Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit alpha | 0.0076 | 0.1227 | 1 |
Schistosoma mansoni | vacuolar proton atpases | 0.0042 | 0.0429 | 0.1254 |
Echinococcus multilocularis | vacuolar H+ ATPase v1 sector subunit A | 0.0052 | 0.0678 | 0.0678 |
Leishmania major | vacuolar proton-ATPase-like protein, putative | 0.0042 | 0.0429 | 0.0273 |
Trypanosoma brucei | ATP synthase subunit beta, mitochondrial | 0.0052 | 0.0678 | 0.108 |
Entamoeba histolytica | V-type ATPase, A subunit, putative | 0.0052 | 0.0678 | 0.198 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0429 | 0.1254 |
Trichomonas vaginalis | vacuolar proton ATPase, putative | 0.0042 | 0.0429 | 0.1254 |
Echinococcus granulosus | nervana 2 | 0.0066 | 0.1007 | 0.1007 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0066 | 0.1007 | 0.1007 |
Leishmania major | ATPase alpha subunit | 0.0046 | 0.053 | 0.06 |
Leishmania major | vacuolar ATP synthase catalytic subunit A, putative | 0.0052 | 0.0678 | 0.108 |
Schistosoma mansoni | transmemberane protein | 0.0066 | 0.1007 | 0.2942 |
Echinococcus multilocularis | nervana 2 | 0.0066 | 0.1007 | 0.1007 |
Giardia lamblia | Vacuolar ATP synthase subunit B | 0.017 | 0.3424 | 1 |
Trypanosoma brucei | V-type ATPase, A subunit, putative | 0.0052 | 0.0678 | 0.108 |
Trichomonas vaginalis | ATP synthase beta subunit, putative | 0.0052 | 0.0678 | 0.198 |
Echinococcus multilocularis | vacuolar ATP synthase subunit b | 0.017 | 0.3424 | 0.3424 |
Trypanosoma cruzi | vacuolar proton translocating ATPase subunit A, putative | 0.0042 | 0.0429 | 0.0273 |
Plasmodium falciparum | V-type proton ATPase subunit a, putative | 0.0042 | 0.0429 | 0.0273 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0066 | 0.1007 | 0.1007 |
Trypanosoma cruzi | V-type proton ATPase subunit B, putative | 0.017 | 0.3424 | 1 |
Plasmodium falciparum | V-type proton ATPase subunit B | 0.017 | 0.3424 | 1 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE BETA CHAIN ATPD | 0.0076 | 0.1227 | 0.5 |
Toxoplasma gondii | vacuolar ATP synthase subunit A, putative | 0.0052 | 0.0678 | 0.108 |
Echinococcus granulosus | nervana 2 | 0.0066 | 0.1007 | 0.1007 |
Entamoeba histolytica | proliferating cell nuclear antigen, putative | 0.0038 | 0.0345 | 0.1009 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.0052 | 0.0678 | 0.108 |
Giardia lamblia | Vacuolar ATP synthase catalytic subunit A | 0.0052 | 0.0678 | 0.108 |
Loa Loa (eye worm) | proliferating cell nuclear antigen | 0.0038 | 0.0345 | 0.1009 |
Loa Loa (eye worm) | V-type ATPase 116kDa subunit family protein | 0.0042 | 0.0429 | 0.1254 |
Plasmodium vivax | vacuolar ATP synthase subunit b, putative | 0.017 | 0.3424 | 1 |
Onchocerca volvulus | ATP synthase subunit alpha, mitochondrial homolog | 0.0076 | 0.1227 | 1 |
Toxoplasma gondii | vacuolar proton translocating ATPase subunit, putative | 0.0042 | 0.0429 | 0.0273 |
Echinococcus granulosus | vacuolar H ATPase v1 sector subunit A | 0.0052 | 0.0678 | 0.0678 |
Giardia lamblia | Vacuolar proton-ATPase subunit, putative | 0.0042 | 0.0429 | 0.0273 |
Plasmodium falciparum | V-type proton ATPase catalytic subunit A | 0.0052 | 0.0678 | 0.108 |
Leishmania major | vacuolar ATP synthase subunit b, putative | 0.017 | 0.3424 | 1 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.0052 | 0.0678 | 0.108 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0046 | 0.053 | 0.06 |
Trichomonas vaginalis | proliferating cell nuclear antigen, putative | 0.0038 | 0.0345 | 0.1009 |
Entamoeba histolytica | V-type ATPase, B subunit, putative | 0.017 | 0.3424 | 1 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA | 0.0076 | 0.1227 | 0.5 |
Schistosoma mansoni | proliferating cell nuclear antigen | 0.0038 | 0.0345 | 0.1009 |
Entamoeba histolytica | vacuolar proton ATPase subunit, putative | 0.0042 | 0.0429 | 0.1254 |
Echinococcus granulosus | ATP synthase subunit alpha mitochondrial | 0.0076 | 0.1227 | 0.1227 |
Echinococcus multilocularis | V type proton ATPase 116 kDa subunit a | 0.0042 | 0.0429 | 0.0429 |
Schistosoma mansoni | ATP synthase alpha subunit vacuolar | 0.0052 | 0.0678 | 0.198 |
Echinococcus granulosus | vacuolar ATP synthase subunit b | 0.017 | 0.3424 | 0.3424 |
Leishmania major | ATPase alpha subunit | 0.0046 | 0.053 | 0.06 |
Echinococcus multilocularis | nervana 2 | 0.0066 | 0.1007 | 0.1007 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0429 | 0.1254 |
Brugia malayi | vacuolar proton pump | 0.0042 | 0.0429 | 0.1254 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0066 | 0.1007 | 0.2942 |
Echinococcus multilocularis | nervana 2 | 0.0066 | 0.1007 | 0.1007 |
Loa Loa (eye worm) | vacuolar ATP synthase subunit B | 0.017 | 0.3424 | 1 |
Brugia malayi | vacuolar ATP synthase subunit B | 0.017 | 0.3424 | 1 |
Schistosoma mansoni | vacuolar proton atpases | 0.0042 | 0.0429 | 0.1254 |
Schistosoma mansoni | ATP synthase subunit beta vacuolar | 0.017 | 0.3424 | 1 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit alpha | 0.0076 | 0.1227 | 1 |
Schistosoma mansoni | vacuolar proton atpases | 0.0042 | 0.0429 | 0.1254 |
Trypanosoma brucei | Vacuolar proton pump subunit B, putative | 0.017 | 0.3424 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0066 | 0.1007 | 0.1007 |
Entamoeba histolytica | vacuolar proton ATPase subunit, putative | 0.0042 | 0.0429 | 0.1254 |
Echinococcus multilocularis | ATP synthase subunit alpha, mitochondrial | 0.0076 | 0.1227 | 0.1227 |
Plasmodium falciparum | ATP synthase subunit beta, mitochondrial | 0.0052 | 0.0678 | 0.108 |
Entamoeba histolytica | vacuolar ATP synthase subunit B, putative | 0.003 | 0.0156 | 0.0455 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1007 | 0.2942 |
Trypanosoma cruzi | vacuolar proton-ATPase-like protein, putative | 0.0042 | 0.0429 | 0.0273 |
Trichomonas vaginalis | ATP synthase alpha subunit mitochondrial, putative | 0.017 | 0.3424 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase alpha chain AtpA | 0.0076 | 0.1227 | 0.5 |
Toxoplasma gondii | vacuolar proton translocating ATPase subunit A, putative | 0.0042 | 0.0429 | 0.0273 |
Echinococcus granulosus | V type proton ATPase 116 kDa subunit a | 0.0042 | 0.0429 | 0.0429 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0032 | 0.0206 | 0.0206 |
Trichomonas vaginalis | ATP synthase, putative | 0.003 | 0.0156 | 0.0455 |
Echinococcus granulosus | ATP synthase subunit beta mitochondrial | 0.0052 | 0.0678 | 0.0678 |
Brugia malayi | ATP synthase beta chain, mitochondrial precursor, putative | 0.0052 | 0.0678 | 0.198 |
Schistosoma mansoni | ATP synthase beta subunit | 0.0052 | 0.0678 | 0.198 |
Trypanosoma cruzi | V-type proton ATPase subunit a, putative | 0.0042 | 0.0429 | 0.0273 |
Brugia malayi | vacuolar ATP synthase catalytic subunit A, osteoclast isoform | 0.0052 | 0.0678 | 0.198 |
Echinococcus granulosus | nervana 2 | 0.0066 | 0.1007 | 0.1007 |
Echinococcus multilocularis | expressed protein | 0.0451 | 1 | 1 |
Plasmodium vivax | vacuolar proton translocating ATPase subunit A, putative | 0.0042 | 0.0429 | 0.0273 |
Brugia malayi | proliferating cell nuclear antigen (PCNA) | 0.0038 | 0.0345 | 0.1009 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.0066 | 0.1007 | 0.2942 |
Echinococcus granulosus | nervana 2 | 0.0066 | 0.1007 | 0.1007 |
Leishmania major | ATPase beta subunit, putative | 0.0052 | 0.0678 | 0.108 |
Trichomonas vaginalis | vacuolar proton ATPase subunit A4, putative | 0.0042 | 0.0429 | 0.1254 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0066 | 0.1007 | 0.1007 |
Loa Loa (eye worm) | vacuolar proton pump | 0.0042 | 0.0429 | 0.1254 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0066 | 0.1007 | 0.1007 |
Brugia malayi | ATP synthase alpha chain, mitochondrial precursor, putative | 0.0076 | 0.1227 | 0.3584 |
Leishmania major | ATPase beta subunit, putative | 0.0052 | 0.0678 | 0.108 |
Echinococcus granulosus | V type proton ATPase 116 kDa subunit a | 0.0042 | 0.0429 | 0.0429 |
Brugia malayi | vacuolar proton pump | 0.0042 | 0.0429 | 0.1254 |
Loa Loa (eye worm) | vacuolar H ATPase family member | 0.0052 | 0.0678 | 0.198 |
Toxoplasma gondii | ATP synthase beta subunit ATP-B | 0.0052 | 0.0678 | 0.108 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1007 | 0.2942 |
Trichomonas vaginalis | proliferating cell nuclear antigen, putative | 0.0038 | 0.0345 | 0.1009 |
Treponema pallidum | V-type ATP synthase subunit B | 0.017 | 0.3424 | 1 |
Trypanosoma cruzi | ATP synthase subunit beta, mitochondrial, putative | 0.0052 | 0.0678 | 0.108 |
Trypanosoma cruzi | Vacuolar proton pump subunit B, putative | 0.017 | 0.3424 | 1 |
Chlamydia trachomatis | V-type ATP synthase subunit B | 0.017 | 0.3424 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 0.0076 | 0.1227 | 0.5 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.0066 | 0.1007 | 0.1007 |
Schistosoma mansoni | ATP synthase alpha subunit mitochondrial | 0.0076 | 0.1227 | 0.3584 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0032 | 0.0206 | 0.0206 |
Echinococcus granulosus | proliferating cell nuclear antigen | 0.0038 | 0.0345 | 0.0345 |
Echinococcus multilocularis | nervana 2 | 0.0066 | 0.1007 | 0.1007 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0066 | 0.1007 | 0.1007 |
Plasmodium falciparum | ATP synthase F1, alpha subunit | 0.0076 | 0.1227 | 0.2865 |
Trichomonas vaginalis | vacuolar proton ATPase, putative | 0.0042 | 0.0429 | 0.1254 |
Trypanosoma brucei | V-type proton ATPase subunit a, putative | 0.0042 | 0.0429 | 0.0273 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0046 | 0.053 | 0.06 |
Echinococcus multilocularis | ATP synthase subunit beta, mitochondrial | 0.0052 | 0.0678 | 0.0678 |
Plasmodium vivax | ATP synthase alpha chain, putative | 0.0076 | 0.1227 | 0.2865 |
Toxoplasma gondii | vacuolar ATP synthase subunit b, putative | 0.017 | 0.3424 | 1 |
Trichomonas vaginalis | ATP synthase, putative | 0.017 | 0.3424 | 1 |
Plasmodium vivax | vacuolar ATP synthase catalytic subunit A, putative | 0.0052 | 0.0678 | 0.108 |
Echinococcus multilocularis | V type proton ATPase 116 kDa subunit a | 0.0042 | 0.0429 | 0.0429 |
Leishmania major | vacuolar proton translocating ATPase subunit A, putative | 0.0042 | 0.0429 | 0.0273 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0066 | 0.1007 | 0.2942 |
Plasmodium vivax | ATP synthase subunit beta, mitochondrial, putative | 0.0052 | 0.0678 | 0.108 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0032 | 0.0206 | 0.0206 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.0066 | 0.1007 | 0.1007 |
Treponema pallidum | V-type ATP synthase subunit B | 0.017 | 0.3424 | 1 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0066 | 0.1007 | 0.2942 |
Schistosoma mansoni | proliferating cell nuclear antigen | 0.0038 | 0.0345 | 0.1009 |
Brugia malayi | V-type ATPase 116kDa subunit family protein | 0.0042 | 0.0429 | 0.1254 |
Echinococcus multilocularis | proliferating cell nuclear antigen | 0.0038 | 0.0345 | 0.0345 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ka(T4) (binding) | = 0.3 % | Ability of the compound to displace L-[125I]-thyoxine from the high affinity prealbumin binding site was expressed as ratio of its apparent association constant to that of DL-thyroxine | ChEMBL. | 7108895 |
Ka(T4) (binding) | = 0.3 % | Ability of the compound to displace L-[125I]-thyoxine from the high affinity prealbumin binding site was expressed as ratio of its apparent association constant to that of DL-thyroxine | ChEMBL. | 7108895 |
pKa | = 9.99 | pKa for compound was evaluated | ChEMBL. | 3336030 |
RBA (binding) | = 0.07 % | Binding affinity to thyroxine binding globulin (unknown origin) relative to T4 | ChEMBL. | 195056 |
Relative ED50 (functional) | = 0.45 | Thyromimetic activity (induction of GPDH) in rat heart expressed as percentage of ratio of the ED50 for T3 | ChEMBL. | 3336030 |
Relative ED50 (functional) | = 1.1 | Thyromimetic activity (induction of GPDH) in rat liver expressed as percentage of ratio of the ED50 for T3 | ChEMBL. | 3336030 |
Relative IC50 (binding) | = 0.08 | Relative binding affinity for T3 thyroid hormone nuclear receptor in rat liver, expressed as percent ratio of IC50 comapred to T3 | ChEMBL. | 3336030 |
Relative IC50 (binding) | = 0.4 | Relative binding affinity towards T3 nuclear receptor in rat heart, expressed as percent ratio of IC50 for T3 to that of compound | ChEMBL. | 3336030 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.