Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.2693 | 0.2693 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.2693 | 0.2693 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0163 | 0.0163 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0343 | 0.0343 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0343 | 0.0343 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.0088 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 0.4055 | 0.4055 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.2693 | 0.2693 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.2693 | 0.2693 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.2693 | 0.2693 |
Brugia malayi | hypothetical protein | 0.012 | 0.1837 | 0.1837 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0533 | 1 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0163 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4055 | 0.4055 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0163 | 0.0163 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0391 | 0.0391 |
Onchocerca volvulus | 0.0047 | 0.0391 | 0.213 | |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0163 | 0.5 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0533 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.2693 | 0.2693 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0343 | 0.0343 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0163 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 0.4055 | 0.4055 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0163 | 0.5 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0533 | 1 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0163 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0163 | 0.0163 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.1837 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0163 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.1837 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.2693 | 0.2693 |
Loa Loa (eye worm) | hyaluronidase | 0.0533 | 1 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0163 | 0.0163 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0343 | 0.0343 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.2693 | 0.2693 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.2693 | 0.2693 |
Schistosoma mansoni | Hyaluronidase | 0.0533 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0163 | 0.0163 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.2693 | 0.2693 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0163 | 1 |
Brugia malayi | hypothetical protein | 0.0233 | 0.4055 | 0.4055 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0163 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.3933 | 0.3933 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0343 | 0.0343 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0391 | 0.0391 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0343 | 0.0343 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0163 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0343 | 0.0343 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0391 | 0.0391 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0163 | 1 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0163 | 0.0163 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.2693 | 0.2693 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1837 | 0.1837 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.2693 | 0.2693 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.0088 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.2693 | 0.2693 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1837 | 0.1837 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0163 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.86 uM | In vitro inhibitory concentration against purified Acetylcholinesterase of human erythrocytes; value ranges from 0.76-1.05 | ChEMBL. | 12431053 |
IC50 (binding) | = 6.4 uM | In vitro inhibitory concentration against Butyrylcholinesterase of horse serum; value ranges from 4.9-11.2 | ChEMBL. | 12431053 |
IC50 (binding) | = 500 uM | In vitro inhibitory concentration against Monoamine oxidase B of rat brain homogenates; value ranges from 260-1100 | ChEMBL. | 12431053 |
IC50 (binding) | = 700 uM | In vitro inhibitory concentration against Monoamine oxidase A of rat brain homogenates; value ranges from 540-850 | ChEMBL. | 12431053 |
Ratio (binding) | = 0.13 | Ratio of the IC50 value against AChE of human erythrocytes to that of BuChE of horse serum | ChEMBL. | 12431053 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.