TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 410.549 | Formula: C25H34N2O3
H donors: 2 H acceptors: 3 LogP: 4.16 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)CCC(=O)N(CCN1CCC(C(C1)C)(C)c1cccc(c1)O)C
InChi: 1S/C25H34N2O3/c1-19-18-27(14-13-25(19,2)21-5-4-6-23(29)17-21)16-15-26(3)24(30)12-9-20-7-10-22(28)11-8-20/h4-8,10-11,17,19,28-29H,9,12-16,18H2,1-3H3
InChiKey: ICALOHJSRJGEMV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.1163	0.5208	0.7151
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0558	0.2881
Schistosoma mansoni	topbp1	0.0083	0.0216	0.0218
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0038	0.0008	0.0008
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0016	0.0016
Echinococcus multilocularis	nAChR subunit	0.0038	0.0008	0.0008
Brugia malayi	Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site.	0.0081	0.0208	0.0211
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0041	0.0024	0.0025
Entamoeba histolytica	zinc finger protein, putative	0.0157	0.0558	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Schistosoma mansoni	chromosome transmission fidelity factor	0.0083	0.0216	0.0218
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0558	0.2881
Trypanosoma brucei	Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative	0.0276	0.111	0.1804
Brugia malayi	Kringle domain containing protein	0.0038	0.0006	0.0001
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0216	0.0061
Loa Loa (eye worm)	LGC-31 protein	0.0038	0.0008	0.0004
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0083	0.0216	0.0061
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0038	0.0008	0.0008
Trypanosoma cruzi	hypothetical protein, conserved	0.0083	0.0216	0.0352
Mycobacterium ulcerans	hypothetical protein	0.0344	0.1423	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Leishmania major	DNA repair protein, putative	0.0276	0.111	0.1857
Echinococcus granulosus	WGR domain containing protein	0.0658	0.2872	0.2986
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0216	0.0289
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0041	0.0024	0.0025
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0041	0.0024	0.0025
Treponema pallidum	DNA ligase (lig)	0.0083	0.0216	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0039	0.0012	0.0009
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0558	0.2881
Trypanosoma cruzi	hypothetical protein, conserved	0.0083	0.0216	0.0352
Mycobacterium ulcerans	glyoxalase GloA	0.0344	0.1423	1
Trypanosoma cruzi	FHA domain containing protein, putative	0.0083	0.0216	0.0352
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0038	0.0008	0.0003
Echinococcus granulosus	hydroxyacylglutathione hydrolase	0.0081	0.0208	0.0217
Onchocerca volvulus	Tankyrase homolog	0.0157	0.0558	0.0929
Toxoplasma gondii	ATPase, AAA family protein	0.0083	0.0216	0.021
Brugia malayi	DKFZp564C0469 protein	0.0083	0.0216	0.0219
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0558	0.2881
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0041	0.0024	0.0025
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0037	0.0005	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0558	0.2881
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0038	0.0008	0.0003
Loa Loa (eye worm)	ACC-1 protein	0.0038	0.0008	0.0004
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0083	0.0216	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0216	0.0061
Entamoeba histolytica	hypothetical protein	0.0157	0.0558	0.0565
Plasmodium falciparum	replication factor C subunit 1, putative	0.0083	0.0216	0.0352
Schistosoma mansoni	nAChR subunit	0.0038	0.0008	0.0002
Echinococcus granulosus	poly ADP ribose polymerase 1	0.2117	0.9617	1
Brugia malayi	Cation transporter family protein	0.0038	0.0008	0.0003
Schistosoma mansoni	hypothetical protein	0.004	0.0016	0.001
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0038	0.0008	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0041	0.0024	0.0025
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0038	0.0008	0.0004
Mycobacterium ulcerans	hypothetical protein	0.0344	0.1423	1
Echinococcus granulosus	nAChR subunit	0.0038	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0038	0.0008	0.0002
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0008	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0558	0.2881
Brugia malayi	WGR domain containing protein	0.2117	0.9617	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0038	0.0008	0.0004
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0008	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0216	0.0289
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0008	0.0002
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0834	0.3689	0.5063
Mycobacterium tuberculosis	Conserved protein TB27.3	0.0344	0.1423	1
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.1163	0.5208	0.5416
Brugia malayi	hypothetical protein	0.004	0.0016	0.0011
Loa Loa (eye worm)	4-hydroxyphenylpyruvate dioxygenase	0.0344	0.1423	0.1948
Echinococcus multilocularis	hydroxyacylglutathione hydrolase	0.0081	0.0208	0.0217
Trypanosoma cruzi	DNA repair protein, putative	0.0276	0.111	0.1857
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0037	0.0005	0.0006
Toxoplasma gondii	hydroxyacylglutathione hydrolase	0.0081	0.0208	0.0202
Echinococcus granulosus	tissue type plasminogen activator	0.0038	0.0006	0.0007
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0038	0.0008	0.0003
Schistosoma mansoni	gynecophoral canal protein	0.0344	0.1423	0.1474
Echinococcus multilocularis	nibrin	0.0083	0.0216	0.0224
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0008	0.0008
Brugia malayi	WGR domain containing protein	0.1163	0.5208	0.5413
Echinococcus multilocularis	glycine receptor subunit beta	0.0038	0.0008	0.0008
Echinococcus granulosus	poly adp ribose polymerase 2	0.1163	0.5208	0.5416
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase	0.0081	0.0208	0.0279
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0038	0.0008	0.0008
Entamoeba histolytica	hypothetical protein	0.0157	0.0558	0.0565
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0037	0.0005	0.0006
Loa Loa (eye worm)	SRC-1	0.0041	0.0024	0.0026
Mycobacterium ulcerans	hypothetical protein	0.0344	0.1423	1
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0083	0.0216	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Schistosoma mansoni	tankyrase	0.0157	0.0558	0.0574
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0083	0.0216	0.0061
Schistosoma mansoni	nAChR subunit	0.0038	0.0008	0.0002
Mycobacterium ulcerans	biphenyl-2,3-diol 1,2-dioxygenase	0.0344	0.1423	1
Echinococcus granulosus	replication factor c subunit 1	0.0083	0.0216	0.0224
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0216	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0276	0.111	0.1519
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0038	0.0008	0.0008
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0041	0.0024	0.0025
Schistosoma mansoni	tyrosine kinase	0.0041	0.0024	0.0018
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0008	0.0008
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.0024	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.2117	0.9617	1
Plasmodium vivax	glyoxalase I, putative	0.0832	0.3677	0.6177
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0038	0.0008	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0344	0.1423	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0216	0.0289
Mycobacterium tuberculosis	Conserved protein	0.0344	0.1423	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0038	0.0008	0.0004
Chlamydia trachomatis	DNA ligase	0.0083	0.0216	0.5
Schistosoma mansoni	tyrosine kinase	0.0041	0.0024	0.0018
Brugia malayi	topoisomerase	0.0083	0.0216	0.0219
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0558	0.2881
Mycobacterium leprae	conserved hypothetical protein	0.0344	0.1423	1
Schistosoma mansoni	nAChR subunit	0.0038	0.0008	0.0002
Schistosoma mansoni	nAChR subunit	0.0038	0.0008	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0216	0.0289
Onchocerca volvulus		0.0038	0.0008	0.0003
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.1163	0.5208	0.8753
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0558	0.2881
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0038	0.0008	0.0008
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0016	0.0016
Schistosoma mansoni	nAChR subunit	0.0038	0.0008	0.0002
Onchocerca volvulus		0.0038	0.0008	0.0003
Brugia malayi	MH2 domain containing protein	0.0131	0.0439	0.0451
Trypanosoma cruzi	Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative	0.0276	0.111	0.1857
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0041	0.0024	0.0025
Toxoplasma gondii	glyoxalase family protein	0.0344	0.1423	0.1418
Onchocerca volvulus	Lactoylglutathione lyase homolog	0.1323	0.5949	1
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0083	0.0216	0.1131
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0216	0.0061
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.1006	0.4483	0.4658
Onchocerca volvulus		0.0038	0.0008	0.0003
Giardia lamblia	Replication factor C, subunit 1	0.0083	0.0216	0.5
Brugia malayi	hypothetical protein	0.0083	0.0216	0.0219
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0038	0.0008	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0216	0.0061
Brugia malayi	Cation transporter family protein	0.0038	0.0008	0.0003
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0038	0.0008	0.0008
Leishmania major	hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative	0.0081	0.0208	0.034
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0037	0.0005	0.0006
Plasmodium vivax	replication factor C subunit 1, putative	0.0083	0.0216	0.0352
Brugia malayi	SRC-1	0.0041	0.0024	0.0019
Brugia malayi	Pax transcription activation domain interacting protein	0.0083	0.0216	0.0219
Trichomonas vaginalis	replication factor C large subunit, putative	0.0083	0.0216	0.0061
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0038	0.0008	0.0003
Entamoeba histolytica	hypothetical protein	0.0083	0.0216	0.0209
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0008	0.0003
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0038	0.0008	0.0008
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0081	0.0208	0.034
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0083	0.0216	0.0061
Schistosoma mansoni	nAChR subunit	0.0038	0.0008	0.0002
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0041	0.0024	0.0025
Trypanosoma cruzi	lactoylglutathione lyase-like protein, putative	0.1323	0.5949	1
Echinococcus granulosus	tyrosine kinase	0.0037	0.0005	0.0006
Mycobacterium ulcerans	hypothetical protein	0.0344	0.1423	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.0024	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0008	0.0002
Onchocerca volvulus	Putative nachr subunit	0.0038	0.0008	0.0003
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0658	0.2872	0.2986
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0329	0.1352	0.1406
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0038	0.0008	0.0008
Brugia malayi	Tnks protein	0.0157	0.0558	0.0575
Echinococcus granulosus	tankyrase	0.0157	0.0558	0.0581
Loa Loa (eye worm)	ACC-1 protein	0.0038	0.0008	0.0004
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0038	0.0008	0.0008
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.0024	0.0025
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0344	0.1423	1
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.1163	0.5208	0.5413
Echinococcus granulosus	nibrin	0.0083	0.0216	0.0224
Echinococcus multilocularis	tankyrase	0.0157	0.0558	0.0581
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0041	0.0024	0.0025
Plasmodium falciparum	cytosolic glyoxalase II	0.0081	0.0208	0.034
Brugia malayi	hypothetical protein	0.0083	0.0216	0.0219
Schistosoma mansoni	4-hydroxyphenylpyruvate dioxygenase	0.0344	0.1423	0.1474
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0008	0.0003
Onchocerca volvulus		0.0083	0.0216	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0038	0.0008	0.0004
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0081	0.0208	0.034
Toxoplasma gondii	glyoxalase I, putative	0.1323	0.5949	0.5947
Plasmodium vivax	glyoxalase I, putative	0.1323	0.5949	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0038	0.0008	0.0002
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0083	0.0216	0.0754
Brugia malayi	excitatory GABA receptor EXP-1A	0.0038	0.0008	0.0003
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0038	0.0008	0.0008
Leishmania major	hypothetical protein, conserved	0.0276	0.111	0.1857
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0038	0.0008	0.0004
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0041	0.0024	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0558	0.2881
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0041	0.0024	0.0025
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0038	0.0008	0.0004
Plasmodium falciparum	glyoxalase I	0.1323	0.5949	1
Echinococcus multilocularis	tissue type plasminogen activator	0.0038	0.0006	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0216	0.0289
Onchocerca volvulus	Putative protein	0.0344	0.1423	0.2384
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0083	0.0216	0.0061
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0008	0.0003
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0008	0.0002
Loa Loa (eye worm)	transcription factor SMAD2	0.0131	0.0439	0.0596
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.2117	0.9617	1
Trypanosoma brucei	DNA repair protein, putative	0.0276	0.111	0.1804
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0041	0.0024	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Mycobacterium ulcerans	hypothetical protein	0.0344	0.1423	1
Schistosoma mansoni	DNA ligase IV	0.0083	0.0216	0.0218
Entamoeba histolytica	hypothetical protein	0.0329	0.1352	0.1392
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0041	0.0024	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0344	0.1423	1
Echinococcus multilocularis	replication factor c subunit 1	0.0083	0.0216	0.0224
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0038	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Mycobacterium tuberculosis	Cadmium inducible protein CadI	0.0344	0.1423	1
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.1163	0.5208	0.8753
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0083	0.0216	0.0219
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0083	0.0216	0.5
Leishmania major	glyoxalase I,trypanothione-dependent glyoxalase I	0.1323	0.5949	1
Mycobacterium ulcerans	hypothetical protein	0.0344	0.1423	1
Plasmodium vivax	hydroxyacyl glutathione hydrolase, putative	0.0081	0.0208	0.034
Plasmodium falciparum	glyoxalase I	0.0832	0.3677	0.6177
Onchocerca volvulus	DNA ligase 3 homolog	0.0276	0.111	0.1857
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Trypanosoma brucei	poly(adp-ribose) polymerase	0.1163	0.5208	1
Onchocerca volvulus		0.0038	0.0008	0.0003
Trypanosoma cruzi	lactoylglutathione lyase-like protein, putative	0.1323	0.5949	1
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0486	0.2078	0.2161
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0008	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0008	0.0003
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0038	0.0008	0.0002
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.1611	0.7281	1
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0329	0.1352	0.1406
Loa Loa (eye worm)	hypothetical protein	0.1323	0.5949	0.817
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0006	0.0001
Mycobacterium tuberculosis	Conserved protein	0.0344	0.1423	1
Mycobacterium ulcerans	glyoxalase GloA	0.0344	0.1423	1
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0329	0.1352	0.1406
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0041	0.0024	0.0025
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0038	0.0008	0.0003
Schistosoma mansoni	topbp1	0.0083	0.0216	0.0218
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0038	0.0008	0.0008
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.2117	0.9617	1
Loa Loa (eye worm)	tnks protein	0.0157	0.0558	0.076
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0008	0.0003
Brugia malayi	Cation transporter family protein	0.0038	0.0008	0.0003
Brugia malayi	Protein kinase domain containing protein	0.0039	0.0012	0.0007
Loa Loa (eye worm)	MH2 domain-containing protein	0.0131	0.0439	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Echinococcus granulosus	glycine receptor subunit beta	0.0038	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0216	0.0289
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0016	0.001
Schistosoma mansoni	nAChR subunit	0.0038	0.0008	0.0002
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0008	0.0008
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0008	0.0003
Echinococcus granulosus	tyrosine protein kinase Blk	0.0037	0.0005	0.0006
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0038	0.0008	0.0008
Echinococcus multilocularis	glycine receptor subunit beta	0.0038	0.0008	0.0008
Onchocerca volvulus		0.0038	0.0008	0.0003
Brugia malayi	4-hydroxyphenylpyruvate dioxygenase family protein	0.0344	0.1423	0.1475
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0008	0.0003
Entamoeba histolytica	hypothetical protein	0.0157	0.0558	0.0565
Entamoeba histolytica	hypothetical protein	0.0157	0.0558	0.0565
Echinococcus granulosus	glycine receptor subunit beta	0.0038	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0008	0.0004
Onchocerca volvulus		0.0038	0.0008	0.0003
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0008	0.0008
Brugia malayi	lactoylglutathione lyase	0.1323	0.5949	0.6184
Onchocerca volvulus	Hydroxyacylglutathione hydrolase, mitochondrial homolog	0.0062	0.0117	0.0187
Schistosoma mansoni	hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II)	0.0081	0.0208	0.021
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0038	0.0008	0.0008
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0083	0.0216	0.0015

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 0 %	Inhibition against Opioid receptor kappa 1 using selective ligand [3H]U69,593	ChEMBL.	9857089
Inhibition (binding)	= 0 %	Inhibition against Opioid receptor kappa 1 using selective ligand [3H]U69,593	ChEMBL.	9857089

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 255107