0159	0.0105
Schistosoma mansoni	peroxidasin	0.0066	0.0451	0.0399
Echinococcus granulosus	peroxidasin	0.0066	0.0451	0.0399
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0136	0.0136
Giardia lamblia	Cathepsin L-like protease	0.0111	0.1006	0.1496
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0269	0.2985	0.2985
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0632	0.0214
Trypanosoma cruzi	cysteine peptidase, putative	0.0501	0.5887	0.5887
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0451	0.0399
Trypanosoma brucei	DNA polymerase eta, putative	0.0043	0.0159	0.018
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0041	0.0136	0.0141
Brugia malayi	prolyl oligopeptidase family protein	0.0128	0.123	0.1182
Echinococcus multilocularis	calpain	0.0041	0.0136	0.0082
Schistosoma mansoni	peptidase Clp (S14 family)	0.0081	0.0632	0.0581
Brugia malayi	Papain family cysteine protease containing protein	0.0269	0.2985	0.2947
Brugia malayi	Cathepsin L-like precursor	0.0342	0.3908	0.3875
Toxoplasma gondii	cathepsin CPC2	0.0111	0.1006	0.171
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0829	1	1
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0071	0.0517	0.0793
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0071	0.0517	0.0465
Giardia lamblia	Encystation-specific protease	0.0111	0.1006	0.1496
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0115	0.1062	0.4342
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0051	0.0263	0.0446
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0501	0.5887	1
Entamoeba histolytica	cysteine protease, putative	0.0269	0.2985	0.4596
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0501	0.5887	1
Echinococcus granulosus	calpain A	0.0041	0.0136	0.0082
Entamoeba histolytica	cysteine protease, putative	0.0111	0.1006	0.0911
Echinococcus multilocularis	calpain family protein 1, d	0.008	0.0624	0.0573
Plasmodium falciparum	serine repeat antigen 6	0.0111	0.1006	0.0911
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0501	0.5887	1
Loa Loa (eye worm)	hypothetical protein	0.0154	0.155	0.1504
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0269	0.2985	0.2947
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0829	1	1
Toxoplasma gondii	prolyl endopeptidase	0.0128	0.123	0.2089
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0746	0.8952	0.8946
Echinococcus multilocularis	muscleblind protein	0.0154	0.155	0.1504
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0501	0.5887	1
Leishmania major	hypothetical protein, conserved	0.0034	0.0054	0.0092
Schistosoma mansoni	cathepsin s	0.0158	0.1602	0.1557
Schistosoma mansoni	cathepsin F (C01 family)	0.0501	0.5887	0.5865
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0269	0.2985	0.4596
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.1006	0.1632
Entamoeba histolytica	cysteine protease, putative	0.0269	0.2985	0.4596
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0501	0.5887	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1006	0.0957
Trypanosoma brucei	calpain-like protein, putative	0.0041	0.0136	0.0141
Echinococcus multilocularis	hypothetical protein	0.0041	0.0136	0.0082
Entamoeba histolytica	cysteine protease, putative	0.0269	0.2985	0.4596
Onchocerca volvulus		0.0501	0.5887	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0501	0.5887	0.5887
Leishmania major	cathepsin L-like protease	0.0501	0.5887	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0501	0.5887	0.5865
Echinococcus multilocularis	cysteine protease	0.0501	0.5887	0.5865
Plasmodium falciparum	serine repeat antigen 3	0.0111	0.1006	0.0911
Brugia malayi	Cathepsin L-like precursor	0.0342	0.3908	0.3875
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0111	0.1006	0.1632
Echinococcus granulosus	cysteine protease	0.0269	0.2985	0.2947
Echinococcus granulosus	proteasome prosome macropain	0.0071	0.0517	0.0465
Echinococcus granulosus	peptidase Clp S14 family	0.0053	0.0285	0.0232
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0071	0.0517	0.0793
Giardia lamblia	Cathepsin B precursor	0.0111	0.1006	0.1496
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0111	0.1006	0.0911
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0501	0.5887	1
Loa Loa (eye worm)	animal heme peroxidase	0.0066	0.0451	0.0399
Loa Loa (eye worm)	animal heme peroxidase	0.0066	0.0451	0.0399
Entamoeba histolytica	cysteine protease, putative	0.0269	0.2985	0.4596
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0178	0.0124
Brugia malayi	Cathepsin L-like precursor	0.0501	0.5887	0.5865
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0111	0.1006	0.0957
Echinococcus multilocularis	cathepsin L	0.0269	0.2985	0.2947
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0111	0.1006	0.0957
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0501	0.5887	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0451	0.0399
Trypanosoma cruzi	cysteine peptidase, putative	0.0501	0.5887	0.5887
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0333	0.3788	0.3788
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0136	0.0231
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0501	0.5887	0.5865
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0501	0.5887	1
Trypanosoma cruzi	prolyl endopeptidase	0.0128	0.123	0.123
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0746	0.8952	0.8946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.1006	0.1632
Echinococcus multilocularis	dna polymerase eta	0.0043	0.0159	0.0105
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0111	0.1006	0.1496
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0342	0.3908	0.3908
Echinococcus multilocularis	calpain A	0.0113	0.1044	0.0995
Echinococcus granulosus	calpain 7 C02 family	0.0041	0.0136	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0829	1	1
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0051	0.0263	0.0263
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0051	0.0263	0.0898
Onchocerca volvulus		0.0501	0.5887	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0111	0.1006	0.0957
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0111	0.1006	0.1632
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0269	0.2985	0.2947
Plasmodium vivax	vivapain-2	0.0501	0.5887	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0501	0.5887	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1006	0.0957
Trypanosoma cruzi	cysteine peptidase, putative	0.0501	0.5887	0.5887
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0111	0.1006	0.1632
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0178	0.0124
Brugia malayi	Animal haem peroxidase family protein	0.0066	0.0451	0.0399
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0111	0.1006	0.1632
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0501	0.5887	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0136	0.0141
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0071	0.0517	0.1995
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0071	0.0517	0.0517
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0501	0.5887	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0136	0.0136
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0111	0.1006	0.0957
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0111	0.1006	0.1632
Plasmodium vivax	vivapain-2	0.0501	0.5887	1
Plasmodium vivax	calpain, putative	0.0041	0.0136	0.0141
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0501	0.5887	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0829	1	1
Leishmania major	cathepsin L-like protease	0.0501	0.5887	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0111	0.1006	0.0911
Leishmania major	DNA polymerase eta, putative	0.0043	0.0159	0.027
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0041	0.0136	0.0136
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0501	0.5887	0.5865
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0982	0.0933
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0111	0.1006	0.1632
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1006	0.0957
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0501	0.5887	1
Echinococcus granulosus	gamma secretase subunit aph 1	0.0746	0.8952	0.8946
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0632	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0501	0.5887	1
Plasmodium falciparum	serine repeat antigen 1	0.0111	0.1006	0.0911
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0109	0.0982	0.0933
Loa Loa (eye worm)	cysteine protease	0.0501	0.5887	0.5865
Brugia malayi	Peroxidasin	0.0066	0.0451	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0451	0.0399
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0111	0.1006	0.0957
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.1006	0.1632
Onchocerca volvulus	Cathepsin L homolog	0.0111	0.1006	0.1632
Brugia malayi	Papain family cysteine protease containing protein	0.0111	0.1006	0.0957
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0501	0.5887	1
Entamoeba histolytica	cysteine protease, putative	0.0269	0.2985	0.4596
Schistosoma mansoni	calpain-7 (C02 family)	0.0041	0.0136	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0451	0.0399
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0128	0.123	0.2089
Echinococcus granulosus	cathepsin b	0.0829	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.1006	0.1632
Plasmodium vivax	serine-repeat antigen (SERA)	0.0111	0.1006	0.1632
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0081	0.0632	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0501	0.5887	1
Brugia malayi	calpain family protein 1	0.0109	0.0982	0.0933
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.1006	0.1632
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.0054	0.0054
Giardia lamblia	Cathepsin B precursor	0.0111	0.1006	0.1496
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0632	0.5
Echinococcus granulosus	muscleblind protein	0.0154	0.155	0.1504
Echinococcus multilocularis	cathepsin b	0.0829	1	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0113	0.1044	0.0995
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0111	0.1006	0.1632
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.1006	0.1632
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0071	0.0517	0.0517
Giardia lamblia	Cathepsin B precursor	0.0333	0.3788	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0269	0.2985	0.5025
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.022	0.2374	1
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0113	0.1044	0.0995
Brugia malayi	Animal haem peroxidase family protein	0.0066	0.0451	0.0399
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0051	0.0263	0.0263
Echinococcus granulosus	calpain 5	0.0041	0.0136	0.0082
Giardia lamblia	Cathepsin L precursor	0.0111	0.1006	0.1496
Giardia lamblia	Cathepsin L precursor	0.0111	0.1006	0.1496
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0071	0.0517	0.0793
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0128	0.123	0.2016
Echinococcus multilocularis	cathepsin b	0.0829	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0501	0.5887	0.5865
Echinococcus granulosus	cathepsin l1	0.0342	0.3908	0.3875
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0111	0.1006	0.1632
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1006	0.0957
Giardia lamblia	Cathepsin L precursor	0.0111	0.1006	0.1496
Onchocerca volvulus	Cathepsin F homolog	0.0501	0.5887	1
Entamoeba histolytica	cysteine protease, putative	0.0269	0.2985	0.4596
Leishmania major	oligopeptidase b	0.0051	0.0263	0.0446
Giardia lamblia	Hypothetical protein	0.0111	0.1006	0.1496
Trypanosoma cruzi	DNA polymerase eta, putative	0.0043	0.0159	0.0159
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0053	0.0285	0.0994
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0081	0.0632	0.0581
Trypanosoma cruzi	major cysteine proteinase, putative	0.0111	0.1006	0.1006
Brugia malayi	Papain family cysteine protease containing protein	0.0111	0.1006	0.0957
Brugia malayi	hypothetical protein	0.0066	0.0451	0.0399
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0501	0.5887	1
Echinococcus multilocularis	cysteine protease	0.0501	0.5887	0.5865
Plasmodium vivax	unspecified product	0.0158	0.1602	0.2654
Giardia lamblia	Cathepsin B precursor	0.0111	0.1006	0.1496
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0111	0.1006	0.0957
Trypanosoma brucei	prolyl endopeptidase	0.0128	0.123	0.2016
Brugia malayi	cathepsin F-like cysteine proteinase	0.0158	0.1602	0.1557
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0746	0.8952	0.8946
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0053	0.0285	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0342	0.3908	0.3875
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0081	0.0632	0.1074
Entamoeba histolytica	cysteine protease, putative	0.0111	0.1006	0.0911
Echinococcus granulosus	cathepsin L	0.0269	0.2985	0.2947
Plasmodium vivax	unspecified product	0.0269	0.2985	0.5025
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0269	0.2985	0.2947
Schistosoma mansoni	cathepsin C	0.0111	0.1006	0.0957
Echinococcus multilocularis	prolyl endopeptidase	0.0128	0.123	0.1182
Trypanosoma brucei	oligopeptidase b	0.0051	0.0263	0.0357
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0041	0.0136	0.0082
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0113	0.1044	0.0995
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0113	0.1044	0.0995
Giardia lamblia	Cysteine protease	0.0111	0.1006	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0501	0.5887	0.5865
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0111	0.1006	0.1632
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0111	0.1006	0.1632
Mycobacterium ulcerans	proteasome PrcB	0.0071	0.0517	0.8007
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0071	0.0517	0.8007
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0632	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0501	0.5887	1
Plasmodium falciparum	serine repeat antigen 7	0.0111	0.1006	0.0911
Giardia lamblia	Cathepsin L precursor	0.0111	0.1006	0.1496
Giardia lamblia	Cathepsin L-like protease	0.0111	0.1006	0.1496
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0178	0.0124
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0342	0.3908	0.3875
Onchocerca volvulus		0.0501	0.5887	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0501	0.5887	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0342	0.3908	0.6608
Echinococcus granulosus	geminin	0.0162	0.165	0.1604
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.1006	0.1632
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0501	0.5887	1
Entamoeba histolytica	cysteine protease, putative	0.0269	0.2985	0.4596
Brugia malayi	Cathepsin L-like precursor	0.0158	0.1602	0.1557
Entamoeba histolytica	cysteine proteinase, putative	0.0342	0.3908	0.6315
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0501	0.5887	0.5865
Brugia malayi	Probable ClpP-like protease	0.0081	0.0632	0.0581
Trypanosoma brucei	Aph-1 protein, putative	0.0291	0.3258	0.5493
Onchocerca volvulus		0.0068	0.047	0.0712
Echinococcus granulosus	calpain A	0.0113	0.1044	0.0995
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0178	0.0124
Brugia malayi	fibroinase precursor	0.0111	0.1006	0.0957
Mycobacterium tuberculosis	Probable peptidase	0.0051	0.0263	0.0898
Echinococcus multilocularis	cathepsin L	0.0111	0.1006	0.0957
Entamoeba histolytica	cysteine proteinase 1, putative	0.0269	0.2985	0.4596
Echinococcus multilocularis	cathepsin L cysteine protease	0.0501	0.5887	0.5865
Trypanosoma brucei	calpain-like protein, putative	0.0041	0.0136	0.0141
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0501	0.5887	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0333	0.3788	0.3754
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0111	0.1006	0.0911
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0501	0.5887	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0269	0.2985	0.5025
Loa Loa (eye worm)	ctsf protein	0.0501	0.5887	0.5865
Loa Loa (eye worm)	calpain family protein 1	0.008	0.0624	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0342	0.3908	0.3875
Giardia lamblia	Cysteine protease	0.0111	0.1006	0.1496
Echinococcus granulosus	cathepsin L cysteine protease	0.0269	0.2985	0.2947
Plasmodium vivax	serine-repeat antigen (SERA)	0.0111	0.1006	0.1632
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0501	0.5887	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0178	0.0124
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0501	0.5887	1
Echinococcus granulosus	dna polymerase eta	0.0043	0.0159	0.0105
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0501	0.5887	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0501	0.5887	1
Echinococcus granulosus	cathepsin L	0.0111	0.1006	0.0957
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0178	0.0124
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0501	0.5887	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0451	0.0399
Trypanosoma cruzi	cysteine peptidase, putative	0.0269	0.2985	0.2985
Leishmania major	cathepsin L-like protease	0.0501	0.5887	1
Onchocerca volvulus		0.0501	0.5887	1
Entamoeba histolytica	cysteine protease, putative	0.0269	0.2985	0.4596
Plasmodium falciparum	serine repeat antigen 2	0.0111	0.1006	0.0911
Echinococcus multilocularis	cathepsin L cysteine protease	0.0501	0.5887	0.5865
Onchocerca volvulus	Peroxidasin homolog	0.0066	0.0451	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0632	0.0581
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0111	0.1006	0.1632
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0111	0.1006	0.0911
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1006	0.0957
Loa Loa (eye worm)	cathepsin B	0.0333	0.3788	0.3754
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0111	0.1006	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0342	0.3908	0.3875
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0828	0.0778
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0071	0.0517	0.0465
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0081	0.0632	0.1074
Brugia malayi	Blistered cuticle protein 3	0.0066	0.0451	0.0399
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0501	0.5887	1
Echinococcus multilocularis	calpain 7 (C02 family)	0.0041	0.0136	0.0082
Echinococcus granulosus	calpain	0.0041	0.0136	0.0082
Entamoeba histolytica	cysteine protease, putative	0.0269	0.2985	0.4596
Toxoplasma gondii	proteasome subunit beta type, putative	0.0071	0.0517	0.0878
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0136	0.0136
Echinococcus granulosus	cathepsin b	0.0829	1	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0111	0.1006	0.0957
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0136	0.0136
Loa Loa (eye worm)	animal heme peroxidase	0.0066	0.0451	0.0399
Schistosoma mansoni	DNA polymerase eta	0.0043	0.0159	0.0105
Giardia lamblia	Cathepsin L precursor	0.0111	0.1006	0.1496
Trypanosoma cruzi	major cysteine proteinase, putative	0.0111	0.1006	0.1006
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1006	0.0957
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0053	0.0285	0.0994
Schistosoma mansoni	cathepsin F (C01 family)	0.0501	0.5887	0.5865
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0632	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0632	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0269	0.2985	0.4596
Toxoplasma gondii	ABC1 family protein	0.0034	0.0054	0.0092
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0111	0.1006	0.0957
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0501	0.5887	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0111	0.1006	0.0957
Toxoplasma gondii	cathepsin CPC1	0.0111	0.1006	0.171
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0111	0.1006	0.1632
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.1006	0.1632
Onchocerca volvulus		0.0111	0.1006	0.1632
Entamoeba histolytica	cysteine proteinase, putative	0.0501	0.5887	1
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0051	0.0263	0.0357
Leishmania major	cathepsin L-like protease	0.0501	0.5887	1
Trypanosoma cruzi	oligopeptidase b	0.0051	0.0263	0.0263
Brugia malayi	Cathepsin L-like precursor	0.0501	0.5887	0.5865
Schistosoma mansoni	hypothetical protein	0.0162	0.165	0.1604
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0051	0.0263	0.0357
Brugia malayi	Animal haem peroxidase family protein	0.0066	0.0451	0.0399
Toxoplasma gondii	cathepsin CPL	0.0501	0.5887	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0501	0.5887	0.5887
Loa Loa (eye worm)	calpain family protein 1	0.0109	0.0982	0.0933
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0501	0.5887	0.5865
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0269	0.2985	0.5025
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0111	0.1006	0.1632
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0111	0.1006	0.1632
Brugia malayi	cathepsin F-like cysteine proteinase	0.0111	0.1006	0.0957
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0158	0.1602	0.1557
Giardia lamblia	Cysteine protease	0.0111	0.1006	0.1496
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.1006	0.1632
Schistosoma mansoni	hypothetical protein	0.0162	0.165	0.1604
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0451	0.0399
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0829	1	1
Echinococcus multilocularis	calpain 5	0.0041	0.0136	0.0082
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0111	0.1006	0.1496
Giardia lamblia	Cathepsin B precursor	0.0111	0.1006	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0451	0.0399
Brugia malayi	Cathepsin L-like precursor	0.0501	0.5887	0.5865
Onchocerca volvulus		0.0501	0.5887	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0158	0.1602	0.1602
Brugia malayi	Papain family cysteine protease containing protein	0.0269	0.2985	0.2947
Echinococcus granulosus	microtubule associated protein 2	0.0659	0.7874	0.7863
Echinococcus multilocularis	microtubule associated protein 2	0.0659	0.7874	0.7863
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0111	0.1006	0.1632
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0111	0.1006	0.0957
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0136	0.0136
Trypanosoma cruzi	Aph-1 protein, putative	0.0291	0.3258	0.3258
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0081	0.0632	0.0991
Brugia malayi	Proteasome A-type and B-type family protein	0.0071	0.0517	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0451	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0451	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0451	0.0399
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0501	0.5887	1
Plasmodium falciparum	serine repeat antigen 9	0.0111	0.1006	0.0911
Entamoeba histolytica	cysteine proteinase, putative	0.0269	0.2985	0.4596
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0451	0.0399
Plasmodium vivax	vivapain-1	0.0269	0.2985	0.5025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0501	0.5887	1
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0051	0.0263	0.3604
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0081	0.0632	0.0581
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0041	0.0136	0.0136
Entamoeba histolytica	cysteine proteinase, putative	0.0269	0.2985	0.4596
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0632	0.5
Loa Loa (eye worm)	hypothetical protein	0.0158	0.1602	0.1557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0111	0.1006	0.1632
Brugia malayi	Cathepsin L-like precursor	0.0501	0.5887	0.5865
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0136	0.0136
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0501	0.5887	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.123	0.1182
Brugia malayi	cathepsin L-like precursor	0.0342	0.3908	0.3875
Onchocerca volvulus		0.0501	0.5887	1
Echinococcus granulosus	cathepsin l1	0.0501	0.5887	0.5865
Trypanosoma cruzi	cysteine proteinase, putative	0.0269	0.2985	0.2985
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0158	0.1602	0.1557
Loa Loa (eye worm)	blistered cuticle protein 3	0.0066	0.0451	0.0399
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0333	0.3788	0.6401
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0178	0.0124
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0333	0.3788	0.6401
Trypanosoma brucei	calpain-like protein, putative	0.0041	0.0136	0.0141
Brugia malayi	Animal haem peroxidase family protein	0.0066	0.0451	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0158	0.1602	0.1557
Entamoeba histolytica	cysteine protease, putative	0.0269	0.2985	0.4596
Plasmodium falciparum	serine repeat antigen 4	0.0111	0.1006	0.0911
Brugia malayi	ImpB/MucB/SamB family protein	0.0043	0.0159	0.0105
Entamoeba histolytica	hypothetical protein	0.0111	0.1006	0.0911
Onchocerca volvulus		0.0066	0.0451	0.0681
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0111	0.1006	0.0957
Brugia malayi	cathepsin L precursor	0.0111	0.1006	0.0957
Entamoeba histolytica	cysteine protease, putative	0.0111	0.1006	0.0911
Trypanosoma cruzi	cysteine proteinase, putative	0.0269	0.2985	0.2985
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0501	0.5887	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0111	0.1006	0.0957
Schistosoma mansoni	cathepsin S (C01 family)	0.0111	0.1006	0.0957
Brugia malayi	calpain 7	0.0041	0.0136	0.0082
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0178	0.0124
Plasmodium vivax	unspecified product	0.0111	0.1006	0.1632
Giardia lamblia	Cathepsin L precursor	0.0111	0.1006	0.1496
Leishmania major	cathepsin L-like protease	0.0501	0.5887	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0501	0.5887	1
Brugia malayi	Animal haem peroxidase family protein	0.0066	0.0451	0.0399
Plasmodium falciparum	serine repeat antigen 5	0.0111	0.1006	0.0911
Brugia malayi	Cathepsin L-like precursor	0.0501	0.5887	0.5865
Onchocerca volvulus	Cathepsin L homolog	0.0501	0.5887	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0451	0.0399
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0333	0.3788	0.6434
Brugia malayi	Papain family cysteine protease containing protein	0.0501	0.5887	0.5865
Giardia lamblia	Hypothetical protein	0.0111	0.1006	0.1496
Trypanosoma cruzi	cysteine protease, putative	0.0269	0.2985	0.2985
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0111	0.1006	0.0957
Schistosoma mansoni	cathepsin B (C01 family)	0.0111	0.1006	0.0957
Loa Loa (eye worm)	fibroinase	0.0501	0.5887	0.5865
Brugia malayi	Cathepsin L-like precursor	0.0501	0.5887	0.5865
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.0054	0.0054
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0071	0.0517	0.0465
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0111	0.1006	0.171
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0111	0.1006	0.1632
Onchocerca volvulus	Chorion peroxidase homolog	0.0066	0.0451	0.0681
Schistosoma mansoni	cathepsin F (C01 family)	0.0342	0.3908	0.3875
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0451	0.0399
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.1006	0.1632
Entamoeba histolytica	cysteine protease, putative	0.0269	0.2985	0.4596
Brugia malayi	calpain family protein 1	0.0109	0.0982	0.0933
Loa Loa (eye worm)	hypothetical protein	0.008	0.0624	0.0573
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0829	1	1
Entamoeba histolytica	cysteine protease, putative	0.0501	0.5887	1
Loa Loa (eye worm)	hypothetical protein	0.0158	0.1602	0.1557
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0178	0.0124
Schistosoma mansoni	calpain-7 (C02 family)	0.0041	0.0136	0.0082
Onchocerca volvulus	Cathepsin L homolog	0.0501	0.5887	1
Brugia malayi	Muscleblind-like protein	0.0154	0.155	0.1504
Entamoeba histolytica	cysteine proteinase, putative	0.0501	0.5887	1
Trypanosoma brucei	calpain-like protein, putative	0.0041	0.0136	0.0141
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0111	0.1006	0.0957
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0136	0.0231
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0501	0.5887	1
Leishmania major	cathepsin L-like protease	0.0501	0.5887	1
Brugia malayi	gamma-secretase subunit aph-1	0.0746	0.8952	0.8946
Onchocerca volvulus	Peroxidase homolog	0.0066	0.0451	0.0681
Toxoplasma gondii	cathepsin B	0.0333	0.3788	0.6434
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0041	0.0136	0.0231
Entamoeba histolytica	cysteine proteinase, putative	0.0269	0.2985	0.4596
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0128	0.123	0.1182
Onchocerca volvulus	Dual oxidase homolog	0.0066	0.0451	0.0681
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0501	0.5887	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0111	0.1006	0.0911
Leishmania major	proteasome beta 5 subunit, putative	0.0071	0.0517	0.0878
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0128	0.123	0.1182
Schistosoma mansoni	microtubule-associated protein tau	0.0659	0.7874	0.7863
Giardia lamblia	Cathepsin B precursor	0.0333	0.3788	1
Schistosoma mansoni	calpain C (C02 family)	0.0041	0.0136	0.0082
Echinococcus multilocularis	muscleblind protein 1	0.0154	0.155	0.1504
Echinococcus granulosus	prolyl endopeptidase	0.0128	0.123	0.1182
Trypanosoma brucei	antigen, putative	0.0041	0.0136	0.0141
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0501	0.5887	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0158	0.1602	0.1602
Onchocerca volvulus		0.0066	0.0451	0.0681
Entamoeba histolytica	cysteine protease, putative	0.0269	0.2985	0.4596
Loa Loa (eye worm)	hypothetical protein	0.0154	0.155	0.1504
Entamoeba histolytica	cysteine protease, putative	0.0111	0.1006	0.0911

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 12 mM	In vitro inhibitory activity against sialyl Lewisx expressing HL60 cell binding Selectin P	ChEMBL.	8544173
IC50 (binding)	= 20.2 mM	In vitro inhibition of HL60 (human leukaemia) cell binding to human recombinant e-selectin.	ChEMBL.	8544173

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 343864

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 253429