TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 259.234 | Formula: C12H14NNaO4
H donors: 1 H acceptors: 4 LogP: 0.96 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: C[C@H]([C@H]1C(=O)N2[C@@H]1[C@@H]1CCCC1=C2C(=O)[O-])O.[Na+]
InChi: 1S/C12H15NO4.Na/c1-5(14)8-9-6-3-2-4-7(6)10(12(16)17)13(9)11(8)15;/h5-6,8-9,14H,2-4H2,1H3,(H,16,17);/q;+1/p-1/t5-,6-,8-,9-;/m1./s1
InChiKey: ZLVXMTFOFWOOIL-RNZQWECKSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0021	0.0066	0.008
Toxoplasma gondii	TIM10 family protein, putative	0.0027	0.0093	0.0037
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2003	0.8225	1
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.2003	0.8225	0.8214
Brugia malayi	TAR-binding protein	0.0054	0.0202	0.0245
Brugia malayi	beta-NAC-like protein	0.002	0.0063	0.0077
Echinococcus granulosus	microtubule associated protein 2	0.0395	0.1607	0.1953
Treponema pallidum	glyceraldehyde 3-phosphate dehydrogenase (gap)	0.2003	0.8225	0.5
Onchocerca volvulus		0.0028	0.0097	0.2211
Brugia malayi	CXXC zinc finger family protein	0.0016	0.0048	0.0059
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2003	0.8225	1
Brugia malayi	beta-lactamase family protein	0.0021	0.0066	0.008
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0653	0.2667	0.262
Echinococcus granulosus	neuropeptide s receptor	0.0265	0.107	0.1301
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.1277	0.5235	0.6365
Schistosoma mansoni	mitochondrial import inner membrane translocase subunit tim10	0.0027	0.0093	0.0113
Schistosoma mansoni	cpg binding protein	0.0017	0.0052	0.0064
Echinococcus multilocularis	cpg binding protein	0.0017	0.0052	0.0064
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.2003	0.8225	1
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2003	0.8225	1
Schistosoma mansoni	hypothetical protein	0.0023	0.0076	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0076	0.0138
Echinococcus granulosus	cpg binding protein	0.0017	0.0052	0.0064
Entamoeba histolytica	hypothetical protein	0.0021	0.0066	0.0003
Loa Loa (eye worm)	transcription factor SMAD2	0.0068	0.0262	0.0473
Entamoeba histolytica	hypothetical protein	0.0021	0.0066	0.0003
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0054	0.0202	0.0364
Toxoplasma gondii	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0027	0.0093	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0098	0.0177
Echinococcus multilocularis	tumor protein p63	0.0193	0.0777	0.0945
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0029	0.0098	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0066	0.0119
Loa Loa (eye worm)	ICD-1 protein	0.002	0.0063	0.0114
Brugia malayi	latrophilin 2 splice variant baaae	0.002	0.0061	0.0074
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0023	0.0076	0.0016
Echinococcus granulosus	dnaJ subfamily B	0.0234	0.0945	0.1148
Trichomonas vaginalis	D-aminoacylase, putative	0.0021	0.0066	0.0003
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH2	0.2003	0.8225	1
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2003	0.8225	1
Schistosoma mansoni	hypothetical protein	0.0009	0.0018	0.0022
Brugia malayi	hypothetical protein	0.0021	0.0067	0.0082
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1277	0.5235	0.6337
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0027	0.0093	0.0037
Mycobacterium tuberculosis	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0624	0.2549	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0021	0.0066	0.008
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0023	0.0076	0.0016
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0066	0.0003
Echinococcus multilocularis	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0023	0.0076	0.0093
Echinococcus granulosus	expressed protein	0.0027	0.0093	0.0113
Schistosoma mansoni	microtubule-associated protein tau	0.0395	0.1607	0.1953
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0021	0.0066	0.008
Entamoeba histolytica	hypothetical protein	0.0021	0.0066	0.0003
Brugia malayi	hypothetical protein	0.0021	0.0066	0.008
Echinococcus granulosus	tar DNA binding protein	0.0054	0.0202	0.0245
Trichomonas vaginalis	esterase, putative	0.0021	0.0066	0.0003
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0009	0.0018	0.0022
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2003	0.8225	1
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2435	1	1
Brugia malayi	glyceraldehyde 3-phosphate dehydrogenase	0.0653	0.2667	0.3243
Onchocerca volvulus		0.0021	0.0066	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0066	0.0119
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.1351	0.5539	1
Wolbachia endosymbiont of Brugia malayi	glyceraldehyde-3-phosphate dehydrogenase, GapA	0.2003	0.8225	0.5
Brugia malayi	RNA binding protein	0.0054	0.0202	0.0245
Brugia malayi	F/Y-rich N-terminus family protein	0.0005	0.0002	0.0002
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.1277	0.5235	0.9451
Plasmodium vivax	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2003	0.8225	1
Echinococcus multilocularis	expressed protein	0.0027	0.0093	0.0113
Loa Loa (eye worm)	MH2 domain-containing protein	0.0068	0.0262	0.0473
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0009	0.0018	0.0022
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0031	0.0109	0.0056
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0202	0.0245
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0653	0.2667	0.262
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0016	0.0048	0.0088
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2003	0.8225	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0005	0.0002	0.0002
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.2003	0.8225	1
Onchocerca volvulus	Huntingtin homolog	0.007	0.0269	1
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH1	0.2003	0.8225	1
Onchocerca volvulus		0.0021	0.0066	0.0777
Onchocerca volvulus	Huntingtin homolog	0.007	0.0269	1
Brugia malayi	Latrophilin receptor protein 2	0.0009	0.0018	0.0022
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.1277	0.5235	0.9451
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0333	0.0601
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0029	0.0098	0.012
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.2003	0.8225	1
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.2003	0.8225	1
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.1351	0.5539	1
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0027	0.0093	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0066	0.0119
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0023	0.0076	0.0093
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0653	0.2667	0.262
Brugia malayi	Mitochondrial import inner membrane translocase subunit TIM10	0.0027	0.0093	0.0113
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0021	0.0066	0.008
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0653	0.2667	0.262
Brugia malayi	beta-lactamase family protein	0.0021	0.0066	0.008
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0009	0.0018	0.0022
Echinococcus granulosus	beta LACTamase domain containing family member	0.0021	0.0066	0.008
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2003	0.8225	0.8214
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0202	0.0245
Toxoplasma gondii	ABC1 family protein	0.0021	0.0066	0.0003
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2003	0.8225	0.8214
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0066	0.0002
Trypanosoma brucei	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2435	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0061	0.011
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.2003	0.8225	0.8214
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2003	0.8225	0.8214
Echinococcus multilocularis	tar DNA binding protein	0.0054	0.0202	0.0245
Brugia malayi	beta-lactamase	0.0021	0.0066	0.008
Brugia malayi	hypothetical protein	0.007	0.0269	0.0328
Chlamydia trachomatis	glyceraldehyde-3-phosphate dehydrogenase	0.2003	0.8225	0.5
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.2003	0.8225	1
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2435	1	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0021	0.0066	0.008
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0727	0.2971	0.3563
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0021	0.0066	0.008
Leishmania major	hypothetical protein, conserved	0.0021	0.0066	0.0002
Toxoplasma gondii	mitochondrial inner membrane translocase subunit TIM17, putative	0.0023	0.0076	0.0016
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.2003	0.8225	0.8214
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0202	0.0245
Schistosoma mansoni	hypothetical protein	0.002	0.0061	0.0074
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.1277	0.5235	0.6365
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0029	0.0098	0.012
Schistosoma mansoni	hypothetical protein	0.0009	0.0018	0.0022
Loa Loa (eye worm)	beta-lactamase	0.0021	0.0066	0.0119
Schistosoma mansoni	hypothetical protein	0.0009	0.0018	0.0022
Schistosoma mansoni	hypothetical protein	0.0009	0.0018	0.0022
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.2003	0.8225	0.8214
Mycobacterium ulcerans	glyceraldehyde 3-phosphate dehydrogenase Gap	0.2003	0.8225	1
Mycobacterium leprae	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0624	0.2549	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0269	0.0487
Echinococcus multilocularis	neuropeptide s receptor	0.0265	0.107	0.1301
Schistosoma mansoni	cpg binding protein	0.0017	0.0052	0.0064
Loa Loa (eye worm)	hypothetical protein	0.007	0.0269	0.0487
Brugia malayi	hypothetical protein	0.0021	0.0067	0.0082
Brugia malayi	MH2 domain containing protein	0.0068	0.0262	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0066	0.0119
Schistosoma mansoni	transcription factor LCR-F1	0.0021	0.0066	0.008
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, cytosolic	0.2003	0.8225	0.8214
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0066	0.0119
Echinococcus granulosus	GPCR family 2	0.0009	0.0018	0.0022
Schistosoma mansoni	hypothetical protein	0.0021	0.0066	0.008
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0018	0.0032
Loa Loa (eye worm)	RNA binding protein	0.0054	0.0202	0.0364
Schistosoma mansoni	hypothetical protein	0.0234	0.0945	0.1148
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0021	0.0066	0.0119
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0727	0.2971	0.3612
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2003	0.8225	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0005	0.0002	0.0002
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.2003	0.8225	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0009	0.0018	0.0022
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2003	0.8225	0.8214
Echinococcus granulosus	transcription factor btf3	0.002	0.0063	0.0077
Echinococcus multilocularis	transcription factor btf3	0.002	0.0063	0.0077
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.2003	0.8225	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0021	0.0066	0.0003
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0653	0.2667	0.262
Loa Loa (eye worm)	transport to inner mitochondrial membrane family member	0.0027	0.0093	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0066	0.0119
Trichomonas vaginalis	penicillin-binding protein, putative	0.0021	0.0066	0.0003
Schistosoma mansoni	cellular tumor antigen P53	0.0028	0.0097	0.0118
Echinococcus granulosus	muscleblind protein	0.0086	0.0333	0.0405
Brugia malayi	RNA recognition motif domain containing protein	0.0054	0.0202	0.0245
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0066	0.0002
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0035	0.0124	0.0151
Trichomonas vaginalis	D-aminoacylase, putative	0.0021	0.0066	0.0003
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.2003	0.8225	0.8214
Echinococcus granulosus	tumor protein p63	0.0193	0.0777	0.0945
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2003	0.8225	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0021	0.0066	0.0003
Echinococcus multilocularis	muscleblind protein	0.0086	0.0333	0.0405
Loa Loa (eye worm)	hypothetical protein	0.1277	0.5235	0.9451
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0009	0.0018	0.0022
Echinococcus multilocularis	GPCR, family 2	0.0009	0.0018	0.0022
Entamoeba histolytica	hypothetical protein	0.0021	0.0066	0.0003
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.2003	0.8225	1
Trypanosoma brucei	hypothetical protein, conserved	0.0021	0.0066	0.0002
Schistosoma mansoni	transcription factor btf3	0.002	0.0063	0.0077
Echinococcus multilocularis	neuropeptide receptor A26	0.0265	0.107	0.1301
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.2003	0.8225	1
Onchocerca volvulus		0.0021	0.0066	0.0777
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0023	0.0076	0.0093
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0009	0.0018	0.0032
Echinococcus multilocularis	dnaJ subfamily B	0.0234	0.0945	0.1148
Echinococcus granulosus	neuropeptide receptor A26	0.0265	0.107	0.1301
Schistosoma mansoni	cpg binding protein	0.0016	0.0048	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0333	0.0601
Echinococcus multilocularis	microtubule associated protein 2	0.0395	0.1607	0.1953
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0202	0.0245
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0132	0.0523	0.1841
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.2003	0.8225	1
Loa Loa (eye worm)	TAR-binding protein	0.0054	0.0202	0.0364
Brugia malayi	Muscleblind-like protein	0.0086	0.0333	0.0405
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.2003	0.8225	0.8214
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0023	0.0076	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0097	0.0176
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0202	0.0245
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1277	0.5235	0.6337
Loa Loa (eye worm)	histone methyltransferase	0.0005	0.0002	0.0003
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.2003	0.8225	0.8214
Echinococcus multilocularis	muscleblind protein 1	0.0086	0.0333	0.0405
Plasmodium falciparum	glyceraldehyde-3-phosphate dehydrogenase	0.2003	0.8225	1

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 0.5 ug ml-1	Compound was evaluated in vitro for antibacterial activity against Staphylococcus aureus 853.	ChEMBL.	No reference
MIC (functional)	= 1 ug ml-1	Compound was evaluated in vitro for antibacterial activity against Staphylococcus aureus 663.	ChEMBL.	No reference
MIC (functional)	= 1 ug ml-1	Compound was evaluated in vitro for antibacterial activity against Clostridium perfringens 615.	ChEMBL.	No reference
MIC (functional)	= 2 ug ml-1	Compound was evaluated in vitro for antibacterial activity against Escherichia coli 1850.	ChEMBL.	No reference
MIC (functional)	= 2 ug ml-1	Compound was evaluated in vitro for antibacterial activity against Escherichia coli 1850.	ChEMBL.	No reference
MIC (functional)	= 8 ug ml-1	Compound was evaluated in vitro for antibacterial activity against Staphylococcus aureus 1131.	ChEMBL.	No reference
MIC (functional)	= 16 ug ml-1	Compound was evaluated in vitro for antibacterial activity against Enterobacter faecalis 850E.	ChEMBL.	No reference
MIC (functional)	> 32 ug ml-1	Compound was evaluated in vitro for antibacterial activity against Pseudomonas aeruginosa 1911.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL148775

Bibliographic References

No literature references available for this target.

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Detailed information for compound 256891