Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0037 | 0.0366 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.1131 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0021 | 0.0041 | 0.1131 |
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Brugia malayi | hypothetical protein | 0.0021 | 0.0041 | 0.1131 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.1131 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0021 | 0.0041 | 0.1131 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0509 | 1 | 0.5 |
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0037 | 0.0366 | 1 |
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0037 | 0.0366 | 1 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0041 | 0.1131 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.1131 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0509 | 1 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0037 | 0.0366 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0509 | 1 | 0.5 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0509 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.1131 |
Schistosoma mansoni | lipoxygenase | 0.0054 | 0.071 | 1 |
Onchocerca volvulus | 0.0021 | 0.0041 | 0.1131 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0366 | 1 |
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.1131 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0021 | 0.0041 | 0.1131 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0054 | 0.071 | 1 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0509 | 1 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0021 | 0.0041 | 0.1131 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0054 | 0.071 | 1 |
Onchocerca volvulus | 0.0021 | 0.0041 | 0.1131 | |
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0021 | 0.0041 | 0.1131 |
Onchocerca volvulus | 0.0037 | 0.0366 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -6.43 | Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma | ChEMBL. | 9836621 |
Log Ki (binding) | = 6.43 | Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma | ChEMBL. | 9836621 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.