Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0087 | 0.0163 | 0.0146 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0474 | 0.1319 | 0.3702 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Brugia malayi | Matrixin family protein | 0.0974 | 0.2817 | 0.4368 |
Brugia malayi | Matrixin family protein | 0.0974 | 0.2817 | 0.4368 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.1186 | 0.3452 | 0.5353 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0181 | 0.0445 | 0.1215 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.015 | 0.035 | 0.0314 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0384 | 0.105 | 0.2937 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0302 | 1 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.1002 | 0.2899 | 0.8217 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0116 | 0.0249 | 0.0661 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0791 | 0.2268 | 0.5255 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0017 | 0.0026 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0306 | 0.0819 | 0.5 |
Echinococcus multilocularis | adam | 0.0067 | 0.0102 | 0.0085 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Mycobacterium ulcerans | glutaminase | 0.0286 | 0.0759 | 0.171 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Echinococcus granulosus | adam | 0.0067 | 0.0102 | 0.0085 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0163 | 0.0253 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0133 | 0.0302 | 0.0285 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0116 | 0.0249 | 0.0233 |
Onchocerca volvulus | Matrilysin homolog | 0.216 | 0.6367 | 1 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0461 | 0.1282 | 0.3223 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.216 | 0.6367 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0311 | 0.0834 | 0.1561 |
Brugia malayi | Matrixin family protein | 0.0974 | 0.2817 | 0.4368 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0133 | 0.0302 | 0.0809 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.3375 | 1 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0087 | 0.0163 | 0.0146 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0133 | 0.0302 | 0.0285 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0087 | 0.0163 | 0.0253 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0241 | 0.0623 | 0.0607 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0067 | 0.0102 | 0.0242 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0124 | 0.0272 | 0.0256 |
Brugia malayi | Disintegrin family protein | 0.0038 | 0.0017 | 0.0026 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.1695 | 0.4974 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0043 | 0.0031 | 0.0014 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0311 | 0.0834 | 0.1886 |
Trypanosoma brucei | unspecified product | 0.0036 | 0.0011 | 0.0352 |
Onchocerca volvulus | 0.0974 | 0.2817 | 0.4278 | |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.1186 | 0.3452 | 1 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0246 | 0.064 | 0.122 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Schistosoma mansoni | hypothetical protein | 0.1214 | 0.3535 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.2314 | 0.3588 |
Schistosoma mansoni | lipoxygenase | 0.0086 | 0.0161 | 0.0409 |
Loa Loa (eye worm) | glutaminase | 0.0286 | 0.0759 | 0.1177 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.0031 | 0.1037 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0116 | 0.0249 | 0.0512 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.1695 | 0.4974 | 1 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.1002 | 0.2899 | 0.8273 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.1466 | 0.4288 | 0.8349 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0102 | 0.0158 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0461 | 0.1282 | 0.3003 |
Schistosoma mansoni | glutaminase | 0.0286 | 0.0759 | 0.211 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 1 |
Onchocerca volvulus | 0.0248 | 0.0645 | 0.0777 | |
Loa Loa (eye worm) | matrixin family protein | 0.216 | 0.6367 | 0.9871 |
Loa Loa (eye worm) | glutaminase 2 | 0.0286 | 0.0759 | 0.1177 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Brugia malayi | Hemopexin family protein | 0.1214 | 0.3535 | 0.5481 |
Echinococcus granulosus | adam 17 protease | 0.0422 | 0.1165 | 0.115 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0791 | 0.2268 | 0.6183 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.015 | 0.035 | 0.0749 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0791 | 0.2268 | 0.3488 |
Echinococcus granulosus | dna polymerase kappa | 0.0043 | 0.0031 | 0.0014 |
Onchocerca volvulus | Matrilysin homolog | 0.0974 | 0.2817 | 0.4278 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0133 | 0.0302 | 0.0468 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0181 | 0.0445 | 0.0689 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0311 | 0.0834 | 0.1826 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0077 | 0.0134 | 0.0117 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0202 | 0.0525 |
Mycobacterium ulcerans | hydrolase | 0.1186 | 0.3452 | 0.8036 |
Brugia malayi | Pre-SET motif family protein | 0.0218 | 0.0555 | 0.086 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0116 | 0.0249 | 0.0387 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0181 | 0.0445 | 0.0428 |
Brugia malayi | glutaminase DH11.1 | 0.0286 | 0.0759 | 0.1177 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Onchocerca volvulus | 0.1214 | 0.3535 | 0.5436 | |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0544 | 0.1531 | 0.3522 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0036 | 0.0011 | 0.0352 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Schistosoma mansoni | lipoxygenase | 0.0124 | 0.0272 | 0.0725 |
Trichomonas vaginalis | set domain proteins, putative | 0.0248 | 0.0645 | 0.2743 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.1002 | 0.2899 | 0.6737 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0181 | 0.0445 | 0.0428 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.0202 | 0.669 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0241 | 0.0623 | 0.0607 |
Brugia malayi | Matrixin family protein | 0.0974 | 0.2817 | 0.4368 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0077 | 0.0134 | 0.0117 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0218 | 0.0555 | 0.086 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0116 | 0.0249 | 0.0512 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.1695 | 0.4974 | 0.5 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0974 | 0.2817 | 0.4368 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0031 | 0.1037 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0116 | 0.0249 | 0.0233 |
Echinococcus multilocularis | adam 17 protease | 0.0384 | 0.105 | 0.1035 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0087 | 0.0163 | 0.0415 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.0031 | 0.1037 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0544 | 0.1531 | 0.4001 |
Loa Loa (eye worm) | matrixin family protein | 0.2188 | 0.645 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.1186 | 0.3452 | 1 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.1466 | 0.4288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0974 | 0.2817 | 0.4368 |
Loa Loa (eye worm) | reprolysin | 0.0038 | 0.0017 | 0.0026 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0133 | 0.0302 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0306 | 0.0819 | 0.352 |
Loa Loa (eye worm) | hypothetical protein | 0.1186 | 0.3452 | 0.5353 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0974 | 0.2817 | 0.7959 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0133 | 0.0302 | 0.0468 |
Trichomonas vaginalis | glutaminase, putative | 0.0286 | 0.0759 | 0.3255 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0302 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0108 | 0.0226 | 0.035 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0544 | 0.1531 | 0.3806 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0133 | 0.0302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0974 | 0.2817 | 0.4368 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0124 | 0.0272 | 0.0256 |
Loa Loa (eye worm) | hypothetical protein | 0.0974 | 0.2817 | 0.4368 |
Brugia malayi | Matrixin family protein | 0.2188 | 0.645 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0791 | 0.2268 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 3.155 uM | Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) | ChEMBL. | 12086483 |
Activity (binding) | = 3.155 uM | Inhibition of HIV-1 reverse transcriptase. | ChEMBL. | 12723956 |
Activity (binding) | = 3.155 uM | Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) | ChEMBL. | 12086483 |
Activity (binding) | = 3.155 uM | Inhibition of HIV-1 reverse transcriptase. | ChEMBL. | 12723956 |
CC50 (functional) | = 427 uM | Cytotoxic concentration required to reduce the viability of mock-infected MT-4 cells by 50%. | ChEMBL. | 1995896 |
IC50 (binding) | = 3.155 mM | Inhibition of HIV-1 reverse transcriptase. | ChEMBL. | 9857095 |
IC50 (binding) | = 3.155 mM | Inhibition of HIV-1 reverse transcriptase. | ChEMBL. | 9857095 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.