Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0133 | 0.0666 | 0.3984 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.1694 | 1 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0307 | 0.1706 | 1 |
Schistosoma mansoni | glutaminase | 0.0288 | 0.1587 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.0126 | 0.189 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.1001 | 0.5854 | 0.6733 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0666 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0108 | 0.0514 | 0.2997 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0126 | 0.189 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.015 | 0.0766 | 0.1076 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0116 | 0.0561 | 0.0512 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.1001 | 0.5854 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0307 | 0.1706 | 0.3534 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.1466 | 0.8633 | 0.8612 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0126 | 0.189 |
Trypanosoma brucei | unspecified product | 0.0036 | 0.0084 | 0.1266 |
Brugia malayi | Pre-SET motif family protein | 0.0219 | 0.1177 | 0.7321 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0048 | 0.0152 | 0.0031 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0063 | 0.0946 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0311 | 0.1729 | 0.1885 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0048 | 0.0152 | 0.2286 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0133 | 0.0666 | 0.3304 |
Echinococcus multilocularis | dna polymerase kappa | 0.0043 | 0.0126 | 0.0856 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0116 | 0.0561 | 0.0512 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0124 | 0.0609 | 0.6722 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0544 | 0.3122 | 0.5334 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.015 | 0.0766 | 0.0752 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0247 | 0.1342 | 0.2293 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0666 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0133 | 0.0666 | 0.3984 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0077 | 0.0329 | 0.3326 |
Schistosoma mansoni | lipoxygenase | 0.0124 | 0.0609 | 0.3617 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0544 | 0.3122 | 0.5209 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0116 | 0.0561 | 0.3302 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0126 | 0.189 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0133 | 0.0666 | 0.3984 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0169 | 0.088 | 0.5382 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0036 | 0.0084 | 0.1266 |
Schistosoma mansoni | lipoxygenase | 0.0087 | 0.0386 | 0.216 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0126 | 0.189 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0307 | 0.1706 | 0.3534 |
Brugia malayi | glutaminase DH11.1 | 0.0288 | 0.1587 | 1 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0048 | 0.0152 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.0288 | 0.1587 | 0.1718 |
Loa Loa (eye worm) | glutaminase 2 | 0.0288 | 0.1587 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0666 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0169 | 0.088 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0126 | 0.189 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0544 | 0.3122 | 0.3522 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0048 | 0.0152 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0307 | 0.1706 | 0.3534 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0077 | 0.0329 | 0.3381 |
Onchocerca volvulus | 0.0169 | 0.088 | 0.633 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0048 | 0.0152 | 0.2286 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0116 | 0.0561 | 0.8429 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0461 | 0.2625 | 0.4485 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.1001 | 0.5854 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0116 | 0.0561 | 0.0958 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0219 | 0.1177 | 0.7321 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0307 | 0.1706 | 0.1578 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0307 | 0.1706 | 0.3534 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0055 | 0.0083 |
Trichomonas vaginalis | glutaminase, putative | 0.0288 | 0.1587 | 0.3268 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0116 | 0.0561 | 0.3302 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0133 | 0.0666 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.088 | 0.5382 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.1694 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0126 | 0.189 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0307 | 0.1706 | 0.3534 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0307 | 0.1706 | 0.3534 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0791 | 0.4597 | 0.7796 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0048 | 0.0152 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0126 | 0.189 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0307 | 0.1706 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0791 | 0.4597 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0133 | 0.0666 | 0.7424 |
Trichomonas vaginalis | set domain proteins, putative | 0.0249 | 0.1358 | 0.2755 |
Loa Loa (eye worm) | glutaminase | 0.0288 | 0.1587 | 1 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.0772 | 0.4487 | 0.4402 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0126 | 0.189 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0116 | 0.0561 | 0.6135 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0048 | 0.0152 | 0.026 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0048 | 0.0152 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0124 | 0.0609 | 0.6749 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0133 | 0.0666 | 0.7403 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0307 | 0.1706 | 0.3534 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0311 | 0.1729 | 0.2766 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0048 | 0.0152 | 0.0031 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0461 | 0.2625 | 0.4338 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0307 | 0.1706 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0169 | 0.088 | 0.5382 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0307 | 0.1706 | 0.3534 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0791 | 0.4597 | 0.5256 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0311 | 0.1729 | 0.2954 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0791 | 0.4597 | 0.4514 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0063 | 0.0051 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0116 | 0.0561 | 0.6167 |
Echinococcus granulosus | dna polymerase kappa | 0.0043 | 0.0126 | 0.0932 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.015 | 0.0766 | 0.1308 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.0126 | 0.189 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.1466 | 0.8633 | 1 |
Onchocerca volvulus | 0.0249 | 0.1358 | 1 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0063 | 0.0946 |
Brugia malayi | polk-prov protein | 0.0033 | 0.0063 | 0.0051 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0169 | 0.088 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0126 | 0.189 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 100 uM | Effective concentration against HIV-1 strain LAV in human peripheral blood mononuclear (PBM) cells. | ChEMBL. | 8496934 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against uninfected PHA-stimulated peripheral blood mononuclear (PBM) cells | ChEMBL. | 8496934 |
IC50 (ADMET) | > 100 uM | Cytotoxic effect against vero cells. | ChEMBL. | 8496934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.