Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0134 | 0.3277 | 0.5214 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.3277 | 0.5214 |
Echinococcus multilocularis | thymidine kinase | 0.024 | 0.6285 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0246 | 0.6454 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.092 | 0.1464 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.2995 | 0.4765 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.024 | 0.6285 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.2995 | 0.4765 |
Echinococcus multilocularis | thymidine kinase | 0.024 | 0.6285 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.2995 | 0.4765 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | thymidine kinase | 0.024 | 0.6285 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.3277 | 0.5214 |
Echinococcus granulosus | thymidine kinase | 0.024 | 0.6285 | 1 |
Echinococcus granulosus | thymidine kinase | 0.024 | 0.6285 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Leishmania major | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | transfer RNA-Ile | 0.024 | 0.6285 | 1 |
Giardia lamblia | Thymidine kinase | 0.0246 | 0.6454 | 0.6454 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 6 % | Percent inhibition of SRS-A induced contraction minus percent inhibition of 25 mM KCl induced contractions at a conc of 5(microM); Percent enhancement of tissue contraction compared to control | ChEMBL. | 7143363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.